Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil
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2007
Authors
Đorđević, SofijaPetrović, Silvana
Dobrić, Silva
Milenković, Marina
Božić, Dragana
Žižić, Slavica
Kukić, Jelena
Article (Published version)
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The root of Carlina acanthifolia All. (Asteraceae) has been traditionally used in the treatment of various disorders including stomach and skin diseases. We studied antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil, in order to validate some of the ethnopharmacological claims. Antimicrobial activity was tested on 15 bacteria and three strains of fungi using the agar diffusion and broth microdilution methods. In assessing anti-inflammatory activity the carrageenan-induced rat paw oedema test was used, while ethanol-induced stress gastric ulcer test in rats was used in testing anti-ulcer activity. Antioxidant properties were evaluated trough the effect of the essential oil on lipid peroxidation (TBA assay) and its capability of quenching 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals. The oil expressed significant antimicrobial activity, being the most active against Gram (+) bacteria: Streptococcus pyogenes, Enteroco...ccus faecalis, Bacillus subtilis and against Candida albicans. In all applied concentrations, Carlina acanthifolia root essential oil reduced carrageenan-induced rat paw oedema in dose-dependent manner, achieving high degree of anti-inflammatory activity. The effect was comparable with that of indomethacin used as a reference drug. In the ethanol-induced stress gastric ulcer test in rats, it was shown that the tested essential oil produced significant dose-dependent gastroprotective activity. The results also pointed out substantial and dose-dependent antioxidant activity of the investigated essential oil, with carlina oxide as the main antioxidant component.
Keywords:
anti-inflammatory activity / antimicrobial activity / antioxidant activity / anti-ulcer activity / Carlina acanthifolia All. / essential oil / rootSource:
Journal of Ethnopharmacology, 2007, 109, 3, 458-463Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-143012)
DOI: 10.1016/j.jep.2006.08.021
ISSN: 0378-8741
PubMed: 17011148
WoS: 000244089700014
Scopus: 2-s2.0-33846056462
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PharmacyTY - JOUR AU - Đorđević, Sofija AU - Petrović, Silvana AU - Dobrić, Silva AU - Milenković, Marina AU - Božić, Dragana AU - Žižić, Slavica AU - Kukić, Jelena PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/946 AB - The root of Carlina acanthifolia All. (Asteraceae) has been traditionally used in the treatment of various disorders including stomach and skin diseases. We studied antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil, in order to validate some of the ethnopharmacological claims. Antimicrobial activity was tested on 15 bacteria and three strains of fungi using the agar diffusion and broth microdilution methods. In assessing anti-inflammatory activity the carrageenan-induced rat paw oedema test was used, while ethanol-induced stress gastric ulcer test in rats was used in testing anti-ulcer activity. Antioxidant properties were evaluated trough the effect of the essential oil on lipid peroxidation (TBA assay) and its capability of quenching 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals. The oil expressed significant antimicrobial activity, being the most active against Gram (+) bacteria: Streptococcus pyogenes, Enterococcus faecalis, Bacillus subtilis and against Candida albicans. In all applied concentrations, Carlina acanthifolia root essential oil reduced carrageenan-induced rat paw oedema in dose-dependent manner, achieving high degree of anti-inflammatory activity. The effect was comparable with that of indomethacin used as a reference drug. In the ethanol-induced stress gastric ulcer test in rats, it was shown that the tested essential oil produced significant dose-dependent gastroprotective activity. The results also pointed out substantial and dose-dependent antioxidant activity of the investigated essential oil, with carlina oxide as the main antioxidant component. PB - Elsevier Ireland Ltd, Clare T2 - Journal of Ethnopharmacology T1 - Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil VL - 109 IS - 3 SP - 458 EP - 463 DO - 10.1016/j.jep.2006.08.021 ER -
@article{ author = "Đorđević, Sofija and Petrović, Silvana and Dobrić, Silva and Milenković, Marina and Božić, Dragana and Žižić, Slavica and Kukić, Jelena", year = "2007", abstract = "The root of Carlina acanthifolia All. (Asteraceae) has been traditionally used in the treatment of various disorders including stomach and skin diseases. We studied antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil, in order to validate some of the ethnopharmacological claims. Antimicrobial activity was tested on 15 bacteria and three strains of fungi using the agar diffusion and broth microdilution methods. In assessing anti-inflammatory activity the carrageenan-induced rat paw oedema test was used, while ethanol-induced stress gastric ulcer test in rats was used in testing anti-ulcer activity. Antioxidant properties were evaluated trough the effect of the essential oil on lipid peroxidation (TBA assay) and its capability of quenching 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals. The oil expressed significant antimicrobial activity, being the most active against Gram (+) bacteria: Streptococcus pyogenes, Enterococcus faecalis, Bacillus subtilis and against Candida albicans. In all applied concentrations, Carlina acanthifolia root essential oil reduced carrageenan-induced rat paw oedema in dose-dependent manner, achieving high degree of anti-inflammatory activity. The effect was comparable with that of indomethacin used as a reference drug. In the ethanol-induced stress gastric ulcer test in rats, it was shown that the tested essential oil produced significant dose-dependent gastroprotective activity. The results also pointed out substantial and dose-dependent antioxidant activity of the investigated essential oil, with carlina oxide as the main antioxidant component.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Journal of Ethnopharmacology", title = "Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil", volume = "109", number = "3", pages = "458-463", doi = "10.1016/j.jep.2006.08.021" }
Đorđević, S., Petrović, S., Dobrić, S., Milenković, M., Božić, D., Žižić, S.,& Kukić, J.. (2007). Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil. in Journal of Ethnopharmacology Elsevier Ireland Ltd, Clare., 109(3), 458-463. https://doi.org/10.1016/j.jep.2006.08.021
Đorđević S, Petrović S, Dobrić S, Milenković M, Božić D, Žižić S, Kukić J. Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil. in Journal of Ethnopharmacology. 2007;109(3):458-463. doi:10.1016/j.jep.2006.08.021 .
Đorđević, Sofija, Petrović, Silvana, Dobrić, Silva, Milenković, Marina, Božić, Dragana, Žižić, Slavica, Kukić, Jelena, "Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil" in Journal of Ethnopharmacology, 109, no. 3 (2007):458-463, https://doi.org/10.1016/j.jep.2006.08.021 . .
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