TY  - JOUR
AU  - Sova, Matej
AU  - Žižak, Željko
AU  - Antić-Stanković, Jelena
AU  - Prijatelj, Matevz
AU  - Turk, Samo
AU  - Juranić, Zorica
AU  - Mlinarić-Rascan, Irena
AU  - Gobec, Stanislav
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1962
AB  - Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of the plant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC(50)s between 42 and 166 mu M) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol or amine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Medicinal Chemistry
T1  - Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines
VL  - 9
IS  - 5
SP  - 633
EP  - 641
DO  - 10.2174/1573406411309050002
ER  - 

@article{
author = "Sova, Matej and Žižak, Željko and Antić-Stanković, Jelena and Prijatelj, Matevz and Turk, Samo and Juranić, Zorica and Mlinarić-Rascan, Irena and Gobec, Stanislav",
year = "2013",
abstract = "Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of the plant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC(50)s between 42 and 166 mu M) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol or amine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Medicinal Chemistry",
title = "Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines",
volume = "9",
number = "5",
pages = "633-641",
doi = "10.2174/1573406411309050002"
}

Sova, M., Žižak, Ž., Antić-Stanković, J., Prijatelj, M., Turk, S., Juranić, Z., Mlinarić-Rascan, I.,& Gobec, S.. (2013). Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines. in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 9(5), 633-641.
https://doi.org/10.2174/1573406411309050002

Sova M, Žižak Ž, Antić-Stanković J, Prijatelj M, Turk S, Juranić Z, Mlinarić-Rascan I, Gobec S. Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines. in Medicinal Chemistry. 2013;9(5):633-641.
doi:10.2174/1573406411309050002 .

Sova, Matej, Žižak, Željko, Antić-Stanković, Jelena, Prijatelj, Matevz, Turk, Samo, Juranić, Zorica, Mlinarić-Rascan, Irena, Gobec, Stanislav, "Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines" in Medicinal Chemistry, 9, no. 5 (2013):633-641,
https://doi.org/10.2174/1573406411309050002 . .

TY  - JOUR
AU  - Injac, Rade
AU  - Srđenović, Branislava
AU  - Prijatelj, Matevz
AU  - Bošković, Marija
AU  - Karljiković-Rajić, Katarina
AU  - Štrukelj, Borut
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1053
PB  - Preston Publ Inc, Niles
T2  - Journal of Chromatographic Science
T1  - Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography
VL  - 46
IS  - 2
SP  - 137
EP  - 143
DO  - 10.1093/chromsci/46.2.137
ER  - 

@article{
author = "Injac, Rade and Srđenović, Branislava and Prijatelj, Matevz and Bošković, Marija and Karljiković-Rajić, Katarina and Štrukelj, Borut",
year = "2008",
publisher = "Preston Publ Inc, Niles",
journal = "Journal of Chromatographic Science",
title = "Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography",
volume = "46",
number = "2",
pages = "137-143",
doi = "10.1093/chromsci/46.2.137"
}

Injac, R., Srđenović, B., Prijatelj, M., Bošković, M., Karljiković-Rajić, K.,& Štrukelj, B.. (2008). Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography. in Journal of Chromatographic Science
Preston Publ Inc, Niles., 46(2), 137-143.
https://doi.org/10.1093/chromsci/46.2.137

Injac R, Srđenović B, Prijatelj M, Bošković M, Karljiković-Rajić K, Štrukelj B. Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography. in Journal of Chromatographic Science. 2008;46(2):137-143.
doi:10.1093/chromsci/46.2.137 .

Injac, Rade, Srđenović, Branislava, Prijatelj, Matevz, Bošković, Marija, Karljiković-Rajić, Katarina, Štrukelj, Borut, "Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography" in Journal of Chromatographic Science, 46, no. 2 (2008):137-143,
https://doi.org/10.1093/chromsci/46.2.137 . .