TY  - JOUR
AU  - Tulić, Lidija
AU  - Vidaković, Snežana
AU  - Tulić, Ivan
AU  - Ćurčić, Marijana
AU  - Stojnić, Jelena
AU  - Jeremić, Katarina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3009
AB  - Background: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. Methods: This prospective study included 82 patients who under went IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation. Results: Patients were divided into two groups depending on the protocol of stimulation. The mean total and mature oocytes number and number of fertilized oocytes were higher in GnRH agonist group. There was no significant difference in biochemical pregnancy, miscarriage and live -birth rate in both groups. Mean serum SOD was significantly lower, while mean serum MDA and SH groups were significantly higher after ovarian stimulation. Delivery rate was higher in patients without OS while miscarriage rate was higher in patients with OS. Conclusions: Our study confirmed that there is a difference in the concentration of oxidative stress parameters before and after ovarian stimulation. IVF outcome is better in patients without OS after ovarian stimulation. However, the protocol of ovarian stimulation is neither associated with a change in oxidative stress parameters nor with the outcome of ART procedures.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF
VL  - 36
IS  - 2
SP  - 163
EP  - 170
DO  - 10.1515/jomb-2017-0001
ER  - 

@article{
author = "Tulić, Lidija and Vidaković, Snežana and Tulić, Ivan and Ćurčić, Marijana and Stojnić, Jelena and Jeremić, Katarina",
year = "2017",
abstract = "Background: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. Methods: This prospective study included 82 patients who under went IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation. Results: Patients were divided into two groups depending on the protocol of stimulation. The mean total and mature oocytes number and number of fertilized oocytes were higher in GnRH agonist group. There was no significant difference in biochemical pregnancy, miscarriage and live -birth rate in both groups. Mean serum SOD was significantly lower, while mean serum MDA and SH groups were significantly higher after ovarian stimulation. Delivery rate was higher in patients without OS while miscarriage rate was higher in patients with OS. Conclusions: Our study confirmed that there is a difference in the concentration of oxidative stress parameters before and after ovarian stimulation. IVF outcome is better in patients without OS after ovarian stimulation. However, the protocol of ovarian stimulation is neither associated with a change in oxidative stress parameters nor with the outcome of ART procedures.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF",
volume = "36",
number = "2",
pages = "163-170",
doi = "10.1515/jomb-2017-0001"
}

Tulić, L., Vidaković, S., Tulić, I., Ćurčić, M., Stojnić, J.,& Jeremić, K.. (2017). Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(2), 163-170.
https://doi.org/10.1515/jomb-2017-0001

Tulić L, Vidaković S, Tulić I, Ćurčić M, Stojnić J, Jeremić K. Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF. in Journal of Medical Biochemistry. 2017;36(2):163-170.
doi:10.1515/jomb-2017-0001 .

Tulić, Lidija, Vidaković, Snežana, Tulić, Ivan, Ćurčić, Marijana, Stojnić, Jelena, Jeremić, Katarina, "Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF" in Journal of Medical Biochemistry, 36, no. 2 (2017):163-170,
https://doi.org/10.1515/jomb-2017-0001 . .