Приказ основних података о документу
Serum uric acid, triglycerides and total bilirubin are associated with Hepatic Steatosis Index in adolescent population
Serumske vrednosti mokraćne kiseline, triglicerida i ukupnog bilirubina su povezane sa Indeksom masne jetre u adolescentnoj populaciji
dc.creator | Klisić, Aleksandra | |
dc.creator | Kavarić, Nebojša | |
dc.creator | Ninić, Ana | |
dc.date.accessioned | 2024-03-26T12:54:40Z | |
dc.date.available | 2024-03-26T12:54:40Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2466-3247 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/5570 | |
dc.description.abstract | Objective: Given the fact that pathophysiological background of non-alcoholic fatty liver disease is not completely elucidated, we aimed to explore the relationship between dyslipidemia, inflammation and oxidative stress with hepatic steatosis index (HSI) in the cohort of adolescent population in Montenegro. Patients and Methods: A total of 136 adolescents participated in this cross-sectional study. Anthropometric and biochemical markers were provided. HSI was calculated. Associations of biochemical parameters with HSI were tested using univariable and multivariable ordinal regression analysis for HSI tertiles as dependent variable. Results: Adjusted odds for uric acid (OR=2.641, P=0.007) and for triglycerides, (OR=5.275, P=0.008) showed their highly significant positive associations with HSI. On the contrary, adjusted odds for bilirubin (OR=0.923, P=0.015), indicated its significant negative independent association with HSI. Although C-reactive protein correlated positively with HSI in univariable analysis (OR=1.962, P<0.001), it lost its independent prediction for HSI in multivariable analysis (OR=1.442, P=0.130). Conclusion: Serum uric acid, triglycerides and total bilirubin are associated with HSI in adolescents. Longitudinal studies are needed to confirm the causal relationship between mentioned biomarkers and hepatic steatosis and to further explore its diagnostic potential in NAFLD in young population. | sr |
dc.description.abstract | Cilj: S obzirom na činjenicu da patofiziološki aspekt nealkoholne steatoze jetre nije u potpunosti razjašnjen, cilj studije je bio da se ispita povezanost dislipidemije, inflamacije i oksidativnog stresa sa Indeksom masne jetre (IMJ) u kohorti adolescentne populacije u Crnoj Gori. Pacijenti i Metode: Ukupno 136 adolescenata je učestvovalo u studiji preseka. Antropometrijski i biohemijski marker su mereni. IMJ je izračunat. Povezanost biohemijskih parametara sa IMJ ispitana je univarijantnom i multivarijantnom ordinalnom regresionom analizom, sa tercilnim vrednostima IMJ kao zavisnom varijablom. Rezultati: Prilagođene odds vrednosti za mokraćnu kiselinu (OR=2,641, P=0,007) i trigliceride (OR=5,275, P=0,008) pokazali su visoko značajnu pozitivnu povezanost sa IMJ. Suprotno tome, prilagođene odds vrednosti za bilirubin (OR=0,923, P=0,015) pokazale su značajnu negativnu povezanost sa IMJ. Premda su vrednosti C- reaktivnog proteina pozitivno korelirale sa IMJ u univarijantnoj (OR=1,962, P<0,001), isti je izgubio nezavisnu predikciju za IMJ u multivarijantnoj analizi (OR=1,442, P=0,130). Zaključak: Serumske vrednosti mokraćne kiseline, triglicerida i ukupnog bilirubina su povezane sa IMJ u adolescenata. Longitudinalne studije su potrebne da potvrde uzročnu povezanost između pomenutih biomarkera i steatoze jetre, kao i da dalje ispitaju njihov dijagnostički potencijal za ovo oboljenje u mlađoj populaciji. | sr |
dc.language.iso | sr | sr |
dc.language.iso | en | sr |
dc.publisher | Udruženje preventivne pedijatrije Srbije | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | sr |
dc.rights | openAccess | sr |
dc.source | Preventivna pedijatrija | sr |
dc.subject | dyslipidemia | sr |
dc.subject | inflammation | sr |
dc.subject | hepatic steatosis | sr |
dc.subject | oxidative stress | sr |
dc.subject | dislipidemija | sr |
dc.subject | inflamacija | sr |
dc.subject | steatoza jetre | sr |
dc.subject | oksidativni stres | sr |
dc.title | Serum uric acid, triglycerides and total bilirubin are associated with Hepatic Steatosis Index in adolescent population | sr |
dc.title | Serumske vrednosti mokraćne kiseline, triglicerida i ukupnog bilirubina su povezane sa Indeksom masne jetre u adolescentnoj populaciji | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.citation.volume | 6 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 71 | |
dc.citation.epage | 76 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/15724/Serum_uric_acid_pub_2020.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_5570 | |
dc.type.version | publishedVersion | sr |