TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Martinović, Martina
AU  - Ćirić, Ana
AU  - Fraj, Jadranka
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5372
AB  - The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh−1cm−2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient’s compliance, were performed.
PB  - Taylor & Francis
T2  - Pharmaceutical Development and Technology
T1  - Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics
VL  - 25
IS  - 3
SP  - 332
EP  - 339
DO  - 10.1080/10837450.2019.1701495
ER  - 

@article{
author = "Đekić, Ljiljana and Martinović, Martina and Ćirić, Ana and Fraj, Jadranka",
year = "2020",
abstract = "The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh−1cm−2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient’s compliance, were performed.",
publisher = "Taylor & Francis",
journal = "Pharmaceutical Development and Technology",
title = "Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics",
volume = "25",
number = "3",
pages = "332-339",
doi = "10.1080/10837450.2019.1701495"
}

Đekić, L., Martinović, M., Ćirić, A.,& Fraj, J.. (2020). Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics. in Pharmaceutical Development and Technology
Taylor & Francis., 25(3), 332-339.
https://doi.org/10.1080/10837450.2019.1701495

Đekić L, Martinović M, Ćirić A, Fraj J. Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics. in Pharmaceutical Development and Technology. 2020;25(3):332-339.
doi:10.1080/10837450.2019.1701495 .

Đekić, Ljiljana, Martinović, Martina, Ćirić, Ana, Fraj, Jadranka, "Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics" in Pharmaceutical Development and Technology, 25, no. 3 (2020):332-339,
https://doi.org/10.1080/10837450.2019.1701495 . .

TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Martinović, Martina
AU  - Dobričić, Vladimir
AU  - Čalija, Bojan
AU  - Medarević, Đorđe
AU  - Primorac, Marija
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3305
AB  - The study is focused on formulation of biocompatible hydrogels with a poorly soluble drug ibuprofen (5%) and comprehensive evaluation and comparison of effect of different bioadhesive polymers on their suitability for application on skin, physical stability during the accelerated and natural aging tests (by performing centrifugation test, light microscopy, differential scanning calorimetry, rheological and pH measurements), and in vitro drug release kinetics. Hydrogels, formulated with xanthan gum 1% (XIB), sodium carboxymethylcellulose 5% (CMCIB), poloxamer 407 16% (PIB), and carbomer 1% (KIB), were soft pseudoplastic semisolids with thixotropy and biocompatible pH. The type of the polymer significantly affected apparent viscosity of the hydrogels and miscibility rate with artificial sweat, their physical stability, and shape, size, and aggregation of the drug crystals and degree of crystallization. The drug release in all investigated hydrogels was diffusion-controlled in accordance with the Higuchi model and sustained for 12 h, with the drug release rate and the amount of drug released depended on the polymer. The described formulation approach enabled discrimination of the hydrogels with unsatisfactory application properties (CMCIB) and physical stability (KIB), and selection of the hydrogel with promising characteristics in terms of all investigated aspects (XIB) which could be considered for further evaluation.
PB  - Elsevier Science Inc, New York
T2  - Journal of Pharmaceutical Sciences
T1  - Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen
VL  - 108
IS  - 3
SP  - 1326
EP  - 1333
DO  - 10.1016/j.xphs.2018.10.054
ER  - 

@article{
author = "Đekić, Ljiljana and Martinović, Martina and Dobričić, Vladimir and Čalija, Bojan and Medarević, Đorđe and Primorac, Marija",
year = "2019",
abstract = "The study is focused on formulation of biocompatible hydrogels with a poorly soluble drug ibuprofen (5%) and comprehensive evaluation and comparison of effect of different bioadhesive polymers on their suitability for application on skin, physical stability during the accelerated and natural aging tests (by performing centrifugation test, light microscopy, differential scanning calorimetry, rheological and pH measurements), and in vitro drug release kinetics. Hydrogels, formulated with xanthan gum 1% (XIB), sodium carboxymethylcellulose 5% (CMCIB), poloxamer 407 16% (PIB), and carbomer 1% (KIB), were soft pseudoplastic semisolids with thixotropy and biocompatible pH. The type of the polymer significantly affected apparent viscosity of the hydrogels and miscibility rate with artificial sweat, their physical stability, and shape, size, and aggregation of the drug crystals and degree of crystallization. The drug release in all investigated hydrogels was diffusion-controlled in accordance with the Higuchi model and sustained for 12 h, with the drug release rate and the amount of drug released depended on the polymer. The described formulation approach enabled discrimination of the hydrogels with unsatisfactory application properties (CMCIB) and physical stability (KIB), and selection of the hydrogel with promising characteristics in terms of all investigated aspects (XIB) which could be considered for further evaluation.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Pharmaceutical Sciences",
title = "Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen",
volume = "108",
number = "3",
pages = "1326-1333",
doi = "10.1016/j.xphs.2018.10.054"
}

Đekić, L., Martinović, M., Dobričić, V., Čalija, B., Medarević, Đ.,& Primorac, M.. (2019). Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen. in Journal of Pharmaceutical Sciences
Elsevier Science Inc, New York., 108(3), 1326-1333.
https://doi.org/10.1016/j.xphs.2018.10.054

Đekić L, Martinović M, Dobričić V, Čalija B, Medarević Đ, Primorac M. Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen. in Journal of Pharmaceutical Sciences. 2019;108(3):1326-1333.
doi:10.1016/j.xphs.2018.10.054 .

Đekić, Ljiljana, Martinović, Martina, Dobričić, Vladimir, Čalija, Bojan, Medarević, Đorđe, Primorac, Marija, "Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen" in Journal of Pharmaceutical Sciences, 108, no. 3 (2019):1326-1333,
https://doi.org/10.1016/j.xphs.2018.10.054 . .

TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Martinović, Martina
AU  - Stepanović-Petrović, Radica
AU  - Micov, Ana
AU  - Tomić, Maja
AU  - Primorac, Marija
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2714
AB  - The study investigated usage of hydrogel of an anionic polymer xanthan gum for design of ibuprofen-loaded hydrogel-thickened microemulsions (HTMs) from the nonionic oil-in-water microemulsion (M). Xanthan gum demonstrated the performances of a thickening agent in physically stable HTMs at 5 +/- 3 degrees C, 20 +/- 3 degrees C, and 40 +/- 1 degrees C during 6 months. The results of physicochemical characterization (pH, conductivity, rheological behaviour, spreadability) indicated that HTMs containing 0.25-1.00% of the polymer had colloidal structure with oil nanodroplets of 1434 +/- 0.98 nm (PdI 0220 +/- 0.075) dispersed in aqueous phase thickened with the polymer gel network which strength depended on the polymer concentration. HTMs with ibuprofen (5%) were evaluated as percutaneous drug delivery carriers. In vitro ibuprofen release from HTMs followed zero order kinetic (r > 0.995) for 12 h, while the referent hydrogel was described by Higuchi model. The HTM with optimized drug release rate and spreadability (HTM1) and the polymer-free microemulsion (M) were assessed and compared with the referent hydrogel in in vivo studies in rats. HTM1 and M were significantly more efficacious than reference hydrogel in producing antihyperalgesic and at lower extent antiedematous activity in prophylactic topical treatment protocol, whilst they were comparable in producing antihyperalgesic/antiedematous effects in therapeutic protocol. Topical treatments produced no obvious skin irritation.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats
VL  - 92
SP  - 255
EP  - 265
DO  - 10.1016/j.ejps.2016.05.005
ER  - 

@article{
author = "Đekić, Ljiljana and Martinović, Martina and Stepanović-Petrović, Radica and Micov, Ana and Tomić, Maja and Primorac, Marija",
year = "2016",
abstract = "The study investigated usage of hydrogel of an anionic polymer xanthan gum for design of ibuprofen-loaded hydrogel-thickened microemulsions (HTMs) from the nonionic oil-in-water microemulsion (M). Xanthan gum demonstrated the performances of a thickening agent in physically stable HTMs at 5 +/- 3 degrees C, 20 +/- 3 degrees C, and 40 +/- 1 degrees C during 6 months. The results of physicochemical characterization (pH, conductivity, rheological behaviour, spreadability) indicated that HTMs containing 0.25-1.00% of the polymer had colloidal structure with oil nanodroplets of 1434 +/- 0.98 nm (PdI 0220 +/- 0.075) dispersed in aqueous phase thickened with the polymer gel network which strength depended on the polymer concentration. HTMs with ibuprofen (5%) were evaluated as percutaneous drug delivery carriers. In vitro ibuprofen release from HTMs followed zero order kinetic (r > 0.995) for 12 h, while the referent hydrogel was described by Higuchi model. The HTM with optimized drug release rate and spreadability (HTM1) and the polymer-free microemulsion (M) were assessed and compared with the referent hydrogel in in vivo studies in rats. HTM1 and M were significantly more efficacious than reference hydrogel in producing antihyperalgesic and at lower extent antiedematous activity in prophylactic topical treatment protocol, whilst they were comparable in producing antihyperalgesic/antiedematous effects in therapeutic protocol. Topical treatments produced no obvious skin irritation.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats",
volume = "92",
pages = "255-265",
doi = "10.1016/j.ejps.2016.05.005"
}

Đekić, L., Martinović, M., Stepanović-Petrović, R., Micov, A., Tomić, M.,& Primorac, M.. (2016). Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 92, 255-265.
https://doi.org/10.1016/j.ejps.2016.05.005

Đekić L, Martinović M, Stepanović-Petrović R, Micov A, Tomić M, Primorac M. Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats. in European Journal of Pharmaceutical Sciences. 2016;92:255-265.
doi:10.1016/j.ejps.2016.05.005 .

Đekić, Ljiljana, Martinović, Martina, Stepanović-Petrović, Radica, Micov, Ana, Tomić, Maja, Primorac, Marija, "Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats" in European Journal of Pharmaceutical Sciences, 92 (2016):255-265,
https://doi.org/10.1016/j.ejps.2016.05.005 . .

TY  - CHAP
AU  - Đekić, Ljiljana
AU  - Martinović, Martina
AU  - Primorac, Marija
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2702
AB  - The current research in cutaneous and percutaneous drug delivery is focused on design of advanced carriers with enhanced applicability, stability, drug-loading capacity, and drug penetration/permeation ability. Microemulsion hydrogels (MHs) are carriers which attract the attention of a growing number of researchers who aimed to enhace dermal or transdermal delivery of drugs which are common therapeutics for different skin disorders or systemic deseases such as infections, androgenic alopecia, rheumatoid arthritis, osteoarthritis, and spondylitis, respectively. Microemulsion hydrogels is a heterogeneous group of the drug delivery systems which usually represent thermodynamically stable systems comprising dispersed oil phase within a continuous aqueous phase which is thickened with a suitable hydrophilic polymer. This chapter summarises a novel observations regarding physicochemical properties, physical and chemical stability, and drug delivery potential of this type of drug delivery systems, based on comprehensive review of the research results from the relevant scientific publications. Particularly, the chapter describes the rheological behaviour of microemulsion hydrogels and elucidates the role of the most commonly used synthetic and natural hydrophilic polymers (such as carbomers, hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), xanthan gum, poloxamers) as gelling agents. Furthermore, the recently established models of the complex structure of different microemulsion hydrogels, the in vitro drug release profiles, the ex vivo permeation profiles, and the in vivo drug delivery availability of different drug molecules from the investigated systems, are described. The skin compatibility and skin irritation potential aspect of the selected hydrogel-thickened microemulsion systems is commented. The most important findings of the selected studies on microemulsion hydrogels were presented in order to illustrate their potential for achievement of topical, regional or transdermal drug delivery, including sustained drug delivery, as well as to compare to that of conventional hydrogels, microemulsions, and creams.
PB  - Nova Science Publishers, Inc.
T2  - Microemulsions: Systems, Properties and Applications
T1  - Microemulsion hydrogels - properties and current applications in drug delivery
SP  - 1
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2702
ER  - 

@inbook{
author = "Đekić, Ljiljana and Martinović, Martina and Primorac, Marija",
year = "2016",
abstract = "The current research in cutaneous and percutaneous drug delivery is focused on design of advanced carriers with enhanced applicability, stability, drug-loading capacity, and drug penetration/permeation ability. Microemulsion hydrogels (MHs) are carriers which attract the attention of a growing number of researchers who aimed to enhace dermal or transdermal delivery of drugs which are common therapeutics for different skin disorders or systemic deseases such as infections, androgenic alopecia, rheumatoid arthritis, osteoarthritis, and spondylitis, respectively. Microemulsion hydrogels is a heterogeneous group of the drug delivery systems which usually represent thermodynamically stable systems comprising dispersed oil phase within a continuous aqueous phase which is thickened with a suitable hydrophilic polymer. This chapter summarises a novel observations regarding physicochemical properties, physical and chemical stability, and drug delivery potential of this type of drug delivery systems, based on comprehensive review of the research results from the relevant scientific publications. Particularly, the chapter describes the rheological behaviour of microemulsion hydrogels and elucidates the role of the most commonly used synthetic and natural hydrophilic polymers (such as carbomers, hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), xanthan gum, poloxamers) as gelling agents. Furthermore, the recently established models of the complex structure of different microemulsion hydrogels, the in vitro drug release profiles, the ex vivo permeation profiles, and the in vivo drug delivery availability of different drug molecules from the investigated systems, are described. The skin compatibility and skin irritation potential aspect of the selected hydrogel-thickened microemulsion systems is commented. The most important findings of the selected studies on microemulsion hydrogels were presented in order to illustrate their potential for achievement of topical, regional or transdermal drug delivery, including sustained drug delivery, as well as to compare to that of conventional hydrogels, microemulsions, and creams.",
publisher = "Nova Science Publishers, Inc.",
journal = "Microemulsions: Systems, Properties and Applications",
booktitle = "Microemulsion hydrogels - properties and current applications in drug delivery",
pages = "1-36",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2702"
}

Đekić, L., Martinović, M.,& Primorac, M.. (2016). Microemulsion hydrogels - properties and current applications in drug delivery. in Microemulsions: Systems, Properties and Applications
Nova Science Publishers, Inc.., 1-36.
https://hdl.handle.net/21.15107/rcub_farfar_2702

Đekić L, Martinović M, Primorac M. Microemulsion hydrogels - properties and current applications in drug delivery. in Microemulsions: Systems, Properties and Applications. 2016;:1-36.
https://hdl.handle.net/21.15107/rcub_farfar_2702 .

Đekić, Ljiljana, Martinović, Martina, Primorac, Marija, "Microemulsion hydrogels - properties and current applications in drug delivery" in Microemulsions: Systems, Properties and Applications (2016):1-36,
https://hdl.handle.net/21.15107/rcub_farfar_2702 .

TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Martinović, Martina
AU  - Stepanović-Petrović, Radica
AU  - Tomić, Maja
AU  - Micov, Ana
AU  - Primorac, Marija
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2426
AB  - Nonionic surfactants (caprylocaproyl macrogol-8 glycerides, octoxynol-12, polysorbate-20, and polyethylene glycol-40 hydrogenated castor oil) (47.03%, w/w), costabilizer (poloxamer 407) (12%-20%, w/w), oil (isopropyl myristate) (5.22%, w/w), water (q.s. ad 100%, w/w), and ibuprofen (5%, w/w) were used to develop oil-in-water microemulsions with Newtonian flow behavior, low viscosity (from 368 +/- 38 to 916 +/- 46 mPa s), and average droplet size from 14.79 +/- 0.31 to 16.54 +/- 0.75 nm. Ibuprofen in vitro release from the microemulsions was in accordance with zero-order kinetics (R-0(2) > 0.99) for at least 12 h. The maximum drug release rate (3.55%h(-1)) was from the microemulsion M3 comprising 16%, w/w of poloxamer 407. The release rate of ibuprofen from the reference hydrogel followed Higuchi kinetics (R-H(2) > 0.99), and drug amount released after the 6th hour was negligible. In a rat model of inflammation, the microemulsion M3 was significantly more efficacious than the reference hydrogel in exerting antihyperalgesic effects in prophylactic topical treatment, whereas they were comparable in therapeutic treatment as well as in producing antiedematous effect in both protocols. No obvious skin irritation was observed in in vivo studies. The developed nonionic surfactants-based microemulsions containing the optimal concentration of poloxamer 407 could be promising carriers for sustained regional delivery of ibuprofen via topical administration.
PB  - Wiley, Hoboken
T2  - Journal of Pharmaceutical Sciences
T1  - Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration
VL  - 104
IS  - 8
SP  - 2501
EP  - 2512
DO  - 10.1002/jps.24494
ER  - 

@article{
author = "Đekić, Ljiljana and Martinović, Martina and Stepanović-Petrović, Radica and Tomić, Maja and Micov, Ana and Primorac, Marija",
year = "2015",
abstract = "Nonionic surfactants (caprylocaproyl macrogol-8 glycerides, octoxynol-12, polysorbate-20, and polyethylene glycol-40 hydrogenated castor oil) (47.03%, w/w), costabilizer (poloxamer 407) (12%-20%, w/w), oil (isopropyl myristate) (5.22%, w/w), water (q.s. ad 100%, w/w), and ibuprofen (5%, w/w) were used to develop oil-in-water microemulsions with Newtonian flow behavior, low viscosity (from 368 +/- 38 to 916 +/- 46 mPa s), and average droplet size from 14.79 +/- 0.31 to 16.54 +/- 0.75 nm. Ibuprofen in vitro release from the microemulsions was in accordance with zero-order kinetics (R-0(2) > 0.99) for at least 12 h. The maximum drug release rate (3.55%h(-1)) was from the microemulsion M3 comprising 16%, w/w of poloxamer 407. The release rate of ibuprofen from the reference hydrogel followed Higuchi kinetics (R-H(2) > 0.99), and drug amount released after the 6th hour was negligible. In a rat model of inflammation, the microemulsion M3 was significantly more efficacious than the reference hydrogel in exerting antihyperalgesic effects in prophylactic topical treatment, whereas they were comparable in therapeutic treatment as well as in producing antiedematous effect in both protocols. No obvious skin irritation was observed in in vivo studies. The developed nonionic surfactants-based microemulsions containing the optimal concentration of poloxamer 407 could be promising carriers for sustained regional delivery of ibuprofen via topical administration.",
publisher = "Wiley, Hoboken",
journal = "Journal of Pharmaceutical Sciences",
title = "Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration",
volume = "104",
number = "8",
pages = "2501-2512",
doi = "10.1002/jps.24494"
}

Đekić, L., Martinović, M., Stepanović-Petrović, R., Tomić, M., Micov, A.,& Primorac, M.. (2015). Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration. in Journal of Pharmaceutical Sciences
Wiley, Hoboken., 104(8), 2501-2512.
https://doi.org/10.1002/jps.24494

Đekić L, Martinović M, Stepanović-Petrović R, Tomić M, Micov A, Primorac M. Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration. in Journal of Pharmaceutical Sciences. 2015;104(8):2501-2512.
doi:10.1002/jps.24494 .

Đekić, Ljiljana, Martinović, Martina, Stepanović-Petrović, Radica, Tomić, Maja, Micov, Ana, Primorac, Marija, "Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration" in Journal of Pharmaceutical Sciences, 104, no. 8 (2015):2501-2512,
https://doi.org/10.1002/jps.24494 . .

TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Krajišnik, Danina
AU  - Martinović, Martina
AU  - Đorđević, Dragana
AU  - Primorac, Marija
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2468
AB  - Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with similar to 60% w/w of phospholipids) for formation of gels, upon addition of water solution of poloxamer 407, was investigated, and formulated systems were evaluated as carriers for percutaneous delivery of ibuprofen. Formulation study of pseudoternary system liquid lecithin/poloxamer 407/water at constant liquid lecithin/poloxamer 407 mass ratio (2.0) revealed that minimum concentrations of liquid lecithin and poloxamer 407 required for formation of gel like systems were 15.75% w/w and 13.13% w/w, respectively, while the maximum content of water was 60.62% w/w. The systems comprising water concentrations in a range from 55 to 60.62% w/w were soft semisolids suitable for topical application, and they were selected for physicochemical and biopharmaceutical evaluation. Analysis of conductivity results and light microscopy examination revealed that investigated systems were water dilutable dispersions of spherical oligolamellar associates of phospholipids and triglyceride molecules in the copolymer water solution. Rheological behavior evaluation results indicated that the investigated gels were thermosensitive shear thinning systems. Ibuprofen (5% w/w) was incorporated by dispersing into the previously prepared carriers. Drug-loaded systems were physically stable at storage temperature from 5 +/- 3 degrees C to 40 +/- 2 degrees C, for 30 days. In vitro ibuprofen release was in accordance with the Higuchi model (r(H) > 0.95) and sustained for 12 h. The obtained results implicated that formulated LLPBGs, optimized regarding drug release and organoleptic properties, represent promising carriers for sustained percutaneous drug delivery of poorly soluble drugs.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen
VL  - 490
IS  - 1-2
SP  - 180
EP  - 189
DO  - 10.1016/j.ijpharm.2015.05.040
ER  - 

@article{
author = "Đekić, Ljiljana and Krajišnik, Danina and Martinović, Martina and Đorđević, Dragana and Primorac, Marija",
year = "2015",
abstract = "Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with similar to 60% w/w of phospholipids) for formation of gels, upon addition of water solution of poloxamer 407, was investigated, and formulated systems were evaluated as carriers for percutaneous delivery of ibuprofen. Formulation study of pseudoternary system liquid lecithin/poloxamer 407/water at constant liquid lecithin/poloxamer 407 mass ratio (2.0) revealed that minimum concentrations of liquid lecithin and poloxamer 407 required for formation of gel like systems were 15.75% w/w and 13.13% w/w, respectively, while the maximum content of water was 60.62% w/w. The systems comprising water concentrations in a range from 55 to 60.62% w/w were soft semisolids suitable for topical application, and they were selected for physicochemical and biopharmaceutical evaluation. Analysis of conductivity results and light microscopy examination revealed that investigated systems were water dilutable dispersions of spherical oligolamellar associates of phospholipids and triglyceride molecules in the copolymer water solution. Rheological behavior evaluation results indicated that the investigated gels were thermosensitive shear thinning systems. Ibuprofen (5% w/w) was incorporated by dispersing into the previously prepared carriers. Drug-loaded systems were physically stable at storage temperature from 5 +/- 3 degrees C to 40 +/- 2 degrees C, for 30 days. In vitro ibuprofen release was in accordance with the Higuchi model (r(H) > 0.95) and sustained for 12 h. The obtained results implicated that formulated LLPBGs, optimized regarding drug release and organoleptic properties, represent promising carriers for sustained percutaneous drug delivery of poorly soluble drugs.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen",
volume = "490",
number = "1-2",
pages = "180-189",
doi = "10.1016/j.ijpharm.2015.05.040"
}

Đekić, L., Krajišnik, D., Martinović, M., Đorđević, D.,& Primorac, M.. (2015). Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 490(1-2), 180-189.
https://doi.org/10.1016/j.ijpharm.2015.05.040

Đekić L, Krajišnik D, Martinović M, Đorđević D, Primorac M. Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen. in International Journal of Pharmaceutics. 2015;490(1-2):180-189.
doi:10.1016/j.ijpharm.2015.05.040 .

Đekić, Ljiljana, Krajišnik, Danina, Martinović, Martina, Đorđević, Dragana, Primorac, Marija, "Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen" in International Journal of Pharmaceutics, 490, no. 1-2 (2015):180-189,
https://doi.org/10.1016/j.ijpharm.2015.05.040 . .