Pecarski, D

Link to this page

http://farfar.pharmacy.bg.ac.rs/APP/faces/author.xhtml?author_id=af0020c5-46fa-4f19-a7d1-2cc408e039d1&item_offset=0&project_offset=0&sort_by=dc.date.issued
Authority KeyName Variants
af0020c5-46fa-4f19-a7d1-2cc408e039d1
  • Pecarski, D (1)
Projects
No records found.

Author's Bibliography

Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests

Dragičević, Nina; Krajišnik, Danina; Milić, Jela; Pecarski, D; Jugović, Z

(Bulgarian Academy of Sciences, 2019) 

TY  - JOUR
AU  - Dragičević, Nina
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Pecarski, D
AU  - Jugović, Z
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3283
AB  - The aim of this study was to develop a semisolid formulation containing liposomes loaded with coenzyme Q10 (Q10). Q10-loaded liposome dispersion prepared from non-hydrogenated lecithin and characterized for particle size, polydispersity index (PDI), pH value and Q10-content was incorporated into carbomer gel, and a liposome gel was obtained. Liposome gel and liposome-free gel were analyzed for flow properties by continuous rheology measurements, pH values and Q10-content, 48 h after preparation and after a temperature stress test (1 cycle: 24 h at 4 o C, 24 h at 20±2 o C and 24 h at 40 o C), in order to predict their long-term stability. Liposomes were identified in liposome dispersion and liposome gel by freeze fracture electron microscopy (FFEM), while their particle size, PDI and zeta potential were determined by photon correlation spectroscopy (PCS). Q10-loaded liposomes were of small particle size (125 nm), homogeneous (PDI=0.2) and negatively charged, and their incorporation into the gel did not significantly change (p&0.05) their particle size and PDI. FFEM confirmed liposomes presence in the liposome gel. Liposome and liposome-free gel revealed non-Newtonian, shear-thinning plastic flow behavior. The temperature stress test revealed that temperature changes did not significantly influence (p&0.05) the pH value, while they significantly decreased (p&0.05) Q10-content in gels. Q10 was significantly more stable (p&0.05) in liposome gel than in liposome-free gel. Rheological parameters of liposome-free gel significantly changed, in contrast to the liposome gel. In conclusion, Q10-loaded liposome gel suitable for dermal use was developed, exhibiting high stability even after subjecting to the temperature stress test.
PB  - Bulgarian Academy of Sciences
T2  - Bulgarian Chemical Communications
T1  - Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests
VL  - 51
IS  - 1
SP  - 117
EP  - 124
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3283
ER  - 
@article{
author = "Dragičević, Nina and Krajišnik, Danina and Milić, Jela and Pecarski, D and Jugović, Z",
year = "2019",
abstract = "The aim of this study was to develop a semisolid formulation containing liposomes loaded with coenzyme Q10 (Q10). Q10-loaded liposome dispersion prepared from non-hydrogenated lecithin and characterized for particle size, polydispersity index (PDI), pH value and Q10-content was incorporated into carbomer gel, and a liposome gel was obtained. Liposome gel and liposome-free gel were analyzed for flow properties by continuous rheology measurements, pH values and Q10-content, 48 h after preparation and after a temperature stress test (1 cycle: 24 h at 4 o C, 24 h at 20±2 o C and 24 h at 40 o C), in order to predict their long-term stability. Liposomes were identified in liposome dispersion and liposome gel by freeze fracture electron microscopy (FFEM), while their particle size, PDI and zeta potential were determined by photon correlation spectroscopy (PCS). Q10-loaded liposomes were of small particle size (125 nm), homogeneous (PDI=0.2) and negatively charged, and their incorporation into the gel did not significantly change (p&0.05) their particle size and PDI. FFEM confirmed liposomes presence in the liposome gel. Liposome and liposome-free gel revealed non-Newtonian, shear-thinning plastic flow behavior. The temperature stress test revealed that temperature changes did not significantly influence (p&0.05) the pH value, while they significantly decreased (p&0.05) Q10-content in gels. Q10 was significantly more stable (p&0.05) in liposome gel than in liposome-free gel. Rheological parameters of liposome-free gel significantly changed, in contrast to the liposome gel. In conclusion, Q10-loaded liposome gel suitable for dermal use was developed, exhibiting high stability even after subjecting to the temperature stress test.",
publisher = "Bulgarian Academy of Sciences",
journal = "Bulgarian Chemical Communications",
title = "Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests",
volume = "51",
number = "1",
pages = "117-124",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3283"
}
Dragičević, N., Krajišnik, D., Milić, J., Pecarski, D.,& Jugović, Z.. (2019). Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests. in Bulgarian Chemical Communications
Bulgarian Academy of Sciences., 51(1), 117-124.
https://hdl.handle.net/21.15107/rcub_farfar_3283
Dragičević N, Krajišnik D, Milić J, Pecarski D, Jugović Z. Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests. in Bulgarian Chemical Communications. 2019;51(1):117-124.
https://hdl.handle.net/21.15107/rcub_farfar_3283 .
Dragičević, Nina, Krajišnik, Danina, Milić, Jela, Pecarski, D, Jugović, Z, "Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests" in Bulgarian Chemical Communications, 51, no. 1 (2019):117-124,
https://hdl.handle.net/21.15107/rcub_farfar_3283 .
2