dc.creator | Pejić, Nataša | |
dc.creator | Blagojević, Slavica | |
dc.creator | Anić, Slobodan | |
dc.creator | Vukojević, Vladana | |
dc.creator | Mijatović, Miroslav D. | |
dc.creator | Ćirić, Jasna S. | |
dc.creator | Marković, Zoran S. | |
dc.creator | Marković, Svetlana D. | |
dc.creator | Kolar-Anić, Ljiljana | |
dc.date.accessioned | 2019-09-02T11:10:02Z | |
dc.date.available | 2019-09-02T11:10:02Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0003-2670 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/942 | |
dc.description.abstract | A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was successfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail. | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142025/RS// | |
dc.rights | restrictedAccess | |
dc.source | Analytica Chimica Acta | |
dc.subject | morphine | en |
dc.subject | Bray-Liebhafsky reaction | en |
dc.subject | quantitative analysis | en |
dc.subject | analyte pulse perturbation | en |
dc.subject | kinetic method | en |
dc.title | Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ћирић, Јасна С.; Марковић, Зоран С.; Мијатовић, Мирослав Д.; Марковић, Светлана Д.; Пејић, Наташа; Колар-Aнић, Љиљана; Aнић, Слободан; Вукојевић, Владана; Благојевић, Славица; | |
dc.citation.volume | 582 | |
dc.citation.issue | 2 | |
dc.citation.spage | 367 | |
dc.citation.epage | 374 | |
dc.citation.other | 582(2): 367-374 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000243665400024 | |
dc.identifier.doi | 10.1016/j.aca.2006.09.026 | |
dc.identifier.pmid | 17386515 | |
dc.identifier.scopus | 2-s2.0-33845672241 | |
dc.type.version | publishedVersion | |