TY  - JOUR
AU  - Vučićević, Katarina
AU  - Rakonjac, Zorica
AU  - Miljković, Branislava
AU  - Janković, Borisav
AU  - Prostran, Milica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2178
AB  - The purpose of the study was to compare peak (C-peak) and trough (C-trough) amikacin levels after twice-daily (TD) or once-daily dosing (OD) in full-term neonates. Additionally, the study aimed to address amikacin pharmacokinetics and its variability. Data included 31 patients born on term. Amikacin daily dose was 15 or 20 mg/kg depending on the neonate's age. Patients randomly received amikacin every 12 or 24 h. In all patients corresponding C-peak and C-trough were taken. Volume of distribution (Vd), clearance (CL) and half-life (t(1/2)) were calculated. Mean C-peak of 21.79 mu g/ml in the TD group was statistically different from C-peak of 36.39 mu g/ml in the OD group. Average C-trough in TD (5.67 mu g/ml) was statistically different from the corresponding 3.99 mu g/ml in the OD group. Mean amikacin Vd, CL, and tin were 0.78 +/- 0.38 l/kg, 86.99 +/- 48.22 ml/h.kg, and 6.81 +/- 2.51 h, respectively. High interindividual pharmacokinetic variability was observed. Further analysis showed that neonatal age contributed to the pharmacokinetic parameters' values. Statistically significant difference in CL and tin was observed between patients age  lt = 2 and > 2 days on therapy initiation. As expected, amikacin given OD achieved higher C-peak and lower C-trough than TD. Based on the results, observed variability in amikacin pharmacokinetics was possibly due to the renal maturation process.
PB  - Japanese Pharmacological Soc, Kyoto
T2  - Journal of Pharmacological Sciences
T1  - Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates
VL  - 124
IS  - 2
SP  - 138
EP  - 143
DO  - 10.1254/jphs.13126FP
ER  - 

@article{
author = "Vučićević, Katarina and Rakonjac, Zorica and Miljković, Branislava and Janković, Borisav and Prostran, Milica",
year = "2014",
abstract = "The purpose of the study was to compare peak (C-peak) and trough (C-trough) amikacin levels after twice-daily (TD) or once-daily dosing (OD) in full-term neonates. Additionally, the study aimed to address amikacin pharmacokinetics and its variability. Data included 31 patients born on term. Amikacin daily dose was 15 or 20 mg/kg depending on the neonate's age. Patients randomly received amikacin every 12 or 24 h. In all patients corresponding C-peak and C-trough were taken. Volume of distribution (Vd), clearance (CL) and half-life (t(1/2)) were calculated. Mean C-peak of 21.79 mu g/ml in the TD group was statistically different from C-peak of 36.39 mu g/ml in the OD group. Average C-trough in TD (5.67 mu g/ml) was statistically different from the corresponding 3.99 mu g/ml in the OD group. Mean amikacin Vd, CL, and tin were 0.78 +/- 0.38 l/kg, 86.99 +/- 48.22 ml/h.kg, and 6.81 +/- 2.51 h, respectively. High interindividual pharmacokinetic variability was observed. Further analysis showed that neonatal age contributed to the pharmacokinetic parameters' values. Statistically significant difference in CL and tin was observed between patients age  lt = 2 and > 2 days on therapy initiation. As expected, amikacin given OD achieved higher C-peak and lower C-trough than TD. Based on the results, observed variability in amikacin pharmacokinetics was possibly due to the renal maturation process.",
publisher = "Japanese Pharmacological Soc, Kyoto",
journal = "Journal of Pharmacological Sciences",
title = "Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates",
volume = "124",
number = "2",
pages = "138-143",
doi = "10.1254/jphs.13126FP"
}

Vučićević, K., Rakonjac, Z., Miljković, B., Janković, B.,& Prostran, M.. (2014). Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates. in Journal of Pharmacological Sciences
Japanese Pharmacological Soc, Kyoto., 124(2), 138-143.
https://doi.org/10.1254/jphs.13126FP

Vučićević K, Rakonjac Z, Miljković B, Janković B, Prostran M. Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates. in Journal of Pharmacological Sciences. 2014;124(2):138-143.
doi:10.1254/jphs.13126FP .

Vučićević, Katarina, Rakonjac, Zorica, Miljković, Branislava, Janković, Borisav, Prostran, Milica, "Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates" in Journal of Pharmacological Sciences, 124, no. 2 (2014):138-143,
https://doi.org/10.1254/jphs.13126FP . .

TY  - JOUR
AU  - Vučićević, Katarina
AU  - Rakonjac, Zorica
AU  - Janković, Borisav Z.
AU  - Vezmar-Kovačević, Sandra
AU  - Miljković, Branislava
AU  - Prostran, Milica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2089
AB  - Gentamicin is readily used for suspected or proven sepsis in neonates, yet it shows considerable inter-individual pharmacokinetic variability, which limits achievements of therapeutic levels. Hence, the aim of this study was to compare peak and trough gentamicin concentrations according to dosing regimen, to evaluate pharmacokinetic parameters, and to consider adjustments of dosing regimen. Babies with infection were treated with 1 h infusion, and daily dose of 5 or 7.5 mg/kg depending on the age. Patients were randomized into two groups: I - dosing interval 12 h (n=8), II - 24 h (n=11). Two steady-state blood samples were obtained. Pharmacokinetic parameters were calculated using one-compartment model. The results showed a difference (p  lt  0.05) in peak gentamicin concentrations between the groups, and tendency of lower trough levels in the group II. Calculated pharmacokinetic parameters included the volume of distribution (Vd) 0.52 +/- 0.47 l/kg, clearance (CL) 0.055 +/- 0.036 l/hkg and a half-life (t(1/2)) of 6.89 +/- 3.21 h. Based on the method for dosing regimen adjustments, there was a need to extend dosing interval to 36 h in 6 patients.
PB  - De Gruyter Open Ltd, Warsaw
T2  - Central European Journal of Medicine
T1  - Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates
VL  - 9
IS  - 3
SP  - 485
EP  - 490
DO  - 10.2478/s11536-013-0298-7
ER  - 

@article{
author = "Vučićević, Katarina and Rakonjac, Zorica and Janković, Borisav Z. and Vezmar-Kovačević, Sandra and Miljković, Branislava and Prostran, Milica",
year = "2014",
abstract = "Gentamicin is readily used for suspected or proven sepsis in neonates, yet it shows considerable inter-individual pharmacokinetic variability, which limits achievements of therapeutic levels. Hence, the aim of this study was to compare peak and trough gentamicin concentrations according to dosing regimen, to evaluate pharmacokinetic parameters, and to consider adjustments of dosing regimen. Babies with infection were treated with 1 h infusion, and daily dose of 5 or 7.5 mg/kg depending on the age. Patients were randomized into two groups: I - dosing interval 12 h (n=8), II - 24 h (n=11). Two steady-state blood samples were obtained. Pharmacokinetic parameters were calculated using one-compartment model. The results showed a difference (p  lt  0.05) in peak gentamicin concentrations between the groups, and tendency of lower trough levels in the group II. Calculated pharmacokinetic parameters included the volume of distribution (Vd) 0.52 +/- 0.47 l/kg, clearance (CL) 0.055 +/- 0.036 l/hkg and a half-life (t(1/2)) of 6.89 +/- 3.21 h. Based on the method for dosing regimen adjustments, there was a need to extend dosing interval to 36 h in 6 patients.",
publisher = "De Gruyter Open Ltd, Warsaw",
journal = "Central European Journal of Medicine",
title = "Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates",
volume = "9",
number = "3",
pages = "485-490",
doi = "10.2478/s11536-013-0298-7"
}

Vučićević, K., Rakonjac, Z., Janković, B. Z., Vezmar-Kovačević, S., Miljković, B.,& Prostran, M.. (2014). Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates. in Central European Journal of Medicine
De Gruyter Open Ltd, Warsaw., 9(3), 485-490.
https://doi.org/10.2478/s11536-013-0298-7

Vučićević K, Rakonjac Z, Janković BZ, Vezmar-Kovačević S, Miljković B, Prostran M. Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates. in Central European Journal of Medicine. 2014;9(3):485-490.
doi:10.2478/s11536-013-0298-7 .

Vučićević, Katarina, Rakonjac, Zorica, Janković, Borisav Z., Vezmar-Kovačević, Sandra, Miljković, Branislava, Prostran, Milica, "Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates" in Central European Journal of Medicine, 9, no. 3 (2014):485-490,
https://doi.org/10.2478/s11536-013-0298-7 . .