TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Bojić, Suzana
AU  - Basta-Jovanović, Gordana
AU  - Radojević, Sanja
AU  - Pavlović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Dopsaj, Violeta
AU  - Naumović, Radomir
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1842
AB  - Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.
PB  - Hindawi Publishing Corporation, New York
T2  - Disease Markers
T1  - Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
SP  - 567
EP  - 572
DO  - 10.1155/2013/183246
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Bojić, Suzana and Basta-Jovanović, Gordana and Radojević, Sanja and Pavlović, Jelena and Kotur-Stevuljević, Jelena and Dopsaj, Violeta and Naumović, Radomir",
year = "2013",
abstract = "Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.",
publisher = "Hindawi Publishing Corporation, New York",
journal = "Disease Markers",
title = "Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy",
pages = "567-572",
doi = "10.1155/2013/183246"
}

Simić-Ogrizović, S., Bojić, S., Basta-Jovanović, G., Radojević, S., Pavlović, J., Kotur-Stevuljević, J., Dopsaj, V.,& Naumović, R.. (2013). Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. in Disease Markers
Hindawi Publishing Corporation, New York., 567-572.
https://doi.org/10.1155/2013/183246

Simić-Ogrizović S, Bojić S, Basta-Jovanović G, Radojević S, Pavlović J, Kotur-Stevuljević J, Dopsaj V, Naumović R. Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. in Disease Markers. 2013;:567-572.
doi:10.1155/2013/183246 .

Simić-Ogrizović, Sanja, Bojić, Suzana, Basta-Jovanović, Gordana, Radojević, Sanja, Pavlović, Jelena, Kotur-Stevuljević, Jelena, Dopsaj, Violeta, Naumović, Radomir, "Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy" in Disease Markers (2013):567-572,
https://doi.org/10.1155/2013/183246 . .

TY  - JOUR
AU  - Dajak, Marijana
AU  - Bontić, Ana
AU  - Ignjatović, Svetlana
AU  - Pavlović, Jelena
AU  - Majkić-Singh, Nada
AU  - Lezaić, Višnja
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1747
AB  - Introduction One of the criteria for chronic kidney disease detection is determination of microalbuminuria. Objective This analysis was performed to evaluate accuracy of three useful methods for microalbuminuria detection in 24h urine collection and in the morning urine specimen calculated from urine albumin creatinine ratio, or with a dipstick in patients with different kidney diseases or kidney function. Methods Microalbuminuria was detected in 74 patients referred to the Outpatient Nephrology Department for kidney function determination or regular nephrology checking. Albumin concentration determined using immunonephelometry was lower than 300 mg/day. Discriminates cutoff values for spot urine test strip and albumin creatinin ratio in predicting 24 h protein 'threshold' excretion were determined using ROC analysis. Results Mean value of 24 h microalbuminuria was 80.3 mg/24 h, and value >30 mg/24 h was present in 71.8% of patient. Correlation coefficients between dipstick microalbuminuria or albumin/creatinine ratio in a spot urine specimen and 24 h microalbuminuria were 0.709 and 0.598 (p lt 0.0001). For pathological value of 24 h microalbuminuria >30 mg/24 h, the coresponding dipstick microalbuminuria value was >= 20 mg/L (AUC 0.849, specificity 95%, positive predictive value 97.3%), and >= 3.55 mg albumin/mmol creatinine ratio (AUC 0.914, specificity 90% and positive predictive value 95.5%). No difference was found between dipstick mikroalbuminuria and albumin/creatinine ratio value. In addition, albumin/creatinine ratio value from 24 h urine was similar to the value obtained from the spot urine sample. Conclusion Obtained results indicated that albuminuria could be determined accurately in spot urine either with the Micral test strip or with albumin creatinine ratio.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients
VL  - 140
IS  - 3-4
SP  - 173
EP  - 178
DO  - 10.2298/SARH1204173D
ER  - 

@article{
author = "Dajak, Marijana and Bontić, Ana and Ignjatović, Svetlana and Pavlović, Jelena and Majkić-Singh, Nada and Lezaić, Višnja",
year = "2012",
abstract = "Introduction One of the criteria for chronic kidney disease detection is determination of microalbuminuria. Objective This analysis was performed to evaluate accuracy of three useful methods for microalbuminuria detection in 24h urine collection and in the morning urine specimen calculated from urine albumin creatinine ratio, or with a dipstick in patients with different kidney diseases or kidney function. Methods Microalbuminuria was detected in 74 patients referred to the Outpatient Nephrology Department for kidney function determination or regular nephrology checking. Albumin concentration determined using immunonephelometry was lower than 300 mg/day. Discriminates cutoff values for spot urine test strip and albumin creatinin ratio in predicting 24 h protein 'threshold' excretion were determined using ROC analysis. Results Mean value of 24 h microalbuminuria was 80.3 mg/24 h, and value >30 mg/24 h was present in 71.8% of patient. Correlation coefficients between dipstick microalbuminuria or albumin/creatinine ratio in a spot urine specimen and 24 h microalbuminuria were 0.709 and 0.598 (p lt 0.0001). For pathological value of 24 h microalbuminuria >30 mg/24 h, the coresponding dipstick microalbuminuria value was >= 20 mg/L (AUC 0.849, specificity 95%, positive predictive value 97.3%), and >= 3.55 mg albumin/mmol creatinine ratio (AUC 0.914, specificity 90% and positive predictive value 95.5%). No difference was found between dipstick mikroalbuminuria and albumin/creatinine ratio value. In addition, albumin/creatinine ratio value from 24 h urine was similar to the value obtained from the spot urine sample. Conclusion Obtained results indicated that albuminuria could be determined accurately in spot urine either with the Micral test strip or with albumin creatinine ratio.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients",
volume = "140",
number = "3-4",
pages = "173-178",
doi = "10.2298/SARH1204173D"
}

Dajak, M., Bontić, A., Ignjatović, S., Pavlović, J., Majkić-Singh, N.,& Lezaić, V.. (2012). Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 140(3-4), 173-178.
https://doi.org/10.2298/SARH1204173D

Dajak M, Bontić A, Ignjatović S, Pavlović J, Majkić-Singh N, Lezaić V. Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients. in Srpski arhiv za celokupno lekarstvo. 2012;140(3-4):173-178.
doi:10.2298/SARH1204173D .

Dajak, Marijana, Bontić, Ana, Ignjatović, Svetlana, Pavlović, Jelena, Majkić-Singh, Nada, Lezaić, Višnja, "Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients" in Srpski arhiv za celokupno lekarstvo, 140, no. 3-4 (2012):173-178,
https://doi.org/10.2298/SARH1204173D . .