TY  - JOUR
AU  - Todorović, Zoran B.
AU  - Ranđelović, Ljiljana M.
AU  - Marjanović, Jelena Z.
AU  - Todorović, Vanja
AU  - Cakić, Milorad
AU  - Cvetković, Olga G.
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2119
AB  - In this study, the nature of the association of heavy metals (Fe, Co, Ni, Cu, Cd, Pb, Mn, and Zn) in sediments of the recent reservoir 'Barje' (Leskovac, Serbia) was investigated. The aim was to make the identification of their substrates, as well as to define the external factors (hydrological and anthropogenic affecting their distribution) which will contribute to a better understanding of the interactions that take place in the reservoir and predict the mobility of the investigated heavy metals. Chemical distribution of heavy metals was tested by using the method of sequential extraction and by data processing using statistical methods such as correlation, cluster and factor analysis. Based on the obtained results it can be concluded that major substrates of heavy metals are in the residual immobile fraction (Fe, Zn and Ni). Since the accumulation has a small organic substance content, Fe and Mn oxides are the most important binding substrates of heavy metals. Although it was determined that lead and cadmium are of the carbonate nature, their concentrations in the reservoir are negligible.
AB  - Cilj ovog rada je da se ispitivanjem prirode asocijacija teških metala (Fe, Co, Ni, Cu, Cd, Pb, Mn, Zn) izvrši identifikacija njihovih supstrata u akumulaciji 'Barje' (Leskovac, Srbija), kao i da se definišu spoljni faktori (hidrološki i antropogeni koji utiču na njihovu raspodelu) što će doprineti boljem razumevanju interakcija koje se odigravaju u akumulaciji i prognozu mobilnosti na osnovu toga. Hemijska raspodela teških metala ispitana je korišćenjem metode sekvencijalne ekstrakcije i obradom dobijenih podataka statističkim metodama kao što su korelaciona, klaster i faktorska analiza. Na osnovu dobijenih rezultata može se zaključiti da se većina teških metala nalazi u rezidualnoj nepokretnoj frakciji (Fe, Zn i Ni). Zato što je u akumulaciji mali sadržaj organske supstance oksidi gvožđa i mangana su najznačajniji supstrati za vezivanje teških metala. Iako je utvrđeno da je olovo i kadmijum karbonatne prirode njihove koncentracije u akumulaciji su zanemarljivo male.
PB  - Univerzitet u Nišu - Tehnološki fakultet, Leskovac
T2  - Savremene tehnologije
T1  - The assessment and distribution of heavy metals in surface sediments from the reservoir 'Barje': Serbia
T1  - Procena sadržaja i raspodele teških metala u površinskom sedimentu akumulacije 'Barje' - Srbija
VL  - 3
IS  - 2
SP  - 85
EP  - 95
DO  - 10.5937/savteh1402085T
ER  - 

@article{
author = "Todorović, Zoran B. and Ranđelović, Ljiljana M. and Marjanović, Jelena Z. and Todorović, Vanja and Cakić, Milorad and Cvetković, Olga G.",
year = "2014",
abstract = "In this study, the nature of the association of heavy metals (Fe, Co, Ni, Cu, Cd, Pb, Mn, and Zn) in sediments of the recent reservoir 'Barje' (Leskovac, Serbia) was investigated. The aim was to make the identification of their substrates, as well as to define the external factors (hydrological and anthropogenic affecting their distribution) which will contribute to a better understanding of the interactions that take place in the reservoir and predict the mobility of the investigated heavy metals. Chemical distribution of heavy metals was tested by using the method of sequential extraction and by data processing using statistical methods such as correlation, cluster and factor analysis. Based on the obtained results it can be concluded that major substrates of heavy metals are in the residual immobile fraction (Fe, Zn and Ni). Since the accumulation has a small organic substance content, Fe and Mn oxides are the most important binding substrates of heavy metals. Although it was determined that lead and cadmium are of the carbonate nature, their concentrations in the reservoir are negligible., Cilj ovog rada je da se ispitivanjem prirode asocijacija teških metala (Fe, Co, Ni, Cu, Cd, Pb, Mn, Zn) izvrši identifikacija njihovih supstrata u akumulaciji 'Barje' (Leskovac, Srbija), kao i da se definišu spoljni faktori (hidrološki i antropogeni koji utiču na njihovu raspodelu) što će doprineti boljem razumevanju interakcija koje se odigravaju u akumulaciji i prognozu mobilnosti na osnovu toga. Hemijska raspodela teških metala ispitana je korišćenjem metode sekvencijalne ekstrakcije i obradom dobijenih podataka statističkim metodama kao što su korelaciona, klaster i faktorska analiza. Na osnovu dobijenih rezultata može se zaključiti da se većina teških metala nalazi u rezidualnoj nepokretnoj frakciji (Fe, Zn i Ni). Zato što je u akumulaciji mali sadržaj organske supstance oksidi gvožđa i mangana su najznačajniji supstrati za vezivanje teških metala. Iako je utvrđeno da je olovo i kadmijum karbonatne prirode njihove koncentracije u akumulaciji su zanemarljivo male.",
publisher = "Univerzitet u Nišu - Tehnološki fakultet, Leskovac",
journal = "Savremene tehnologije",
title = "The assessment and distribution of heavy metals in surface sediments from the reservoir 'Barje': Serbia, Procena sadržaja i raspodele teških metala u površinskom sedimentu akumulacije 'Barje' - Srbija",
volume = "3",
number = "2",
pages = "85-95",
doi = "10.5937/savteh1402085T"
}

Todorović, Z. B., Ranđelović, L. M., Marjanović, J. Z., Todorović, V., Cakić, M.,& Cvetković, O. G.. (2014). The assessment and distribution of heavy metals in surface sediments from the reservoir 'Barje': Serbia. in Savremene tehnologije
Univerzitet u Nišu - Tehnološki fakultet, Leskovac., 3(2), 85-95.
https://doi.org/10.5937/savteh1402085T

Todorović ZB, Ranđelović LM, Marjanović JZ, Todorović V, Cakić M, Cvetković OG. The assessment and distribution of heavy metals in surface sediments from the reservoir 'Barje': Serbia. in Savremene tehnologije. 2014;3(2):85-95.
doi:10.5937/savteh1402085T .

Todorović, Zoran B., Ranđelović, Ljiljana M., Marjanović, Jelena Z., Todorović, Vanja, Cakić, Milorad, Cvetković, Olga G., "The assessment and distribution of heavy metals in surface sediments from the reservoir 'Barje': Serbia" in Savremene tehnologije, 3, no. 2 (2014):85-95,
https://doi.org/10.5937/savteh1402085T . .

TY  - JOUR
AU  - Savić, Ivana
AU  - Nikolić, Katarina
AU  - Nikolić, Goran
AU  - Savić, Ivan
AU  - Agbaba, Danica
AU  - Cakić, Milorad
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1970
AB  - New formulation for treatment a copper deficiency in human organism was developed and optimized by application of mathematical modeling. This formulation contained copper (II) complex with polysaccharide pullulan, as active substance. The binder concentration [polyvinyl pyrrolidone (PVP %)], the disintegrant concentration (corn starch %) and the resistance to crushing (hardness) were taken as independent variables. In vitro measured drug release characteristics of the tablets at pH 1.20 and 7.56 were studied as response variables. Initially, the created full factorial 2(3) model showed that the resistance to crushing has the most significant effect on copper (II) complex release from the formulation. Optimal tablet formulation F2, with lower Hardness (50 N), lower Starch (20.0%) and higher PVP (2.7%) concentrations, is selected using the partial least squares (PLS) regression modeling. The selected formulation F2 has expressed the best drug release profile at both pH (98.66% pH = 1.20; 93.35% pH = 7.56), and the lowest variation of tablets weight. The presented theoretical approach and created PLS model can be readily applied in future copper complexes studies and formulation design.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Application of mathematical modeling for the development and optimization formulation with bioactive copper complex
VL  - 39
IS  - 7
SP  - 1084
EP  - 1090
DO  - 10.3109/03639045.2012.707208
ER  - 

@article{
author = "Savić, Ivana and Nikolić, Katarina and Nikolić, Goran and Savić, Ivan and Agbaba, Danica and Cakić, Milorad",
year = "2013",
abstract = "New formulation for treatment a copper deficiency in human organism was developed and optimized by application of mathematical modeling. This formulation contained copper (II) complex with polysaccharide pullulan, as active substance. The binder concentration [polyvinyl pyrrolidone (PVP %)], the disintegrant concentration (corn starch %) and the resistance to crushing (hardness) were taken as independent variables. In vitro measured drug release characteristics of the tablets at pH 1.20 and 7.56 were studied as response variables. Initially, the created full factorial 2(3) model showed that the resistance to crushing has the most significant effect on copper (II) complex release from the formulation. Optimal tablet formulation F2, with lower Hardness (50 N), lower Starch (20.0%) and higher PVP (2.7%) concentrations, is selected using the partial least squares (PLS) regression modeling. The selected formulation F2 has expressed the best drug release profile at both pH (98.66% pH = 1.20; 93.35% pH = 7.56), and the lowest variation of tablets weight. The presented theoretical approach and created PLS model can be readily applied in future copper complexes studies and formulation design.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Application of mathematical modeling for the development and optimization formulation with bioactive copper complex",
volume = "39",
number = "7",
pages = "1084-1090",
doi = "10.3109/03639045.2012.707208"
}

Savić, I., Nikolić, K., Nikolić, G., Savić, I., Agbaba, D.,& Cakić, M.. (2013). Application of mathematical modeling for the development and optimization formulation with bioactive copper complex. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 39(7), 1084-1090.
https://doi.org/10.3109/03639045.2012.707208

Savić I, Nikolić K, Nikolić G, Savić I, Agbaba D, Cakić M. Application of mathematical modeling for the development and optimization formulation with bioactive copper complex. in Drug Development and Industrial Pharmacy. 2013;39(7):1084-1090.
doi:10.3109/03639045.2012.707208 .

Savić, Ivana, Nikolić, Katarina, Nikolić, Goran, Savić, Ivan, Agbaba, Danica, Cakić, Milorad, "Application of mathematical modeling for the development and optimization formulation with bioactive copper complex" in Drug Development and Industrial Pharmacy, 39, no. 7 (2013):1084-1090,
https://doi.org/10.3109/03639045.2012.707208 . .