Приказ основних података о документу
Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma lentantha
dc.creator | Kundaković, Tatjana | |
dc.creator | Fokialakis, N. | |
dc.creator | Dobrić, Silva | |
dc.creator | Pratsinis, H | |
dc.creator | Kletsas, D | |
dc.creator | Kovačević, Nada | |
dc.creator | Chinou, I | |
dc.date.accessioned | 2019-09-02T11:07:41Z | |
dc.date.available | 2019-09-02T11:07:41Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0944-7113 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/849 | |
dc.description.abstract | The root extracts of Onosma leptanhtha were evaluated for their anti-iflammatory and cytotoxic activities. The cyclohexane extract, which appeared as the most active in both assays, has been further subjected to bioassay-directed fractionation to afford the naphthazarine derivatives: beta,beta-dimethylacrylshikonin (1), isovalerylshikonin (2) and acetylshikonin (3). The evaluation of the anti-inflammatory activity was performed on carrageenan-induced rat paw edema test. All the tested compounds proved to be active, while compound 3 showed the best anti-inflammatory effect. In addition, the cytotoxic activity of the extracts and isolated compounds, was also assayed against L1210 murine lymphoblastic leukemia cell line, and human fibrosarcoma HT-1080 cells. Compound I exhibited remarkable cytotoxic activity (390nM for L1210 cells), which is superior to that of shikonin, which was used as control. | en |
dc.publisher | Elsevier Gmbh, Urban & Fischer Verlag, Jena | |
dc.rights | restrictedAccess | |
dc.source | Phytomedicine | |
dc.subject | Onosma leptantha | en |
dc.subject | naphthazarines | en |
dc.subject | shikonin-derivatives | en |
dc.subject | anti-inflammatory activity | en |
dc.subject | cytotoxicity | en |
dc.title | Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma lentantha | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Кундаковић, Татјана; Клетсас, Д; Пратсинис, Х; Ковачевић, Нада; Цхиноу, И; Фокиалакис, Н.; Добрић, Силва; | |
dc.citation.volume | 13 | |
dc.citation.issue | 4 | |
dc.citation.spage | 290 | |
dc.citation.epage | 294 | |
dc.citation.other | 13(4): 290-294 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000236556000013 | |
dc.identifier.doi | 10.1016/j.phymed.2004.10.009 | |
dc.identifier.pmid | 16492534 | |
dc.identifier.scopus | 2-s2.0-32844466342 | |
dc.type.version | publishedVersion |