Study of antioxidative, anthnflammatory and gastroprotective activities of aqueous extract of herb Cirsium Ligulare boiss. (Asteraceae)
Ispitivanje antioksidativne, antiinflamatorne i gastroprotektivne aktivnosti vodenog ekstrakta herbe Cirsium Ligulare boiss. (Asteraceae)
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Decoction or infusion prepared fronr herb of Cirsiunt ligulare Boiss'
(Asteraceae) is used in folk medicine as tonics. particularly in inflammatory, liver and
stomach diseases. Data on phytochemical and pharmaco-toxicological investigation of
genus Cirsiunt are inadequate,-while there are almost no investigation data related to C
ligulare.
The aim of this study was to estimate antioxidative, anti-inflammatory and
gastroprotective activities of aqueous extract crf C. ligulare herb prepared as 50lo and
l}%decoction. An antioxidative activiry was determined by using the method of DPPH
radical neutralizatiol. Investigations o1'antiinflammatory (model of systemic
inflammatory reaction induced by endotoxin of E. coli and canageenan-induced rat paw
oedema model), as well as gastioprotective (stress-ulcer produced by absolute ethanol)
activities were conducted on adult female Wistar rats that r.vere given the extract per os'
Indomethacin and ranitidine were used as reference drugs ...for evaluation of an antiinflammatory
and an anti-ulcer action, respectively.
The results dernonstrated that the aqueous extract of C. ligulare herb produced
strong untio*iaative activity, diminished body weight loss induced by endotoxin,
significantly reduced .ur.ug..nan-induced paw oedema, and prevented ulcerogenic
action of absolute ethanol. Eoth anti-inflammatory and gastroprotective actions of the
extract tested were comparable to those of the reference drugs'
These resultslustitr, the traditional use of C. ligularehetb and imply the need for
its detailed phytochemicar and pharmacological investigations.
Čaj pripremljen od nadzemnog dela biljke Cirsiunt ligulareBoiss. (Asteraceae) koristi se u narodnoj medicin i za jačanje organizma, posebno kod zapaljenjskih procesa, oboljenja jetre i zma,posebno kod zaparjenskih procesa, stomadnih p.oul.*u. u Iiteratuii ima veoma 'ruro
yT podataka o ;l:f:Z,' [?:il[[: ], #; n: *:]:T^i,, i
"" "i#, a ro d a C i r s i u m, J o k j e s a m a b i,j k a
U ovom radu, izlozeni su rezultati ispitivanja antioksidativne, antiinflamatorne i gastroprotektivne aktivnosti vodenog .krtrakta c tiguioi-r, priprernljenog kao 5% i r0% dekokt' Antioksidativna aktivnost ilpitunu je meto-dom neut ralizacije DppH radikala. Ispitivanje antiinflamatorne (nrodel sistemsk "
-.upurjenske
endotoksinom E' coli i model ieakcrje izazvane karageninom-iz uruuiog edema Sapice pacova) i gastroprotektivne (stres-ulkus izan'an Jpsolutninr etanorom) aktivnosti sprovedeno je na odraslim Zenkama wistar pacova [ojima je ekstrakt primenjivan per os. Kao poredbeni lekovi' korisieni su indom...eturin 1zi procenu antiinflamatornog dejstva) i ranitidin (za procenu gastroprotektivnog Jejstva). Rezultati pokazuju da voJeni ekstrakt c. ligulare ispoljava snaZnu antioksidativnu aktivnost, iu urnanjuje gubitak teresne mase do kojeg dovodi primena endotoksina' da znad'ajno smanju;. lalr"Sapice izazvankarageninom, kao i da spredava ispoljavanje ulce.rogenog o.lrtuu ufiotrrnog etanora. Antiinflamatorno i
i:,'*"ffil*il.::,ffil','J;"ispitivanog .trtlakta uitl ;e upor.aruo sa onim postignutim
Dobijeni rentltati opravdavaju tradicionalnu upotrebu.helbe c. tigutare i ukazuju na potrebu za njenim detaljnijim heinij;k* i farmakotosLi.n ispitivanjima.
Izvor:
Arhiv za farmaciju, 2006, 56, 5, 894-895Izdavač:
- Savez farmaceutskih udruženja Srbije, Beograd
Napomena:
- IV Kongres farmaceuta Srbije sa međunarodnim učešćem, 29. novembar – 2. decembar 2006 godine, Beograd
Institucija/grupa
PharmacyTY - CONF AU - Dobrić, Silva AU - Kukić, Jelena AU - Petrović, Silvana PY - 2006 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/783 AB - Decoction or infusion prepared fronr herb of Cirsiunt ligulare Boiss' (Asteraceae) is used in folk medicine as tonics. particularly in inflammatory, liver and stomach diseases. Data on phytochemical and pharmaco-toxicological investigation of genus Cirsiunt are inadequate,-while there are almost no investigation data related to C ligulare. The aim of this study was to estimate antioxidative, anti-inflammatory and gastroprotective activities of aqueous extract crf C. ligulare herb prepared as 50lo and l}%decoction. An antioxidative activiry was determined by using the method of DPPH radical neutralizatiol. Investigations o1'antiinflammatory (model of systemic inflammatory reaction induced by endotoxin of E. coli and canageenan-induced rat paw oedema model), as well as gastioprotective (stress-ulcer produced by absolute ethanol) activities were conducted on adult female Wistar rats that r.vere given the extract per os' Indomethacin and ranitidine were used as reference drugs for evaluation of an antiinflammatory and an anti-ulcer action, respectively. The results dernonstrated that the aqueous extract of C. ligulare herb produced strong untio*iaative activity, diminished body weight loss induced by endotoxin, significantly reduced .ur.ug..nan-induced paw oedema, and prevented ulcerogenic action of absolute ethanol. Eoth anti-inflammatory and gastroprotective actions of the extract tested were comparable to those of the reference drugs' These resultslustitr, the traditional use of C. ligularehetb and imply the need for its detailed phytochemicar and pharmacological investigations. AB - Čaj pripremljen od nadzemnog dela biljke Cirsiunt ligulareBoiss. (Asteraceae) koristi se u narodnoj medicin i za jačanje organizma, posebno kod zapaljenjskih procesa, oboljenja jetre i zma,posebno kod zaparjenskih procesa, stomadnih p.oul.*u. u Iiteratuii ima veoma 'ruro yT podataka o ;l:f:Z,' [?:il[[: ], #; n: *:]:T^i,, i "" "i#, a ro d a C i r s i u m, J o k j e s a m a b i,j k a U ovom radu, izlozeni su rezultati ispitivanja antioksidativne, antiinflamatorne i gastroprotektivne aktivnosti vodenog .krtrakta c tiguioi-r, priprernljenog kao 5% i r0% dekokt' Antioksidativna aktivnost ilpitunu je meto-dom neut ralizacije DppH radikala. Ispitivanje antiinflamatorne (nrodel sistemsk " -.upurjenske endotoksinom E' coli i model ieakcrje izazvane karageninom-iz uruuiog edema Sapice pacova) i gastroprotektivne (stres-ulkus izan'an Jpsolutninr etanorom) aktivnosti sprovedeno je na odraslim Zenkama wistar pacova [ojima je ekstrakt primenjivan per os. Kao poredbeni lekovi' korisieni su indometurin 1zi procenu antiinflamatornog dejstva) i ranitidin (za procenu gastroprotektivnog Jejstva). Rezultati pokazuju da voJeni ekstrakt c. ligulare ispoljava snaZnu antioksidativnu aktivnost, iu urnanjuje gubitak teresne mase do kojeg dovodi primena endotoksina' da znad'ajno smanju;. lalr"Sapice izazvankarageninom, kao i da spredava ispoljavanje ulce.rogenog o.lrtuu ufiotrrnog etanora. Antiinflamatorno i i:,'*"ffil*il.::,ffil','J;"ispitivanog .trtlakta uitl ;e upor.aruo sa onim postignutim Dobijeni rentltati opravdavaju tradicionalnu upotrebu.helbe c. tigutare i ukazuju na potrebu za njenim detaljnijim heinij;k* i farmakotosLi.n ispitivanjima. PB - Savez farmaceutskih udruženja Srbije, Beograd C3 - Arhiv za farmaciju T1 - Study of antioxidative, anthnflammatory and gastroprotective activities of aqueous extract of herb Cirsium Ligulare boiss. (Asteraceae) T1 - Ispitivanje antioksidativne, antiinflamatorne i gastroprotektivne aktivnosti vodenog ekstrakta herbe Cirsium Ligulare boiss. (Asteraceae) VL - 56 IS - 5 SP - 894 EP - 895 UR - https://hdl.handle.net/21.15107/rcub_farfar_783 ER -
@conference{ author = "Dobrić, Silva and Kukić, Jelena and Petrović, Silvana", year = "2006", abstract = "Decoction or infusion prepared fronr herb of Cirsiunt ligulare Boiss' (Asteraceae) is used in folk medicine as tonics. particularly in inflammatory, liver and stomach diseases. Data on phytochemical and pharmaco-toxicological investigation of genus Cirsiunt are inadequate,-while there are almost no investigation data related to C ligulare. The aim of this study was to estimate antioxidative, anti-inflammatory and gastroprotective activities of aqueous extract crf C. ligulare herb prepared as 50lo and l}%decoction. An antioxidative activiry was determined by using the method of DPPH radical neutralizatiol. Investigations o1'antiinflammatory (model of systemic inflammatory reaction induced by endotoxin of E. coli and canageenan-induced rat paw oedema model), as well as gastioprotective (stress-ulcer produced by absolute ethanol) activities were conducted on adult female Wistar rats that r.vere given the extract per os' Indomethacin and ranitidine were used as reference drugs for evaluation of an antiinflammatory and an anti-ulcer action, respectively. The results dernonstrated that the aqueous extract of C. ligulare herb produced strong untio*iaative activity, diminished body weight loss induced by endotoxin, significantly reduced .ur.ug..nan-induced paw oedema, and prevented ulcerogenic action of absolute ethanol. Eoth anti-inflammatory and gastroprotective actions of the extract tested were comparable to those of the reference drugs' These resultslustitr, the traditional use of C. ligularehetb and imply the need for its detailed phytochemicar and pharmacological investigations., Čaj pripremljen od nadzemnog dela biljke Cirsiunt ligulareBoiss. (Asteraceae) koristi se u narodnoj medicin i za jačanje organizma, posebno kod zapaljenjskih procesa, oboljenja jetre i zma,posebno kod zaparjenskih procesa, stomadnih p.oul.*u. u Iiteratuii ima veoma 'ruro yT podataka o ;l:f:Z,' [?:il[[: ], #; n: *:]:T^i,, i "" "i#, a ro d a C i r s i u m, J o k j e s a m a b i,j k a U ovom radu, izlozeni su rezultati ispitivanja antioksidativne, antiinflamatorne i gastroprotektivne aktivnosti vodenog .krtrakta c tiguioi-r, priprernljenog kao 5% i r0% dekokt' Antioksidativna aktivnost ilpitunu je meto-dom neut ralizacije DppH radikala. Ispitivanje antiinflamatorne (nrodel sistemsk " -.upurjenske endotoksinom E' coli i model ieakcrje izazvane karageninom-iz uruuiog edema Sapice pacova) i gastroprotektivne (stres-ulkus izan'an Jpsolutninr etanorom) aktivnosti sprovedeno je na odraslim Zenkama wistar pacova [ojima je ekstrakt primenjivan per os. Kao poredbeni lekovi' korisieni su indometurin 1zi procenu antiinflamatornog dejstva) i ranitidin (za procenu gastroprotektivnog Jejstva). Rezultati pokazuju da voJeni ekstrakt c. ligulare ispoljava snaZnu antioksidativnu aktivnost, iu urnanjuje gubitak teresne mase do kojeg dovodi primena endotoksina' da znad'ajno smanju;. lalr"Sapice izazvankarageninom, kao i da spredava ispoljavanje ulce.rogenog o.lrtuu ufiotrrnog etanora. Antiinflamatorno i i:,'*"ffil*il.::,ffil','J;"ispitivanog .trtlakta uitl ;e upor.aruo sa onim postignutim Dobijeni rentltati opravdavaju tradicionalnu upotrebu.helbe c. tigutare i ukazuju na potrebu za njenim detaljnijim heinij;k* i farmakotosLi.n ispitivanjima.", publisher = "Savez farmaceutskih udruženja Srbije, Beograd", journal = "Arhiv za farmaciju", title = "Study of antioxidative, anthnflammatory and gastroprotective activities of aqueous extract of herb Cirsium Ligulare boiss. (Asteraceae), Ispitivanje antioksidativne, antiinflamatorne i gastroprotektivne aktivnosti vodenog ekstrakta herbe Cirsium Ligulare boiss. (Asteraceae)", volume = "56", number = "5", pages = "894-895", url = "https://hdl.handle.net/21.15107/rcub_farfar_783" }
Dobrić, S., Kukić, J.,& Petrović, S.. (2006). Study of antioxidative, anthnflammatory and gastroprotective activities of aqueous extract of herb Cirsium Ligulare boiss. (Asteraceae). in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije, Beograd., 56(5), 894-895. https://hdl.handle.net/21.15107/rcub_farfar_783
Dobrić S, Kukić J, Petrović S. Study of antioxidative, anthnflammatory and gastroprotective activities of aqueous extract of herb Cirsium Ligulare boiss. (Asteraceae). in Arhiv za farmaciju. 2006;56(5):894-895. https://hdl.handle.net/21.15107/rcub_farfar_783 .
Dobrić, Silva, Kukić, Jelena, Petrović, Silvana, "Study of antioxidative, anthnflammatory and gastroprotective activities of aqueous extract of herb Cirsium Ligulare boiss. (Asteraceae)" in Arhiv za farmaciju, 56, no. 5 (2006):894-895, https://hdl.handle.net/21.15107/rcub_farfar_783 .