TY  - JOUR
AU  - Janićijević, Jelena
AU  - Milić, Jela
AU  - Čalija, Bojan
AU  - Micov, Ana
AU  - Stepanović-Petrović, Radica
AU  - Tomić, Maja
AU  - Daković, Aleksandra
AU  - Dobričić, Vladimir
AU  - Nedić-Vasiljević, Bojana
AU  - Krajišnik, Danina
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3050
AB  - Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.
PB  - Royal Soc Chemistry, Cambridge
T2  - Journal of Materials Chemistry B
T1  - Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite
VL  - 6
IS  - 36
SP  - 5812
EP  - 5822
DO  - 10.1039/c8tb01376d
ER  - 

@article{
author = "Janićijević, Jelena and Milić, Jela and Čalija, Bojan and Micov, Ana and Stepanović-Petrović, Radica and Tomić, Maja and Daković, Aleksandra and Dobričić, Vladimir and Nedić-Vasiljević, Bojana and Krajišnik, Danina",
year = "2018",
abstract = "Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Journal of Materials Chemistry B",
title = "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite",
volume = "6",
number = "36",
pages = "5812-5822",
doi = "10.1039/c8tb01376d"
}

Janićijević, J., Milić, J., Čalija, B., Micov, A., Stepanović-Petrović, R., Tomić, M., Daković, A., Dobričić, V., Nedić-Vasiljević, B.,& Krajišnik, D.. (2018). Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B
Royal Soc Chemistry, Cambridge., 6(36), 5812-5822.
https://doi.org/10.1039/c8tb01376d

Janićijević J, Milić J, Čalija B, Micov A, Stepanović-Petrović R, Tomić M, Daković A, Dobričić V, Nedić-Vasiljević B, Krajišnik D. Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B. 2018;6(36):5812-5822.
doi:10.1039/c8tb01376d .

Janićijević, Jelena, Milić, Jela, Čalija, Bojan, Micov, Ana, Stepanović-Petrović, Radica, Tomić, Maja, Daković, Aleksandra, Dobričić, Vladimir, Nedić-Vasiljević, Bojana, Krajišnik, Danina, "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite" in Journal of Materials Chemistry B, 6, no. 36 (2018):5812-5822,
https://doi.org/10.1039/c8tb01376d . .

TY  - CHAP
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Janićijević, Jelena
AU  - Milić, Jela
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2819
AB  - In the last two decades several representatives of natural silica-based materials (clays, zeolites, and diatomites) have emerged in biomedical applications due to their favorable physicochemical and functionality-related characteristics along with good biocompatibility. The possibility of their use in drug delivery as carriers for NSAIDs, as one of the most widely prescribed drugs, is particularly interesting since it would overcome some of the therapy-related side effects and improve patience compliance.This chapter gives an overview of natural silica-based materials' characteristics relevant for their pharmaceutical use, along with various examples of their structure modification in order to obtain materials with improved functional properties as potential drug carriers. A review on application of these materials in drug delivery of NSAIDs is presented including evaluation of techniques used for drug silica based carrier characterization in addition to investigation of their biopharmaceutical performances.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
T1  - Natural and Modified Silica-Based Materials as Carriers for NSAIDs
SP  - 219
EP  - 258
DO  - 10.1016/B978-0-12-804017-1.00008-X
ER  - 

@inbook{
author = "Krajišnik, Danina and Daković, Aleksandra and Janićijević, Jelena and Milić, Jela",
year = "2017",
abstract = "In the last two decades several representatives of natural silica-based materials (clays, zeolites, and diatomites) have emerged in biomedical applications due to their favorable physicochemical and functionality-related characteristics along with good biocompatibility. The possibility of their use in drug delivery as carriers for NSAIDs, as one of the most widely prescribed drugs, is particularly interesting since it would overcome some of the therapy-related side effects and improve patience compliance.This chapter gives an overview of natural silica-based materials' characteristics relevant for their pharmaceutical use, along with various examples of their structure modification in order to obtain materials with improved functional properties as potential drug carriers. A review on application of these materials in drug delivery of NSAIDs is presented including evaluation of techniques used for drug silica based carrier characterization in addition to investigation of their biopharmaceutical performances.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a",
booktitle = "Natural and Modified Silica-Based Materials as Carriers for NSAIDs",
pages = "219-258",
doi = "10.1016/B978-0-12-804017-1.00008-X"
}

Krajišnik, D., Daković, A., Janićijević, J.,& Milić, J.. (2017). Natural and Modified Silica-Based Materials as Carriers for NSAIDs. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
Elsevier Inc.., 219-258.
https://doi.org/10.1016/B978-0-12-804017-1.00008-X

Krajišnik D, Daković A, Janićijević J, Milić J. Natural and Modified Silica-Based Materials as Carriers for NSAIDs. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:219-258.
doi:10.1016/B978-0-12-804017-1.00008-X .

Krajišnik, Danina, Daković, Aleksandra, Janićijević, Jelena, Milić, Jela, "Natural and Modified Silica-Based Materials as Carriers for NSAIDs" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):219-258,
https://doi.org/10.1016/B978-0-12-804017-1.00008-X . .

TY  - JOUR
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Janićijević, Jelena
AU  - Daković, Aleksandra
AU  - Krajišnik, Danina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2784
AB  - This study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies revealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP.
PB  - Mineralogical Soc, Twickenham
T2  - Clay Minerals
T1  - Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release
VL  - 52
IS  - 4
SP  - 413
EP  - 426
DO  - 10.1180/claymin.2017.052.04.01
ER  - 

@article{
author = "Čalija, Bojan and Milić, Jela and Janićijević, Jelena and Daković, Aleksandra and Krajišnik, Danina",
year = "2017",
abstract = "This study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies revealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP.",
publisher = "Mineralogical Soc, Twickenham",
journal = "Clay Minerals",
title = "Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release",
volume = "52",
number = "4",
pages = "413-426",
doi = "10.1180/claymin.2017.052.04.01"
}

Čalija, B., Milić, J., Janićijević, J., Daković, A.,& Krajišnik, D.. (2017). Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release. in Clay Minerals
Mineralogical Soc, Twickenham., 52(4), 413-426.
https://doi.org/10.1180/claymin.2017.052.04.01

Čalija B, Milić J, Janićijević J, Daković A, Krajišnik D. Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release. in Clay Minerals. 2017;52(4):413-426.
doi:10.1180/claymin.2017.052.04.01 .

Čalija, Bojan, Milić, Jela, Janićijević, Jelena, Daković, Aleksandra, Krajišnik, Danina, "Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release" in Clay Minerals, 52, no. 4 (2017):413-426,
https://doi.org/10.1180/claymin.2017.052.04.01 . .

TY  - JOUR
AU  - Janićijević, Jelena
AU  - Krajišnik, Danina
AU  - Čalija, Bojan
AU  - Nedić-Vasiljević, Bojana
AU  - Dobričić, Vladimir
AU  - Daković, Aleksandra
AU  - Antonijević, Milan D.
AU  - Milić, Jela
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2360
AB  - Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium
VL  - 496
IS  - 2
SP  - 466
EP  - 474
DO  - 10.1016/j.ijpharm.2015.10.047
ER  - 

@article{
author = "Janićijević, Jelena and Krajišnik, Danina and Čalija, Bojan and Nedić-Vasiljević, Bojana and Dobričić, Vladimir and Daković, Aleksandra and Antonijević, Milan D. and Milić, Jela",
year = "2015",
abstract = "Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium",
volume = "496",
number = "2",
pages = "466-474",
doi = "10.1016/j.ijpharm.2015.10.047"
}

Janićijević, J., Krajišnik, D., Čalija, B., Nedić-Vasiljević, B., Dobričić, V., Daković, A., Antonijević, M. D.,& Milić, J.. (2015). Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 496(2), 466-474.
https://doi.org/10.1016/j.ijpharm.2015.10.047

Janićijević J, Krajišnik D, Čalija B, Nedić-Vasiljević B, Dobričić V, Daković A, Antonijević MD, Milić J. Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics. 2015;496(2):466-474.
doi:10.1016/j.ijpharm.2015.10.047 .

Janićijević, Jelena, Krajišnik, Danina, Čalija, Bojan, Nedić-Vasiljević, Bojana, Dobričić, Vladimir, Daković, Aleksandra, Antonijević, Milan D., Milić, Jela, "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium" in International Journal of Pharmaceutics, 496, no. 2 (2015):466-474,
https://doi.org/10.1016/j.ijpharm.2015.10.047 . .

TY  - JOUR
AU  - Janićijević, Jelena
AU  - Krajišnik, Danina
AU  - Čalija, Bojan
AU  - Dobričić, Vladimir
AU  - Daković, Aleksandra
AU  - Krstić, Jugoslav
AU  - Marković, Marija
AU  - Milić, Jela
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2101
AB  - Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.
PB  - Elsevier Science BV, Amsterdam
T2  - Materials Science & Engineering C: Materials for Biological Applications
T1  - Inorganically modified diatomite as a potential prolonged-release drug carrier
VL  - 42
SP  - 412
EP  - 420
DO  - 10.1016/j.msec.2014.05.052
ER  - 

@article{
author = "Janićijević, Jelena and Krajišnik, Danina and Čalija, Bojan and Dobričić, Vladimir and Daković, Aleksandra and Krstić, Jugoslav and Marković, Marija and Milić, Jela",
year = "2014",
abstract = "Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Materials Science & Engineering C: Materials for Biological Applications",
title = "Inorganically modified diatomite as a potential prolonged-release drug carrier",
volume = "42",
pages = "412-420",
doi = "10.1016/j.msec.2014.05.052"
}

Janićijević, J., Krajišnik, D., Čalija, B., Dobričić, V., Daković, A., Krstić, J., Marković, M.,& Milić, J.. (2014). Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C: Materials for Biological Applications
Elsevier Science BV, Amsterdam., 42, 412-420.
https://doi.org/10.1016/j.msec.2014.05.052

Janićijević J, Krajišnik D, Čalija B, Dobričić V, Daković A, Krstić J, Marković M, Milić J. Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C: Materials for Biological Applications. 2014;42:412-420.
doi:10.1016/j.msec.2014.05.052 .

Janićijević, Jelena, Krajišnik, Danina, Čalija, Bojan, Dobričić, Vladimir, Daković, Aleksandra, Krstić, Jugoslav, Marković, Marija, Milić, Jela, "Inorganically modified diatomite as a potential prolonged-release drug carrier" in Materials Science & Engineering C: Materials for Biological Applications, 42 (2014):412-420,
https://doi.org/10.1016/j.msec.2014.05.052 . .