TY  - CONF
AU  - Erić, Slavica
AU  - Vasilić, Đorđe
AU  - Ilić, Katarina
AU  - Zloh, Mire
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5011
AB  - The effects of Satureja Montana (SM) on retroviruses such as HIV-1 and SARS-CoV2, have been recorded in literature. Water-soluble phenols are confered as associated with inhibition of reverse transcriptases, whilst the potential oil constituents in treating viremias remains to be further explored. Investigation of some other Satureja spp. essential oils on HIV-1 and SARS-CoV2 viruses in vitro showed moderate inhibitory effects on its development. 
Screening of SM essential oil constituents on various targets was performed by SwissTarget Prediction program. Among 34 constituents in data set, 17 constituents showed certain probability of interaction with targets: 1-octen-3-ol, 2-hexenal, α-phellandrene, α-copaene, α-pinene, α-terpinene, α-terpinolene, α-tujene, aromadendren, β-myrcene, β-pinene, borneol, cis-ocimene, δ-cadinene, eugenol methylethar and γ-terpinene. Predicted interactions with targets include adenosine receptors 1, 2, and 3, as part of adenosine signaling, which modulation can help in adaptation and reduced damage due to cytokine storm associated with severe acute respiratory syndrome of corona virus type 2 (SARS CoV2). Accordingly, enhancing cellular ATP level can be benefitial for strengthening innate immune response against the virus. Regarding other targets predicted for interaction, possible following underlaying processes are included in effects of SM oil-soluble constituents: gland stimulation, transport enhancing, conjugation and subsequent elimination of foreign agents, hormone metabolism, up-regulation of host IER1α endoplasmatic reticulum stress response and interferon sygnaling pathways, transcription alterations, inhibition of cell proliferation, stabilization of DNA folding. The possible modulation of predicted CXC motif chemokine receptor type 3 (CXCR3) indicates possible role of SM constituents on T cell trafficking and function in identifying and destroying virus-infected cells. Recent findings provide the more detailed information about role of predicted carboanhidrase in biosynthesis processes, apart from known pH modulation, by equilibrating the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Synergistic action of medical plants constituents, as shown in case of SM, represent a sort of engineering, whilst detailed elucidation of particular molecular mechanisms involved in processes can help in precise indication, monitoring of pharmacological effects and improved application of possible therapy.
PB  - International Association of Physical Chemists
C3  - 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6
T1  - Investigation of molecular mechanism of action of Satureja Montana essential oil constituents related to effects on viremias
SP  - 43
EP  - 43
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5011
ER  - 

@conference{
author = "Erić, Slavica and Vasilić, Đorđe and Ilić, Katarina and Zloh, Mire",
year = "2023",
abstract = "The effects of Satureja Montana (SM) on retroviruses such as HIV-1 and SARS-CoV2, have been recorded in literature. Water-soluble phenols are confered as associated with inhibition of reverse transcriptases, whilst the potential oil constituents in treating viremias remains to be further explored. Investigation of some other Satureja spp. essential oils on HIV-1 and SARS-CoV2 viruses in vitro showed moderate inhibitory effects on its development. 
Screening of SM essential oil constituents on various targets was performed by SwissTarget Prediction program. Among 34 constituents in data set, 17 constituents showed certain probability of interaction with targets: 1-octen-3-ol, 2-hexenal, α-phellandrene, α-copaene, α-pinene, α-terpinene, α-terpinolene, α-tujene, aromadendren, β-myrcene, β-pinene, borneol, cis-ocimene, δ-cadinene, eugenol methylethar and γ-terpinene. Predicted interactions with targets include adenosine receptors 1, 2, and 3, as part of adenosine signaling, which modulation can help in adaptation and reduced damage due to cytokine storm associated with severe acute respiratory syndrome of corona virus type 2 (SARS CoV2). Accordingly, enhancing cellular ATP level can be benefitial for strengthening innate immune response against the virus. Regarding other targets predicted for interaction, possible following underlaying processes are included in effects of SM oil-soluble constituents: gland stimulation, transport enhancing, conjugation and subsequent elimination of foreign agents, hormone metabolism, up-regulation of host IER1α endoplasmatic reticulum stress response and interferon sygnaling pathways, transcription alterations, inhibition of cell proliferation, stabilization of DNA folding. The possible modulation of predicted CXC motif chemokine receptor type 3 (CXCR3) indicates possible role of SM constituents on T cell trafficking and function in identifying and destroying virus-infected cells. Recent findings provide the more detailed information about role of predicted carboanhidrase in biosynthesis processes, apart from known pH modulation, by equilibrating the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Synergistic action of medical plants constituents, as shown in case of SM, represent a sort of engineering, whilst detailed elucidation of particular molecular mechanisms involved in processes can help in precise indication, monitoring of pharmacological effects and improved application of possible therapy.",
publisher = "International Association of Physical Chemists",
journal = "10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6",
title = "Investigation of molecular mechanism of action of Satureja Montana essential oil constituents related to effects on viremias",
pages = "43-43",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5011"
}

Erić, S., Vasilić, Đ., Ilić, K.,& Zloh, M.. (2023). Investigation of molecular mechanism of action of Satureja Montana essential oil constituents related to effects on viremias. in 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6
International Association of Physical Chemists., 43-43.
https://hdl.handle.net/21.15107/rcub_farfar_5011

Erić S, Vasilić Đ, Ilić K, Zloh M. Investigation of molecular mechanism of action of Satureja Montana essential oil constituents related to effects on viremias. in 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6. 2023;:43-43.
https://hdl.handle.net/21.15107/rcub_farfar_5011 .

Erić, Slavica, Vasilić, Đorđe, Ilić, Katarina, Zloh, Mire, "Investigation of molecular mechanism of action of Satureja Montana essential oil constituents related to effects on viremias" in 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6 (2023):43-43,
https://hdl.handle.net/21.15107/rcub_farfar_5011 .

TY  - JOUR
AU  - Tadić, Ivana
AU  - Tasić, Ljiljana
AU  - Vujasinović-Stupar, Nada
AU  - Ilić, Katarina
AU  - Stevanović, Dejan
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2241
AB  - Osteoporosis is a chronic disease with increasing incidence that predominantly occurs in female population. There are evidences that bisphosphonates, selective estrogen receptor modulators, denosumab, teriparatide and strontium renalate, prevent vertebral fractures while alendronate, risedronate, zoledronic acid, denosumab and strontium renalate prevent hip fractures. Although these drugs are effective in osteoporosis treatment, their use is limited by their side-effects and low-adherence. The aim of this review article was to compare efficacy of new drugs for osteoporosis currently in phase 2 and 3 clinical trials. After reviewing 57 articles available on PubMed and Scopus databases that evaluated efficacy of osteoporosis medications, 10 papers, that fulfilled the review criteria, were selected for the analysis. Finally, the efficacy of five drugs was compared. Efficacy was evaluated by the values of bone mineral density (BMD) and bone turnover markers (BTM). In all the analyzed articles the BMD increased and changes of BTM were noted. The highest increase of lumbar BMD from the baseline values was achieved after six months of subcutaneous application of 20 μg/day teriparatide (11.3%). The lowest increase of BMD in the same region was recorded after six months of risedronate therapy 100 mg per os once monthly (2.1%). From ten selected articles, only one has reported data about fracture risk.
AB  - Osteoporoza je hronična bolest koja je sve više zastupljena i to pretežno kod osoba ženskog pola. Postoje dokazi da bisfosfonati, selektivni modulatori estrogenskih receptora, denosumab, teriparatid i stroncijum ranelat mogu da preveniraju prelom kuka. Iako su ovi lekovi efikasni u lečenju osteoporoze, njihova upotreba je ograničena usled ispoljavanja neželjenih reakcija, a time i postojanja niske adherencije bolesnika. Cilj ovog preglednog rada bio je upoređivanje efikasnosti novih lekova za lečenje osteoporoze koji su trenutno u 2. i 3. fazi kliničkih istraživanja. Nakon pregleda 57 originalnih radova koji su imali za cilj da pokažu efikasnost lekova u lečenju osteoporoze, dostupnih na PubMed i Scopus bazi, za analizu je odabrano 10 radova koji su zadovoljili kriterijume za pretraživanje. Na kraju analize, poređena je efikasnost pet lekova. Efikasnost je evaluirana na osnovu vrednosti mineralne koštane gustine (BMD) i koštanih markera (BTM). Povećanje BMD vrednosti i promene u vrednostima BTM zabeležene su u svim radovima. Najveće povećanje BMD (za 11,3%) lumbalnog skeletnog regiona postignuto je nakon šestomesečne subkutane terapije teriparatidom u dozi 20 μg dnevno. Najmanje povećanje BMD (za 2,1%) istog skeletnog regiona zabeleženo je nakon šestomesečne per os terapije risedronatom u dozi od 100 mg jednom mesečno. Od deset analiziranih studija, samo je jedna prikazala podatke o riziku od frakture.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš
T2  - Acta Facultatis Medicae Naissensis
T1  - New drugs for osteoporosis therapy: A review of the clinical trials phase 2 and 3
T1  - Novi lekovi u terapiji osteoporoze - pregled 2. i 3. - faze kliničkih istraživanja
VL  - 31
IS  - 1
SP  - 29
EP  - 39
DO  - 10.2478/afmnai-2014-0003
ER  - 

@article{
author = "Tadić, Ivana and Tasić, Ljiljana and Vujasinović-Stupar, Nada and Ilić, Katarina and Stevanović, Dejan",
year = "2014",
abstract = "Osteoporosis is a chronic disease with increasing incidence that predominantly occurs in female population. There are evidences that bisphosphonates, selective estrogen receptor modulators, denosumab, teriparatide and strontium renalate, prevent vertebral fractures while alendronate, risedronate, zoledronic acid, denosumab and strontium renalate prevent hip fractures. Although these drugs are effective in osteoporosis treatment, their use is limited by their side-effects and low-adherence. The aim of this review article was to compare efficacy of new drugs for osteoporosis currently in phase 2 and 3 clinical trials. After reviewing 57 articles available on PubMed and Scopus databases that evaluated efficacy of osteoporosis medications, 10 papers, that fulfilled the review criteria, were selected for the analysis. Finally, the efficacy of five drugs was compared. Efficacy was evaluated by the values of bone mineral density (BMD) and bone turnover markers (BTM). In all the analyzed articles the BMD increased and changes of BTM were noted. The highest increase of lumbar BMD from the baseline values was achieved after six months of subcutaneous application of 20 μg/day teriparatide (11.3%). The lowest increase of BMD in the same region was recorded after six months of risedronate therapy 100 mg per os once monthly (2.1%). From ten selected articles, only one has reported data about fracture risk., Osteoporoza je hronična bolest koja je sve više zastupljena i to pretežno kod osoba ženskog pola. Postoje dokazi da bisfosfonati, selektivni modulatori estrogenskih receptora, denosumab, teriparatid i stroncijum ranelat mogu da preveniraju prelom kuka. Iako su ovi lekovi efikasni u lečenju osteoporoze, njihova upotreba je ograničena usled ispoljavanja neželjenih reakcija, a time i postojanja niske adherencije bolesnika. Cilj ovog preglednog rada bio je upoređivanje efikasnosti novih lekova za lečenje osteoporoze koji su trenutno u 2. i 3. fazi kliničkih istraživanja. Nakon pregleda 57 originalnih radova koji su imali za cilj da pokažu efikasnost lekova u lečenju osteoporoze, dostupnih na PubMed i Scopus bazi, za analizu je odabrano 10 radova koji su zadovoljili kriterijume za pretraživanje. Na kraju analize, poređena je efikasnost pet lekova. Efikasnost je evaluirana na osnovu vrednosti mineralne koštane gustine (BMD) i koštanih markera (BTM). Povećanje BMD vrednosti i promene u vrednostima BTM zabeležene su u svim radovima. Najveće povećanje BMD (za 11,3%) lumbalnog skeletnog regiona postignuto je nakon šestomesečne subkutane terapije teriparatidom u dozi 20 μg dnevno. Najmanje povećanje BMD (za 2,1%) istog skeletnog regiona zabeleženo je nakon šestomesečne per os terapije risedronatom u dozi od 100 mg jednom mesečno. Od deset analiziranih studija, samo je jedna prikazala podatke o riziku od frakture.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš",
journal = "Acta Facultatis Medicae Naissensis",
title = "New drugs for osteoporosis therapy: A review of the clinical trials phase 2 and 3, Novi lekovi u terapiji osteoporoze - pregled 2. i 3. - faze kliničkih istraživanja",
volume = "31",
number = "1",
pages = "29-39",
doi = "10.2478/afmnai-2014-0003"
}

Tadić, I., Tasić, L., Vujasinović-Stupar, N., Ilić, K.,& Stevanović, D.. (2014). New drugs for osteoporosis therapy: A review of the clinical trials phase 2 and 3. in Acta Facultatis Medicae Naissensis
Univerzitet u Nišu - Medicinski fakultet, Niš., 31(1), 29-39.
https://doi.org/10.2478/afmnai-2014-0003

Tadić I, Tasić L, Vujasinović-Stupar N, Ilić K, Stevanović D. New drugs for osteoporosis therapy: A review of the clinical trials phase 2 and 3. in Acta Facultatis Medicae Naissensis. 2014;31(1):29-39.
doi:10.2478/afmnai-2014-0003 .

Tadić, Ivana, Tasić, Ljiljana, Vujasinović-Stupar, Nada, Ilić, Katarina, Stevanović, Dejan, "New drugs for osteoporosis therapy: A review of the clinical trials phase 2 and 3" in Acta Facultatis Medicae Naissensis, 31, no. 1 (2014):29-39,
https://doi.org/10.2478/afmnai-2014-0003 . .

TY  - JOUR
AU  - Milosavljević, Jelena
AU  - Ilić, Katarina
AU  - Krajnović, Dušanka
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2245
AB  - Emergency hormonal contraception is used to prevent unintended pregnancy postcoitally. The mechanism of action of the most frequently used hormonal preparations for emergency contraception, levonorgestrel (LNG) and ulipristal acetate (UPA), is still not fully known, but clinical trials indicate that they act by inhibiting or delaying ovulation. LNG has a long history of use for emergency contraception, proven safety and high efficacy if administered in the preovulation period. The newest emergency contraceptive, UPA, available only with a prescription, is indicated within this period of 120 hours after sexual intercourse and the data indicate that UPA does not lose efficacy within this period. Clinical trials showed its noninferiority versus LNG and its effect on the potentially occurring pregnancy is being additionally monitored. However, many misconceptions and controversial opinions about emergency contraception are still present, even among pharmacists. A search of Medline database identified 20 papers published from January 1993 to December 2012, on pharmacists' knowledge, attitudes and practices related to emergency contraception. In these papers, the attitudes of pharmacists pertaining to the dispensing regime of emergency contraception were different. Research in Australia has shown that personal attitudes and religious convictions influence the practice of dispensing emergency contraception. In the research conducted in New Mexico, 30% of pharmacists were against prescribing emergency contraception for religious or moral reasons. There were no published data in regards to pharmacists' knowledge, attitudes and dispensing practice in Serbia and such research is highly recommended.
AB  - Hitna hormonska kontracepcija se koristi za sprečavanje neželjene trudnoće postkoitalno. Mehanizam dejstva najčešće korišćenih preparata hitne kontracepcije, levonorgestrela (LNG) i ulipristal-acetata (UPA) još uvek nije u potpnosti poznat, ali klinička ispitivanja ukazuju da je u pitanju inhibicija ili odlaganje ovulacije. Za hitnu kontracepciju dugo se koristi LNG, jer ima dokazanu bezbednost i visoku efikasnost, ukoliko se primeni u periodu pre ovulacije. Najnoviji preparat iz ove grupe, UPA, koji se izdaje samo na recept, može se primeniti u periodu od 120 sati nakon seksualnog odnosa. U kliničkim ispitivanjima se nije pokazao lošijim u odnosu na LNG, a njegov uticaj na eventualno nastalu trudnoću se dodatno prati. Podaci ukazuju na činjenicu da UPA ne gubi na efikasnosti u periodu od 120 sati. Međutim, prisutne su mnoge zablude i kontroverzna mišljenja o hitnoj kontracepciji, čak i među farmaceutima. Pretraživanjem Medline baze podataka nađeno je 20 radova objavljenih u periodu od januara 1993. do decembra 2012. godine koji razmatraju znanje, stavove i praksu farmaceuta u vezi sa hitnom kontracepcijom. U ovim radovima se stavovi farmaceuta razlikuju po pitanju režima izdavanja hitne kontracepcije. Istraživanje u Australiji pokazalo je da lični stavovi i religijska uverenja utiču na način izdavanja hitne kontracepcije. U istraživanju u Novom Meksiku 30% farmaceuta je bilo protiv propisivanja hitne kontracepcije iz religioznih ili moralnih razloga. Među pronađenim radovima nije bilo podataka o istraživanjima iz Srbije. Preporuka je da se sprovedu istraživanja o znanju, stavovima i praksi farmaceuta u vezi sa hitnom hormonskom kontracepcijom u Srbiji.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš
T2  - Acta Facultatis Medicae Naissensis
T1  - Mechanism of action, efficacy and safety of emergency hormonal contraception (levonorgestrel and ulipristal acetate) and attitudes of pharmacists
T1  - Mehanizam dejstva, efikasnost i bezbednost hitne hormonske kontracepcije (levonorgestrela i ulipristal acetata) i stavovi farmaceuta
VL  - 31
IS  - 3
SP  - 155
EP  - 161
DO  - 10.2478/afmnai-2014-0019
ER  - 

@article{
author = "Milosavljević, Jelena and Ilić, Katarina and Krajnović, Dušanka",
year = "2014",
abstract = "Emergency hormonal contraception is used to prevent unintended pregnancy postcoitally. The mechanism of action of the most frequently used hormonal preparations for emergency contraception, levonorgestrel (LNG) and ulipristal acetate (UPA), is still not fully known, but clinical trials indicate that they act by inhibiting or delaying ovulation. LNG has a long history of use for emergency contraception, proven safety and high efficacy if administered in the preovulation period. The newest emergency contraceptive, UPA, available only with a prescription, is indicated within this period of 120 hours after sexual intercourse and the data indicate that UPA does not lose efficacy within this period. Clinical trials showed its noninferiority versus LNG and its effect on the potentially occurring pregnancy is being additionally monitored. However, many misconceptions and controversial opinions about emergency contraception are still present, even among pharmacists. A search of Medline database identified 20 papers published from January 1993 to December 2012, on pharmacists' knowledge, attitudes and practices related to emergency contraception. In these papers, the attitudes of pharmacists pertaining to the dispensing regime of emergency contraception were different. Research in Australia has shown that personal attitudes and religious convictions influence the practice of dispensing emergency contraception. In the research conducted in New Mexico, 30% of pharmacists were against prescribing emergency contraception for religious or moral reasons. There were no published data in regards to pharmacists' knowledge, attitudes and dispensing practice in Serbia and such research is highly recommended., Hitna hormonska kontracepcija se koristi za sprečavanje neželjene trudnoće postkoitalno. Mehanizam dejstva najčešće korišćenih preparata hitne kontracepcije, levonorgestrela (LNG) i ulipristal-acetata (UPA) još uvek nije u potpnosti poznat, ali klinička ispitivanja ukazuju da je u pitanju inhibicija ili odlaganje ovulacije. Za hitnu kontracepciju dugo se koristi LNG, jer ima dokazanu bezbednost i visoku efikasnost, ukoliko se primeni u periodu pre ovulacije. Najnoviji preparat iz ove grupe, UPA, koji se izdaje samo na recept, može se primeniti u periodu od 120 sati nakon seksualnog odnosa. U kliničkim ispitivanjima se nije pokazao lošijim u odnosu na LNG, a njegov uticaj na eventualno nastalu trudnoću se dodatno prati. Podaci ukazuju na činjenicu da UPA ne gubi na efikasnosti u periodu od 120 sati. Međutim, prisutne su mnoge zablude i kontroverzna mišljenja o hitnoj kontracepciji, čak i među farmaceutima. Pretraživanjem Medline baze podataka nađeno je 20 radova objavljenih u periodu od januara 1993. do decembra 2012. godine koji razmatraju znanje, stavove i praksu farmaceuta u vezi sa hitnom kontracepcijom. U ovim radovima se stavovi farmaceuta razlikuju po pitanju režima izdavanja hitne kontracepcije. Istraživanje u Australiji pokazalo je da lični stavovi i religijska uverenja utiču na način izdavanja hitne kontracepcije. U istraživanju u Novom Meksiku 30% farmaceuta je bilo protiv propisivanja hitne kontracepcije iz religioznih ili moralnih razloga. Među pronađenim radovima nije bilo podataka o istraživanjima iz Srbije. Preporuka je da se sprovedu istraživanja o znanju, stavovima i praksi farmaceuta u vezi sa hitnom hormonskom kontracepcijom u Srbiji.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš",
journal = "Acta Facultatis Medicae Naissensis",
title = "Mechanism of action, efficacy and safety of emergency hormonal contraception (levonorgestrel and ulipristal acetate) and attitudes of pharmacists, Mehanizam dejstva, efikasnost i bezbednost hitne hormonske kontracepcije (levonorgestrela i ulipristal acetata) i stavovi farmaceuta",
volume = "31",
number = "3",
pages = "155-161",
doi = "10.2478/afmnai-2014-0019"
}

Milosavljević, J., Ilić, K.,& Krajnović, D.. (2014). Mechanism of action, efficacy and safety of emergency hormonal contraception (levonorgestrel and ulipristal acetate) and attitudes of pharmacists. in Acta Facultatis Medicae Naissensis
Univerzitet u Nišu - Medicinski fakultet, Niš., 31(3), 155-161.
https://doi.org/10.2478/afmnai-2014-0019

Milosavljević J, Ilić K, Krajnović D. Mechanism of action, efficacy and safety of emergency hormonal contraception (levonorgestrel and ulipristal acetate) and attitudes of pharmacists. in Acta Facultatis Medicae Naissensis. 2014;31(3):155-161.
doi:10.2478/afmnai-2014-0019 .

Milosavljević, Jelena, Ilić, Katarina, Krajnović, Dušanka, "Mechanism of action, efficacy and safety of emergency hormonal contraception (levonorgestrel and ulipristal acetate) and attitudes of pharmacists" in Acta Facultatis Medicae Naissensis, 31, no. 3 (2014):155-161,
https://doi.org/10.2478/afmnai-2014-0019 . .

TY  - JOUR
AU  - Odalović, Marina
AU  - Vezmar-Kovačević, Sandra
AU  - Nordeng, Hedvig
AU  - Ilić, Katarina
AU  - Sabo, Ana
AU  - Tasić, Ljiljana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1987
AB  - Background Drug use in pregnancy is often reason of concern for mothers and their physicians. However, only few studies investigated predictors of drug use in pregnancy. Objectives To examine maternal characteristics as predictors of medication use in the 6 months before pregnancy and during the first 6 months of pregnancy. To examine whether prescription and over-the-counter (OTC) medication use in the 6 months before pregnancy had an impact on medication use in pregnancy. Setting Six maternity care units and five community pharmacies. Method Data were collected using a specially designed self-reported questionnaire during the period March 2009-March 2010. Logistic regression was used to identify factors associated with medication use. Main outcome measure Adjusted odds ratios (aOR) and 95 % confidence intervals (CI) were used as association measures. Results A total of 236 women were included in the analysis. After controlling for maternal characteristics, parity of more than one was associated with lower prescription medication use in pregnancy (aOR 0.46; 95 % CI 0.22-0.93), higher household income with higher OTC medication use before pregnancy (aOR 3.13; 95 % CI 1.22-8.00), and miscarriage with higher C and D Food and Drug Administration (FDA) risk category medication use in pregnancy (aOR 3.65; 95 % CI 1.30-10.25). Prescription medication use before pregnancy was associated with higher prescription medication use in pregnancy (aOR 2.49; 95 % CI 1.12-5.52), OTC medication use before pregnancy with higher OTC medication use in pregnancy (aOR 35.95; 95 % CI 7.95-162.49), and C and D FDA risk category medication use before pregnancy with the same category medication use in pregnancy (aOR 3.54; 95 % CI 1.23-10.17). Conclusion Different maternal characteristics were shown as predictors of medication use before and during pregnancy. However, medication use before pregnancy was shown as the most important predicting factor for the medication use in pregnancy.
PB  - Springer, Dordrecht
T2  - International Journal of Clinical Pharmacy
T1  - Predictors of the use of medications before and during pregnancy
VL  - 35
IS  - 3
SP  - 408
EP  - 416
DO  - 10.1007/s11096-013-9750-7
ER  - 

@article{
author = "Odalović, Marina and Vezmar-Kovačević, Sandra and Nordeng, Hedvig and Ilić, Katarina and Sabo, Ana and Tasić, Ljiljana",
year = "2013",
abstract = "Background Drug use in pregnancy is often reason of concern for mothers and their physicians. However, only few studies investigated predictors of drug use in pregnancy. Objectives To examine maternal characteristics as predictors of medication use in the 6 months before pregnancy and during the first 6 months of pregnancy. To examine whether prescription and over-the-counter (OTC) medication use in the 6 months before pregnancy had an impact on medication use in pregnancy. Setting Six maternity care units and five community pharmacies. Method Data were collected using a specially designed self-reported questionnaire during the period March 2009-March 2010. Logistic regression was used to identify factors associated with medication use. Main outcome measure Adjusted odds ratios (aOR) and 95 % confidence intervals (CI) were used as association measures. Results A total of 236 women were included in the analysis. After controlling for maternal characteristics, parity of more than one was associated with lower prescription medication use in pregnancy (aOR 0.46; 95 % CI 0.22-0.93), higher household income with higher OTC medication use before pregnancy (aOR 3.13; 95 % CI 1.22-8.00), and miscarriage with higher C and D Food and Drug Administration (FDA) risk category medication use in pregnancy (aOR 3.65; 95 % CI 1.30-10.25). Prescription medication use before pregnancy was associated with higher prescription medication use in pregnancy (aOR 2.49; 95 % CI 1.12-5.52), OTC medication use before pregnancy with higher OTC medication use in pregnancy (aOR 35.95; 95 % CI 7.95-162.49), and C and D FDA risk category medication use before pregnancy with the same category medication use in pregnancy (aOR 3.54; 95 % CI 1.23-10.17). Conclusion Different maternal characteristics were shown as predictors of medication use before and during pregnancy. However, medication use before pregnancy was shown as the most important predicting factor for the medication use in pregnancy.",
publisher = "Springer, Dordrecht",
journal = "International Journal of Clinical Pharmacy",
title = "Predictors of the use of medications before and during pregnancy",
volume = "35",
number = "3",
pages = "408-416",
doi = "10.1007/s11096-013-9750-7"
}

Odalović, M., Vezmar-Kovačević, S., Nordeng, H., Ilić, K., Sabo, A.,& Tasić, L.. (2013). Predictors of the use of medications before and during pregnancy. in International Journal of Clinical Pharmacy
Springer, Dordrecht., 35(3), 408-416.
https://doi.org/10.1007/s11096-013-9750-7

Odalović M, Vezmar-Kovačević S, Nordeng H, Ilić K, Sabo A, Tasić L. Predictors of the use of medications before and during pregnancy. in International Journal of Clinical Pharmacy. 2013;35(3):408-416.
doi:10.1007/s11096-013-9750-7 .

Odalović, Marina, Vezmar-Kovačević, Sandra, Nordeng, Hedvig, Ilić, Katarina, Sabo, Ana, Tasić, Ljiljana, "Predictors of the use of medications before and during pregnancy" in International Journal of Clinical Pharmacy, 35, no. 3 (2013):408-416,
https://doi.org/10.1007/s11096-013-9750-7 . .

TY  - JOUR
AU  - Odalović, Marina
AU  - Vezmar-Kovačević, Sandra
AU  - Ilić, Katarina
AU  - Sabo, Ana
AU  - Tasić, Ljiljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1636
AB  - Background Observation of drug use patterns during pregnancy is necessary for the recognition of potential bad practices and improvement of safe drug use in pregnancy. Objective To investigate prescription and over the counter drug use among Serbian women in the 6 months before pregnancy and in the first 6 months of pregnancy, and to evaluate the drugs used according to the risk to a fetus. Setting Six maternity care units and five community pharmacies Method A multi-center study was performed in Serbia during the period from March 2009-March 2010. A self-reporting questionnaire was used as a data source. Food and Drug Administration (FDA) risk classification system was used to determine the risk of used drugs for the fetus. Differences between subgroups were assessed using McNemar's test on paired proportions. Main outcome measure Proportion of women exposed to drugs or class of drugs. Results The overall drug exposure was higher in pregnancy (34.7 %) than before pregnancy (29.9 %), p > 0.05, in the cohort of 311 pregnant women. A significantly greater prescription drug use, 19.0 versus 27.3 % of women, p  lt  0.05, and less selfmedication with over the counter drugs in pregnancy, 15.1 versus 8.7 %, p  lt  0.05, were observed. Commonly used drugs were musculoskeletal drugs, analgesics/antipyretics and respiratory system drugs before pregnancy (13.8, 12.5, and 6.4 % of women, respectively), and progestogens, analgesics/antipyretics, and antibiotics for the systemic use in pregnancy (9.0, 7.7, and 7.4 %, respectively). A greater exposure to drugs belonging to the FDA risk category A (3.9 vs. 60.8 %, p  lt  0.05), B (18.0 vs. 19.6 %, p > 0.05), C (10.0 vs. 10.3 %, p > 0.05) and D (2.9 vs. 10.9 %, p  lt  0.05), as well as less exposure to drugs belonging to category X (0.3 vs. 0 %, p > 0.05) were observed in pregnancy. Folic acid was used by 60.8 % of women in pregnancy, and by only 3.9 % before pregnancy. Conclusion Besides higher overall drug use in pregnancy than before pregnancy, particularly the use of progestogens, and, subsequently, D category drugs, less selfmedication with over the counter drugs was observed in pregnancy. Insufficient use of folic acid before pregnancy requires public health service activities.
PB  - Springer, Dordrecht
T2  - International Journal of Clinical Pharmacy
T1  - Drug use before and during pregnancy in Serbia
VL  - 34
IS  - 5
SP  - 719
EP  - 727
DO  - 10.1007/s11096-012-9665-8
ER  - 

@article{
author = "Odalović, Marina and Vezmar-Kovačević, Sandra and Ilić, Katarina and Sabo, Ana and Tasić, Ljiljana",
year = "2012",
abstract = "Background Observation of drug use patterns during pregnancy is necessary for the recognition of potential bad practices and improvement of safe drug use in pregnancy. Objective To investigate prescription and over the counter drug use among Serbian women in the 6 months before pregnancy and in the first 6 months of pregnancy, and to evaluate the drugs used according to the risk to a fetus. Setting Six maternity care units and five community pharmacies Method A multi-center study was performed in Serbia during the period from March 2009-March 2010. A self-reporting questionnaire was used as a data source. Food and Drug Administration (FDA) risk classification system was used to determine the risk of used drugs for the fetus. Differences between subgroups were assessed using McNemar's test on paired proportions. Main outcome measure Proportion of women exposed to drugs or class of drugs. Results The overall drug exposure was higher in pregnancy (34.7 %) than before pregnancy (29.9 %), p > 0.05, in the cohort of 311 pregnant women. A significantly greater prescription drug use, 19.0 versus 27.3 % of women, p  lt  0.05, and less selfmedication with over the counter drugs in pregnancy, 15.1 versus 8.7 %, p  lt  0.05, were observed. Commonly used drugs were musculoskeletal drugs, analgesics/antipyretics and respiratory system drugs before pregnancy (13.8, 12.5, and 6.4 % of women, respectively), and progestogens, analgesics/antipyretics, and antibiotics for the systemic use in pregnancy (9.0, 7.7, and 7.4 %, respectively). A greater exposure to drugs belonging to the FDA risk category A (3.9 vs. 60.8 %, p  lt  0.05), B (18.0 vs. 19.6 %, p > 0.05), C (10.0 vs. 10.3 %, p > 0.05) and D (2.9 vs. 10.9 %, p  lt  0.05), as well as less exposure to drugs belonging to category X (0.3 vs. 0 %, p > 0.05) were observed in pregnancy. Folic acid was used by 60.8 % of women in pregnancy, and by only 3.9 % before pregnancy. Conclusion Besides higher overall drug use in pregnancy than before pregnancy, particularly the use of progestogens, and, subsequently, D category drugs, less selfmedication with over the counter drugs was observed in pregnancy. Insufficient use of folic acid before pregnancy requires public health service activities.",
publisher = "Springer, Dordrecht",
journal = "International Journal of Clinical Pharmacy",
title = "Drug use before and during pregnancy in Serbia",
volume = "34",
number = "5",
pages = "719-727",
doi = "10.1007/s11096-012-9665-8"
}

Odalović, M., Vezmar-Kovačević, S., Ilić, K., Sabo, A.,& Tasić, L.. (2012). Drug use before and during pregnancy in Serbia. in International Journal of Clinical Pharmacy
Springer, Dordrecht., 34(5), 719-727.
https://doi.org/10.1007/s11096-012-9665-8

Odalović M, Vezmar-Kovačević S, Ilić K, Sabo A, Tasić L. Drug use before and during pregnancy in Serbia. in International Journal of Clinical Pharmacy. 2012;34(5):719-727.
doi:10.1007/s11096-012-9665-8 .

Odalović, Marina, Vezmar-Kovačević, Sandra, Ilić, Katarina, Sabo, Ana, Tasić, Ljiljana, "Drug use before and during pregnancy in Serbia" in International Journal of Clinical Pharmacy, 34, no. 5 (2012):719-727,
https://doi.org/10.1007/s11096-012-9665-8 . .

TY  - JOUR
AU  - Đukić, Mirjana
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Ilić, Katarina
AU  - Đurđević, Dragan
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1778
AB  - Contact herbicide paraquat (DQ) is bipyridylium compound, which undergoes redox metabolism; hence enlarged in humans radical production mediated its toxicity. Target organs of systemic effect of PQ poisoning are lung and kidney. The mechanism of PQ-induced neurotoxicity is not elucidated till now. The objective of our study was to examine the role of nitric oxide (NOx) in PQ-induced neurotoxicity, primarily focusing on glutathione cycles [total glutathione content (GSH) and glutathione peroxidase (GPx) activity]. In order to investigate the role of NOx in oxidative stress (OS) and/or nitrosative stress (NS) response to PQ neurotoxicity, we used NG-nitro-L-arginine methyl ester (L-NAME), a non-selective inhibitor of nitric oxide synthase (NOS) in the pretreatment of PQ administration. Study was conducted on Wistar rats randomly divided in groups (n=8 for controls and n=24 for experimental groups) depending on the applied treatments. The tested compounds were intrastriatally (i.s.) administered. Measuring of GSH content and GPx activity was performed at 30 min, 24 hours and 7 days after treatments. Parkinsonism’s like symptoms were observed only in the group of rats treated with PQ. The L-NAME protected animals from PQ-induced neurotoxicity, which could be concluded from the absence of Parkinsonism’s like symptoms and reduced OS/NS response in the striatum of rats pretreated with L-NAME.
AB  - Kontaktni herbicid parakvat (PK) je dipiridinsko jedinjenje, koje podleže redoks metabolizmu i svoju toksičnost ispoljava posredstvom povećanog stvaranja slobodnih radikala. Ciljni organi sistemskog toksičnog efekta PK kod čoveka su pluća i bubrezi. Mehanizam PKindukovane neurotoksičnosti do sada još uvek nije u potpunosti rasvetljen. Cilj našeg rada bio je da se ispita uloga azot oksida (NOx) u neurotoksičnosti PK, sa posebnim osvrtom na glutationski ciklus [glutation (GSH) i enzim glutation peroksidazu (GPx)]. U cilju da se istraži uloga NOx u oksidativnom stresu (OS) i / ili nitrosativnom stresu (NS), kao odgovoru na neurotoksičnost PK. U predtretmanu parakvatom koristili smo NG-nitro- L-arginin metil estar (L-NAME), neselektivni inhibitor azot oksid sintetaze (NOS), aplikovan je pre davanja PQ . Studija je sprovedena na pacovima Wistar soja nasumice podeljenim u grupe (n = 8 za kontrolnu grupu i n = 24 za eksperimentalne grupe) u zavisnosti od tretmana. Testirana jedinjenja su intrastrijatalno (i.s.) aplikovana. Merenje sadržaja GSH i aktivnosti GPx izvršena su 30 min, 24 sata i 7 dana posle tretmana. Parkinsonizam je kao simptom primećen samo u grupi pacova tretiranih PK - om. L-NAME je ispoljio zaštitni efekat kod životinja kod kojih je i.s. davan PK, što bi se moglo zaključiti na osnovu odsustva simptoma parkinsonizma i smanjenog OS/NS odgovora u strijatumu u grupi pretretiranoj sa L-NAME.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - The effect of pre-treatment with l-name on glutathione and glutathione peroxidase in parquat-induced neurotoxicity in rat striatum
T1  - Efekat predtretmana sa l-name na glutation i glutation peroksidazu u strijatumu pacova na neurotoksičnost izazvanu parakvatom
VL  - 62
IS  - 3
SP  - 237
EP  - 251
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1778
ER  - 

@article{
author = "Đukić, Mirjana and Ninković, Milica and Stevanović, Ivana and Ilić, Katarina and Đurđević, Dragan",
year = "2012",
abstract = "Contact herbicide paraquat (DQ) is bipyridylium compound, which undergoes redox metabolism; hence enlarged in humans radical production mediated its toxicity. Target organs of systemic effect of PQ poisoning are lung and kidney. The mechanism of PQ-induced neurotoxicity is not elucidated till now. The objective of our study was to examine the role of nitric oxide (NOx) in PQ-induced neurotoxicity, primarily focusing on glutathione cycles [total glutathione content (GSH) and glutathione peroxidase (GPx) activity]. In order to investigate the role of NOx in oxidative stress (OS) and/or nitrosative stress (NS) response to PQ neurotoxicity, we used NG-nitro-L-arginine methyl ester (L-NAME), a non-selective inhibitor of nitric oxide synthase (NOS) in the pretreatment of PQ administration. Study was conducted on Wistar rats randomly divided in groups (n=8 for controls and n=24 for experimental groups) depending on the applied treatments. The tested compounds were intrastriatally (i.s.) administered. Measuring of GSH content and GPx activity was performed at 30 min, 24 hours and 7 days after treatments. Parkinsonism’s like symptoms were observed only in the group of rats treated with PQ. The L-NAME protected animals from PQ-induced neurotoxicity, which could be concluded from the absence of Parkinsonism’s like symptoms and reduced OS/NS response in the striatum of rats pretreated with L-NAME., Kontaktni herbicid parakvat (PK) je dipiridinsko jedinjenje, koje podleže redoks metabolizmu i svoju toksičnost ispoljava posredstvom povećanog stvaranja slobodnih radikala. Ciljni organi sistemskog toksičnog efekta PK kod čoveka su pluća i bubrezi. Mehanizam PKindukovane neurotoksičnosti do sada još uvek nije u potpunosti rasvetljen. Cilj našeg rada bio je da se ispita uloga azot oksida (NOx) u neurotoksičnosti PK, sa posebnim osvrtom na glutationski ciklus [glutation (GSH) i enzim glutation peroksidazu (GPx)]. U cilju da se istraži uloga NOx u oksidativnom stresu (OS) i / ili nitrosativnom stresu (NS), kao odgovoru na neurotoksičnost PK. U predtretmanu parakvatom koristili smo NG-nitro- L-arginin metil estar (L-NAME), neselektivni inhibitor azot oksid sintetaze (NOS), aplikovan je pre davanja PQ . Studija je sprovedena na pacovima Wistar soja nasumice podeljenim u grupe (n = 8 za kontrolnu grupu i n = 24 za eksperimentalne grupe) u zavisnosti od tretmana. Testirana jedinjenja su intrastrijatalno (i.s.) aplikovana. Merenje sadržaja GSH i aktivnosti GPx izvršena su 30 min, 24 sata i 7 dana posle tretmana. Parkinsonizam je kao simptom primećen samo u grupi pacova tretiranih PK - om. L-NAME je ispoljio zaštitni efekat kod životinja kod kojih je i.s. davan PK, što bi se moglo zaključiti na osnovu odsustva simptoma parkinsonizma i smanjenog OS/NS odgovora u strijatumu u grupi pretretiranoj sa L-NAME.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The effect of pre-treatment with l-name on glutathione and glutathione peroxidase in parquat-induced neurotoxicity in rat striatum, Efekat predtretmana sa l-name na glutation i glutation peroksidazu u strijatumu pacova na neurotoksičnost izazvanu parakvatom",
volume = "62",
number = "3",
pages = "237-251",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1778"
}

Đukić, M., Ninković, M., Stevanović, I., Ilić, K.,& Đurđević, D.. (2012). The effect of pre-treatment with l-name on glutathione and glutathione peroxidase in parquat-induced neurotoxicity in rat striatum. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 62(3), 237-251.
https://hdl.handle.net/21.15107/rcub_farfar_1778

Đukić M, Ninković M, Stevanović I, Ilić K, Đurđević D. The effect of pre-treatment with l-name on glutathione and glutathione peroxidase in parquat-induced neurotoxicity in rat striatum. in Arhiv za farmaciju. 2012;62(3):237-251.
https://hdl.handle.net/21.15107/rcub_farfar_1778 .

Đukić, Mirjana, Ninković, Milica, Stevanović, Ivana, Ilić, Katarina, Đurđević, Dragan, "The effect of pre-treatment with l-name on glutathione and glutathione peroxidase in parquat-induced neurotoxicity in rat striatum" in Arhiv za farmaciju, 62, no. 3 (2012):237-251,
https://hdl.handle.net/21.15107/rcub_farfar_1778 .

TY  - JOUR
AU  - Đukić, Mirjana
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Ćurčić, Marijana
AU  - Ilić, Katarina
AU  - Đurđević, Dragan
AU  - Vujanović, Dragana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1781
AB  - Most commonly observed central nervous system (CNS) effects induced by systemic toxicity of herbicide diquat (DQ) are general depression and lethargy. Generally, it is accepted that DQ exerts its toxicity through the production of superoxide anion radical (O2 ●-) during its redox metabolism in the presence of molecular oxygen, which further initiates radical chain reaction, contributing developing of oxidative stress (OS) as well. Mechanisms of DQ neurotoxic effect is not rationalized till now. The objective of the study was to examine whether OS contributes to DQ neurotxicity. For this purpose, male Wistar rats were intrastriataly (i.s.) treated with DQ and oxidative status parameters such as: superoxide anion radical (O2 ●-); nitrates (NO3 -), as a final metabolite of reactive nitogen species; malondialdehyde (MDA), an indicator of lipid peroxidation; activity of superoxide dismutase (SOD); glutathione peroxidase (GPx), and glutathione (GSH), were measured in the hippocampus at 30 minutes, 24 hours and 7 days post treatment. Noteworthy, mortality rate (30 - 40 %) was observed in the group of rats treated with DQ, within 2-3 hours after awakening from anesthesia. Additionally, lethargy was the only neurological symptom observed in that group. Analyzed parameters indicate that OS mediates DQ neurotxicity, which is documented with significant increase of lipid peroxidation.
AB  - Najčešće zapaženi efekti sistemskog trovanja herbicidom dikvatom (DK) na centralni nervni sistem (CNS) su opšta depresija i letargija. Opšte je prihvaćeno da se toksičnost DK ostvaruje posredstvom povećanog stvaranja superoksid anjon radikala (O2 ●-) tokom njegovog redoks metabolizma, u prisustvu molekularnog kiseonika, koji dalje inicira lančanu reakciju radikalskog tipa i razvoj oksidativnog stresa (OS). Do danas mehanizmi neurotoksičnog efekta DK nisu u potpunosti poznati. Cilj ove studije je bio da ispitamo da li OS posreduje u neurotoksičnosti indukovanoj DK. Eksperiment je sproveden na mužjacima Wistar pacova, intrastrijatalno tretiranih (i.s.) DK. Parametri oksidativnog statusa, kao što su: superoksid anjon radikal (O2 ●-), nitrati (NO3 -), kao finalni metaboliti reaktivnih vrsta azota; malondialdehid (MDA), indikator lipidne peroksidacije; aktivnost enzima; superoksid dizmutaze (SOD) i glutation peroksidaze (GPx); i glutation (GSH) mereni su u hipokampusu, 30 minuta, 24 sati i 7 dana posle tretmana. Stopa smrtnosti od 30 do 40 % ustanovljena je u grupi pacova tretiranih DK, tokom 2-3 sata od buđenja iz anestezije. Dodatno, pacovi ove grupe su pokazali neurološke simptome letargije. Značajno povećana lipidna peroksidacija pokazuju da OS posreduje u neurotoksičnom odgovoru indukovanom i.s. primenom DK.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Oxidative and nitrosative stress: Mediators of diquat neurotoxicity
T1  - Oksidativni i nitrozativni stres - medijatori neurotoksičnosti dikvata
VL  - 62
IS  - 5
SP  - 443
EP  - 460
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1781
ER  - 

@article{
author = "Đukić, Mirjana and Ninković, Milica and Stevanović, Ivana and Ćurčić, Marijana and Ilić, Katarina and Đurđević, Dragan and Vujanović, Dragana",
year = "2012",
abstract = "Most commonly observed central nervous system (CNS) effects induced by systemic toxicity of herbicide diquat (DQ) are general depression and lethargy. Generally, it is accepted that DQ exerts its toxicity through the production of superoxide anion radical (O2 ●-) during its redox metabolism in the presence of molecular oxygen, which further initiates radical chain reaction, contributing developing of oxidative stress (OS) as well. Mechanisms of DQ neurotoxic effect is not rationalized till now. The objective of the study was to examine whether OS contributes to DQ neurotxicity. For this purpose, male Wistar rats were intrastriataly (i.s.) treated with DQ and oxidative status parameters such as: superoxide anion radical (O2 ●-); nitrates (NO3 -), as a final metabolite of reactive nitogen species; malondialdehyde (MDA), an indicator of lipid peroxidation; activity of superoxide dismutase (SOD); glutathione peroxidase (GPx), and glutathione (GSH), were measured in the hippocampus at 30 minutes, 24 hours and 7 days post treatment. Noteworthy, mortality rate (30 - 40 %) was observed in the group of rats treated with DQ, within 2-3 hours after awakening from anesthesia. Additionally, lethargy was the only neurological symptom observed in that group. Analyzed parameters indicate that OS mediates DQ neurotxicity, which is documented with significant increase of lipid peroxidation., Najčešće zapaženi efekti sistemskog trovanja herbicidom dikvatom (DK) na centralni nervni sistem (CNS) su opšta depresija i letargija. Opšte je prihvaćeno da se toksičnost DK ostvaruje posredstvom povećanog stvaranja superoksid anjon radikala (O2 ●-) tokom njegovog redoks metabolizma, u prisustvu molekularnog kiseonika, koji dalje inicira lančanu reakciju radikalskog tipa i razvoj oksidativnog stresa (OS). Do danas mehanizmi neurotoksičnog efekta DK nisu u potpunosti poznati. Cilj ove studije je bio da ispitamo da li OS posreduje u neurotoksičnosti indukovanoj DK. Eksperiment je sproveden na mužjacima Wistar pacova, intrastrijatalno tretiranih (i.s.) DK. Parametri oksidativnog statusa, kao što su: superoksid anjon radikal (O2 ●-), nitrati (NO3 -), kao finalni metaboliti reaktivnih vrsta azota; malondialdehid (MDA), indikator lipidne peroksidacije; aktivnost enzima; superoksid dizmutaze (SOD) i glutation peroksidaze (GPx); i glutation (GSH) mereni su u hipokampusu, 30 minuta, 24 sati i 7 dana posle tretmana. Stopa smrtnosti od 30 do 40 % ustanovljena je u grupi pacova tretiranih DK, tokom 2-3 sata od buđenja iz anestezije. Dodatno, pacovi ove grupe su pokazali neurološke simptome letargije. Značajno povećana lipidna peroksidacija pokazuju da OS posreduje u neurotoksičnom odgovoru indukovanom i.s. primenom DK.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Oxidative and nitrosative stress: Mediators of diquat neurotoxicity, Oksidativni i nitrozativni stres - medijatori neurotoksičnosti dikvata",
volume = "62",
number = "5",
pages = "443-460",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1781"
}

Đukić, M., Ninković, M., Stevanović, I., Ćurčić, M., Ilić, K., Đurđević, D.,& Vujanović, D.. (2012). Oxidative and nitrosative stress: Mediators of diquat neurotoxicity. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 62(5), 443-460.
https://hdl.handle.net/21.15107/rcub_farfar_1781

Đukić M, Ninković M, Stevanović I, Ćurčić M, Ilić K, Đurđević D, Vujanović D. Oxidative and nitrosative stress: Mediators of diquat neurotoxicity. in Arhiv za farmaciju. 2012;62(5):443-460.
https://hdl.handle.net/21.15107/rcub_farfar_1781 .

Đukić, Mirjana, Ninković, Milica, Stevanović, Ivana, Ćurčić, Marijana, Ilić, Katarina, Đurđević, Dragan, Vujanović, Dragana, "Oxidative and nitrosative stress: Mediators of diquat neurotoxicity" in Arhiv za farmaciju, 62, no. 5 (2012):443-460,
https://hdl.handle.net/21.15107/rcub_farfar_1781 .

TY  - JOUR
AU  - Đukić, Mirjana
AU  - Jovanović, Marina
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Ilić, Katarina
AU  - Ćurčić, Marijana
AU  - Vekić, Jelena
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1653
AB  - Paraquat (PQ), a widely used herbicide is a well-known free radical producing agent. The mechanistic pathways of PQ neurotoxicity were examined by assessing oxidative/nitrosative stress markers. Focus was on the role of glutathione (GSH) cycle and to examine whether the pre-treatment with enzyme glutathione reductase (GR) could protect the vulnerable brain regions (VBRs) against harmful oxidative effect of PQ. The study was conducted on Wistar rats, randomly divided in five groups: intact-control group, (n = 8) and four experimental groups (n = 24). All tested compounds were administered intrastriatally (i.s.) in one single dose. The following parameters of oxidative status were measured in the striatum, hippocampus and cortex, at 30 min, 24 h and 7 days post treatment: superoxide anion radical (O-2(center dot-)), nitrate (NO3-). malondialdehyde (MDA), superoxide dismutase (SOD), total GSH (tGSH) and its oxidized, disulfide form (GSSG) and glutathione peroxidase (GPx). Results obtained from the intact and the sham operated groups were not statistically different, confirming that invasive i.s. route of administration would not influence the reliability of results. Also, similar pattern of changes were observed between ipsi- and contra- lateral side of examined VBRs, indicating rapid spatial spreading of oxidative stress. Mortality of the animals (10%), within 24 h, along with symptoms of Parkinsonism, after awakening from anesthesia for 2-3 h, were observed in the PQ group, only. Increased levels of O2(center dot-), NO3- and MDA, increased ratio of GSSG/GSH and considerably high activity of GPx were measured at 30 min after the treatment. Cytotoxic effect of PQ was documented by drastic drop of all measured parameters and extremely high peak of the ratio GSSG/GSH at 24th hrs after the PQ i.s. injection. In the GR + PQ group, markedly low activity of GPx and low content of NO3- (in striatum and cortex) were measured during whole experiment, while increase value was observed only for O-2(center dot-), at 7th days. We concluded that oxidative/nitrosative stress and excitotoxicity are the most important events since the early stage of PQ induced neurotoxicity. Based on the ratio GSSG/GSH, the oxidation of GSH to GSSG is probably dominant way of GHS depletion and main reason for reduced antioxidative defense against PQ harmful oxidative effect. The GR pre-treatment resulted in the absence of Parkinson's disease-like symptoms and mortality of the rats. Additionally, oxidative/nitrosative stress did not developed, as well as almost diminished metabolism of the VBRs at 24th hours (as has been documented in the PQgroup) did not occurred in the GR + PQ suggesting a neuroprotective role for the GR in PQ induced neurotoxicity.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Protective role of glutathione reductase in paraquat induced neurotoxicity
VL  - 199
IS  - 2
SP  - 74
EP  - 86
DO  - 10.1016/j.cbi.2012.05.008
ER  - 

@article{
author = "Đukić, Mirjana and Jovanović, Marina and Ninković, Milica and Stevanović, Ivana and Ilić, Katarina and Ćurčić, Marijana and Vekić, Jelena",
year = "2012",
abstract = "Paraquat (PQ), a widely used herbicide is a well-known free radical producing agent. The mechanistic pathways of PQ neurotoxicity were examined by assessing oxidative/nitrosative stress markers. Focus was on the role of glutathione (GSH) cycle and to examine whether the pre-treatment with enzyme glutathione reductase (GR) could protect the vulnerable brain regions (VBRs) against harmful oxidative effect of PQ. The study was conducted on Wistar rats, randomly divided in five groups: intact-control group, (n = 8) and four experimental groups (n = 24). All tested compounds were administered intrastriatally (i.s.) in one single dose. The following parameters of oxidative status were measured in the striatum, hippocampus and cortex, at 30 min, 24 h and 7 days post treatment: superoxide anion radical (O-2(center dot-)), nitrate (NO3-). malondialdehyde (MDA), superoxide dismutase (SOD), total GSH (tGSH) and its oxidized, disulfide form (GSSG) and glutathione peroxidase (GPx). Results obtained from the intact and the sham operated groups were not statistically different, confirming that invasive i.s. route of administration would not influence the reliability of results. Also, similar pattern of changes were observed between ipsi- and contra- lateral side of examined VBRs, indicating rapid spatial spreading of oxidative stress. Mortality of the animals (10%), within 24 h, along with symptoms of Parkinsonism, after awakening from anesthesia for 2-3 h, were observed in the PQ group, only. Increased levels of O2(center dot-), NO3- and MDA, increased ratio of GSSG/GSH and considerably high activity of GPx were measured at 30 min after the treatment. Cytotoxic effect of PQ was documented by drastic drop of all measured parameters and extremely high peak of the ratio GSSG/GSH at 24th hrs after the PQ i.s. injection. In the GR + PQ group, markedly low activity of GPx and low content of NO3- (in striatum and cortex) were measured during whole experiment, while increase value was observed only for O-2(center dot-), at 7th days. We concluded that oxidative/nitrosative stress and excitotoxicity are the most important events since the early stage of PQ induced neurotoxicity. Based on the ratio GSSG/GSH, the oxidation of GSH to GSSG is probably dominant way of GHS depletion and main reason for reduced antioxidative defense against PQ harmful oxidative effect. The GR pre-treatment resulted in the absence of Parkinson's disease-like symptoms and mortality of the rats. Additionally, oxidative/nitrosative stress did not developed, as well as almost diminished metabolism of the VBRs at 24th hours (as has been documented in the PQgroup) did not occurred in the GR + PQ suggesting a neuroprotective role for the GR in PQ induced neurotoxicity.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Protective role of glutathione reductase in paraquat induced neurotoxicity",
volume = "199",
number = "2",
pages = "74-86",
doi = "10.1016/j.cbi.2012.05.008"
}

Đukić, M., Jovanović, M., Ninković, M., Stevanović, I., Ilić, K., Ćurčić, M.,& Vekić, J.. (2012). Protective role of glutathione reductase in paraquat induced neurotoxicity. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 199(2), 74-86.
https://doi.org/10.1016/j.cbi.2012.05.008

Đukić M, Jovanović M, Ninković M, Stevanović I, Ilić K, Ćurčić M, Vekić J. Protective role of glutathione reductase in paraquat induced neurotoxicity. in Chemico-Biological Interactions. 2012;199(2):74-86.
doi:10.1016/j.cbi.2012.05.008 .

Đukić, Mirjana, Jovanović, Marina, Ninković, Milica, Stevanović, Ivana, Ilić, Katarina, Ćurčić, Marijana, Vekić, Jelena, "Protective role of glutathione reductase in paraquat induced neurotoxicity" in Chemico-Biological Interactions, 199, no. 2 (2012):74-86,
https://doi.org/10.1016/j.cbi.2012.05.008 . .

TY  - JOUR
AU  - Ilić, Katarina
AU  - Hadžibegović, Senka
AU  - Đorđević, Brižita
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1592
AB  - Oxidative stress, which develops due to imbalance of free radicals and antioxidant factors, has an important role in oxidative stress. The combination of different antioxidants can act sinergistically in the neutralization of free radicals, nitric oxide increase, improvement of vasodilatation and lowering blood pressure. This paper reviews the impact of certain food ingredients (vitamins, oligoelements, proteins) on prevention of hypertension and blood pressure lowering. Literature was found by searching the Medline database from 1995 to 2010 by using the following keywords: hypertension, prevention of hypertension, antioxidants, electrolytes, and nutrients. Excesive natrium intake as well as insufficiency of microelements in nutrition such as calcium, magnesium, zink and selenium contributes to the development of hypertension. A numerous nutritients used in prevention and treatment of hypertension (hydrolisates of soy proteins, whey, sardines, wheat germs, ω-3 and ω-6 unsaturated fatty acids, green and black tea, mushrooms, vitamin B6, L-arginine, flavonoids, taurine, allicin from garlic, active principles of hawtorn) have effects similar to certain groups of antihipertensive drugs (diuretics, beta blockers, calcium channel blockers, ACE inhibitors, angiotensin receptors blockers, central α-agonists, direct vasodilatators). Natural components are of importance in the prevention of hypertension but their potency is not sufficient to lower high blood pressure. However, certain individual components of natural food in combination with antihypertensive drugs may act synergistically, and with proper diet drug therapy can achieve a better effect.
AB  - Hipertenzija je masovno oboljenje sa visokom stopom smrtnosti od komplikacija koje nastaju. Promena stila života, posebno načina ishrane ima značajnu ulogu u prevenciji nastanka hipertenzije i u odlaganju pojave komplikacija. Ovaj rad razmatra uticaj pojedinih sastojaka hrane (vitamina, oligoelemenata, proteina) na prevenciju i smanjenje povišenog krvnog pritiska. Literatura je pronađena pretraživanjem Medline baze u periodu od 1995. do 2010. godine korišćenjem sledećih ključnih reči: hipertenzija, prevencija hipertenzije, antioksidansi, elektroliti, nutrijenti. Razvoju hipertenzije doprinosi i prekomeran unos natrijuma, kao i nedostatak elektrolita i mikroelemenata u ishrani, kao što su: kalijum, magnezijum, kalcijum, cink i selen. Brojni nutrijenti koji se koriste u prevenciji i tretmanu hipertenzije (hidrolizati proteina soje, surutke, sardine i pšeničnih klica, ω-3 i ω-6 polinezasićene masne kiseline, zeleni i crni čaj, pečurke, vitamin B6, L-arginin, flavonoidi, taurin, alicin iz belog luka, aktivni sastojci gloga) imaju dejstvo slično pojedinim grupama antihipertenzivnih lekova (diuretici, β-blokatori, blokatori kalcijumskih kanala, ACE inhibitori i blokatori angiotenzinskih receptora, centralni α-agonisti, direktni vazodilatatori). Prirodne komponente su od značaja u prevenciji hipertenzije, ali njihova potentnost nije dovoljna da smanji povećani krvni pritisak. Međutim, pojedine prirodne komponente hrane u kombinaciji sa antihipertenzivnim lekovima mogu delovati sinergistički, te se uz odgovarajuću ishranu medikamentoznom terapijom može postići bolji efekat.
PB  - Društvo za ishranu Srbije, Beograd
T2  - Hrana i ishrana
T1  - Relevance of some nutrients in the pre­vention and treatment of hypertension
T1  - Značaj pojedinih nutrijenata u prevenciji i tretmanu hipertenzije
VL  - 52
IS  - 1
SP  - 15
EP  - 22
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1592
ER  - 

@article{
author = "Ilić, Katarina and Hadžibegović, Senka and Đorđević, Brižita",
year = "2011",
abstract = "Oxidative stress, which develops due to imbalance of free radicals and antioxidant factors, has an important role in oxidative stress. The combination of different antioxidants can act sinergistically in the neutralization of free radicals, nitric oxide increase, improvement of vasodilatation and lowering blood pressure. This paper reviews the impact of certain food ingredients (vitamins, oligoelements, proteins) on prevention of hypertension and blood pressure lowering. Literature was found by searching the Medline database from 1995 to 2010 by using the following keywords: hypertension, prevention of hypertension, antioxidants, electrolytes, and nutrients. Excesive natrium intake as well as insufficiency of microelements in nutrition such as calcium, magnesium, zink and selenium contributes to the development of hypertension. A numerous nutritients used in prevention and treatment of hypertension (hydrolisates of soy proteins, whey, sardines, wheat germs, ω-3 and ω-6 unsaturated fatty acids, green and black tea, mushrooms, vitamin B6, L-arginine, flavonoids, taurine, allicin from garlic, active principles of hawtorn) have effects similar to certain groups of antihipertensive drugs (diuretics, beta blockers, calcium channel blockers, ACE inhibitors, angiotensin receptors blockers, central α-agonists, direct vasodilatators). Natural components are of importance in the prevention of hypertension but their potency is not sufficient to lower high blood pressure. However, certain individual components of natural food in combination with antihypertensive drugs may act synergistically, and with proper diet drug therapy can achieve a better effect., Hipertenzija je masovno oboljenje sa visokom stopom smrtnosti od komplikacija koje nastaju. Promena stila života, posebno načina ishrane ima značajnu ulogu u prevenciji nastanka hipertenzije i u odlaganju pojave komplikacija. Ovaj rad razmatra uticaj pojedinih sastojaka hrane (vitamina, oligoelemenata, proteina) na prevenciju i smanjenje povišenog krvnog pritiska. Literatura je pronađena pretraživanjem Medline baze u periodu od 1995. do 2010. godine korišćenjem sledećih ključnih reči: hipertenzija, prevencija hipertenzije, antioksidansi, elektroliti, nutrijenti. Razvoju hipertenzije doprinosi i prekomeran unos natrijuma, kao i nedostatak elektrolita i mikroelemenata u ishrani, kao što su: kalijum, magnezijum, kalcijum, cink i selen. Brojni nutrijenti koji se koriste u prevenciji i tretmanu hipertenzije (hidrolizati proteina soje, surutke, sardine i pšeničnih klica, ω-3 i ω-6 polinezasićene masne kiseline, zeleni i crni čaj, pečurke, vitamin B6, L-arginin, flavonoidi, taurin, alicin iz belog luka, aktivni sastojci gloga) imaju dejstvo slično pojedinim grupama antihipertenzivnih lekova (diuretici, β-blokatori, blokatori kalcijumskih kanala, ACE inhibitori i blokatori angiotenzinskih receptora, centralni α-agonisti, direktni vazodilatatori). Prirodne komponente su od značaja u prevenciji hipertenzije, ali njihova potentnost nije dovoljna da smanji povećani krvni pritisak. Međutim, pojedine prirodne komponente hrane u kombinaciji sa antihipertenzivnim lekovima mogu delovati sinergistički, te se uz odgovarajuću ishranu medikamentoznom terapijom može postići bolji efekat.",
publisher = "Društvo za ishranu Srbije, Beograd",
journal = "Hrana i ishrana",
title = "Relevance of some nutrients in the pre­vention and treatment of hypertension, Značaj pojedinih nutrijenata u prevenciji i tretmanu hipertenzije",
volume = "52",
number = "1",
pages = "15-22",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1592"
}

Ilić, K., Hadžibegović, S.,& Đorđević, B.. (2011). Relevance of some nutrients in the pre­vention and treatment of hypertension. in Hrana i ishrana
Društvo za ishranu Srbije, Beograd., 52(1), 15-22.
https://hdl.handle.net/21.15107/rcub_farfar_1592

Ilić K, Hadžibegović S, Đorđević B. Relevance of some nutrients in the pre­vention and treatment of hypertension. in Hrana i ishrana. 2011;52(1):15-22.
https://hdl.handle.net/21.15107/rcub_farfar_1592 .

Ilić, Katarina, Hadžibegović, Senka, Đorđević, Brižita, "Relevance of some nutrients in the pre­vention and treatment of hypertension" in Hrana i ishrana, 52, no. 1 (2011):15-22,
https://hdl.handle.net/21.15107/rcub_farfar_1592 .

TY  - JOUR
AU  - Erić, Slavica
AU  - Ilić, Katarina
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1431
AB  - Multidrug resistance (MDR) is a significant obstacle to providing effective chemotherapy to many patients suffering from different types of cancer. Although resistance to anticancer drugs may be developed by different mechanisms, one of the underlying mechanisms of classical MDR is cellular overexpression of P-glycoprotein (P-gp) which acts as an efflux pump for different substrates in cells, resulting in decreased concentration of anticancer drugs in cancer cells. Inhibiting P-gp as a method to reverse MDR in cancer patients has been studied extensively. The development of Pgp inhibitors from first to third generation is presented in this work. First-generation inhibitors (eg. cyclosporin A, verapamil) are limited by their toxicity, whereas secondgeneration inhibitors (eg. valspodar, biricodar) showed reduced toxicity but were confounded by unpredictable pharmacokinetic interactions with anticancer drugs as well as interactions with other transporter proteins. Third-generation inhibitors (tariquidar, zosuquidar, laniquidar and ONT-093) show high potency and specificity for P-gp. The continued development of these agents may establish the true therapeutic potential of Pgp- mediated MDR reversal.
AB  - Multipla rezistencija na lekove (multidrug resistance, MDR) predstavlja značajnu prepreku u primeni efektivne terapije za mnoge pacijente koji su oboleli od različitih tipova kancera. Mada rezistencija na antikancerogene lekove može da nastane usled dejstva različitih mehanizama, klasična multipla rezistencija je uglavnom povezana sa povećanom ekspresijom P-glikoproteina (P-gp) koji deluje kao pumpa za izbacivanje (engl. efflux pump) različitih supstrata iz ćelije, što dovodi do smanjenja koncentracije antikancerogenih lekova u tumorskoj ćeliji. Inhibicija P-gp kao mogućnost prevazilaženja rezistencije je dosta proučavana poslednjih godina. U ovom radu prikazan je razvoj P-gp inhibitora od prve do treće generacije. Upotreba prve generacije inhibitora, kao što su ciklosporin A i verapamil, ograničena je zbog njihove toksičnosti, dok je druga generacija inhibitora, kojoj pripadaju valspodar i birikodar, pokazala smanjenu toksičnost, ali i neočekivane farmakokinetičke interakcije sa antikancerogenim lekovima, kao i sa drugim transportnim proteinima. Treća generacija inhibitora (tarikvidar, zosukvidar, lanikvidar i ONT-093) pokazala je veliku aktivnost i specifičnost za P-gp. Dalji razvoj ovih lekova predstavlja značajan terapijski potencijal za prevazilaženje rezistencije na antikancerogene lekove.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - P-gp inhibitors as modulators of multidrug resistance on anticancer drugs
T1  - Inhibitori P-glikoproteina kao modulatori rezistencije na antikancerogene lekove
VL  - 60
IS  - 3
SP  - 271
EP  - 284
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1431
ER  - 

@article{
author = "Erić, Slavica and Ilić, Katarina",
year = "2010",
abstract = "Multidrug resistance (MDR) is a significant obstacle to providing effective chemotherapy to many patients suffering from different types of cancer. Although resistance to anticancer drugs may be developed by different mechanisms, one of the underlying mechanisms of classical MDR is cellular overexpression of P-glycoprotein (P-gp) which acts as an efflux pump for different substrates in cells, resulting in decreased concentration of anticancer drugs in cancer cells. Inhibiting P-gp as a method to reverse MDR in cancer patients has been studied extensively. The development of Pgp inhibitors from first to third generation is presented in this work. First-generation inhibitors (eg. cyclosporin A, verapamil) are limited by their toxicity, whereas secondgeneration inhibitors (eg. valspodar, biricodar) showed reduced toxicity but were confounded by unpredictable pharmacokinetic interactions with anticancer drugs as well as interactions with other transporter proteins. Third-generation inhibitors (tariquidar, zosuquidar, laniquidar and ONT-093) show high potency and specificity for P-gp. The continued development of these agents may establish the true therapeutic potential of Pgp- mediated MDR reversal., Multipla rezistencija na lekove (multidrug resistance, MDR) predstavlja značajnu prepreku u primeni efektivne terapije za mnoge pacijente koji su oboleli od različitih tipova kancera. Mada rezistencija na antikancerogene lekove može da nastane usled dejstva različitih mehanizama, klasična multipla rezistencija je uglavnom povezana sa povećanom ekspresijom P-glikoproteina (P-gp) koji deluje kao pumpa za izbacivanje (engl. efflux pump) različitih supstrata iz ćelije, što dovodi do smanjenja koncentracije antikancerogenih lekova u tumorskoj ćeliji. Inhibicija P-gp kao mogućnost prevazilaženja rezistencije je dosta proučavana poslednjih godina. U ovom radu prikazan je razvoj P-gp inhibitora od prve do treće generacije. Upotreba prve generacije inhibitora, kao što su ciklosporin A i verapamil, ograničena je zbog njihove toksičnosti, dok je druga generacija inhibitora, kojoj pripadaju valspodar i birikodar, pokazala smanjenu toksičnost, ali i neočekivane farmakokinetičke interakcije sa antikancerogenim lekovima, kao i sa drugim transportnim proteinima. Treća generacija inhibitora (tarikvidar, zosukvidar, lanikvidar i ONT-093) pokazala je veliku aktivnost i specifičnost za P-gp. Dalji razvoj ovih lekova predstavlja značajan terapijski potencijal za prevazilaženje rezistencije na antikancerogene lekove.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "P-gp inhibitors as modulators of multidrug resistance on anticancer drugs, Inhibitori P-glikoproteina kao modulatori rezistencije na antikancerogene lekove",
volume = "60",
number = "3",
pages = "271-284",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1431"
}

Erić, S.,& Ilić, K.. (2010). P-gp inhibitors as modulators of multidrug resistance on anticancer drugs. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 60(3), 271-284.
https://hdl.handle.net/21.15107/rcub_farfar_1431

Erić S, Ilić K. P-gp inhibitors as modulators of multidrug resistance on anticancer drugs. in Arhiv za farmaciju. 2010;60(3):271-284.
https://hdl.handle.net/21.15107/rcub_farfar_1431 .

Erić, Slavica, Ilić, Katarina, "P-gp inhibitors as modulators of multidrug resistance on anticancer drugs" in Arhiv za farmaciju, 60, no. 3 (2010):271-284,
https://hdl.handle.net/21.15107/rcub_farfar_1431 .

TY  - JOUR
AU  - Ilić, Katarina
AU  - Kuntić, Vesna
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1015
AB  - Biomarkeri imaju široku primenu u modernoj medicini i biologiji. Oni su promenili način dijagnostikovanja i klasifikacije bolesti, praćenja efekata terapije, određivanja toksičnosti, a imaju i sve veću primenu u razvoju novih lekova. Karakteristike biomarkera određuju i njihovu primenu. Biomarkeri koji imaju malu moć predviđanja korisnosti tretmana koriste se u ranim fazama razvoja lekova za preliminarni skrining. Biomarkeri velike prediktivne moći mogu biti upotrebljeni kao surogatni parametri u proceni efikasnosti i bezbednosti tretmana. Surogatni parametri validirani u kliničkim istraživanjima i prihvaćeni od strane regulatornih agencija mogu biti korišćeni i za registraciju lekova, naročito za ubrzanu registraciju antiinfektivnih lekova i hemoterapeutika. Međutim, za registraciju antikancerskih lekova regulatorne agencije insistiraju na neophodnosti prospektivnih postmarketinških studija da bi se dokazalo postojanje korelacije surogatnih parametara sa kliničkom koristi od primenjenog tretmana. .
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Significance of biomarkers and surrogate endpoints in preclinical and clinical trials
T1  - Uloga biomarkera i surogatnih parametara u pretkliničkim i kliničkim ispitivanjima lekova
VL  - 64
IS  - 8
SP  - 561
EP  - 567
DO  - 10.2298/VSP0708561I
ER  - 

@article{
author = "Ilić, Katarina and Kuntić, Vesna",
year = "2007",
abstract = "Biomarkeri imaju široku primenu u modernoj medicini i biologiji. Oni su promenili način dijagnostikovanja i klasifikacije bolesti, praćenja efekata terapije, određivanja toksičnosti, a imaju i sve veću primenu u razvoju novih lekova. Karakteristike biomarkera određuju i njihovu primenu. Biomarkeri koji imaju malu moć predviđanja korisnosti tretmana koriste se u ranim fazama razvoja lekova za preliminarni skrining. Biomarkeri velike prediktivne moći mogu biti upotrebljeni kao surogatni parametri u proceni efikasnosti i bezbednosti tretmana. Surogatni parametri validirani u kliničkim istraživanjima i prihvaćeni od strane regulatornih agencija mogu biti korišćeni i za registraciju lekova, naročito za ubrzanu registraciju antiinfektivnih lekova i hemoterapeutika. Međutim, za registraciju antikancerskih lekova regulatorne agencije insistiraju na neophodnosti prospektivnih postmarketinških studija da bi se dokazalo postojanje korelacije surogatnih parametara sa kliničkom koristi od primenjenog tretmana. .",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Significance of biomarkers and surrogate endpoints in preclinical and clinical trials, Uloga biomarkera i surogatnih parametara u pretkliničkim i kliničkim ispitivanjima lekova",
volume = "64",
number = "8",
pages = "561-567",
doi = "10.2298/VSP0708561I"
}

Ilić, K.,& Kuntić, V.. (2007). Significance of biomarkers and surrogate endpoints in preclinical and clinical trials. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 64(8), 561-567.
https://doi.org/10.2298/VSP0708561I

Ilić K, Kuntić V. Significance of biomarkers and surrogate endpoints in preclinical and clinical trials. in Vojnosanitetski pregled. 2007;64(8):561-567.
doi:10.2298/VSP0708561I .

Ilić, Katarina, Kuntić, Vesna, "Significance of biomarkers and surrogate endpoints in preclinical and clinical trials" in Vojnosanitetski pregled, 64, no. 8 (2007):561-567,
https://doi.org/10.2298/VSP0708561I . .

TY  - JOUR
AU  - Kuntić, Vesna
AU  - Pejić, Nataša
AU  - Ivković, Branka
AU  - Vujić, Zorica
AU  - Ilić, Katarina
AU  - Micić, Svetlana
AU  - Vukojević, Vladana
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/944
AB  - A rapid and sensitive assay for quantitative determination of rutin in oral dosage forms based on isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed and validated. Using a C-18 reverse-phase analytical column, the following conditions were chosen as optimal: mobile phase methanol-water 1:1 (v/v), pH 2.8 (adjusted with phosphoric acid), flow rate = 1 mL min(-1) and temperature T = 40.0 degrees C. Linearity was observed in the concentration range 8-120 mu g mL(-1) with a correlation coefficient of 0.99982 and the limit of detection (LOD) = 2.6 mu g mL(-1), and limit of quantification (LOQ) = 8.0 mu g mL(-1). Intra- and inter-day precision were within acceptable limits. Robustness test indicated that the mobile phase composition and pH influence mainly the separation. The proposed method allowed direct determination of rutin in pharmaceutical dosage forms in the presence of excipients, but is not suitable for preparations where compounds structurally/chemically related to rutin may be present.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Isocratic RP-HPLC method for rutin determination in solid oral dosage forms
VL  - 43
IS  - 2
SP  - 718
EP  - 721
DO  - 10.1016/j.jpba.2006.07.019
ER  - 

@article{
author = "Kuntić, Vesna and Pejić, Nataša and Ivković, Branka and Vujić, Zorica and Ilić, Katarina and Micić, Svetlana and Vukojević, Vladana",
year = "2007",
abstract = "A rapid and sensitive assay for quantitative determination of rutin in oral dosage forms based on isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed and validated. Using a C-18 reverse-phase analytical column, the following conditions were chosen as optimal: mobile phase methanol-water 1:1 (v/v), pH 2.8 (adjusted with phosphoric acid), flow rate = 1 mL min(-1) and temperature T = 40.0 degrees C. Linearity was observed in the concentration range 8-120 mu g mL(-1) with a correlation coefficient of 0.99982 and the limit of detection (LOD) = 2.6 mu g mL(-1), and limit of quantification (LOQ) = 8.0 mu g mL(-1). Intra- and inter-day precision were within acceptable limits. Robustness test indicated that the mobile phase composition and pH influence mainly the separation. The proposed method allowed direct determination of rutin in pharmaceutical dosage forms in the presence of excipients, but is not suitable for preparations where compounds structurally/chemically related to rutin may be present.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Isocratic RP-HPLC method for rutin determination in solid oral dosage forms",
volume = "43",
number = "2",
pages = "718-721",
doi = "10.1016/j.jpba.2006.07.019"
}

Kuntić, V., Pejić, N., Ivković, B., Vujić, Z., Ilić, K., Micić, S.,& Vukojević, V.. (2007). Isocratic RP-HPLC method for rutin determination in solid oral dosage forms. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 43(2), 718-721.
https://doi.org/10.1016/j.jpba.2006.07.019

Kuntić V, Pejić N, Ivković B, Vujić Z, Ilić K, Micić S, Vukojević V. Isocratic RP-HPLC method for rutin determination in solid oral dosage forms. in Journal of Pharmaceutical and Biomedical Analysis. 2007;43(2):718-721.
doi:10.1016/j.jpba.2006.07.019 .

Kuntić, Vesna, Pejić, Nataša, Ivković, Branka, Vujić, Zorica, Ilić, Katarina, Micić, Svetlana, Vukojević, Vladana, "Isocratic RP-HPLC method for rutin determination in solid oral dosage forms" in Journal of Pharmaceutical and Biomedical Analysis, 43, no. 2 (2007):718-721,
https://doi.org/10.1016/j.jpba.2006.07.019 . .