TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, Slavica
AU  - Vučinić-Mihailović, Violeta
AU  - Videnović-Ivanov, Jelica
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3078
AB  - Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.
PB  - Mattioli 1885, Fidenza
T2  - Sarcoidosis Vasculitis and Diffuse Lung Diseases
T1  - Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis
VL  - 35
IS  - 3
SP  - 198
EP  - 205
DO  - 10.36141/svdld.v35i3.6573
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3078
ER  - 

@article{
author = "Ivanišević, Jasmina and Vekić, Jelena and Zeljković, Aleksandra and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Vučinić-Mihailović, Violeta and Videnović-Ivanov, Jelica and Jelić-Ivanović, Zorana",
year = "2018",
abstract = "Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.",
publisher = "Mattioli 1885, Fidenza",
journal = "Sarcoidosis Vasculitis and Diffuse Lung Diseases",
title = "Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis",
volume = "35",
number = "3",
pages = "198-205",
doi = "10.36141/svdld.v35i3.6573",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3078"
}

Ivanišević, J., Vekić, J., Zeljković, A., Stefanović, A., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Spasić, S., Vučinić-Mihailović, V., Videnović-Ivanov, J.,& Jelić-Ivanović, Z.. (2018). Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis. in Sarcoidosis Vasculitis and Diffuse Lung Diseases
Mattioli 1885, Fidenza., 35(3), 198-205.
https://doi.org/10.36141/svdld.v35i3.6573
https://hdl.handle.net/21.15107/rcub_farfar_3078

Ivanišević J, Vekić J, Zeljković A, Stefanović A, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Spasić S, Vučinić-Mihailović V, Videnović-Ivanov J, Jelić-Ivanović Z. Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis. in Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2018;35(3):198-205.
doi:10.36141/svdld.v35i3.6573
https://hdl.handle.net/21.15107/rcub_farfar_3078 .

Ivanišević, Jasmina, Vekić, Jelena, Zeljković, Aleksandra, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Vučinić-Mihailović, Violeta, Videnović-Ivanov, Jelica, Jelić-Ivanović, Zorana, "Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis" in Sarcoidosis Vasculitis and Diffuse Lung Diseases, 35, no. 3 (2018):198-205,
https://doi.org/10.36141/svdld.v35i3.6573 .,
https://hdl.handle.net/21.15107/rcub_farfar_3078 .

TY  - JOUR
AU  - Popević, Spasoje
AU  - Šumarac, Zorica
AU  - Jovanović, Dragana
AU  - Babić, Dragan
AU  - Stjepanović, Mihailo
AU  - Jovičić, Snežana
AU  - Sobić-Saranović, Dragana
AU  - Filipović, Snežana
AU  - Gvozdenović, Branko
AU  - Omcikus, Maja
AU  - Milovanović, Andela
AU  - Videnović-Ivanov, Jelica
AU  - Radović, Ana
AU  - Zugić, Vladimir
AU  - Vučinić-Mihailović, Violeta
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2749
AB  - Background: Until now, a proper biomarker(s) to evaluate sarcoidosis activity has not been recognized. The aims of this study were to evaluate the sensitivity and specificity of the two biomarkers of sarcoidosis activity already in use (serum angiotensin converting enzyme - ACE and serum chitotriosidase) in a population of 430 sarcoidosis patients. The activities of these markers were also analyzed in a group of 264 healthy controls. Methods: Four hundred and thirty biopsy positive sarcoidosis patients were divided into groups with active and inactive disease, and groups with acute or chronic disease. In a subgroup of 55 sarcoidosis patients, activity was also assessed by F-18 fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) scanning. Both serum chitotriosidase and ACE levels showed non-normal distribution, so nonparametric tests were used in statistical analysis. Results: Serum chitotriosidase activities were almost 6 times higher in patients with active sarcoidosis than in healthy controls and inactive disease. A serum chitotriosidase value of 100 nmol/mL/h had the sensitivity of 82.5% and specificity of 70.0%. A serum ACE activity cutoff value of 32.0 U/L had the sensitivity of 66.0% and the specificity of 54%. A statistically significant correlation was obtained between the focal granulomatous activity detected on F-18-FDG PET/CT and serum chitotriosidase levels, but no such correlation was found with ACE. The levels of serum chitotriosidase activity significantly correlated with the disease duration (P lt 0.0001). Also, serum chitotriosidase significantly correlated with clinical outcome status (COS) categories (rho=0.272, P=0.001). Conclusions: Serum chitotriosidase proved to be a reliable biomarker of sarcoidosis activity and disease chronicity.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Verifying Sarcoidosis Activity: Chitotriosidase Versus ACE in Sarcoidosis - A Case-Control Study
VL  - 35
IS  - 4
SP  - 390
EP  - 400
DO  - 10.1515/jomb-2016-0017
ER  - 

@article{
author = "Popević, Spasoje and Šumarac, Zorica and Jovanović, Dragana and Babić, Dragan and Stjepanović, Mihailo and Jovičić, Snežana and Sobić-Saranović, Dragana and Filipović, Snežana and Gvozdenović, Branko and Omcikus, Maja and Milovanović, Andela and Videnović-Ivanov, Jelica and Radović, Ana and Zugić, Vladimir and Vučinić-Mihailović, Violeta",
year = "2016",
abstract = "Background: Until now, a proper biomarker(s) to evaluate sarcoidosis activity has not been recognized. The aims of this study were to evaluate the sensitivity and specificity of the two biomarkers of sarcoidosis activity already in use (serum angiotensin converting enzyme - ACE and serum chitotriosidase) in a population of 430 sarcoidosis patients. The activities of these markers were also analyzed in a group of 264 healthy controls. Methods: Four hundred and thirty biopsy positive sarcoidosis patients were divided into groups with active and inactive disease, and groups with acute or chronic disease. In a subgroup of 55 sarcoidosis patients, activity was also assessed by F-18 fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) scanning. Both serum chitotriosidase and ACE levels showed non-normal distribution, so nonparametric tests were used in statistical analysis. Results: Serum chitotriosidase activities were almost 6 times higher in patients with active sarcoidosis than in healthy controls and inactive disease. A serum chitotriosidase value of 100 nmol/mL/h had the sensitivity of 82.5% and specificity of 70.0%. A serum ACE activity cutoff value of 32.0 U/L had the sensitivity of 66.0% and the specificity of 54%. A statistically significant correlation was obtained between the focal granulomatous activity detected on F-18-FDG PET/CT and serum chitotriosidase levels, but no such correlation was found with ACE. The levels of serum chitotriosidase activity significantly correlated with the disease duration (P lt 0.0001). Also, serum chitotriosidase significantly correlated with clinical outcome status (COS) categories (rho=0.272, P=0.001). Conclusions: Serum chitotriosidase proved to be a reliable biomarker of sarcoidosis activity and disease chronicity.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Verifying Sarcoidosis Activity: Chitotriosidase Versus ACE in Sarcoidosis - A Case-Control Study",
volume = "35",
number = "4",
pages = "390-400",
doi = "10.1515/jomb-2016-0017"
}

Popević, S., Šumarac, Z., Jovanović, D., Babić, D., Stjepanović, M., Jovičić, S., Sobić-Saranović, D., Filipović, S., Gvozdenović, B., Omcikus, M., Milovanović, A., Videnović-Ivanov, J., Radović, A., Zugić, V.,& Vučinić-Mihailović, V.. (2016). Verifying Sarcoidosis Activity: Chitotriosidase Versus ACE in Sarcoidosis - A Case-Control Study. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(4), 390-400.
https://doi.org/10.1515/jomb-2016-0017

Popević S, Šumarac Z, Jovanović D, Babić D, Stjepanović M, Jovičić S, Sobić-Saranović D, Filipović S, Gvozdenović B, Omcikus M, Milovanović A, Videnović-Ivanov J, Radović A, Zugić V, Vučinić-Mihailović V. Verifying Sarcoidosis Activity: Chitotriosidase Versus ACE in Sarcoidosis - A Case-Control Study. in Journal of Medical Biochemistry. 2016;35(4):390-400.
doi:10.1515/jomb-2016-0017 .

Popević, Spasoje, Šumarac, Zorica, Jovanović, Dragana, Babić, Dragan, Stjepanović, Mihailo, Jovičić, Snežana, Sobić-Saranović, Dragana, Filipović, Snežana, Gvozdenović, Branko, Omcikus, Maja, Milovanović, Andela, Videnović-Ivanov, Jelica, Radović, Ana, Zugić, Vladimir, Vučinić-Mihailović, Violeta, "Verifying Sarcoidosis Activity: Chitotriosidase Versus ACE in Sarcoidosis - A Case-Control Study" in Journal of Medical Biochemistry, 35, no. 4 (2016):390-400,
https://doi.org/10.1515/jomb-2016-0017 . .

TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Spasić, Slavica
AU  - Vučinić-Mihailović, Violeta
AU  - Videnović-Ivanov, Jelica
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2594
AB  - Background It has been reported that high-density lipoprotein (HDL) particles have anti-inflammatory and antioxidant roles thanks to different enzymes such as paraoxonase 1 (PON1). Under inflammatory and oxidative stress conditions, HDL particles may lose their protective properties. Sarcoidosis is an inflammatory disease characterized by excessive oxidative stress. Serum amyloid A (SAA) is produced in liver and in granulomas, and its concentration increases in inflammatory conditions contributing to increased catabolism of HDL particles. The aim of our study was to determine PON1 activity, SAA concentration and their associations in patients with sarcoidosis. Materials and methods Inflammatory [high-sensitive C-reactive protein (hsCRP), angiotensin-converting enzyme (ACE), SAA], lipid [total cholesterol (TC), HDL-cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG)] oxidative stress status parameters [total oxidant status (TOS), malondialdehyde (MDA), pro-oxidant-antioxidant balance (PAB), sulfhydryl (SH) groups] and PON1 activities were determined in serum of 72 patients with sarcoidosis and 62 healthy subjects. Results HsCRP (P  lt  0.05), TC, LDL-c, TG, SAA, TOS, MDA and PAB (P  lt  0.001) were significantly higher, whereas HDL-c, SH groups and PON1 activity (P  lt  0.001) were significantly lower in patients with sarcoidosis when compared with controls. PON1 showed significant association with SAA, MDA and PAB. It was shown that 71% of decrease in PON1 activity may be explained by increase in TOS, PAB and SAA concentration. Conclusions We found decreased PON1 activity and increased SAA concentration in patients with sarcoidosis. Inflammatory condition presented by high SAA was implicated in impaired HDL functionality evident through dysregulated PON1 activity. Excessive oxidative stress was also involved in dysregulation of PON1 activity.
PB  - Wiley-Blackwell, Hoboken
T2  - European Journal of Clinical Investigation
T1  - Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients
VL  - 46
IS  - 5
SP  - 418
EP  - 424
DO  - 10.1111/eci.12610
ER  - 

@article{
author = "Ivanišević, Jasmina and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Spasić, Slavica and Vučinić-Mihailović, Violeta and Videnović-Ivanov, Jelica and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background It has been reported that high-density lipoprotein (HDL) particles have anti-inflammatory and antioxidant roles thanks to different enzymes such as paraoxonase 1 (PON1). Under inflammatory and oxidative stress conditions, HDL particles may lose their protective properties. Sarcoidosis is an inflammatory disease characterized by excessive oxidative stress. Serum amyloid A (SAA) is produced in liver and in granulomas, and its concentration increases in inflammatory conditions contributing to increased catabolism of HDL particles. The aim of our study was to determine PON1 activity, SAA concentration and their associations in patients with sarcoidosis. Materials and methods Inflammatory [high-sensitive C-reactive protein (hsCRP), angiotensin-converting enzyme (ACE), SAA], lipid [total cholesterol (TC), HDL-cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG)] oxidative stress status parameters [total oxidant status (TOS), malondialdehyde (MDA), pro-oxidant-antioxidant balance (PAB), sulfhydryl (SH) groups] and PON1 activities were determined in serum of 72 patients with sarcoidosis and 62 healthy subjects. Results HsCRP (P  lt  0.05), TC, LDL-c, TG, SAA, TOS, MDA and PAB (P  lt  0.001) were significantly higher, whereas HDL-c, SH groups and PON1 activity (P  lt  0.001) were significantly lower in patients with sarcoidosis when compared with controls. PON1 showed significant association with SAA, MDA and PAB. It was shown that 71% of decrease in PON1 activity may be explained by increase in TOS, PAB and SAA concentration. Conclusions We found decreased PON1 activity and increased SAA concentration in patients with sarcoidosis. Inflammatory condition presented by high SAA was implicated in impaired HDL functionality evident through dysregulated PON1 activity. Excessive oxidative stress was also involved in dysregulation of PON1 activity.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "European Journal of Clinical Investigation",
title = "Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients",
volume = "46",
number = "5",
pages = "418-424",
doi = "10.1111/eci.12610"
}

Ivanišević, J., Kotur-Stevuljević, J., Stefanović, A., Spasić, S., Vučinić-Mihailović, V., Videnović-Ivanov, J.,& Jelić-Ivanović, Z.. (2016). Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients. in European Journal of Clinical Investigation
Wiley-Blackwell, Hoboken., 46(5), 418-424.
https://doi.org/10.1111/eci.12610

Ivanišević J, Kotur-Stevuljević J, Stefanović A, Spasić S, Vučinić-Mihailović V, Videnović-Ivanov J, Jelić-Ivanović Z. Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients. in European Journal of Clinical Investigation. 2016;46(5):418-424.
doi:10.1111/eci.12610 .

Ivanišević, Jasmina, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Spasić, Slavica, Vučinić-Mihailović, Violeta, Videnović-Ivanov, Jelica, Jelić-Ivanović, Zorana, "Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients" in European Journal of Clinical Investigation, 46, no. 5 (2016):418-424,
https://doi.org/10.1111/eci.12610 . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, Slavica
AU  - Videnović-Ivanov, Jelica
AU  - Ivanišević, Jasmina
AU  - Vučinić-Mihailović, Violeta
AU  - Gojković, Tamara
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1912
AB  - Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P  lt  .001), but more LDL II and III (P  lt  .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size (P  lt  .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.
PB  - Coll Amer Pathologists, Northfield
T2  - Archives of Pathology & Laboratory Medicine
T1  - Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis
VL  - 137
IS  - 12
SP  - 1780
EP  - 1787
DO  - 10.5858/arpa.2012-0299-OA
ER  - 

@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Videnović-Ivanov, Jelica and Ivanišević, Jasmina and Vučinić-Mihailović, Violeta and Gojković, Tamara",
year = "2013",
abstract = "Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P  lt  .001), but more LDL II and III (P  lt  .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size (P  lt  .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.",
publisher = "Coll Amer Pathologists, Northfield",
journal = "Archives of Pathology & Laboratory Medicine",
title = "Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis",
volume = "137",
number = "12",
pages = "1780-1787",
doi = "10.5858/arpa.2012-0299-OA"
}

Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Spasić, S., Videnović-Ivanov, J., Ivanišević, J., Vučinić-Mihailović, V.,& Gojković, T.. (2013). Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis. in Archives of Pathology & Laboratory Medicine
Coll Amer Pathologists, Northfield., 137(12), 1780-1787.
https://doi.org/10.5858/arpa.2012-0299-OA

Vekić J, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Spasić S, Videnović-Ivanov J, Ivanišević J, Vučinić-Mihailović V, Gojković T. Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis. in Archives of Pathology & Laboratory Medicine. 2013;137(12):1780-1787.
doi:10.5858/arpa.2012-0299-OA .

Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Videnović-Ivanov, Jelica, Ivanišević, Jasmina, Vučinić-Mihailović, Violeta, Gojković, Tamara, "Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis" in Archives of Pathology & Laboratory Medicine, 137, no. 12 (2013):1780-1787,
https://doi.org/10.5858/arpa.2012-0299-OA . .

TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
AU  - Videnović-Ivanov, Jelica
AU  - Vučinić-Mihailović, Violeta
AU  - Ilić, Jasmina
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1762
AB  - Objectives: Sarcoidosis is an inflammatory disease characterised by enhanced production of reactive oxygen species and alterations in the circulating lipid profile. Both attributes are thought to play a role in its pathogenesis. However, current knowledge regarding the significance of blood oxidative stress/anti-oxidant defence as well as alterations in lipid status parameters in sarcoidosis is scarce. The aim of our study was to assess these parameters and their inter-relationships, as well as their potential for patient-control discrimination. Design and methods: Oxidative stress status and anti-oxidant defence parameters were determined in serum and erythrocytes and lipid status parameters were assessed in the serum of 213 treated sarcoidosis patients and 90 controls. Results: Malondialdehyde, superoxide anion, total oxidant status, prooxidant-antioxidant balance and triglycerides were significantly higher whereas total anti-oxidant status, superoxide dismutase activity and HDL-cholesterol were significantly lower in sarcoidosis patients compared with controls. Total sulfhydryl group content was higher in patients compared with controls. Serum and erythrocyte malondialdehyde exhibited the strongest ability to predict disease presence. Elevated oxidative stress was characterised by higher clinical accuracy compared with lipid status abnormality. Some oxidative stress and lipid status markers were significantly associated in sarcoidosis. Conclusions: Sarcoidosis is characterised by increased oxidative stress, diminished overall anti-oxidative protection and alterations in the circulating lipid profile. Both oxidative stress and lipid status parameters demonstrated the potential to discriminate sarcoidosis from controls which was particularly evident from the point of view of oxidative stress status parameters. Association between these parameters may indicate an increased risk for atherosclerosis development.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Dyslipidemia and oxidative stress in sarcoidosis patients
VL  - 45
IS  - 9
SP  - 677
EP  - 682
DO  - 10.1016/j.clinbiochem.2012.03.009
ER  - 

@article{
author = "Ivanišević, Jasmina and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Jelić-Ivanović, Zorana and Spasić, Slavica and Videnović-Ivanov, Jelica and Vučinić-Mihailović, Violeta and Ilić, Jasmina",
year = "2012",
abstract = "Objectives: Sarcoidosis is an inflammatory disease characterised by enhanced production of reactive oxygen species and alterations in the circulating lipid profile. Both attributes are thought to play a role in its pathogenesis. However, current knowledge regarding the significance of blood oxidative stress/anti-oxidant defence as well as alterations in lipid status parameters in sarcoidosis is scarce. The aim of our study was to assess these parameters and their inter-relationships, as well as their potential for patient-control discrimination. Design and methods: Oxidative stress status and anti-oxidant defence parameters were determined in serum and erythrocytes and lipid status parameters were assessed in the serum of 213 treated sarcoidosis patients and 90 controls. Results: Malondialdehyde, superoxide anion, total oxidant status, prooxidant-antioxidant balance and triglycerides were significantly higher whereas total anti-oxidant status, superoxide dismutase activity and HDL-cholesterol were significantly lower in sarcoidosis patients compared with controls. Total sulfhydryl group content was higher in patients compared with controls. Serum and erythrocyte malondialdehyde exhibited the strongest ability to predict disease presence. Elevated oxidative stress was characterised by higher clinical accuracy compared with lipid status abnormality. Some oxidative stress and lipid status markers were significantly associated in sarcoidosis. Conclusions: Sarcoidosis is characterised by increased oxidative stress, diminished overall anti-oxidative protection and alterations in the circulating lipid profile. Both oxidative stress and lipid status parameters demonstrated the potential to discriminate sarcoidosis from controls which was particularly evident from the point of view of oxidative stress status parameters. Association between these parameters may indicate an increased risk for atherosclerosis development.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Dyslipidemia and oxidative stress in sarcoidosis patients",
volume = "45",
number = "9",
pages = "677-682",
doi = "10.1016/j.clinbiochem.2012.03.009"
}

Ivanišević, J., Kotur-Stevuljević, J., Stefanović, A., Jelić-Ivanović, Z., Spasić, S., Videnović-Ivanov, J., Vučinić-Mihailović, V.,& Ilić, J.. (2012). Dyslipidemia and oxidative stress in sarcoidosis patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 45(9), 677-682.
https://doi.org/10.1016/j.clinbiochem.2012.03.009

Ivanišević J, Kotur-Stevuljević J, Stefanović A, Jelić-Ivanović Z, Spasić S, Videnović-Ivanov J, Vučinić-Mihailović V, Ilić J. Dyslipidemia and oxidative stress in sarcoidosis patients. in Clinical Biochemistry. 2012;45(9):677-682.
doi:10.1016/j.clinbiochem.2012.03.009 .

Ivanišević, Jasmina, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Jelić-Ivanović, Zorana, Spasić, Slavica, Videnović-Ivanov, Jelica, Vučinić-Mihailović, Violeta, Ilić, Jasmina, "Dyslipidemia and oxidative stress in sarcoidosis patients" in Clinical Biochemistry, 45, no. 9 (2012):677-682,
https://doi.org/10.1016/j.clinbiochem.2012.03.009 . .