Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines
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1990
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Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range.
Ključne reči:
1,4-Benzodiazepine / Acid-base equilibria / Heterogeneous equilibria / Monoprotic base / Two-phase bufferIzvor:
The Analyst, 1990, 115, 4, 383-387Institucija/grupa
PharmacyTY - JOUR AU - Pfendt, Lidija AU - Sladić, Dušan AU - Janjić, T.J AU - Popović, Gordana PY - 1990 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/76 AB - Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range. T2 - The Analyst T1 - Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines VL - 115 IS - 4 SP - 383 EP - 387 DO - 10.1039/an9901500383 ER -
@article{ author = "Pfendt, Lidija and Sladić, Dušan and Janjić, T.J and Popović, Gordana", year = "1990", abstract = "Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range.", journal = "The Analyst", title = "Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines", volume = "115", number = "4", pages = "383-387", doi = "10.1039/an9901500383" }
Pfendt, L., Sladić, D., Janjić, T.J,& Popović, G.. (1990). Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines. in The Analyst, 115(4), 383-387. https://doi.org/10.1039/an9901500383
Pfendt L, Sladić D, Janjić T, Popović G. Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines. in The Analyst. 1990;115(4):383-387. doi:10.1039/an9901500383 .
Pfendt, Lidija, Sladić, Dušan, Janjić, T.J, Popović, Gordana, "Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines" in The Analyst, 115, no. 4 (1990):383-387, https://doi.org/10.1039/an9901500383 . .