Potentiometric and volumetric determination of 6-mercaptopurine
Abstract
Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being determined potentiometrically with sodium hydroxide. The other two methods involve titration with chloramine-T, with potentiometric and visual end-point-detection. All methods afford accurate and reproducible results and can be used for routine assay of 6-mercaptopurine in tablets.
Keywords:
6-mercaptopurine / potentiometric titration / Puri-netholSource:
Mikrochimica Acta, 1990, 100, 1-2, 69-73Publisher:
- Springer-Verlag
Collections
Institution/Community
PharmacyTY - JOUR AU - Nikolić, Kosta AU - Velašević, Ksenija PY - 1990 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/70 AB - Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being determined potentiometrically with sodium hydroxide. The other two methods involve titration with chloramine-T, with potentiometric and visual end-point-detection. All methods afford accurate and reproducible results and can be used for routine assay of 6-mercaptopurine in tablets. PB - Springer-Verlag T2 - Mikrochimica Acta T1 - Potentiometric and volumetric determination of 6-mercaptopurine VL - 100 IS - 1-2 SP - 69 EP - 73 DO - 10.1007/BF01244500 ER -
@article{ author = "Nikolić, Kosta and Velašević, Ksenija", year = "1990", abstract = "Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being determined potentiometrically with sodium hydroxide. The other two methods involve titration with chloramine-T, with potentiometric and visual end-point-detection. All methods afford accurate and reproducible results and can be used for routine assay of 6-mercaptopurine in tablets.", publisher = "Springer-Verlag", journal = "Mikrochimica Acta", title = "Potentiometric and volumetric determination of 6-mercaptopurine", volume = "100", number = "1-2", pages = "69-73", doi = "10.1007/BF01244500" }
Nikolić, K.,& Velašević, K.. (1990). Potentiometric and volumetric determination of 6-mercaptopurine. in Mikrochimica Acta Springer-Verlag., 100(1-2), 69-73. https://doi.org/10.1007/BF01244500
Nikolić K, Velašević K. Potentiometric and volumetric determination of 6-mercaptopurine. in Mikrochimica Acta. 1990;100(1-2):69-73. doi:10.1007/BF01244500 .
Nikolić, Kosta, Velašević, Ksenija, "Potentiometric and volumetric determination of 6-mercaptopurine" in Mikrochimica Acta, 100, no. 1-2 (1990):69-73, https://doi.org/10.1007/BF01244500 . .