TY  - JOUR
AU  - Bubić-Pajić, Nataša
AU  - Todosijević, Marija N.
AU  - Vuleta, Gordana
AU  - Cekić, Nebojša
AU  - Dobričić, Vladimir
AU  - Vučen, Sonja
AU  - Čalija, Bojan
AU  - Lukić, Milica
AU  - Ilić, Tanja
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2837
AB  - Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.
PB  - Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb
T2  - Acta Pharmaceutica
T1  - Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance
VL  - 67
IS  - 4
SP  - 415
EP  - 439
DO  - 10.1515/acph-2017-0036
ER  - 

@article{
author = "Bubić-Pajić, Nataša and Todosijević, Marija N. and Vuleta, Gordana and Cekić, Nebojša and Dobričić, Vladimir and Vučen, Sonja and Čalija, Bojan and Lukić, Milica and Ilić, Tanja and Savić, Snežana",
year = "2017",
abstract = "Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.",
publisher = "Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb",
journal = "Acta Pharmaceutica",
title = "Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance",
volume = "67",
number = "4",
pages = "415-439",
doi = "10.1515/acph-2017-0036"
}

Bubić-Pajić, N., Todosijević, M. N., Vuleta, G., Cekić, N., Dobričić, V., Vučen, S., Čalija, B., Lukić, M., Ilić, T.,& Savić, S.. (2017). Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance. in Acta Pharmaceutica
Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb., 67(4), 415-439.
https://doi.org/10.1515/acph-2017-0036

Bubić-Pajić N, Todosijević MN, Vuleta G, Cekić N, Dobričić V, Vučen S, Čalija B, Lukić M, Ilić T, Savić S. Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance. in Acta Pharmaceutica. 2017;67(4):415-439.
doi:10.1515/acph-2017-0036 .

Bubić-Pajić, Nataša, Todosijević, Marija N., Vuleta, Gordana, Cekić, Nebojša, Dobričić, Vladimir, Vučen, Sonja, Čalija, Bojan, Lukić, Milica, Ilić, Tanja, Savić, Snežana, "Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance" in Acta Pharmaceutica, 67, no. 4 (2017):415-439,
https://doi.org/10.1515/acph-2017-0036 . .

TY  - JOUR
AU  - Savić, Vedrana
AU  - Todosijević, Marija N.
AU  - Ilić, Tanja
AU  - Lukić, Milica
AU  - Mitsou, Evgenia
AU  - Papadimitriou, Vassiliki
AU  - Avramiotis, Spyridon
AU  - Marković, Bojan
AU  - Cekić, Nebojša
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2823
AB  - In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene glycol monocaprylate as oil phase. The influence of excipients on the size of microemulsion region in pseudo-ternary phase diagrams and their ability to form different types of microemulsions was evaluated. The comprehensive physicochemical characterization of microemulsions and the evaluation of their structure was performed, while the localization of tacrolimus in microemulsions was further investigated using electron paramagnetic resonance spectroscopy. Moreover, stability studies proved no change in tacrolimus content during one year of storage at room temperature. In addition, in vivo skin performance indicated no skin irritation potential of blank microemulsions, whereas in vitro release testing using Franz diffusion cells showed superior release rate of tacrolimus from microemulsions (0.98 +/- 0.10 and 0.92 +/- 0.11 mu g/cm(2)/h for two bicontinuous and 1.00 +/- 0.24 mu g/cm(2)/h for oil-in-water microemulsion) compared to referent Protopic ointment (0.15 +/- 0.08 mu g/cm(2)/h). Furthermore, ex vivo penetration assessed through porcine ear skin using tape stripping, confirmed superiority of two microemulsions related to the reference, implying developed microemulsions as promising carriers for dermal delivery of tacrolimus.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances
VL  - 529
IS  - 1-2
SP  - 491
EP  - 505
DO  - 10.1016/j.ijpharm.2017.07.036
ER  - 

@article{
author = "Savić, Vedrana and Todosijević, Marija N. and Ilić, Tanja and Lukić, Milica and Mitsou, Evgenia and Papadimitriou, Vassiliki and Avramiotis, Spyridon and Marković, Bojan and Cekić, Nebojša and Savić, Snežana",
year = "2017",
abstract = "In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene glycol monocaprylate as oil phase. The influence of excipients on the size of microemulsion region in pseudo-ternary phase diagrams and their ability to form different types of microemulsions was evaluated. The comprehensive physicochemical characterization of microemulsions and the evaluation of their structure was performed, while the localization of tacrolimus in microemulsions was further investigated using electron paramagnetic resonance spectroscopy. Moreover, stability studies proved no change in tacrolimus content during one year of storage at room temperature. In addition, in vivo skin performance indicated no skin irritation potential of blank microemulsions, whereas in vitro release testing using Franz diffusion cells showed superior release rate of tacrolimus from microemulsions (0.98 +/- 0.10 and 0.92 +/- 0.11 mu g/cm(2)/h for two bicontinuous and 1.00 +/- 0.24 mu g/cm(2)/h for oil-in-water microemulsion) compared to referent Protopic ointment (0.15 +/- 0.08 mu g/cm(2)/h). Furthermore, ex vivo penetration assessed through porcine ear skin using tape stripping, confirmed superiority of two microemulsions related to the reference, implying developed microemulsions as promising carriers for dermal delivery of tacrolimus.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances",
volume = "529",
number = "1-2",
pages = "491-505",
doi = "10.1016/j.ijpharm.2017.07.036"
}

Savić, V., Todosijević, M. N., Ilić, T., Lukić, M., Mitsou, E., Papadimitriou, V., Avramiotis, S., Marković, B., Cekić, N.,& Savić, S.. (2017). Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 529(1-2), 491-505.
https://doi.org/10.1016/j.ijpharm.2017.07.036

Savić V, Todosijević MN, Ilić T, Lukić M, Mitsou E, Papadimitriou V, Avramiotis S, Marković B, Cekić N, Savić S. Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. in International Journal of Pharmaceutics. 2017;529(1-2):491-505.
doi:10.1016/j.ijpharm.2017.07.036 .

Savić, Vedrana, Todosijević, Marija N., Ilić, Tanja, Lukić, Milica, Mitsou, Evgenia, Papadimitriou, Vassiliki, Avramiotis, Spyridon, Marković, Bojan, Cekić, Nebojša, Savić, Snežana, "Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances" in International Journal of Pharmaceutics, 529, no. 1-2 (2017):491-505,
https://doi.org/10.1016/j.ijpharm.2017.07.036 . .

TY  - CHAP
AU  - Isailović, Tanja
AU  - Todosijević, Marija N.
AU  - Đorđević, Sanela
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2997
AB  - Considering the superior advantages over traditional formulation approaches, micro/nanoemulsions represent very attractive carriers worth exploring for improving dermal/transdermal delivery of NSAIDs. Currently, natural-origin sucrose esters are of increasing interest for research community, due to their high environmental compatibility, low skin sensitization potential, and skin penetration enhancement. In this context, the present chapter provides an overview of sucrose esters' potential in the development of biocompatible micro/nanoemulsions for topical administration of NSAIDs. The formation and performances of sucrose ester-based micro/nanoemulsions are governed by numerous factors which should be carefully considered, such as (1) chain length and monoester content of the sucrose esters, (2) nature and concentration of the cosurfactant, oil, and aqueous phase, (3) the components' weight ratio, and (4) physicochemical characteristics of NSAID. Therefore, here we review the key researches regarding NSAID-loaded sucrose ester-based micro/nanoemulsions, starting from the formulation design consideration, through physicochemical characterization and dermal/transdermal availability assessment of developed systems.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
T1  - Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs- Practical Formulation Approach, Physicochemical and Biopharmaceutical Characteristics/Performances
SP  - 179
EP  - 217
DO  - 10.1016/B978-0-12-804017-1.00007-8
ER  - 

@inbook{
author = "Isailović, Tanja and Todosijević, Marija N. and Đorđević, Sanela and Savić, Snežana",
year = "2017",
abstract = "Considering the superior advantages over traditional formulation approaches, micro/nanoemulsions represent very attractive carriers worth exploring for improving dermal/transdermal delivery of NSAIDs. Currently, natural-origin sucrose esters are of increasing interest for research community, due to their high environmental compatibility, low skin sensitization potential, and skin penetration enhancement. In this context, the present chapter provides an overview of sucrose esters' potential in the development of biocompatible micro/nanoemulsions for topical administration of NSAIDs. The formation and performances of sucrose ester-based micro/nanoemulsions are governed by numerous factors which should be carefully considered, such as (1) chain length and monoester content of the sucrose esters, (2) nature and concentration of the cosurfactant, oil, and aqueous phase, (3) the components' weight ratio, and (4) physicochemical characteristics of NSAID. Therefore, here we review the key researches regarding NSAID-loaded sucrose ester-based micro/nanoemulsions, starting from the formulation design consideration, through physicochemical characterization and dermal/transdermal availability assessment of developed systems.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a",
booktitle = "Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs- Practical Formulation Approach, Physicochemical and Biopharmaceutical Characteristics/Performances",
pages = "179-217",
doi = "10.1016/B978-0-12-804017-1.00007-8"
}

Isailović, T., Todosijević, M. N., Đorđević, S.,& Savić, S.. (2017). Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs- Practical Formulation Approach, Physicochemical and Biopharmaceutical Characteristics/Performances. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
Elsevier Inc.., 179-217.
https://doi.org/10.1016/B978-0-12-804017-1.00007-8

Isailović T, Todosijević MN, Đorđević S, Savić S. Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs- Practical Formulation Approach, Physicochemical and Biopharmaceutical Characteristics/Performances. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:179-217.
doi:10.1016/B978-0-12-804017-1.00007-8 .

Isailović, Tanja, Todosijević, Marija N., Đorđević, Sanela, Savić, Snežana, "Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs- Practical Formulation Approach, Physicochemical and Biopharmaceutical Characteristics/Performances" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):179-217,
https://doi.org/10.1016/B978-0-12-804017-1.00007-8 . .

TY  - JOUR
AU  - Todosijević, Marija N.
AU  - Brezesinski, Gerald
AU  - Savić, Snežana
AU  - Neubert, Reinhard H. H.
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2949
AB  - Up to now, the molecular mechanism of the penetration enhancing effect of sucrose esters (SEs) on stratum corneum (SC) has not been explained in details. In this study, variety of surface sensitive techniques, including surface pressure-area (pi-A) isotherms, infrared reflection-absorption spectroscopy (IRRAS), and Brewster angle microscopy (BAM), have been used to investigate interactions between SEs and SC intercellular lipids. A monolayer of the mixture of ceramide AS C18:18, stearic acid and cholesterol in the molar ratio of 1:1:0.7 on an aqueous subphase is a good model to mimic a single layer of intercellular SC lipids. The pi-A isotherms of mixed monolayers and parameters derived from the curves demonstrated the interaction between nonionic surfactants such as SEs and SC lipids. With increasing SE concentration, the resultant monolayer films became more fluid and better compressible. IRRAS measurements showed that SEs disordered the acyl chains of SC lipids, and the BAM images demonstrated the modification of the domain structures in SC monolayers. Longer chain-SE has a stronger disordering effect and is better miscible with ceramides in comparison to SE with a shorter hydrophobic part. In conclusion, this study demonstrates the disordering effect of SEs on the biomimetic SC model, pointing out that small changes in the structure of surfactant may have a strong influence on a penetration enhancement of lipophilic drugs through intercellular lipids of skin.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers
VL  - 99
SP  - 161
EP  - 172
DO  - 10.1016/j.ejps.2016.12.002
ER  - 

@article{
author = "Todosijević, Marija N. and Brezesinski, Gerald and Savić, Snežana and Neubert, Reinhard H. H.",
year = "2017",
abstract = "Up to now, the molecular mechanism of the penetration enhancing effect of sucrose esters (SEs) on stratum corneum (SC) has not been explained in details. In this study, variety of surface sensitive techniques, including surface pressure-area (pi-A) isotherms, infrared reflection-absorption spectroscopy (IRRAS), and Brewster angle microscopy (BAM), have been used to investigate interactions between SEs and SC intercellular lipids. A monolayer of the mixture of ceramide AS C18:18, stearic acid and cholesterol in the molar ratio of 1:1:0.7 on an aqueous subphase is a good model to mimic a single layer of intercellular SC lipids. The pi-A isotherms of mixed monolayers and parameters derived from the curves demonstrated the interaction between nonionic surfactants such as SEs and SC lipids. With increasing SE concentration, the resultant monolayer films became more fluid and better compressible. IRRAS measurements showed that SEs disordered the acyl chains of SC lipids, and the BAM images demonstrated the modification of the domain structures in SC monolayers. Longer chain-SE has a stronger disordering effect and is better miscible with ceramides in comparison to SE with a shorter hydrophobic part. In conclusion, this study demonstrates the disordering effect of SEs on the biomimetic SC model, pointing out that small changes in the structure of surfactant may have a strong influence on a penetration enhancement of lipophilic drugs through intercellular lipids of skin.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers",
volume = "99",
pages = "161-172",
doi = "10.1016/j.ejps.2016.12.002"
}

Todosijević, M. N., Brezesinski, G., Savić, S.,& Neubert, R. H. H.. (2017). Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 99, 161-172.
https://doi.org/10.1016/j.ejps.2016.12.002

Todosijević MN, Brezesinski G, Savić S, Neubert RHH. Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers. in European Journal of Pharmaceutical Sciences. 2017;99:161-172.
doi:10.1016/j.ejps.2016.12.002 .

Todosijević, Marija N., Brezesinski, Gerald, Savić, Snežana, Neubert, Reinhard H. H., "Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers" in European Journal of Pharmaceutical Sciences, 99 (2017):161-172,
https://doi.org/10.1016/j.ejps.2016.12.002 . .

TY  - JOUR
AU  - Todosijević, Marija N.
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Marković, Bojan
AU  - Gasperlin, Mirjana
AU  - Ranđelović, Danijela
AU  - Lukić, Milica
AU  - Savić, Snežana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2362
AB  - To elaborate the decisive role of surfactants in promotion of aceclofenac' skin absorption, potentially avoiding irritation, we developed non-ionic microemulsions varying natural or synthetic surfactants: sucrose esters (laurate or myristate) vs. polysorbate 80. A comprehensive physicochemical characterization indicated no significant influence of the solubilized nonsteroidal anti-inflammatory drug on the bicontinuous structure of blank formulations. To evaluate skin tolerability of isopropyl alcohol, a sucrose ester-based microemulsion containing transcutol P as a cosurfactant was also developed. The measured skin parameters strongly depended on the (co)surfactant type, showing higher compatibility of the microemulsions containing sucrose ester and isopropyl alcohol. In vitro release results, in vivo tape stripping and pharmacokinetics in rats confirmed superiority of the sucrose ester-over polysorbate-based microemulsions (total amounts of aceclofenac penetrated 60.81 +/- 5.97 and 60.86 +/- 3.67 vs. 27.00 +/- 5.09 mu g/cm(2), and its maximum plasma concentrations 275.57 +/- 109.49 and 281.31 +/- 76.76 vs. 150.23 +/- 69.74 ng/ml for sucrose laurate- and myristate- vs. polysorbate 80-based microemulsions, respectively). Hence, sugar-based excipients increased delivery of aceclofenac through stratum corneum by increasing its fluidity, showing overall more satisfying safety profiles. In conclusion, sucrose ester-based microemulsions proved to be promising carriers for dermal/transdermal aceclofenac delivery.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance
VL  - 496
IS  - 2
SP  - 931
EP  - 941
DO  - 10.1016/j.ijpharm.2015.10.048
ER  - 

@article{
author = "Todosijević, Marija N. and Savić, Miroslav and Batinić, Bojan and Marković, Bojan and Gasperlin, Mirjana and Ranđelović, Danijela and Lukić, Milica and Savić, Snežana",
year = "2015",
abstract = "To elaborate the decisive role of surfactants in promotion of aceclofenac' skin absorption, potentially avoiding irritation, we developed non-ionic microemulsions varying natural or synthetic surfactants: sucrose esters (laurate or myristate) vs. polysorbate 80. A comprehensive physicochemical characterization indicated no significant influence of the solubilized nonsteroidal anti-inflammatory drug on the bicontinuous structure of blank formulations. To evaluate skin tolerability of isopropyl alcohol, a sucrose ester-based microemulsion containing transcutol P as a cosurfactant was also developed. The measured skin parameters strongly depended on the (co)surfactant type, showing higher compatibility of the microemulsions containing sucrose ester and isopropyl alcohol. In vitro release results, in vivo tape stripping and pharmacokinetics in rats confirmed superiority of the sucrose ester-over polysorbate-based microemulsions (total amounts of aceclofenac penetrated 60.81 +/- 5.97 and 60.86 +/- 3.67 vs. 27.00 +/- 5.09 mu g/cm(2), and its maximum plasma concentrations 275.57 +/- 109.49 and 281.31 +/- 76.76 vs. 150.23 +/- 69.74 ng/ml for sucrose laurate- and myristate- vs. polysorbate 80-based microemulsions, respectively). Hence, sugar-based excipients increased delivery of aceclofenac through stratum corneum by increasing its fluidity, showing overall more satisfying safety profiles. In conclusion, sucrose ester-based microemulsions proved to be promising carriers for dermal/transdermal aceclofenac delivery.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance",
volume = "496",
number = "2",
pages = "931-941",
doi = "10.1016/j.ijpharm.2015.10.048"
}

Todosijević, M. N., Savić, M., Batinić, B., Marković, B., Gasperlin, M., Ranđelović, D., Lukić, M.,& Savić, S.. (2015). Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 496(2), 931-941.
https://doi.org/10.1016/j.ijpharm.2015.10.048

Todosijević MN, Savić M, Batinić B, Marković B, Gasperlin M, Ranđelović D, Lukić M, Savić S. Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance. in International Journal of Pharmaceutics. 2015;496(2):931-941.
doi:10.1016/j.ijpharm.2015.10.048 .

Todosijević, Marija N., Savić, Miroslav, Batinić, Bojan, Marković, Bojan, Gasperlin, Mirjana, Ranđelović, Danijela, Lukić, Milica, Savić, Snežana, "Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance" in International Journal of Pharmaceutics, 496, no. 2 (2015):931-941,
https://doi.org/10.1016/j.ijpharm.2015.10.048 . .

TY  - JOUR
AU  - Todosijević, Marija N.
AU  - Cekić, Nebojša
AU  - Savić, Miroslav
AU  - Gasperlin, Mirjana
AU  - Ranđelović, Danijela
AU  - Savić, Snežana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2125
AB  - We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.
PB  - Springer, New York
T2  - Colloid and Polymer Science
T1  - Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design
VL  - 292
IS  - 12
SP  - 3061
EP  - 3076
DO  - 10.1007/s00396-014-3351-4
ER  - 

@article{
author = "Todosijević, Marija N. and Cekić, Nebojša and Savić, Miroslav and Gasperlin, Mirjana and Ranđelović, Danijela and Savić, Snežana",
year = "2014",
abstract = "We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.",
publisher = "Springer, New York",
journal = "Colloid and Polymer Science",
title = "Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design",
volume = "292",
number = "12",
pages = "3061-3076",
doi = "10.1007/s00396-014-3351-4"
}

Todosijević, M. N., Cekić, N., Savić, M., Gasperlin, M., Ranđelović, D.,& Savić, S.. (2014). Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design. in Colloid and Polymer Science
Springer, New York., 292(12), 3061-3076.
https://doi.org/10.1007/s00396-014-3351-4

Todosijević MN, Cekić N, Savić M, Gasperlin M, Ranđelović D, Savić S. Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design. in Colloid and Polymer Science. 2014;292(12):3061-3076.
doi:10.1007/s00396-014-3351-4 .

Todosijević, Marija N., Cekić, Nebojša, Savić, Miroslav, Gasperlin, Mirjana, Ranđelović, Danijela, Savić, Snežana, "Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design" in Colloid and Polymer Science, 292, no. 12 (2014):3061-3076,
https://doi.org/10.1007/s00396-014-3351-4 . .

TY  - CONF
AU  - Todosijević, Marija N.
AU  - Vujović, V.
AU  - Vezmar-Kovačević, Sandra
AU  - Miljković, Branislava
AU  - Brzaković, B.
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1848
PB  - Springer, Dordrecht
C3  - International Journal of Clinical Pharmacy
T1  - The influence of age, gender and comedication on lamotrigine clearance in patients with epilepsy
VL  - 35
IS  - 5
SP  - 870
EP  - 870
DO  - 10.1007/s11096-013-9801-0
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1848
ER  - 

@conference{
author = "Todosijević, Marija N. and Vujović, V. and Vezmar-Kovačević, Sandra and Miljković, Branislava and Brzaković, B.",
year = "2013",
publisher = "Springer, Dordrecht",
journal = "International Journal of Clinical Pharmacy",
title = "The influence of age, gender and comedication on lamotrigine clearance in patients with epilepsy",
volume = "35",
number = "5",
pages = "870-870",
doi = "10.1007/s11096-013-9801-0",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1848"
}

Todosijević, M. N., Vujović, V., Vezmar-Kovačević, S., Miljković, B.,& Brzaković, B.. (2013). The influence of age, gender and comedication on lamotrigine clearance in patients with epilepsy. in International Journal of Clinical Pharmacy
Springer, Dordrecht., 35(5), 870-870.
https://doi.org/10.1007/s11096-013-9801-0
https://hdl.handle.net/21.15107/rcub_farfar_1848

Todosijević MN, Vujović V, Vezmar-Kovačević S, Miljković B, Brzaković B. The influence of age, gender and comedication on lamotrigine clearance in patients with epilepsy. in International Journal of Clinical Pharmacy. 2013;35(5):870-870.
doi:10.1007/s11096-013-9801-0
https://hdl.handle.net/21.15107/rcub_farfar_1848 .

Todosijević, Marija N., Vujović, V., Vezmar-Kovačević, Sandra, Miljković, Branislava, Brzaković, B., "The influence of age, gender and comedication on lamotrigine clearance in patients with epilepsy" in International Journal of Clinical Pharmacy, 35, no. 5 (2013):870-870,
https://doi.org/10.1007/s11096-013-9801-0 .,
https://hdl.handle.net/21.15107/rcub_farfar_1848 .