Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites
Reversno-fazna tankoslojna hromatografija nekih inhibitora angiotenzin-konvertujućih enzima (ACE) i njihovih aktivnih metabolita
2006
Autori
Odović, JadrankaStojimirović, Biljana
Aleksić, Mirjana
Milojković-Opsenica, Dušanka
Tešić, Živoslav
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The chromatographic behaviour of some ACE inhibitors and their active metabolites was examined under conditions of reversed-phase thin-layer chromatography on RP-18 silica using water-methanol, water-ethanol and water-acetone as binary solvent systems. The relationship between the R M values and the concentration of organic modifier in the mobile phases was linear. It was found that an increase in the content of the organicmodifier in the employed solvent systems led to a decrease of the R M values, i.e., of the retention. Also, the more hydrophobic compounds had a longer retention. Based on regression analysis of the plots, the lipophilicity parameters R M 0 and c 0 were calculated. The chromatographically obtained lipophilicity parameters were correlated with the calculated log P values.
Ispitivano je hromatografsko ponašanje nekih ACE inhibitora i njihovih aktivnih metabolita u uslovima reversno-fazne tankoslojne hromatografije na RP-18 silika-gelu primenom sledećih binarnih sistema rastvarača voda-metanol, voda-etanol i voda-aceton. Utvrđena je linearna zavisnost između RM-vrednosti i koncentracije organskog modifikatora u mobilnoj fazi. Nađeno je da povećanje sadržaja organskog modifikatora u upotrebljenom rastvaraču dovodi do opadanja RM-vrednosti, odnosno do slabljenja retencije. Jača retencija uočena je za hidrofobnije supstance. Na osnovu odgovarajućih regresionih podataka, izračunati su parametri lipofilnosti RM 0 i c0. Hromatografski utvrđeni parametri lipofilnosti korelisani su sa izračunatim log P vrednostima.
Ključne reči:
ACE inhibitors / reversed-phase thin-layer chromatography / lipophilicityIzvor:
Journal of the Serbian Chemical Society, 2006, 71, 6, 621-628Izdavač:
- Srpsko hemijsko društvo, Beograd
DOI: 10.2298/JSC0606621O
ISSN: 0352-5139
WoS: 000240444400007
Scopus: 2-s2.0-33748985335
Institucija/grupa
PharmacyTY - JOUR AU - Odović, Jadranka AU - Stojimirović, Biljana AU - Aleksić, Mirjana AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav PY - 2006 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/877 AB - The chromatographic behaviour of some ACE inhibitors and their active metabolites was examined under conditions of reversed-phase thin-layer chromatography on RP-18 silica using water-methanol, water-ethanol and water-acetone as binary solvent systems. The relationship between the R M values and the concentration of organic modifier in the mobile phases was linear. It was found that an increase in the content of the organicmodifier in the employed solvent systems led to a decrease of the R M values, i.e., of the retention. Also, the more hydrophobic compounds had a longer retention. Based on regression analysis of the plots, the lipophilicity parameters R M 0 and c 0 were calculated. The chromatographically obtained lipophilicity parameters were correlated with the calculated log P values. AB - Ispitivano je hromatografsko ponašanje nekih ACE inhibitora i njihovih aktivnih metabolita u uslovima reversno-fazne tankoslojne hromatografije na RP-18 silika-gelu primenom sledećih binarnih sistema rastvarača voda-metanol, voda-etanol i voda-aceton. Utvrđena je linearna zavisnost između RM-vrednosti i koncentracije organskog modifikatora u mobilnoj fazi. Nađeno je da povećanje sadržaja organskog modifikatora u upotrebljenom rastvaraču dovodi do opadanja RM-vrednosti, odnosno do slabljenja retencije. Jača retencija uočena je za hidrofobnije supstance. Na osnovu odgovarajućih regresionih podataka, izračunati su parametri lipofilnosti RM 0 i c0. Hromatografski utvrđeni parametri lipofilnosti korelisani su sa izračunatim log P vrednostima. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites T1 - Reversno-fazna tankoslojna hromatografija nekih inhibitora angiotenzin-konvertujućih enzima (ACE) i njihovih aktivnih metabolita VL - 71 IS - 6 SP - 621 EP - 628 DO - 10.2298/JSC0606621O ER -
@article{ author = "Odović, Jadranka and Stojimirović, Biljana and Aleksić, Mirjana and Milojković-Opsenica, Dušanka and Tešić, Živoslav", year = "2006", abstract = "The chromatographic behaviour of some ACE inhibitors and their active metabolites was examined under conditions of reversed-phase thin-layer chromatography on RP-18 silica using water-methanol, water-ethanol and water-acetone as binary solvent systems. The relationship between the R M values and the concentration of organic modifier in the mobile phases was linear. It was found that an increase in the content of the organicmodifier in the employed solvent systems led to a decrease of the R M values, i.e., of the retention. Also, the more hydrophobic compounds had a longer retention. Based on regression analysis of the plots, the lipophilicity parameters R M 0 and c 0 were calculated. The chromatographically obtained lipophilicity parameters were correlated with the calculated log P values., Ispitivano je hromatografsko ponašanje nekih ACE inhibitora i njihovih aktivnih metabolita u uslovima reversno-fazne tankoslojne hromatografije na RP-18 silika-gelu primenom sledećih binarnih sistema rastvarača voda-metanol, voda-etanol i voda-aceton. Utvrđena je linearna zavisnost između RM-vrednosti i koncentracije organskog modifikatora u mobilnoj fazi. Nađeno je da povećanje sadržaja organskog modifikatora u upotrebljenom rastvaraču dovodi do opadanja RM-vrednosti, odnosno do slabljenja retencije. Jača retencija uočena je za hidrofobnije supstance. Na osnovu odgovarajućih regresionih podataka, izračunati su parametri lipofilnosti RM 0 i c0. Hromatografski utvrđeni parametri lipofilnosti korelisani su sa izračunatim log P vrednostima.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites, Reversno-fazna tankoslojna hromatografija nekih inhibitora angiotenzin-konvertujućih enzima (ACE) i njihovih aktivnih metabolita", volume = "71", number = "6", pages = "621-628", doi = "10.2298/JSC0606621O" }
Odović, J., Stojimirović, B., Aleksić, M., Milojković-Opsenica, D.,& Tešić, Ž.. (2006). Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 71(6), 621-628. https://doi.org/10.2298/JSC0606621O
Odović J, Stojimirović B, Aleksić M, Milojković-Opsenica D, Tešić Ž. Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites. in Journal of the Serbian Chemical Society. 2006;71(6):621-628. doi:10.2298/JSC0606621O .
Odović, Jadranka, Stojimirović, Biljana, Aleksić, Mirjana, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites" in Journal of the Serbian Chemical Society, 71, no. 6 (2006):621-628, https://doi.org/10.2298/JSC0606621O . .