Modification of selectively acid-etched halloysite by mucoadhesive chitosan derivatives: New bionanocomposites with improved functional properties
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2024
Authors
Jauković, ValentinaČalija, Bojan
Ivković, Branka
Khutoryanskiy, Vitaliy V.
Abu Elella, Mahmoud H.
Kurćubić, Ivana
Medarević, Đorđe
Stojanović, Jovica
Damjanović, Ana
Krajišnik, Danina
Article (Published version)
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In this study, the modification of selectively acid-etched halloysite (eHal) by low molecular weight chitosan (LChi) and its methacrylated derivative (MeLChi) is investigated to form new bionanocomposites with improved functional properties. The formation of nanocomposites was confirmed by various instrumental techniques (ζ-potential measurements, SEM, FT-IR, DSC, XRD and 1H NMR). Both nanocomposites exhibited improved functional properties while preserving the tubular structure of halloysite. The cytotoxic activity of eHal and eHal-polycation nanocomposites against normal human lung fibroblasts (MRC5) was determined using MTT assay. The results showed good biocompatibility of the prepared nanocomposites, with a cell survival rate of more than 90 %. The mucoadhesive properties of eHal and the corresponding chitosan nanocomposites were investigated in vitro. Primarily, ζ-potential measurements revealed electrostatic interactions between the eHal-polycation nanocomposites and mucin. The ...absorption study showed that the eHal-MeLChi nanocomposites could adsorb a greater amount of mucin (≈82 %) than the eHal-LChi nanocomposites (≈72 %) and eHal (≈58 %) after 8 h of incubation. Furthermore, the compacts of the tested samples were prepared by direct compression, and the detachment force against the mucin compact was measured using a texture analyzer. A significantly higher detachment force of the eHal-MeLChi nanocomposite compact (1.59 ± 0.07 N) from the mucin compact was determined compared to the eHal-LChi (1.35 ± 0.08 N) and eHal (0.98 ± 0.08 N) samples, demonstrating their improved mucoadhesive potential. In summary, this study demonstrates that functionalization of eHal with MeLChi may be a useful approach for the preparation of nanocomposites as potential carriers for mucoadhesive dosage forms.
Keywords:
Acid-etched / Chitosan / Halloysite / Methacrylated chitosan / Mucoadhesive propertiesSource:
Materials Chemistry and Physics, 2024, 325Publisher:
- Elsevier Ltd.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
- AniNutBiomedCLAYs - Composite clays as advanced materials in animal nutrition and biomedicine (RS-ScienceFundRS-Ideje-7748088)
DOI: 10.1016/j.matchemphys.2024.129756
ISSN: 0254-0584
Scopus: 2-s2.0-85199336751
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PharmacyTY - JOUR AU - Jauković, Valentina AU - Čalija, Bojan AU - Ivković, Branka AU - Khutoryanskiy, Vitaliy V. AU - Abu Elella, Mahmoud H. AU - Kurćubić, Ivana AU - Medarević, Đorđe AU - Stojanović, Jovica AU - Damjanović, Ana AU - Krajišnik, Danina PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5713 AB - In this study, the modification of selectively acid-etched halloysite (eHal) by low molecular weight chitosan (LChi) and its methacrylated derivative (MeLChi) is investigated to form new bionanocomposites with improved functional properties. The formation of nanocomposites was confirmed by various instrumental techniques (ζ-potential measurements, SEM, FT-IR, DSC, XRD and 1H NMR). Both nanocomposites exhibited improved functional properties while preserving the tubular structure of halloysite. The cytotoxic activity of eHal and eHal-polycation nanocomposites against normal human lung fibroblasts (MRC5) was determined using MTT assay. The results showed good biocompatibility of the prepared nanocomposites, with a cell survival rate of more than 90 %. The mucoadhesive properties of eHal and the corresponding chitosan nanocomposites were investigated in vitro. Primarily, ζ-potential measurements revealed electrostatic interactions between the eHal-polycation nanocomposites and mucin. The absorption study showed that the eHal-MeLChi nanocomposites could adsorb a greater amount of mucin (≈82 %) than the eHal-LChi nanocomposites (≈72 %) and eHal (≈58 %) after 8 h of incubation. Furthermore, the compacts of the tested samples were prepared by direct compression, and the detachment force against the mucin compact was measured using a texture analyzer. A significantly higher detachment force of the eHal-MeLChi nanocomposite compact (1.59 ± 0.07 N) from the mucin compact was determined compared to the eHal-LChi (1.35 ± 0.08 N) and eHal (0.98 ± 0.08 N) samples, demonstrating their improved mucoadhesive potential. In summary, this study demonstrates that functionalization of eHal with MeLChi may be a useful approach for the preparation of nanocomposites as potential carriers for mucoadhesive dosage forms. PB - Elsevier Ltd. T2 - Materials Chemistry and Physics T1 - Modification of selectively acid-etched halloysite by mucoadhesive chitosan derivatives: New bionanocomposites with improved functional properties VL - 325 DO - 10.1016/j.matchemphys.2024.129756 ER -
@article{ author = "Jauković, Valentina and Čalija, Bojan and Ivković, Branka and Khutoryanskiy, Vitaliy V. and Abu Elella, Mahmoud H. and Kurćubić, Ivana and Medarević, Đorđe and Stojanović, Jovica and Damjanović, Ana and Krajišnik, Danina", year = "2024", abstract = "In this study, the modification of selectively acid-etched halloysite (eHal) by low molecular weight chitosan (LChi) and its methacrylated derivative (MeLChi) is investigated to form new bionanocomposites with improved functional properties. The formation of nanocomposites was confirmed by various instrumental techniques (ζ-potential measurements, SEM, FT-IR, DSC, XRD and 1H NMR). Both nanocomposites exhibited improved functional properties while preserving the tubular structure of halloysite. The cytotoxic activity of eHal and eHal-polycation nanocomposites against normal human lung fibroblasts (MRC5) was determined using MTT assay. The results showed good biocompatibility of the prepared nanocomposites, with a cell survival rate of more than 90 %. The mucoadhesive properties of eHal and the corresponding chitosan nanocomposites were investigated in vitro. Primarily, ζ-potential measurements revealed electrostatic interactions between the eHal-polycation nanocomposites and mucin. The absorption study showed that the eHal-MeLChi nanocomposites could adsorb a greater amount of mucin (≈82 %) than the eHal-LChi nanocomposites (≈72 %) and eHal (≈58 %) after 8 h of incubation. Furthermore, the compacts of the tested samples were prepared by direct compression, and the detachment force against the mucin compact was measured using a texture analyzer. A significantly higher detachment force of the eHal-MeLChi nanocomposite compact (1.59 ± 0.07 N) from the mucin compact was determined compared to the eHal-LChi (1.35 ± 0.08 N) and eHal (0.98 ± 0.08 N) samples, demonstrating their improved mucoadhesive potential. In summary, this study demonstrates that functionalization of eHal with MeLChi may be a useful approach for the preparation of nanocomposites as potential carriers for mucoadhesive dosage forms.", publisher = "Elsevier Ltd.", journal = "Materials Chemistry and Physics", title = "Modification of selectively acid-etched halloysite by mucoadhesive chitosan derivatives: New bionanocomposites with improved functional properties", volume = "325", doi = "10.1016/j.matchemphys.2024.129756" }
Jauković, V., Čalija, B., Ivković, B., Khutoryanskiy, V. V., Abu Elella, M. H., Kurćubić, I., Medarević, Đ., Stojanović, J., Damjanović, A.,& Krajišnik, D.. (2024). Modification of selectively acid-etched halloysite by mucoadhesive chitosan derivatives: New bionanocomposites with improved functional properties. in Materials Chemistry and Physics Elsevier Ltd.., 325. https://doi.org/10.1016/j.matchemphys.2024.129756
Jauković V, Čalija B, Ivković B, Khutoryanskiy VV, Abu Elella MH, Kurćubić I, Medarević Đ, Stojanović J, Damjanović A, Krajišnik D. Modification of selectively acid-etched halloysite by mucoadhesive chitosan derivatives: New bionanocomposites with improved functional properties. in Materials Chemistry and Physics. 2024;325. doi:10.1016/j.matchemphys.2024.129756 .
Jauković, Valentina, Čalija, Bojan, Ivković, Branka, Khutoryanskiy, Vitaliy V., Abu Elella, Mahmoud H., Kurćubić, Ivana, Medarević, Đorđe, Stojanović, Jovica, Damjanović, Ana, Krajišnik, Danina, "Modification of selectively acid-etched halloysite by mucoadhesive chitosan derivatives: New bionanocomposites with improved functional properties" in Materials Chemistry and Physics, 325 (2024), https://doi.org/10.1016/j.matchemphys.2024.129756 . .