@article{
author = "Lakić, Dragana and Tadić, Ivana and Odalović, Marina and Tasić, Ljiljana and Sabo, Ana and Mećava, Aleksandra",
year = "2014",
abstract = "Introduction. Respiratory infections are the most common infections in children. The aims of the study were to analyze the use of antibiotics for respiratory infections in the period 2008 - 2010 in children's population in region of Niš and to estimate the rational use of antibiotics in relation to the recommendations of the National Guidelines for physicians in primary care. Material and methods. Data source was a Pharmacy Niš database. Antibiotics prescriptions were selected for the following diagnoses: H65-H75 (acute otitis media, mastoiditis), J01 (acute sinusitis), J02-J03 (tonsillopharyngitis), J12-J18 (community acquired pneumonia), J20 (acute bronchitis), J32 (chronic sinusitis), J42 (chronic bronchitis). Antibiotic consumption was expressed in defined daily dose/1000 inhabitants/day. Results. The most widely prescribed antibiotic for the treatment of upper respiratory tract infections in children during the three years was amoxicillin (34.63; 32.50 and 31.00 defined daily dose/1000 inhabitants/day in 2008, 2009 and 2010, respectively). In the treatment of infections of the middle ear and mastoid, the combination of amoxicillin and clavulanic acid, was the most prescribed antibiotics (60% of total consumption of antibiotics for this indication). Azithromycin was the most widely prescribed antibiotic for the treatment of lower respiratory tract infections in children during the observed period (6.92; 8.20 and 7.18 defined daily dose/1000 inhabitans/day in 2008, 2009 and 2010, respectively). Conclusion. Recommendations of national guidelines are not complied with the treatment of upper and lower respiratory infections in the children population in region of Niš. This could be a sign of potentially irrational use of antibiotics that need to be further examined. Education of physicians can influence irrational use of antibiotics., Uvod. Infekcije respiratornog sistema predstavljaju najčešće infekcije kod dece. Ciljevi ovog rada jesu analiza potrošnje antibiotika u lečenju infekcija gornjih i donjih respiratornih puteva kod dece u Nišavskom okrugu i procena racionalnosti upotrebe antibiotika u odnosu na preporuke Nacionalnog vodiča za lekare u primarnoj zdravstvenoj zaštiti. Materijal i metode. Kao izvor podataka korišćena je baza podataka Apoteke Niš za period 2008-2010. godine. Selektovani su svi izdati recepti antibiotika propisani deci starosti 0-19 godina za terapiju infekcija respiratornog trakta uključujući infekcije srednjeg uva ((H65-H75 (akutni otitis media i mastoiditis), J01 (akutni sinuzitis), J02-J03 (tonzilofaringitis), J32 (hronični sinuzitis) (J12-J18 (blaga do umerena pneumonija izazvana vanbolničkim uzročnikom), J20 (akutni bronhitis), J42 (hronični bronhitis)). Potrošnja je izražena u definitivnoj dnevnoj dozi/1 000 stanovnika/dan. Rezultati. Najpropisivaniji antibiotik za terapiju infekcija gornjeg respiratornog trakta kod dece u posmatranom periodu bio je amoksicilin (34,63; 32,5 i 31 definitivnoj dnevnoj dozi/1 000 stanovnika/ dan tokom 2008, 2009. i 2010. godine). Za terapiju infekcije srednjeg uva i mastoidnog nastavka najčešće je korišćena kombinacija amoksicilina i klavulanske kiseline (60% ukupne potrošnje svih antibiotika za ovu indikaciju). Azitromicin je bio najpropisivaniji antibiotik za terapiju infekcija donjeg respiratornog trakta kod dece tokom posmatranog perioda (6,92; 8,2 i 7,18 definitivnoj dnevnoj dozi/1 000 stanovnika/dan tokom 2008, 2009. i 2010. godine). Zaključak. Preporuke nacionalnih vodiča nisu poštovane ni u slučaju terapije gornjih ni donjih respiratornih infekcija kod dece u Nišavskom regionu. To može biti znak potencijalno neracionalne upotrebe antibiotika koju je potrebno dodatno istražiti. Dodatna edukacija lekara mogla bi uticati na smanjivanje neracionalne upotrebe antibiotika.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad",
journal = "Medicinski pregled",
title = "Analysis of antibiotic consumption for treating respiratory tract infections in children and compliance with the national clinical guidelines, Analiza potrošnje antibiotika za lečenje infekcija respiratornog trakta u dečjoj populaciji i usklađenosti sa nacionalnim vodičima dobre kliničke prakse",
volume = "67",
number = "9-10",
pages = "282-289",
doi = "10.2298/MPNS1410282L"
}
