TY  - JOUR
AU  - Juranić, Zorica
AU  - Radić, Jelena
AU  - Konić-Ristić, Aleksandra
AU  - Jelić, Svetislav
AU  - Mihaljević, Biljana
AU  - Stanković, Ivan
AU  - Matković, Suzana
AU  - Besu, Irina
AU  - Gavrilović, Dušica
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1071
AB  - Background: Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. The aim of this work was to assess whether some of food antigens contribute to the imbalance of immune response by screening the sera of MM patients for their immunoreactivity to food constituent gliadin, to tissue transglutaminase-2 (tTG-2) and to Ro/SSA antigen. Sera from 61 patients with MM in various stages of disease, before, or after some cycles of conventional therapy were analyzed by commercial Binding Site ELISA tests. The control group consisted of 50 healthy volunteers. Statistical analysis of data obtained was performed by Mann Whitney Test. Results: The higher serum IgA immunoreactivity to gliadin was found in 14/56 patients and in one of control people. The enhanced serum IgG immunoreactivity to gliadin was found in only two of tested patients and in two controls. The enhanced IgA immunoreactivity to tTG-2 was found in 10/49 patients' sera, while 4/45 patients had higher serum IgG immunoreactivity. The enhanced serum IgG immunoreactivity to RoSSA antigen was found in 9/47 analyzed MM patients' sera. Statistical analysis of data obtained revealed that only the levels of anti-tTG-2 IgA immunoreactivity in patients with MM were significantly higher than these obtained in healthy controls (P  lt  0.02) Conclusion: Data obtained showed the existence of the enhanced serum immunoreactivity to gliadin, tTG-2 and Ro/SSA antigens in some patients with MM. These at least partially could contribute to the immunological imbalance frequently found in this disease.
PB  - BMC, LONDON
T2  - BMC Immunology
T1  - Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma
VL  - 9
DO  - 10.1186/1471-2172-9-22
ER  - 

@article{
author = "Juranić, Zorica and Radić, Jelena and Konić-Ristić, Aleksandra and Jelić, Svetislav and Mihaljević, Biljana and Stanković, Ivan and Matković, Suzana and Besu, Irina and Gavrilović, Dušica",
year = "2008",
abstract = "Background: Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. The aim of this work was to assess whether some of food antigens contribute to the imbalance of immune response by screening the sera of MM patients for their immunoreactivity to food constituent gliadin, to tissue transglutaminase-2 (tTG-2) and to Ro/SSA antigen. Sera from 61 patients with MM in various stages of disease, before, or after some cycles of conventional therapy were analyzed by commercial Binding Site ELISA tests. The control group consisted of 50 healthy volunteers. Statistical analysis of data obtained was performed by Mann Whitney Test. Results: The higher serum IgA immunoreactivity to gliadin was found in 14/56 patients and in one of control people. The enhanced serum IgG immunoreactivity to gliadin was found in only two of tested patients and in two controls. The enhanced IgA immunoreactivity to tTG-2 was found in 10/49 patients' sera, while 4/45 patients had higher serum IgG immunoreactivity. The enhanced serum IgG immunoreactivity to RoSSA antigen was found in 9/47 analyzed MM patients' sera. Statistical analysis of data obtained revealed that only the levels of anti-tTG-2 IgA immunoreactivity in patients with MM were significantly higher than these obtained in healthy controls (P  lt  0.02) Conclusion: Data obtained showed the existence of the enhanced serum immunoreactivity to gliadin, tTG-2 and Ro/SSA antigens in some patients with MM. These at least partially could contribute to the immunological imbalance frequently found in this disease.",
publisher = "BMC, LONDON",
journal = "BMC Immunology",
title = "Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma",
volume = "9",
doi = "10.1186/1471-2172-9-22"
}

Juranić, Z., Radić, J., Konić-Ristić, A., Jelić, S., Mihaljević, B., Stanković, I., Matković, S., Besu, I.,& Gavrilović, D.. (2008). Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma. in BMC Immunology
BMC, LONDON., 9.
https://doi.org/10.1186/1471-2172-9-22

Juranić Z, Radić J, Konić-Ristić A, Jelić S, Mihaljević B, Stanković I, Matković S, Besu I, Gavrilović D. Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma. in BMC Immunology. 2008;9.
doi:10.1186/1471-2172-9-22 .

Juranić, Zorica, Radić, Jelena, Konić-Ristić, Aleksandra, Jelić, Svetislav, Mihaljević, Biljana, Stanković, Ivan, Matković, Suzana, Besu, Irina, Gavrilović, Dušica, "Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma" in BMC Immunology, 9 (2008),
https://doi.org/10.1186/1471-2172-9-22 . .