TY  - JOUR
AU  - Jović, Žarko
AU  - Živanović, Ljiljana
AU  - Radisić, Marina
AU  - Protić, Ana
AU  - Malesevic, Marija
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1700
PB  - Oxford Univ Press Inc, Cary
T2  - Journal of Chromatographic Science
T1  - Chemometrically Assisted Development and Validation of LC-UV and LC-MS Methods for Simultaneous Determination of Torasemide and its Impurities
VL  - 50
IS  - 4
SP  - 324
EP  - 334
DO  - 10.1093/chromsci/bms033
ER  - 

@article{
author = "Jović, Žarko and Živanović, Ljiljana and Radisić, Marina and Protić, Ana and Malesevic, Marija",
year = "2012",
publisher = "Oxford Univ Press Inc, Cary",
journal = "Journal of Chromatographic Science",
title = "Chemometrically Assisted Development and Validation of LC-UV and LC-MS Methods for Simultaneous Determination of Torasemide and its Impurities",
volume = "50",
number = "4",
pages = "324-334",
doi = "10.1093/chromsci/bms033"
}

Jović, Ž., Živanović, L., Radisić, M., Protić, A.,& Malesevic, M.. (2012). Chemometrically Assisted Development and Validation of LC-UV and LC-MS Methods for Simultaneous Determination of Torasemide and its Impurities. in Journal of Chromatographic Science
Oxford Univ Press Inc, Cary., 50(4), 324-334.
https://doi.org/10.1093/chromsci/bms033

Jović Ž, Živanović L, Radisić M, Protić A, Malesevic M. Chemometrically Assisted Development and Validation of LC-UV and LC-MS Methods for Simultaneous Determination of Torasemide and its Impurities. in Journal of Chromatographic Science. 2012;50(4):324-334.
doi:10.1093/chromsci/bms033 .

Jović, Žarko, Živanović, Ljiljana, Radisić, Marina, Protić, Ana, Malesevic, Marija, "Chemometrically Assisted Development and Validation of LC-UV and LC-MS Methods for Simultaneous Determination of Torasemide and its Impurities" in Journal of Chromatographic Science, 50, no. 4 (2012):324-334,
https://doi.org/10.1093/chromsci/bms033 . .

TY  - JOUR
AU  - Malesevic, Marija
AU  - Živanović, Ljiljana
AU  - Protić, Ana
AU  - Jović, Žarko
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1485
AB  - Multiresponse optimization methodology in combination with experimental design was employed as a powerful technique for simultaneous optimization of input variables significant for evaluation of chromatographic behaviour of zolpidem tartrate, zolpacid, oxozolpidem, zolpyridine and zolpaldehyde towards various responses. In the first stage of the investigation fractional factorial design was used to decrease the number of variables that should be studied in detail. Among examined variables, pH of the mobile phase, percentage of organic modifier and buffer concentration showed to be statistically important and were consequently optimized with central composite design and Derringer's desirability function. Four responses were considered, the retention factors of zolpacid and zolpaldehyde (the first and last peak) and the resolutions between critical peaks. Optimal conditions included Luna C-18(2) analytical column (250 mm x 4.6 mm, 5 mu m particle size), mobile phase consisted of methanol-10 mM ammonium acetate (68.4:31.6, v/v, pH 5.4) and column temperature of 35 degrees C. The flow rate of the mobile phase was 1 mL min(-1) and the detection was performed at 254 nm. At the end, the method was successfully validated in accordance with ICH guideline and subsequently applied to the analysis of commercially available zolpidem tartrate tablets.
PB  - Springer Heidelberg, Heidelberg
T2  - Chromatographia
T1  - Multiobjective Optimization Approach in Evaluation of Chromatographic Behaviour of Zolpidem Tartrate and Its Degradation Products
VL  - 74
IS  - 3-4
SP  - 197
EP  - 208
DO  - 10.1007/s10337-011-2064-9
ER  - 

@article{
author = "Malesevic, Marija and Živanović, Ljiljana and Protić, Ana and Jović, Žarko",
year = "2011",
abstract = "Multiresponse optimization methodology in combination with experimental design was employed as a powerful technique for simultaneous optimization of input variables significant for evaluation of chromatographic behaviour of zolpidem tartrate, zolpacid, oxozolpidem, zolpyridine and zolpaldehyde towards various responses. In the first stage of the investigation fractional factorial design was used to decrease the number of variables that should be studied in detail. Among examined variables, pH of the mobile phase, percentage of organic modifier and buffer concentration showed to be statistically important and were consequently optimized with central composite design and Derringer's desirability function. Four responses were considered, the retention factors of zolpacid and zolpaldehyde (the first and last peak) and the resolutions between critical peaks. Optimal conditions included Luna C-18(2) analytical column (250 mm x 4.6 mm, 5 mu m particle size), mobile phase consisted of methanol-10 mM ammonium acetate (68.4:31.6, v/v, pH 5.4) and column temperature of 35 degrees C. The flow rate of the mobile phase was 1 mL min(-1) and the detection was performed at 254 nm. At the end, the method was successfully validated in accordance with ICH guideline and subsequently applied to the analysis of commercially available zolpidem tartrate tablets.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "Multiobjective Optimization Approach in Evaluation of Chromatographic Behaviour of Zolpidem Tartrate and Its Degradation Products",
volume = "74",
number = "3-4",
pages = "197-208",
doi = "10.1007/s10337-011-2064-9"
}

Malesevic, M., Živanović, L., Protić, A.,& Jović, Ž.. (2011). Multiobjective Optimization Approach in Evaluation of Chromatographic Behaviour of Zolpidem Tartrate and Its Degradation Products. in Chromatographia
Springer Heidelberg, Heidelberg., 74(3-4), 197-208.
https://doi.org/10.1007/s10337-011-2064-9

Malesevic M, Živanović L, Protić A, Jović Ž. Multiobjective Optimization Approach in Evaluation of Chromatographic Behaviour of Zolpidem Tartrate and Its Degradation Products. in Chromatographia. 2011;74(3-4):197-208.
doi:10.1007/s10337-011-2064-9 .

Malesevic, Marija, Živanović, Ljiljana, Protić, Ana, Jović, Žarko, "Multiobjective Optimization Approach in Evaluation of Chromatographic Behaviour of Zolpidem Tartrate and Its Degradation Products" in Chromatographia, 74, no. 3-4 (2011):197-208,
https://doi.org/10.1007/s10337-011-2064-9 . .