TY  - JOUR
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Perić, M.
AU  - Nežić, D.
AU  - Đukanović, B.
AU  - Lešić, A.
AU  - Bumbaširević, M.
AU  - Marković-Lipkovski, Jasmina
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/871
AB  - Resveratrol, a polyphenol present in wine, has been thought to be responsible for cardiovascular benefits associated with moderate wine consumption. It is also present in the plant Polygonum Cuspidatum. The mechanism of cardiovascular benefits probably includes vasorelaxation, antioxidant and anti-platelet effects of resveratrol. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanism(s) of resveratrol induced vasorelaxation in human internal mammary artery (HIMA) with endothelium. HIMA rings were precontracted by phenylephrine. Resveratrol induced relaxation of the HIMA rings with endothelium. LNAME, an inhibitor of NO synthase, and methylene blue, an inhibitor of guanylate cyclase, abolished relaxation of HIMA induced by resveratrol. Highly selective blocker of ATP-sensitive K channels, glibenclamide as well as a nonselective blocker of big Ca-sensitive K+ channels, charybdotoxin did not block resveratrol-induced relaxation of HIMA. 4-Aminopyridine and margatoxin, blockers of voltage-gated K+ (KV) channels, abolished endothelium-dependent relaxation of HIMA, induced by resveratrol. In conclusion, we have shown that resveratrol induces relaxation of HIMA with endothelium. It seems that NO and smooth muscle KV channels are included in this relaxation.
AB  - Smatra se da rezveratrol kao jedna polifenolna komponenta prisutna u značajnim količinama u crnom vinu, smanjuje rizik od razvoja ateroskleroze i koronarne bolesti. U mehanizam kardioprotektivnog delovanja verovatno su uključ eni antioksidativno, antitrombocitno i vazodilatatorno delovanje rezveratrola. Mehanizam vazodilatacije još uvek nije poznat, pa je cilj ovog rada bio da se ispitaju efekti i mehanizam vazorelaksantnog delovanja rezveratrola na humanoj unutraš njoj torakalnoj arteriji sa endotelom. Unutrašnja torakalna arterija je prekontrahovana fenilefrinom. Rezveratrol je koncentracijski-zavisno relaksirao unutrašnju torakalnu arteriju čoveka. L-NAME, inhibitor NO sintaze, i metilensko plavo, inhibitor solubilne gvanilat ciklaze, su antagonizovali relaksaciju unutrašnje torakalne arterije sa intaktnim endotelom, prouzrokovanu rezveratrolom. Visoko selektivni blokator ATP-senzitivnih K+ kanala, glibenklamid, kao i neselektivni blokator velikih Ca-senzitivnih K+ kanala, karibdotoksin nisu antagonizovali rezveratrolom indukovanu relaksaciju unutrašnje torakalne arterije. 4-Aminopiridin i margatoksin, blokatori voltažnih K+ kanala su antagonizovali relaksaciju prouzrokovanu rezveratrolom. Na osnovu ovih činjenica se može zaključiti da je endotel-zavisna relaksacija unutrašnje torakalne arterije čoveka, prouzrokovana rezveratrolom, verovatno posredovana NO. Izgleda, da su 4-aminopiriin- i margatoksin-senzitivni K-kanali smešteni u membrani vaskularnih glatko-mišićnih ćelija humane unutrašnje torakalne arterije, uključeni u mehanizam endotel-zavisne relaksacije prouzrokovane rezveratrolom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Endothelium-dependent relaxation of internal mammary artery produced by resveratrol
T1  - Endotel-zavisna relaksacija unutrašnje torakalne arterije prouzrokovana rezveratrolom
VL  - 56
IS  - 2-3
SP  - 203
EP  - 213
DO  - 10.2298/AVB0603203N
ER  - 

@article{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Perić, M. and Nežić, D. and Đukanović, B. and Lešić, A. and Bumbaširević, M. and Marković-Lipkovski, Jasmina",
year = "2006",
abstract = "Resveratrol, a polyphenol present in wine, has been thought to be responsible for cardiovascular benefits associated with moderate wine consumption. It is also present in the plant Polygonum Cuspidatum. The mechanism of cardiovascular benefits probably includes vasorelaxation, antioxidant and anti-platelet effects of resveratrol. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanism(s) of resveratrol induced vasorelaxation in human internal mammary artery (HIMA) with endothelium. HIMA rings were precontracted by phenylephrine. Resveratrol induced relaxation of the HIMA rings with endothelium. LNAME, an inhibitor of NO synthase, and methylene blue, an inhibitor of guanylate cyclase, abolished relaxation of HIMA induced by resveratrol. Highly selective blocker of ATP-sensitive K channels, glibenclamide as well as a nonselective blocker of big Ca-sensitive K+ channels, charybdotoxin did not block resveratrol-induced relaxation of HIMA. 4-Aminopyridine and margatoxin, blockers of voltage-gated K+ (KV) channels, abolished endothelium-dependent relaxation of HIMA, induced by resveratrol. In conclusion, we have shown that resveratrol induces relaxation of HIMA with endothelium. It seems that NO and smooth muscle KV channels are included in this relaxation., Smatra se da rezveratrol kao jedna polifenolna komponenta prisutna u značajnim količinama u crnom vinu, smanjuje rizik od razvoja ateroskleroze i koronarne bolesti. U mehanizam kardioprotektivnog delovanja verovatno su uključ eni antioksidativno, antitrombocitno i vazodilatatorno delovanje rezveratrola. Mehanizam vazodilatacije još uvek nije poznat, pa je cilj ovog rada bio da se ispitaju efekti i mehanizam vazorelaksantnog delovanja rezveratrola na humanoj unutraš njoj torakalnoj arteriji sa endotelom. Unutrašnja torakalna arterija je prekontrahovana fenilefrinom. Rezveratrol je koncentracijski-zavisno relaksirao unutrašnju torakalnu arteriju čoveka. L-NAME, inhibitor NO sintaze, i metilensko plavo, inhibitor solubilne gvanilat ciklaze, su antagonizovali relaksaciju unutrašnje torakalne arterije sa intaktnim endotelom, prouzrokovanu rezveratrolom. Visoko selektivni blokator ATP-senzitivnih K+ kanala, glibenklamid, kao i neselektivni blokator velikih Ca-senzitivnih K+ kanala, karibdotoksin nisu antagonizovali rezveratrolom indukovanu relaksaciju unutrašnje torakalne arterije. 4-Aminopiridin i margatoksin, blokatori voltažnih K+ kanala su antagonizovali relaksaciju prouzrokovanu rezveratrolom. Na osnovu ovih činjenica se može zaključiti da je endotel-zavisna relaksacija unutrašnje torakalne arterije čoveka, prouzrokovana rezveratrolom, verovatno posredovana NO. Izgleda, da su 4-aminopiriin- i margatoksin-senzitivni K-kanali smešteni u membrani vaskularnih glatko-mišićnih ćelija humane unutrašnje torakalne arterije, uključeni u mehanizam endotel-zavisne relaksacije prouzrokovane rezveratrolom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Endothelium-dependent relaxation of internal mammary artery produced by resveratrol, Endotel-zavisna relaksacija unutrašnje torakalne arterije prouzrokovana rezveratrolom",
volume = "56",
number = "2-3",
pages = "203-213",
doi = "10.2298/AVB0603203N"
}

Novaković, A., Gojković-Bukarica, L., Perić, M., Nežić, D., Đukanović, B., Lešić, A., Bumbaširević, M.,& Marković-Lipkovski, J.. (2006). Endothelium-dependent relaxation of internal mammary artery produced by resveratrol. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 56(2-3), 203-213.
https://doi.org/10.2298/AVB0603203N

Novaković A, Gojković-Bukarica L, Perić M, Nežić D, Đukanović B, Lešić A, Bumbaširević M, Marković-Lipkovski J. Endothelium-dependent relaxation of internal mammary artery produced by resveratrol. in Acta veterinaria. 2006;56(2-3):203-213.
doi:10.2298/AVB0603203N .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Perić, M., Nežić, D., Đukanović, B., Lešić, A., Bumbaširević, M., Marković-Lipkovski, Jasmina, "Endothelium-dependent relaxation of internal mammary artery produced by resveratrol" in Acta veterinaria, 56, no. 2-3 (2006):203-213,
https://doi.org/10.2298/AVB0603203N . .

TY  - JOUR
AU  - Nežić, D.
AU  - Milojević, Predrag
AU  - Ćirković, M.
AU  - Knežević, A.
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Jović, M.
AU  - Đukanović, B.
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/630
AB  - Coronary artery bypass grafting (CABG) is the standard surgical procedure for the treatment of advanced coronary artery disease. CABG surgery has been demonstrated to improve symptoms and, in specific subgroups of patients, to prolong life. Despite its success, the long-term outcome of coronary bypass surgery is strongly influenced by the fate of the vascular conduits used. Previous long-term studies have shown unsatisfactory patency of saphenous vein grafts used for myocardial revascularisation, compared with internal mammary artery grafts. Recently, the use of radial artery for CABG has enjoyed a revival, on the basis of the belief that it will help improving long-term results of coronary operations. The recent reports of encouraging mid-term and long-term patency rates of the radial artery, supports its continued use as a bypass conduit. In this paper, we review the current knowledge about the radial artery as a bypass graft, with special emphasis on the clinical results.
AB  - Hirurška revaskularizacija miokarda je standardna procedura u tretmanu uznapredovale koronarne bolesti. Dokazano je da koronarna hirurgija uklanja simptome i produžava život određenih kategorija koronarnih bolesnika. Dugotrajni rezultati hirurške revaskularizacije miokarda u velikoj meri ovise o promenama koje se vremenom javljaju na upotrebljenom graftu. Studije dugoročnog praćenja operisanih bolesnika potvrdile su izuzetan kvalitet i prednost grafta unutarnje torakalne arterije u odnosu na venski graft. U skorije vreme obnovljeno je interesovanje za graft radijalne arterije, sa uverenjem da će njegova primena omogućiti bolje dugoročne rezultate. U poslednje vreme prikazani su radovi koji potvrđuju izuzetnu kratkoročnu i dugoročnu prohodnost grafta radijalne arterije i govore u prilog intenzivnije primene toga grafta u hirurškoj revaskularizaciji miokarda. Na prikaz je pregled sadanjih saznanja o radijalnoj arteriji kao graftu u kardiohirurgiji, sa posebnim osvrtom na kliničke rezultate.
PB  - Udruženje hirurga Jugoslavije, Beograd
T2  - Acta chirurgica iugoslavica
T1  - The radial artery for coronary artery bypass grafting
VL  - 52
IS  - 3
SP  - 11
EP  - 19
DO  - 10.2298/ACI0503011N
ER  - 

@article{
author = "Nežić, D. and Milojević, Predrag and Ćirković, M. and Knežević, A. and Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Jović, M. and Đukanović, B.",
year = "2005",
abstract = "Coronary artery bypass grafting (CABG) is the standard surgical procedure for the treatment of advanced coronary artery disease. CABG surgery has been demonstrated to improve symptoms and, in specific subgroups of patients, to prolong life. Despite its success, the long-term outcome of coronary bypass surgery is strongly influenced by the fate of the vascular conduits used. Previous long-term studies have shown unsatisfactory patency of saphenous vein grafts used for myocardial revascularisation, compared with internal mammary artery grafts. Recently, the use of radial artery for CABG has enjoyed a revival, on the basis of the belief that it will help improving long-term results of coronary operations. The recent reports of encouraging mid-term and long-term patency rates of the radial artery, supports its continued use as a bypass conduit. In this paper, we review the current knowledge about the radial artery as a bypass graft, with special emphasis on the clinical results., Hirurška revaskularizacija miokarda je standardna procedura u tretmanu uznapredovale koronarne bolesti. Dokazano je da koronarna hirurgija uklanja simptome i produžava život određenih kategorija koronarnih bolesnika. Dugotrajni rezultati hirurške revaskularizacije miokarda u velikoj meri ovise o promenama koje se vremenom javljaju na upotrebljenom graftu. Studije dugoročnog praćenja operisanih bolesnika potvrdile su izuzetan kvalitet i prednost grafta unutarnje torakalne arterije u odnosu na venski graft. U skorije vreme obnovljeno je interesovanje za graft radijalne arterije, sa uverenjem da će njegova primena omogućiti bolje dugoročne rezultate. U poslednje vreme prikazani su radovi koji potvrđuju izuzetnu kratkoročnu i dugoročnu prohodnost grafta radijalne arterije i govore u prilog intenzivnije primene toga grafta u hirurškoj revaskularizaciji miokarda. Na prikaz je pregled sadanjih saznanja o radijalnoj arteriji kao graftu u kardiohirurgiji, sa posebnim osvrtom na kliničke rezultate.",
publisher = "Udruženje hirurga Jugoslavije, Beograd",
journal = "Acta chirurgica iugoslavica",
title = "The radial artery for coronary artery bypass grafting",
volume = "52",
number = "3",
pages = "11-19",
doi = "10.2298/ACI0503011N"
}

Nežić, D., Milojević, P., Ćirković, M., Knežević, A., Novaković, A., Gojković-Bukarica, L., Jović, M.,& Đukanović, B.. (2005). The radial artery for coronary artery bypass grafting. in Acta chirurgica iugoslavica
Udruženje hirurga Jugoslavije, Beograd., 52(3), 11-19.
https://doi.org/10.2298/ACI0503011N

Nežić D, Milojević P, Ćirković M, Knežević A, Novaković A, Gojković-Bukarica L, Jović M, Đukanović B. The radial artery for coronary artery bypass grafting. in Acta chirurgica iugoslavica. 2005;52(3):11-19.
doi:10.2298/ACI0503011N .

Nežić, D., Milojević, Predrag, Ćirković, M., Knežević, A., Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Jović, M., Đukanović, B., "The radial artery for coronary artery bypass grafting" in Acta chirurgica iugoslavica, 52, no. 3 (2005):11-19,
https://doi.org/10.2298/ACI0503011N . .

TY  - JOUR
AU  - Gojković-Bukarica, Ljiljana
AU  - Kazić, T
AU  - Beleslin Cokić, B
AU  - Novaković, Aleksandra
AU  - Perić, M
AU  - Sajić, Zoran
AU  - Bojić, M
AU  - Đukanović, B
AU  - Kanjuh, Vladimir
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/275
AB  - To investigate whether the antivasoconstrictor effect of P1075, a potassium channel openers, could be partly due to modulation of neurotransmitter release from adrenergic nerve endings we analysed the presynaptic and postsynaptic effects of P1075 on the isolated human saphenous vein (HSV). The HSV rings were contracted by electrical field stimulation (EFS) or by exogenous noradrenaline (10 μM; NA). The repetitive transmural EFS was carried out at 20 Hz with square wave pulses of 0.3 ms duration and supramaximal voltage. The contraction of the HSV in response to transmural EFS recorded in our experiments are neurogenic in nature, as this effect was abolished by tetrodotoxin (1 μM). We have also found that phentolamine (1 μM) inhibited almost completly (90 ″ 2%) the HSV contractions to EFS suggesting that this response was mediated by NA release from perivascular sympathetic nerve endings activating postjuncional α adrenoceptors. P1075 (0.01-10 μM) induced a concentration-dependent inhibition of both neurogenic contractions, and contractions evoked by exogenous NA of the HSV with pEC 50 values of of 6.48 ″ 0.05 and 6.36″ 0.08. The difference between the pEC 50 values (r) was not statistically significant (P > 0.05). These results suggest that the antivasoconstrictor effect of P1075 on the HSV might be postsynaptic, and associated with opening of the smooth muscle potassium channels.
PB  - BMJ Publishing Group
T2  - Heart
T1  - The antivasoconstrictor effect of P1075 on the isolated human saphenous vein
VL  - 83
IS  - SUPPL. 2
UR  - https://hdl.handle.net/21.15107/rcub_farfar_275
ER  - 

@article{
author = "Gojković-Bukarica, Ljiljana and Kazić, T and Beleslin Cokić, B and Novaković, Aleksandra and Perić, M and Sajić, Zoran and Bojić, M and Đukanović, B and Kanjuh, Vladimir",
year = "2000",
abstract = "To investigate whether the antivasoconstrictor effect of P1075, a potassium channel openers, could be partly due to modulation of neurotransmitter release from adrenergic nerve endings we analysed the presynaptic and postsynaptic effects of P1075 on the isolated human saphenous vein (HSV). The HSV rings were contracted by electrical field stimulation (EFS) or by exogenous noradrenaline (10 μM; NA). The repetitive transmural EFS was carried out at 20 Hz with square wave pulses of 0.3 ms duration and supramaximal voltage. The contraction of the HSV in response to transmural EFS recorded in our experiments are neurogenic in nature, as this effect was abolished by tetrodotoxin (1 μM). We have also found that phentolamine (1 μM) inhibited almost completly (90 ″ 2%) the HSV contractions to EFS suggesting that this response was mediated by NA release from perivascular sympathetic nerve endings activating postjuncional α adrenoceptors. P1075 (0.01-10 μM) induced a concentration-dependent inhibition of both neurogenic contractions, and contractions evoked by exogenous NA of the HSV with pEC 50 values of of 6.48 ″ 0.05 and 6.36″ 0.08. The difference between the pEC 50 values (r) was not statistically significant (P > 0.05). These results suggest that the antivasoconstrictor effect of P1075 on the HSV might be postsynaptic, and associated with opening of the smooth muscle potassium channels.",
publisher = "BMJ Publishing Group",
journal = "Heart",
title = "The antivasoconstrictor effect of P1075 on the isolated human saphenous vein",
volume = "83",
number = "SUPPL. 2",
url = "https://hdl.handle.net/21.15107/rcub_farfar_275"
}

Gojković-Bukarica, L., Kazić, T., Beleslin Cokić, B., Novaković, A., Perić, M., Sajić, Z., Bojić, M., Đukanović, B.,& Kanjuh, V.. (2000). The antivasoconstrictor effect of P1075 on the isolated human saphenous vein. in Heart
BMJ Publishing Group., 83(SUPPL. 2).
https://hdl.handle.net/21.15107/rcub_farfar_275

Gojković-Bukarica L, Kazić T, Beleslin Cokić B, Novaković A, Perić M, Sajić Z, Bojić M, Đukanović B, Kanjuh V. The antivasoconstrictor effect of P1075 on the isolated human saphenous vein. in Heart. 2000;83(SUPPL. 2).
https://hdl.handle.net/21.15107/rcub_farfar_275 .

Gojković-Bukarica, Ljiljana, Kazić, T, Beleslin Cokić, B, Novaković, Aleksandra, Perić, M, Sajić, Zoran, Bojić, M, Đukanović, B, Kanjuh, Vladimir, "The antivasoconstrictor effect of P1075 on the isolated human saphenous vein" in Heart, 83, no. SUPPL. 2 (2000),
https://hdl.handle.net/21.15107/rcub_farfar_275 .