TY  - JOUR
AU  - Ninković, Milica
AU  - Maličević, Živorad
AU  - Jelenković, Ankica V.
AU  - Jovanović, D.M
AU  - Đukić, Mirjana
AU  - Vasiljević, Ivana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/887
AB  - As a part of blood-brain barrier, brain capillaries participate in pathophysiological events during systemic inflammation. We investigated the effects of 7-nitroindazole (7-NI), selective neuronal nitric oxide synthase (NOS) inhibitor, to oxidative status (OS) of brain capillaries. Adult Wistar rats were randomized at groups: control group (CG) (sham operated), sepsis group (GS) (cecal ligation and perforation with inoculation of Escherichia coli (ATCC 25922), 7-NI group (G7-NI), (30 mg/ kg b/w i. p.) and 7-NI + sepsis group (G7-NIS), (7-NI was applied 30 minutes before operation). Lipid peroxidation index (LPI), nitrite concentration, superoxide dismutase (SOD) activity and superoxide anion (O2*-) content were determined 3, 6, 24 and 48 hour in each group. Cerebral capillaries were separated from non-vascular brain tissue using sucrose gradient. Compared to controls, LPI, nitrite and O2*- increased at SG. In the G7-NIS, LPI reached control values at the 24th and 48th hour, while nitrite were decreased at the 3rd and 24th hour, compared to controls. In the same group, O2*- decreased at the 3rd, 6th and 24th hour, although SOD showed variable activity. The systematic nNOS inhibition with 7-NI forces OS on early terms of sepsis, but lately it contributes to the normalization of OS in cerebral capillaries.
T2  - Acta Physiologica Hungarica
T1  - Oxidative stress in the rats brain capillaries in sepsis - The influence of 7-nitroindazole
VL  - 93
IS  - 4
SP  - 315
EP  - 323
DO  - 10.1556/APhysiol.93.2006.4.7
ER  - 

@article{
author = "Ninković, Milica and Maličević, Živorad and Jelenković, Ankica V. and Jovanović, D.M and Đukić, Mirjana and Vasiljević, Ivana",
year = "2006",
abstract = "As a part of blood-brain barrier, brain capillaries participate in pathophysiological events during systemic inflammation. We investigated the effects of 7-nitroindazole (7-NI), selective neuronal nitric oxide synthase (NOS) inhibitor, to oxidative status (OS) of brain capillaries. Adult Wistar rats were randomized at groups: control group (CG) (sham operated), sepsis group (GS) (cecal ligation and perforation with inoculation of Escherichia coli (ATCC 25922), 7-NI group (G7-NI), (30 mg/ kg b/w i. p.) and 7-NI + sepsis group (G7-NIS), (7-NI was applied 30 minutes before operation). Lipid peroxidation index (LPI), nitrite concentration, superoxide dismutase (SOD) activity and superoxide anion (O2*-) content were determined 3, 6, 24 and 48 hour in each group. Cerebral capillaries were separated from non-vascular brain tissue using sucrose gradient. Compared to controls, LPI, nitrite and O2*- increased at SG. In the G7-NIS, LPI reached control values at the 24th and 48th hour, while nitrite were decreased at the 3rd and 24th hour, compared to controls. In the same group, O2*- decreased at the 3rd, 6th and 24th hour, although SOD showed variable activity. The systematic nNOS inhibition with 7-NI forces OS on early terms of sepsis, but lately it contributes to the normalization of OS in cerebral capillaries.",
journal = "Acta Physiologica Hungarica",
title = "Oxidative stress in the rats brain capillaries in sepsis - The influence of 7-nitroindazole",
volume = "93",
number = "4",
pages = "315-323",
doi = "10.1556/APhysiol.93.2006.4.7"
}

Ninković, M., Maličević, Ž., Jelenković, A. V., Jovanović, D.M, Đukić, M.,& Vasiljević, I.. (2006). Oxidative stress in the rats brain capillaries in sepsis - The influence of 7-nitroindazole. in Acta Physiologica Hungarica, 93(4), 315-323.
https://doi.org/10.1556/APhysiol.93.2006.4.7

Ninković M, Maličević Ž, Jelenković AV, Jovanović D, Đukić M, Vasiljević I. Oxidative stress in the rats brain capillaries in sepsis - The influence of 7-nitroindazole. in Acta Physiologica Hungarica. 2006;93(4):315-323.
doi:10.1556/APhysiol.93.2006.4.7 .

Ninković, Milica, Maličević, Živorad, Jelenković, Ankica V., Jovanović, D.M, Đukić, Mirjana, Vasiljević, Ivana, "Oxidative stress in the rats brain capillaries in sepsis - The influence of 7-nitroindazole" in Acta Physiologica Hungarica, 93, no. 4 (2006):315-323,
https://doi.org/10.1556/APhysiol.93.2006.4.7 . .