@conference{
author = "Krstevska, Aleksandra and Nedelkov, Ivana and Petrović, Maša and Ibrić, Svetlana and Mirković, Dušica and Cvijić, Sandra",
year = "2023",
abstract = "Precipitation of a drug substance in the small intestine
is a phenomenon relevant to weak bases due to their pH-
dependent solubility. Because of the low solubility at
higher pH, upon entry in the small intestine, a weak base
may get into a supersaturated state, which is
thermodynamically unstable and tends to precipitate
(Makitalo, 2019). Consequently, precipitation in the
gastrointestinal (GI) tract may significantly limit oral
bioavailability (BA) of poorly soluble, weak bases.
Several in vitro and in silico tools are available for
assessing the precipitation kinetics of weakly basic
compounds (Kou et al., 2018). The dynamic nature of
physiologically based in silico models and their ability to
treat drug dissolution and precipitation as variables
affecting concomitant drug bioperformance make in silico
models a powerful tool to assess the impact of these
variables on drug absorption.
The aim of this work was to in silico evaluate the
influence of possible variations in the values of GI
physiological parameters on the potential precipitation and
absorption of a weakly basic, poorly soluble and highly
permeable compound. ...",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound",
volume = "69",
number = "Suppl 1",
pages = "127-128",
doi = "10.33320/maced.pharm.bull.2023.69.03.062"
}