TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Cirković, Violeta
AU  - Heleta, Mirjana
AU  - Krajišnik, Danina
AU  - Primorac, Marija
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1878
AB  - The present study describes a screening approach in design of microemulsion preconcentrates (self-microemulsifying systems) comprising: PEG-8 caprylic/capric glycerides (Labrasol (R)) (surfactant), PEG-40 hydrogenated castor oil (Cremophor (R) RH40) (cosurfactant) (at surfactant-to-cosurfactant mass ratios 9:1, 7:3, 5:5, 3:7 and 1:9), and 10% w/w or 20% w/w of medium-chain triglycerides or olive oil (oil). The self-microemulsifying ability of the prepared surfactant/cosurfactant/oil mixtures in water and 0.1 M HCl (pH 1.2), was evaluated by droplet size and zeta potential analysis and cross-polarized light microscopy. The formation of microemulsions was observed only in the presence of medium-chain triglycerides at surfactant-to-cosurfactant ratios 7:3 and 5:5 (in the mixtures containing 10% w/w of the oil phase) and 3:7 and 1:9 (when 20% w/w of the same oil was used). The obtained results provide new implications for development of microemulsion preconcentrates suitable as delivery systems for food and pharmaceutical applications.
PB  - Carl Hanser Verlag, Munich
T2  - Tenside Surfactants Detergents
T1  - Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation
VL  - 50
IS  - 6
SP  - 409
EP  - 413
DO  - 10.3139/113.110272
ER  - 

@article{
author = "Đekić, Ljiljana and Cirković, Violeta and Heleta, Mirjana and Krajišnik, Danina and Primorac, Marija",
year = "2013",
abstract = "The present study describes a screening approach in design of microemulsion preconcentrates (self-microemulsifying systems) comprising: PEG-8 caprylic/capric glycerides (Labrasol (R)) (surfactant), PEG-40 hydrogenated castor oil (Cremophor (R) RH40) (cosurfactant) (at surfactant-to-cosurfactant mass ratios 9:1, 7:3, 5:5, 3:7 and 1:9), and 10% w/w or 20% w/w of medium-chain triglycerides or olive oil (oil). The self-microemulsifying ability of the prepared surfactant/cosurfactant/oil mixtures in water and 0.1 M HCl (pH 1.2), was evaluated by droplet size and zeta potential analysis and cross-polarized light microscopy. The formation of microemulsions was observed only in the presence of medium-chain triglycerides at surfactant-to-cosurfactant ratios 7:3 and 5:5 (in the mixtures containing 10% w/w of the oil phase) and 3:7 and 1:9 (when 20% w/w of the same oil was used). The obtained results provide new implications for development of microemulsion preconcentrates suitable as delivery systems for food and pharmaceutical applications.",
publisher = "Carl Hanser Verlag, Munich",
journal = "Tenside Surfactants Detergents",
title = "Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation",
volume = "50",
number = "6",
pages = "409-413",
doi = "10.3139/113.110272"
}

Đekić, L., Cirković, V., Heleta, M., Krajišnik, D.,& Primorac, M.. (2013). Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation. in Tenside Surfactants Detergents
Carl Hanser Verlag, Munich., 50(6), 409-413.
https://doi.org/10.3139/113.110272

Đekić L, Cirković V, Heleta M, Krajišnik D, Primorac M. Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation. in Tenside Surfactants Detergents. 2013;50(6):409-413.
doi:10.3139/113.110272 .

Đekić, Ljiljana, Cirković, Violeta, Heleta, Mirjana, Krajišnik, Danina, Primorac, Marija, "Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation" in Tenside Surfactants Detergents, 50, no. 6 (2013):409-413,
https://doi.org/10.3139/113.110272 . .