TY  - CONF
AU  - Repić, Aleksandra
AU  - Lukić, Vera
AU  - Ždrale, Branislava
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Petar
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5484
AB  - Olovo (Pb) i kadmijum (Cd) su toksični metali kojima je stanovništvo primarno izloženo iz životne i/
ili radne sredine. Dugotrajna izloženost čak i niskim koncentracijama Pb i Cd može doprineti razvoju
različitih bolesti. Cilj istraživanja je određivanje nivoa Pb i Cd u punoj krvi stanovnika Beograda dobrovoljnih
davaoca krvi i identifikovanje faktora koji utiču na njihove koncentracije. ...
AB  - Lead (Pb) and cadmium (Cd) are toxic metals whose primary exposure is through the living and/or working environment. Even long-term exposure to low concentrations can affect the development of some disorders. The aim of this study was to determine the levels of Pb and Cd in the whole blood of the residents of Belgrade, voluntary blood donors, and to identify factors that most influence their concentrations. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda
T1  - The influence of individual factors and lifestyle on the level of lead and cadmium in the blood of Belgrade residents
SP  - 46
EP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5484
ER  - 

@conference{
author = "Repić, Aleksandra and Lukić, Vera and Ždrale, Branislava and Vukelić, Dragana and Buha-Đorđević, Aleksandra and Bulat, Petar and Bulat, Zorica",
year = "2023",
abstract = "Olovo (Pb) i kadmijum (Cd) su toksični metali kojima je stanovništvo primarno izloženo iz životne i/
ili radne sredine. Dugotrajna izloženost čak i niskim koncentracijama Pb i Cd može doprineti razvoju
različitih bolesti. Cilj istraživanja je određivanje nivoa Pb i Cd u punoj krvi stanovnika Beograda dobrovoljnih
davaoca krvi i identifikovanje faktora koji utiču na njihove koncentracije. ..., Lead (Pb) and cadmium (Cd) are toxic metals whose primary exposure is through the living and/or working environment. Even long-term exposure to low concentrations can affect the development of some disorders. The aim of this study was to determine the levels of Pb and Cd in the whole blood of the residents of Belgrade, voluntary blood donors, and to identify factors that most influence their concentrations. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda, The influence of individual factors and lifestyle on the level of lead and cadmium in the blood of Belgrade residents",
pages = "46-47",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5484"
}

Repić, A., Lukić, V., Ždrale, B., Vukelić, D., Buha-Đorđević, A., Bulat, P.,& Bulat, Z.. (2023). Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 46-47.
https://hdl.handle.net/21.15107/rcub_farfar_5484

Repić A, Lukić V, Ždrale B, Vukelić D, Buha-Đorđević A, Bulat P, Bulat Z. Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:46-47.
https://hdl.handle.net/21.15107/rcub_farfar_5484 .

Repić, Aleksandra, Lukić, Vera, Ždrale, Branislava, Vukelić, Dragana, Buha-Đorđević, Aleksandra, Bulat, Petar, Bulat, Zorica, "Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):46-47,
https://hdl.handle.net/21.15107/rcub_farfar_5484 .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Đukić-Ćosić, Danijela
AU  - Aćimović, Miodrag
AU  - Bojanić, Nebojša
AU  - Bartolović, Daniela
AU  - Bulat, Petar
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4675
AB  - Testis cancer (TC) is the most common malignancy of young men. Current evidence from studies, alongside genetics and hormonal status, suggests a significant role of toxic metals, cadmium (Cd) and lead (Pb), in the origin and development of TC. Besides oxidative stress and endocrine disruption, interaction with bioelements is one of the critical mechanisms of Cd and Pb toxicity and malign transformation. This study aimed to investigate metal levels in blood, healthy, and tumor testis tissue and to reveal hormone, oxidative status, and bioelements levels in patients with TC. The study enrolled 52 patients with TC and 61 healthy volunteers. Toxic metals and bioelements levels were analyzed by atomic absorption spectrophotometry (AAS) while electrochemiluminescence immunoassay (ECLIA) and spectrophotometry methods were used for hormone and oxidative parameters evaluation. Significantly higher blood Cd levels were depicted in TC cohort. Furthermore, blood Cd elevation was associated with a 1.98 higher probability of TC developing. However, a metal concentration between healthy and tumor testis tissue did not differ significantly. Lower levels of estradiol and testosterone, established in a cohort of TC patients, followed the significant role of hormones in TC development. At the same time, ischemia-modified albumin (IMA) has been recognized as a parameter with very good accuracy as a potential diagnostic marker for TC. The study revealed different distribution patterns of copper (Cu) and zinc (Zn) in the three compartments of the patients, as well significant correlation between essential metals Cu/Zn and toxic metals Cd/Pb indicating metal-metal interactions as pivotal mechanisms of metals toxicity.
PB  - Elsevier Ltd
T2  - Chemosphere
T1  - Cadmium and lead implication in testis cancer; is there a connection?
VL  - 330
DO  - 10.1016/j.chemosphere.2023.138698
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Đukić-Ćosić, Danijela and Aćimović, Miodrag and Bojanić, Nebojša and Bartolović, Daniela and Bulat, Petar and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Testis cancer (TC) is the most common malignancy of young men. Current evidence from studies, alongside genetics and hormonal status, suggests a significant role of toxic metals, cadmium (Cd) and lead (Pb), in the origin and development of TC. Besides oxidative stress and endocrine disruption, interaction with bioelements is one of the critical mechanisms of Cd and Pb toxicity and malign transformation. This study aimed to investigate metal levels in blood, healthy, and tumor testis tissue and to reveal hormone, oxidative status, and bioelements levels in patients with TC. The study enrolled 52 patients with TC and 61 healthy volunteers. Toxic metals and bioelements levels were analyzed by atomic absorption spectrophotometry (AAS) while electrochemiluminescence immunoassay (ECLIA) and spectrophotometry methods were used for hormone and oxidative parameters evaluation. Significantly higher blood Cd levels were depicted in TC cohort. Furthermore, blood Cd elevation was associated with a 1.98 higher probability of TC developing. However, a metal concentration between healthy and tumor testis tissue did not differ significantly. Lower levels of estradiol and testosterone, established in a cohort of TC patients, followed the significant role of hormones in TC development. At the same time, ischemia-modified albumin (IMA) has been recognized as a parameter with very good accuracy as a potential diagnostic marker for TC. The study revealed different distribution patterns of copper (Cu) and zinc (Zn) in the three compartments of the patients, as well significant correlation between essential metals Cu/Zn and toxic metals Cd/Pb indicating metal-metal interactions as pivotal mechanisms of metals toxicity.",
publisher = "Elsevier Ltd",
journal = "Chemosphere",
title = "Cadmium and lead implication in testis cancer; is there a connection?",
volume = "330",
doi = "10.1016/j.chemosphere.2023.138698"
}

Anđelković, M., Buha-Đorđević, A., Vukelić, D., Đukić-Ćosić, D., Aćimović, M., Bojanić, N., Bartolović, D., Bulat, P., Antonijević, B.,& Bulat, Z.. (2023). Cadmium and lead implication in testis cancer; is there a connection?. in Chemosphere
Elsevier Ltd., 330.
https://doi.org/10.1016/j.chemosphere.2023.138698

Anđelković M, Buha-Đorđević A, Vukelić D, Đukić-Ćosić D, Aćimović M, Bojanić N, Bartolović D, Bulat P, Antonijević B, Bulat Z. Cadmium and lead implication in testis cancer; is there a connection?. in Chemosphere. 2023;330.
doi:10.1016/j.chemosphere.2023.138698 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Đukić-Ćosić, Danijela, Aćimović, Miodrag, Bojanić, Nebojša, Bartolović, Daniela, Bulat, Petar, Antonijević, Biljana, Bulat, Zorica, "Cadmium and lead implication in testis cancer; is there a connection?" in Chemosphere, 330 (2023),
https://doi.org/10.1016/j.chemosphere.2023.138698 . .

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Antonijević-Miljaković, Evica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Bulat, Petar
AU  - Radovanović, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4650
AB  - Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found to induce various toxic mechanisms leading to organ physiological disruption. Therefore, the purpose of the study was to simulate low-dose Pb exposure in an animal model with the aim of assessing oxidative status and essential element levels as the main mechanism of Pb toxicity in the liver and kidneys. Furthermore, dose–response modelling was performed in order to determine the benchmark dose (BMD). Forty-two male Wistar rats were divided into seven groups: one control group, and six groups treated for 28 days with 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg b.w./day, respectively. Oxidative status parameters (superoxide dismutase activity (SOD), superoxide anion radical (O2−), malondialdehyde (MDA), total sulfhydryl groups (SHG), and advanced oxidation protein products (AOPP)) and Pb, copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) levels were measured. Lowering Cu levels (BMD: 2.7 ng/kg b.w./day), raising AOPP levels (BMD: 0.25 µg/kg b.w./day) in the liver, and inhibiting SOD (BMD: 1.3 ng/kg b.w./day) in the kidneys appear to be the main mechanisms of Pb toxicity. The lowest BMD was derived for a decrease in Cu levels in liver, indicating that this effect is the most sensitive.
PB  - MDPI
T2  - Toxics
T1  - Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats
VL  - 11
IS  - 3
DO  - 10.3390/toxics11030256
ER  - 

@article{
author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Antonijević-Miljaković, Evica and Baralić, Katarina and Živančević, Katarina and Bulat, Petar and Radovanović, Jelena and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found to induce various toxic mechanisms leading to organ physiological disruption. Therefore, the purpose of the study was to simulate low-dose Pb exposure in an animal model with the aim of assessing oxidative status and essential element levels as the main mechanism of Pb toxicity in the liver and kidneys. Furthermore, dose–response modelling was performed in order to determine the benchmark dose (BMD). Forty-two male Wistar rats were divided into seven groups: one control group, and six groups treated for 28 days with 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg b.w./day, respectively. Oxidative status parameters (superoxide dismutase activity (SOD), superoxide anion radical (O2−), malondialdehyde (MDA), total sulfhydryl groups (SHG), and advanced oxidation protein products (AOPP)) and Pb, copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) levels were measured. Lowering Cu levels (BMD: 2.7 ng/kg b.w./day), raising AOPP levels (BMD: 0.25 µg/kg b.w./day) in the liver, and inhibiting SOD (BMD: 1.3 ng/kg b.w./day) in the kidneys appear to be the main mechanisms of Pb toxicity. The lowest BMD was derived for a decrease in Cu levels in liver, indicating that this effect is the most sensitive.",
publisher = "MDPI",
journal = "Toxics",
title = "Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats",
volume = "11",
number = "3",
doi = "10.3390/toxics11030256"
}

Vukelić, D., Buha-Đorđević, A., Anđelković, M., Antonijević-Miljaković, E., Baralić, K., Živančević, K., Bulat, P., Radovanović, J., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2023). Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats. in Toxics
MDPI., 11(3).
https://doi.org/10.3390/toxics11030256

Vukelić D, Buha-Đorđević A, Anđelković M, Antonijević-Miljaković E, Baralić K, Živančević K, Bulat P, Radovanović J, Đukić-Ćosić D, Antonijević B, Bulat Z. Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats. in Toxics. 2023;11(3).
doi:10.3390/toxics11030256 .

Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Antonijević-Miljaković, Evica, Baralić, Katarina, Živančević, Katarina, Bulat, Petar, Radovanović, Jelena, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats" in Toxics, 11, no. 3 (2023),
https://doi.org/10.3390/toxics11030256 . .

TY  - CONF
AU  - Repić, Aleksandra
AU  - Lukić, Vera
AU  - Ždrale, Branislava
AU  - Javorac, Dragana
AU  - Bulat, Petar
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4639
AB  - The microelements chromium, cobalt and nickel are necessary for the proper
functioning of the organism. At higher concentrations, they can cause toxic effects (organ
disfunction, genetic damage). They are widespread in the enviroment. They reach our body
through food, water, air and/or skin. The aim of this study was to determine the reference
values of chromium, cobalt and nickel in the blood of adult residents of Belgrade and
determine the degree of influence of individual, socioeconomic factors and lifestyle habits on
blood levels of these metals. The study population consisted of adults, healthy population, 18
to 65 years of age, who were voluntary blood donors. The study included 715 men (72.7%)
and 269 women (27.3%). Blood collected in vacutainers with heparin, was used for analysis.
984 samples were analysed. The metals were determined using inductively coupled plasma
mass spectrometry (7700x, Agilent, USA), with octopol reactive system and micro-flow
nebulizer. The average age of participants was 37.2 10.8. The reference values of the
analysed metals, shown as the 95 percentile, were 0.95µg/L, 0.62µg/L and 1.46µg/L for
chromium, cobalt and nickel, respectively, and were in good correlation with the values
obtained in biomonitoring studies conducted in Europe. This study showed that population
of Serbian origin had significantly lower blood concentrations of chromium, that cobalt blood
levels in women were significantly higher and cobalt and nickel levels increased with age in
both sexes. Education and economic status, cigarette smoking and sports did not significantly
affect the levels of these metals in the blood.
AB  - Mikroelementi hrom, kobalt i nikl su potrebni za pravilno funkcionisanje organizma. U
većim koncentracijama mogu ispoljiti toksične efekte poput ometanja pravilne funkcije
organa i dovesti do genetskih oštećenja i karcinogeneze. Široko su rasprostranjeni u životnoj
sredini. Putem hrane, vode, vazduha i/ili kože dospevaju u naš organizam. Cilj rada bio je da
se utvrde referentne vrednosti hroma, kobalta i nikla u krvi odraslih stanovnika grada
Beograda, kao i stepen uticaja individualnih, socioekonomskih faktora i životnih navika na
nivoe ovih metala u krvi. Ispitivanu populaciju je činilo odraslo, zdravo stanovništvo,ukupno
715 muškaraca (72,7%) i 269 žena (27,3%) od 18 do 65 godina starosti, koji su bili
dobrovoljni davaoci krvi. Za analizu je korišćena krv sakupljana u vakutejnere sa heparinom.
Analizirano je 984 uzoraka. Koncentracija metala je određena metodom masene
spektrometrije sa induktivno spregnutom plazmom (7700x, Agilent, USA), sa oktopol
reaktivnim sistemom i „micro‐flow“ raspršivačem. Prosečna starost ispitanika iznosila je
37,210,8 godina. Referentne vrednosti ispitivanih metala u krvi, prikazane kao 95. percentil
su 0,95 µg/L, 0,62 µg/L i 1,46 µg/L za hrom, kobalt i nikl, redom, su u dobroj korelaciji sa
vrednostima dobijenim u biomonitoring studijama sprovedenim u Evropi. Istraživanje
uticaja individualnih faktora je pokazalo da je hrom izmeren u značajno nižim
koncentracijama kod stanovništva srpske nacionalnosti, da su nivoi kobalta u krvi žena
značajno viši i da se nivoi kobalta i nikla povećavaju sa starenjem kod oba pola. Obrazovanje
i ekonomski status, pušenje cigareta i bavljenje sportom ne utiču statistički značajno na
nivoe ovih metala u krvi.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Determination of chromium, cobalt and nickel in the blood of the adult population living in Belgrade
T1  - Određivanje nivoa hroma, kobalta i nikla u krvi odraslog stanovništva na teritoriji Beograda
VL  - 72
IS  - 4 suplement
SP  - S603
EP  - S604
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4639
ER  - 

@conference{
author = "Repić, Aleksandra and Lukić, Vera and Ždrale, Branislava and Javorac, Dragana and Bulat, Petar and Bulat, Zorica",
year = "2022",
abstract = "The microelements chromium, cobalt and nickel are necessary for the proper
functioning of the organism. At higher concentrations, they can cause toxic effects (organ
disfunction, genetic damage). They are widespread in the enviroment. They reach our body
through food, water, air and/or skin. The aim of this study was to determine the reference
values of chromium, cobalt and nickel in the blood of adult residents of Belgrade and
determine the degree of influence of individual, socioeconomic factors and lifestyle habits on
blood levels of these metals. The study population consisted of adults, healthy population, 18
to 65 years of age, who were voluntary blood donors. The study included 715 men (72.7%)
and 269 women (27.3%). Blood collected in vacutainers with heparin, was used for analysis.
984 samples were analysed. The metals were determined using inductively coupled plasma
mass spectrometry (7700x, Agilent, USA), with octopol reactive system and micro-flow
nebulizer. The average age of participants was 37.2 10.8. The reference values of the
analysed metals, shown as the 95 percentile, were 0.95µg/L, 0.62µg/L and 1.46µg/L for
chromium, cobalt and nickel, respectively, and were in good correlation with the values
obtained in biomonitoring studies conducted in Europe. This study showed that population
of Serbian origin had significantly lower blood concentrations of chromium, that cobalt blood
levels in women were significantly higher and cobalt and nickel levels increased with age in
both sexes. Education and economic status, cigarette smoking and sports did not significantly
affect the levels of these metals in the blood., Mikroelementi hrom, kobalt i nikl su potrebni za pravilno funkcionisanje organizma. U
većim koncentracijama mogu ispoljiti toksične efekte poput ometanja pravilne funkcije
organa i dovesti do genetskih oštećenja i karcinogeneze. Široko su rasprostranjeni u životnoj
sredini. Putem hrane, vode, vazduha i/ili kože dospevaju u naš organizam. Cilj rada bio je da
se utvrde referentne vrednosti hroma, kobalta i nikla u krvi odraslih stanovnika grada
Beograda, kao i stepen uticaja individualnih, socioekonomskih faktora i životnih navika na
nivoe ovih metala u krvi. Ispitivanu populaciju je činilo odraslo, zdravo stanovništvo,ukupno
715 muškaraca (72,7%) i 269 žena (27,3%) od 18 do 65 godina starosti, koji su bili
dobrovoljni davaoci krvi. Za analizu je korišćena krv sakupljana u vakutejnere sa heparinom.
Analizirano je 984 uzoraka. Koncentracija metala je određena metodom masene
spektrometrije sa induktivno spregnutom plazmom (7700x, Agilent, USA), sa oktopol
reaktivnim sistemom i „micro‐flow“ raspršivačem. Prosečna starost ispitanika iznosila je
37,210,8 godina. Referentne vrednosti ispitivanih metala u krvi, prikazane kao 95. percentil
su 0,95 µg/L, 0,62 µg/L i 1,46 µg/L za hrom, kobalt i nikl, redom, su u dobroj korelaciji sa
vrednostima dobijenim u biomonitoring studijama sprovedenim u Evropi. Istraživanje
uticaja individualnih faktora je pokazalo da je hrom izmeren u značajno nižim
koncentracijama kod stanovništva srpske nacionalnosti, da su nivoi kobalta u krvi žena
značajno viši i da se nivoi kobalta i nikla povećavaju sa starenjem kod oba pola. Obrazovanje
i ekonomski status, pušenje cigareta i bavljenje sportom ne utiču statistički značajno na
nivoe ovih metala u krvi.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Determination of chromium, cobalt and nickel in the blood of the adult population living in Belgrade, Određivanje nivoa hroma, kobalta i nikla u krvi odraslog stanovništva na teritoriji Beograda",
volume = "72",
number = "4 suplement",
pages = "S603-S604",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4639"
}

Repić, A., Lukić, V., Ždrale, B., Javorac, D., Bulat, P.,& Bulat, Z.. (2022). Determination of chromium, cobalt and nickel in the blood of the adult population living in Belgrade. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S603-S604.
https://hdl.handle.net/21.15107/rcub_farfar_4639

Repić A, Lukić V, Ždrale B, Javorac D, Bulat P, Bulat Z. Determination of chromium, cobalt and nickel in the blood of the adult population living in Belgrade. in Arhiv za farmaciju. 2022;72(4 suplement):S603-S604.
https://hdl.handle.net/21.15107/rcub_farfar_4639 .

Repić, Aleksandra, Lukić, Vera, Ždrale, Branislava, Javorac, Dragana, Bulat, Petar, Bulat, Zorica, "Determination of chromium, cobalt and nickel in the blood of the adult population living in Belgrade" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S603-S604,
https://hdl.handle.net/21.15107/rcub_farfar_4639 .

TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Bulat, Petar
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4052
AB  - We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening
VL  - 161
DO  - 10.1016/j.fct.2022.112839
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Božić, Dragica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Bulat, Petar and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening",
volume = "161",
doi = "10.1016/j.fct.2022.112839"
}

Živančević, K., Baralić, K., Božić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B., Bulat, P.,& Đukić-Ćosić, D.. (2022). Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. in Food and Chemical Toxicology
Elsevier Ltd., 161.
https://doi.org/10.1016/j.fct.2022.112839

Živančević K, Baralić K, Božić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Bulat P, Đukić-Ćosić D. Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. in Food and Chemical Toxicology. 2022;161.
doi:10.1016/j.fct.2022.112839 .

Živančević, Katarina, Baralić, Katarina, Božić, Dragica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Bulat, Petar, Đukić-Ćosić, Danijela, "Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening" in Food and Chemical Toxicology, 161 (2022),
https://doi.org/10.1016/j.fct.2022.112839 . .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Antonijević, Biljana
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Bulat, Petar
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonić, Tamara
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3962
AB  - Exposure to lead (Pb) is still rising concern worldwide, having in mind that even low-dose exposure can induce various harmful effects. Thus, in-depth knowledge of the targets of Pb toxicity and corresponding mechanisms is essential. In the presented study, the six groups (male Wistar rats, n = 6) received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, each day by oral gavage, while the control group received distilled water only. All animals were sacrificed 24 h after the treatment, and blood was collected for the analysis of hematological, biochemical, oxidative status and essential elements levels. An external and internal dose-response relationship was performed using PROASTweb 70.1 software. The results showed that low doses of Pb affect hematological parameters and lipid profile after 28 days. The possible mechanisms at examined Pb dose levels were a decrease in SOD, O2•􀀀 and Cu and an increase in Zn levels. The dose-dependent nature of changes in cholesterol, HDL cholesterol, O2.-, SOD, AOPP in serum and hemoglobin, Fe, Zn, Cu in blood were obtained in this study. The most sensitive parameters that were alerted are Cu blood levels (BMDL5: 1.4 ng/kg b.w./day) and SOD activity (BMDL5: 0.5 μg/kg b.w./day). The presented results provide information that may be useful in further assessing the health risks of low-level Pb exposure.
PB  - Elsevier Ltd
T2  - Environmental Pollution
T1  - Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses
VL  - 291
DO  - 10.1016/j.envpol.2021.118103
ER  - 

@article{
author = "Javorac, Dragana and Antonijević, Biljana and Anđelković, Milena and Repić, Aleksandra and Bulat, Petar and Buha-Đorđević, Aleksandra and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonić, Tamara and Bulat, Zorica",
year = "2021",
abstract = "Exposure to lead (Pb) is still rising concern worldwide, having in mind that even low-dose exposure can induce various harmful effects. Thus, in-depth knowledge of the targets of Pb toxicity and corresponding mechanisms is essential. In the presented study, the six groups (male Wistar rats, n = 6) received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, each day by oral gavage, while the control group received distilled water only. All animals were sacrificed 24 h after the treatment, and blood was collected for the analysis of hematological, biochemical, oxidative status and essential elements levels. An external and internal dose-response relationship was performed using PROASTweb 70.1 software. The results showed that low doses of Pb affect hematological parameters and lipid profile after 28 days. The possible mechanisms at examined Pb dose levels were a decrease in SOD, O2•􀀀 and Cu and an increase in Zn levels. The dose-dependent nature of changes in cholesterol, HDL cholesterol, O2.-, SOD, AOPP in serum and hemoglobin, Fe, Zn, Cu in blood were obtained in this study. The most sensitive parameters that were alerted are Cu blood levels (BMDL5: 1.4 ng/kg b.w./day) and SOD activity (BMDL5: 0.5 μg/kg b.w./day). The presented results provide information that may be useful in further assessing the health risks of low-level Pb exposure.",
publisher = "Elsevier Ltd",
journal = "Environmental Pollution",
title = "Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses",
volume = "291",
doi = "10.1016/j.envpol.2021.118103"
}

Javorac, D., Antonijević, B., Anđelković, M., Repić, A., Bulat, P., Buha-Đorđević, A., Baralić, K., Đukić-Ćosić, D., Antonić, T.,& Bulat, Z.. (2021). Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses. in Environmental Pollution
Elsevier Ltd., 291.
https://doi.org/10.1016/j.envpol.2021.118103

Javorac D, Antonijević B, Anđelković M, Repić A, Bulat P, Buha-Đorđević A, Baralić K, Đukić-Ćosić D, Antonić T, Bulat Z. Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses. in Environmental Pollution. 2021;291.
doi:10.1016/j.envpol.2021.118103 .

Javorac, Dragana, Antonijević, Biljana, Anđelković, Milena, Repić, Aleksandra, Bulat, Petar, Buha-Đorđević, Aleksandra, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonić, Tamara, Bulat, Zorica, "Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses" in Environmental Pollution, 291 (2021),
https://doi.org/10.1016/j.envpol.2021.118103 . .

TY  - JOUR
AU  - Repić, Aleksandra
AU  - Bulat, Petar
AU  - Antonijević, Biljana
AU  - Antunović, Marko
AU  - Džudović, Jelena
AU  - Buha, Aleksandra
AU  - Bulat, Zorica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3486
AB  - According to theWorld Health Organization, in 2015, the Serbian population ranked among the highest ones in Europe in terms of smoking habit: 44.3%males and 36.2%females aged 18–64 smoked tobacco. In the last 7 years, 25%of total mortality inmen and 9%in women from Serbia were associated with smoking. Tobacco smoking is one of the most important sources of exposure to many toxic substances in general population. Our study confirmed higher blood levels of two toxic metals, cadmium and lead, in the blood of smokers (3.5 and 1.5 times higher than in non-smokers, respectively). Furthermore, smoking habits, such as number of smoked cigarettes per day, smoking period and cigarette type, along with age, were shown to influence these metals’ blood concentration. Higher blood levels of Cd and Pb were found in smokers consuming more than 10 cigarettes per day for more than 10 years. The present study also highlighted the importance of the controlled tobacco production, since it was shown that consumption of illicit tobacco could manifold the exposure to toxic metals that can subsequently increase the frequency of related diseases as well.
PB  - Springer-Verlag GmbH Germany, part of Springer Nature
T2  - Environmental Science and Pollution Research
T1  - The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people
VL  - 27
SP  - 751
EP  - 760
DO  - 10.1007/s11356-019-06840-1
ER  - 

@article{
author = "Repić, Aleksandra and Bulat, Petar and Antonijević, Biljana and Antunović, Marko and Džudović, Jelena and Buha, Aleksandra and Bulat, Zorica",
year = "2020",
abstract = "According to theWorld Health Organization, in 2015, the Serbian population ranked among the highest ones in Europe in terms of smoking habit: 44.3%males and 36.2%females aged 18–64 smoked tobacco. In the last 7 years, 25%of total mortality inmen and 9%in women from Serbia were associated with smoking. Tobacco smoking is one of the most important sources of exposure to many toxic substances in general population. Our study confirmed higher blood levels of two toxic metals, cadmium and lead, in the blood of smokers (3.5 and 1.5 times higher than in non-smokers, respectively). Furthermore, smoking habits, such as number of smoked cigarettes per day, smoking period and cigarette type, along with age, were shown to influence these metals’ blood concentration. Higher blood levels of Cd and Pb were found in smokers consuming more than 10 cigarettes per day for more than 10 years. The present study also highlighted the importance of the controlled tobacco production, since it was shown that consumption of illicit tobacco could manifold the exposure to toxic metals that can subsequently increase the frequency of related diseases as well.",
publisher = "Springer-Verlag GmbH Germany, part of Springer Nature",
journal = "Environmental Science and Pollution Research",
title = "The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people",
volume = "27",
pages = "751-760",
doi = "10.1007/s11356-019-06840-1"
}

Repić, A., Bulat, P., Antonijević, B., Antunović, M., Džudović, J., Buha, A.,& Bulat, Z.. (2020). The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people. in Environmental Science and Pollution Research
Springer-Verlag GmbH Germany, part of Springer Nature., 27, 751-760.
https://doi.org/10.1007/s11356-019-06840-1

Repić A, Bulat P, Antonijević B, Antunović M, Džudović J, Buha A, Bulat Z. The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people. in Environmental Science and Pollution Research. 2020;27:751-760.
doi:10.1007/s11356-019-06840-1 .

Repić, Aleksandra, Bulat, Petar, Antonijević, Biljana, Antunović, Marko, Džudović, Jelena, Buha, Aleksandra, Bulat, Zorica, "The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people" in Environmental Science and Pollution Research, 27 (2020):751-760,
https://doi.org/10.1007/s11356-019-06840-1 . .

TY  - JOUR
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Buha, Aleksandra
AU  - Bulat, Petar
AU  - Pavlović, Zoran
AU  - Matović, Vesna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3003
AB  - The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10mg kg(-1) bw, as aqueous solution of Cd-chloride), and a Cd+ Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg(-1) bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4: 1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn,Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?
VL  - 68
IS  - 1
SP  - 38
EP  - 45
DO  - 10.1515/aiht-2017-68-2919
ER  - 

@article{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Antonijević, Biljana and Buha, Aleksandra and Bulat, Petar and Pavlović, Zoran and Matović, Vesna",
year = "2017",
abstract = "The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10mg kg(-1) bw, as aqueous solution of Cd-chloride), and a Cd+ Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg(-1) bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4: 1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn,Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?",
volume = "68",
number = "1",
pages = "38-45",
doi = "10.1515/aiht-2017-68-2919"
}

Bulat, Z., Đukić-Ćosić, D., Antonijević, B., Buha, A., Bulat, P., Pavlović, Z.,& Matović, V.. (2017). Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 68(1), 38-45.
https://doi.org/10.1515/aiht-2017-68-2919

Bulat Z, Đukić-Ćosić D, Antonijević B, Buha A, Bulat P, Pavlović Z, Matović V. Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2017;68(1):38-45.
doi:10.1515/aiht-2017-68-2919 .

Bulat, Zorica, Đukić-Ćosić, Danijela, Antonijević, Biljana, Buha, Aleksandra, Bulat, Petar, Pavlović, Zoran, Matović, Vesna, "Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 68, no. 1 (2017):38-45,
https://doi.org/10.1515/aiht-2017-68-2919 . .

TY  - CONF
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Buha, Aleksandra
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1855
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Can Zn supplementation mitigate Cd-induced bioelements disturbances in liver and kidneys?
VL  - 221
IS  - Supplement
SP  - S101
EP  - S101
DO  - 10.1016/j.toxlet.2013.05.148
ER  - 

@conference{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Buha, Aleksandra and Bulat, Petar and Matović, Vesna",
year = "2013",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Can Zn supplementation mitigate Cd-induced bioelements disturbances in liver and kidneys?",
volume = "221",
number = "Supplement",
pages = "S101-S101",
doi = "10.1016/j.toxlet.2013.05.148"
}

Bulat, Z., Đukić-Ćosić, D., Buha, A., Bulat, P.,& Matović, V.. (2013). Can Zn supplementation mitigate Cd-induced bioelements disturbances in liver and kidneys?. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 221(Supplement), S101-S101.
https://doi.org/10.1016/j.toxlet.2013.05.148

Bulat Z, Đukić-Ćosić D, Buha A, Bulat P, Matović V. Can Zn supplementation mitigate Cd-induced bioelements disturbances in liver and kidneys?. in Toxicology Letters. 2013;221(Supplement):S101-S101.
doi:10.1016/j.toxlet.2013.05.148 .

Bulat, Zorica, Đukić-Ćosić, Danijela, Buha, Aleksandra, Bulat, Petar, Matović, Vesna, "Can Zn supplementation mitigate Cd-induced bioelements disturbances in liver and kidneys?" in Toxicology Letters, 221, no. Supplement (2013):S101-S101,
https://doi.org/10.1016/j.toxlet.2013.05.148 . .

TY  - CONF
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Buha, Aleksandra
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1699
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effect of prolonged Zn + Cu + Mg treatment on Cd level in kidney of Cd-intoxicated rabbits
VL  - 211
IS  - Supplement
SP  - S142
EP  - S143
DO  - 10.1016/j.toxlet.2012.03.521
ER  - 

@conference{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Buha, Aleksandra and Bulat, Petar and Matović, Vesna",
year = "2012",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effect of prolonged Zn + Cu + Mg treatment on Cd level in kidney of Cd-intoxicated rabbits",
volume = "211",
number = "Supplement",
pages = "S142-S143",
doi = "10.1016/j.toxlet.2012.03.521"
}

Bulat, Z., Đukić-Ćosić, D., Ćurčić, M., Buha, A., Bulat, P.,& Matović, V.. (2012). Effect of prolonged Zn + Cu + Mg treatment on Cd level in kidney of Cd-intoxicated rabbits. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 211(Supplement), S142-S143.
https://doi.org/10.1016/j.toxlet.2012.03.521

Bulat Z, Đukić-Ćosić D, Ćurčić M, Buha A, Bulat P, Matović V. Effect of prolonged Zn + Cu + Mg treatment on Cd level in kidney of Cd-intoxicated rabbits. in Toxicology Letters. 2012;211(Supplement):S142-S143.
doi:10.1016/j.toxlet.2012.03.521 .

Bulat, Zorica, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Buha, Aleksandra, Bulat, Petar, Matović, Vesna, "Effect of prolonged Zn + Cu + Mg treatment on Cd level in kidney of Cd-intoxicated rabbits" in Toxicology Letters, 211, no. Supplement (2012):S142-S143,
https://doi.org/10.1016/j.toxlet.2012.03.521 . .

TY  - JOUR
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Petar
AU  - Vujanović, Dragana
AU  - Buha, Aleksandra
AU  - Matović, Vesna
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1743
AB  - The present study is designed to investigate whether magnesium (Mg) supplementation may prevent Cd-induced alterations in zinc (Zn), copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of Zn, Cu, and Mg were estimated in blood, urine, and organs (brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone) of rabbits given Cd (10 mg/kg b.w.) and rabbits cotreated with Mg (40 mg/kg b.w.) orally, as aqueous solutions of Cd chloride and Mg acetate every day for 4 weeks. Samples were mineralized with conc. HNO3 and HClO4 (4:1) and metals concentrations were determined by atomic absorption spectrophotometry (AAS). Magnesium supplementation succeeded to overcome Cd-induced disbalance of investigated bioelements. Beneficial effects of Mg were observed on Zn levels in blood and urine, on Cu levels in urine, and on Mg levels in blood. Magnesium pretreatment also managed to counteract or reduce all Cd-induced changes in levels of Cu and Mg in organs, while it did not exert this effect on Zn levels. These findings suggest that enhanced dietary Mg intake during Cd exposure can have at least partly beneficial effect on Cd-induced alterations in homeostasis of zinc, copper, and magnesium.
PB  - Hindawi Publishing Corporation, New York
T2  - Sensors
T1  - Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication
DO  - 10.1100/2012/572514
ER  - 

@article{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Petar and Vujanović, Dragana and Buha, Aleksandra and Matović, Vesna",
year = "2012",
abstract = "The present study is designed to investigate whether magnesium (Mg) supplementation may prevent Cd-induced alterations in zinc (Zn), copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of Zn, Cu, and Mg were estimated in blood, urine, and organs (brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone) of rabbits given Cd (10 mg/kg b.w.) and rabbits cotreated with Mg (40 mg/kg b.w.) orally, as aqueous solutions of Cd chloride and Mg acetate every day for 4 weeks. Samples were mineralized with conc. HNO3 and HClO4 (4:1) and metals concentrations were determined by atomic absorption spectrophotometry (AAS). Magnesium supplementation succeeded to overcome Cd-induced disbalance of investigated bioelements. Beneficial effects of Mg were observed on Zn levels in blood and urine, on Cu levels in urine, and on Mg levels in blood. Magnesium pretreatment also managed to counteract or reduce all Cd-induced changes in levels of Cu and Mg in organs, while it did not exert this effect on Zn levels. These findings suggest that enhanced dietary Mg intake during Cd exposure can have at least partly beneficial effect on Cd-induced alterations in homeostasis of zinc, copper, and magnesium.",
publisher = "Hindawi Publishing Corporation, New York",
journal = "Sensors",
title = "Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication",
doi = "10.1100/2012/572514"
}

Bulat, Z., Đukić-Ćosić, D., Antonijević, B., Bulat, P., Vujanović, D., Buha, A.,& Matović, V.. (2012). Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication. in Sensors
Hindawi Publishing Corporation, New York..
https://doi.org/10.1100/2012/572514

Bulat Z, Đukić-Ćosić D, Antonijević B, Bulat P, Vujanović D, Buha A, Matović V. Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication. in Sensors. 2012;.
doi:10.1100/2012/572514 .

Bulat, Zorica, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Petar, Vujanović, Dragana, Buha, Aleksandra, Matović, Vesna, "Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication" in Sensors (2012),
https://doi.org/10.1100/2012/572514 . .

TY  - CONF
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Buha, Aleksandra
AU  - Vukomanović, Predrag
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1472
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication
VL  - 205
IS  - Supplement
SP  - S194
EP  - S194
DO  - 10.1016/j.toxlet.2011.05.671
ER  - 

@conference{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Buha, Aleksandra and Vukomanović, Predrag and Bulat, Petar and Matović, Vesna",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication",
volume = "205",
number = "Supplement",
pages = "S194-S194",
doi = "10.1016/j.toxlet.2011.05.671"
}

Bulat, Z., Đukić-Ćosić, D., Ćurčić, M., Buha, A., Vukomanović, P., Bulat, P.,& Matović, V.. (2011). Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205(Supplement), S194-S194.
https://doi.org/10.1016/j.toxlet.2011.05.671

Bulat Z, Đukić-Ćosić D, Ćurčić M, Buha A, Vukomanović P, Bulat P, Matović V. Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication. in Toxicology Letters. 2011;205(Supplement):S194-S194.
doi:10.1016/j.toxlet.2011.05.671 .

Bulat, Zorica, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Buha, Aleksandra, Vukomanović, Predrag, Bulat, Petar, Matović, Vesna, "Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication" in Toxicology Letters, 205, no. Supplement (2011):S194-S194,
https://doi.org/10.1016/j.toxlet.2011.05.671 . .

TY  - CONF
AU  - Plamenac-Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1269
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effect of magnesium supplementation on blood cadmium, zinc and copper levels in rabbits exposed to prolonged cadmium intoxication
VL  - 189
IS  - Supplement
SP  - S225
EP  - S226
DO  - 10.1016/j.toxlet.2009.06.530
ER  - 

@conference{
author = "Plamenac-Bulat, Zorica and Đukić-Ćosić, Danijela and Bulat, Petar and Matović, Vesna",
year = "2009",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effect of magnesium supplementation on blood cadmium, zinc and copper levels in rabbits exposed to prolonged cadmium intoxication",
volume = "189",
number = "Supplement",
pages = "S225-S226",
doi = "10.1016/j.toxlet.2009.06.530"
}

Plamenac-Bulat, Z., Đukić-Ćosić, D., Bulat, P.,& Matović, V.. (2009). Effect of magnesium supplementation on blood cadmium, zinc and copper levels in rabbits exposed to prolonged cadmium intoxication. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 189(Supplement), S225-S226.
https://doi.org/10.1016/j.toxlet.2009.06.530

Plamenac-Bulat Z, Đukić-Ćosić D, Bulat P, Matović V. Effect of magnesium supplementation on blood cadmium, zinc and copper levels in rabbits exposed to prolonged cadmium intoxication. in Toxicology Letters. 2009;189(Supplement):S225-S226.
doi:10.1016/j.toxlet.2009.06.530 .

Plamenac-Bulat, Zorica, Đukić-Ćosić, Danijela, Bulat, Petar, Matović, Vesna, "Effect of magnesium supplementation on blood cadmium, zinc and copper levels in rabbits exposed to prolonged cadmium intoxication" in Toxicology Letters, 189, no. Supplement (2009):S225-S226,
https://doi.org/10.1016/j.toxlet.2009.06.530 . .

TY  - JOUR
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Dokić, M.
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1274
AB  - Although cadmium (Cd) is extensively used for nickel-cadmium battery production, few recent reports are available on the effect of this toxic metal on the imbalance of biometals in occupational exposure. The current study was carried out to determine the Cd level and its effect on the content of bioelements: zinc, cooper, magnesium, and iron in blood and urine of workers exposed to Cd during nickel-cadmium battery production. beta(2)-Microglobulins (beta(2)-MG), as indicators of kidney damage, were determined in urine. The study group comprised 32 male nickel-cadmium battery workers, and the control group had 15 male construction workers with no history of Cd exposure. Levels of Cd and bioelements were determined in blood and urine by atomic absorption spectrophotometry. Cd concentration in blood of exposed workers was around 10 mu g/L and in urine ranged from 1.93 to 8.76 mu g/g creatinine (cr). Urine Cd concentration was significantly higher in exposed workers than in the controls, although no statistical difference in beta(2)-MG content was observed in urine between the two groups. Blood Zn and Mg level were significantly reduced and urine Zn level was increased in Cd-exposed group when compared with controls. The mean Cd concentrations in blood and urine did not exceed the recommended reference values of 10 mu g/L in blood and 10 mu g/g cr in urine. Cd exposure resulted in disturbances of Zn in blood and urine and Mg in blood but had no effect on Cu and Fe content in biological fluids. Toxicology and Industrial Health 2009; 25: 129-135.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Toxicology in Vitro
T1  - Blood and urine cadmium and bioelements profile in nickel-cadmium battery workers in Serbia
VL  - 25
IS  - 2
SP  - 129
EP  - 135
DO  - 10.1177/0748233709104488
ER  - 

@article{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Dokić, M. and Bulat, Petar and Matović, Vesna",
year = "2009",
abstract = "Although cadmium (Cd) is extensively used for nickel-cadmium battery production, few recent reports are available on the effect of this toxic metal on the imbalance of biometals in occupational exposure. The current study was carried out to determine the Cd level and its effect on the content of bioelements: zinc, cooper, magnesium, and iron in blood and urine of workers exposed to Cd during nickel-cadmium battery production. beta(2)-Microglobulins (beta(2)-MG), as indicators of kidney damage, were determined in urine. The study group comprised 32 male nickel-cadmium battery workers, and the control group had 15 male construction workers with no history of Cd exposure. Levels of Cd and bioelements were determined in blood and urine by atomic absorption spectrophotometry. Cd concentration in blood of exposed workers was around 10 mu g/L and in urine ranged from 1.93 to 8.76 mu g/g creatinine (cr). Urine Cd concentration was significantly higher in exposed workers than in the controls, although no statistical difference in beta(2)-MG content was observed in urine between the two groups. Blood Zn and Mg level were significantly reduced and urine Zn level was increased in Cd-exposed group when compared with controls. The mean Cd concentrations in blood and urine did not exceed the recommended reference values of 10 mu g/L in blood and 10 mu g/g cr in urine. Cd exposure resulted in disturbances of Zn in blood and urine and Mg in blood but had no effect on Cu and Fe content in biological fluids. Toxicology and Industrial Health 2009; 25: 129-135.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Toxicology in Vitro",
title = "Blood and urine cadmium and bioelements profile in nickel-cadmium battery workers in Serbia",
volume = "25",
number = "2",
pages = "129-135",
doi = "10.1177/0748233709104488"
}

Bulat, Z., Đukić-Ćosić, D., Dokić, M., Bulat, P.,& Matović, V.. (2009). Blood and urine cadmium and bioelements profile in nickel-cadmium battery workers in Serbia. in Toxicology in Vitro
Sage Publications Inc, Thousand Oaks., 25(2), 129-135.
https://doi.org/10.1177/0748233709104488

Bulat Z, Đukić-Ćosić D, Dokić M, Bulat P, Matović V. Blood and urine cadmium and bioelements profile in nickel-cadmium battery workers in Serbia. in Toxicology in Vitro. 2009;25(2):129-135.
doi:10.1177/0748233709104488 .

Bulat, Zorica, Đukić-Ćosić, Danijela, Dokić, M., Bulat, Petar, Matović, Vesna, "Blood and urine cadmium and bioelements profile in nickel-cadmium battery workers in Serbia" in Toxicology in Vitro, 25, no. 2 (2009):129-135,
https://doi.org/10.1177/0748233709104488 . .

TY  - CONF
AU  - Plamenac-Bulat, Zorica
AU  - Đokić, Marija
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1111
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium
VL  - 180
IS  - Supplement
SP  - S144
EP  - S144
DO  - 10.1016/j.toxlet.2008.06.353
ER  - 

@conference{
author = "Plamenac-Bulat, Zorica and Đokić, Marija and Đukić-Ćosić, Danijela and Bulat, Petar and Matović, Vesna",
year = "2008",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium",
volume = "180",
number = "Supplement",
pages = "S144-S144",
doi = "10.1016/j.toxlet.2008.06.353"
}

Plamenac-Bulat, Z., Đokić, M., Đukić-Ćosić, D., Bulat, P.,& Matović, V.. (2008). Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 180(Supplement), S144-S144.
https://doi.org/10.1016/j.toxlet.2008.06.353

Plamenac-Bulat Z, Đokić M, Đukić-Ćosić D, Bulat P, Matović V. Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium. in Toxicology Letters. 2008;180(Supplement):S144-S144.
doi:10.1016/j.toxlet.2008.06.353 .

Plamenac-Bulat, Zorica, Đokić, Marija, Đukić-Ćosić, Danijela, Bulat, Petar, Matović, Vesna, "Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium" in Toxicology Letters, 180, no. Supplement (2008):S144-S144,
https://doi.org/10.1016/j.toxlet.2008.06.353 . .

TY  - JOUR
AU  - Žarković, Miloš
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Ćirić, Jasmina
AU  - Beleslin, Biljana
AU  - Savić, Slavica
AU  - Stojković, Mirjana
AU  - Bulat, Petar
AU  - Trbojević, Bozo
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1026
AB  - Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.
PB  - Bioscientifica Ltd, Bristol
T2  - European Journal of Endocrinology
T1  - Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans
VL  - 159
IS  - 5
SP  - 649
EP  - 652
DO  - 10.1530/EJE-08-0544
ER  - 

@article{
author = "Žarković, Miloš and Ignjatović, Svetlana and Dajak, Marijana and Ćirić, Jasmina and Beleslin, Biljana and Savić, Slavica and Stojković, Mirjana and Bulat, Petar and Trbojević, Bozo",
year = "2008",
abstract = "Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.",
publisher = "Bioscientifica Ltd, Bristol",
journal = "European Journal of Endocrinology",
title = "Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans",
volume = "159",
number = "5",
pages = "649-652",
doi = "10.1530/EJE-08-0544"
}

Žarković, M., Ignjatović, S., Dajak, M., Ćirić, J., Beleslin, B., Savić, S., Stojković, M., Bulat, P.,& Trbojević, B.. (2008). Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. in European Journal of Endocrinology
Bioscientifica Ltd, Bristol., 159(5), 649-652.
https://doi.org/10.1530/EJE-08-0544

Žarković M, Ignjatović S, Dajak M, Ćirić J, Beleslin B, Savić S, Stojković M, Bulat P, Trbojević B. Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. in European Journal of Endocrinology. 2008;159(5):649-652.
doi:10.1530/EJE-08-0544 .

Žarković, Miloš, Ignjatović, Svetlana, Dajak, Marijana, Ćirić, Jasmina, Beleslin, Biljana, Savić, Slavica, Stojković, Mirjana, Bulat, Petar, Trbojević, Bozo, "Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans" in European Journal of Endocrinology, 159, no. 5 (2008):649-652,
https://doi.org/10.1530/EJE-08-0544 . .

TY  - JOUR
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Maličević, Živorad
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1104
AB  - The objective of this study was to examine the influence of oral supplementation with Zn or Mg on Cd content in the blood and organs of rabbits exposed to prolonged Cd intoxication. Rabbits were divided into the following groups: Cd group-received orally every day for 4 weeks 10 mg Cd/kg body weight (b.w.), Cd+Zn group and Cd+Mg group-exposed to Cd and supplemented with 20 mg Zn/kg b.w. or 40 mg Mg/kg b.w. 1 h after Cd treatment. Cd content in biological material was determined by atomic absorption spectrophotometry. Blood Cd concentration was determined in all investigated groups at time 0 and after 10, 14, 18, 22, 25, and 28 days, whereas Cd content in the brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone was determined after 28 days. Blood Cd concentration was significantly increased in all groups from the 14th day of Cd intoxication and lasted till the end of the experiment. Zn or Mg supplementation significantly reduced blood Cd content on the 18th and 25th days. Supplementation with Zn or Mg significantly decreased Cd concentration in the kidney, spleen, and bone and, in addition, Zn reduced Cd content in the brain. Supplementation with Zn or Mg in Cd-intoxicated rabbits caused similar reduction of blood Cd concentration; however, reduction of tissue Cd content was more pronounced in Zn- than in Mg-supplemented group.
PB  - Humana Press Inc, Totowa
T2  - Biological Trace Element Research
T1  - Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits
VL  - 124
IS  - 2
SP  - 110
EP  - 117
DO  - 10.1007/s12011-008-8128-5
ER  - 

@article{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Maličević, Živorad and Bulat, Petar and Matović, Vesna",
year = "2008",
abstract = "The objective of this study was to examine the influence of oral supplementation with Zn or Mg on Cd content in the blood and organs of rabbits exposed to prolonged Cd intoxication. Rabbits were divided into the following groups: Cd group-received orally every day for 4 weeks 10 mg Cd/kg body weight (b.w.), Cd+Zn group and Cd+Mg group-exposed to Cd and supplemented with 20 mg Zn/kg b.w. or 40 mg Mg/kg b.w. 1 h after Cd treatment. Cd content in biological material was determined by atomic absorption spectrophotometry. Blood Cd concentration was determined in all investigated groups at time 0 and after 10, 14, 18, 22, 25, and 28 days, whereas Cd content in the brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone was determined after 28 days. Blood Cd concentration was significantly increased in all groups from the 14th day of Cd intoxication and lasted till the end of the experiment. Zn or Mg supplementation significantly reduced blood Cd content on the 18th and 25th days. Supplementation with Zn or Mg significantly decreased Cd concentration in the kidney, spleen, and bone and, in addition, Zn reduced Cd content in the brain. Supplementation with Zn or Mg in Cd-intoxicated rabbits caused similar reduction of blood Cd concentration; however, reduction of tissue Cd content was more pronounced in Zn- than in Mg-supplemented group.",
publisher = "Humana Press Inc, Totowa",
journal = "Biological Trace Element Research",
title = "Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits",
volume = "124",
number = "2",
pages = "110-117",
doi = "10.1007/s12011-008-8128-5"
}

Bulat, Z., Đukić-Ćosić, D., Maličević, Ž., Bulat, P.,& Matović, V.. (2008). Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits. in Biological Trace Element Research
Humana Press Inc, Totowa., 124(2), 110-117.
https://doi.org/10.1007/s12011-008-8128-5

Bulat Z, Đukić-Ćosić D, Maličević Ž, Bulat P, Matović V. Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits. in Biological Trace Element Research. 2008;124(2):110-117.
doi:10.1007/s12011-008-8128-5 .

Bulat, Zorica, Đukić-Ćosić, Danijela, Maličević, Živorad, Bulat, Petar, Matović, Vesna, "Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits" in Biological Trace Element Research, 124, no. 2 (2008):110-117,
https://doi.org/10.1007/s12011-008-8128-5 . .