TY  - JOUR
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Grahovac, Lazar
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5516
AB  - Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.
PB  - MDPI
T2  - Antioxidants
T1  - Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies
VL  - 13
IS  - 2
DO  - 10.3390/antiox13020147
ER  - 

@article{
author = "Baralić, Katarina and Živanović, Jovana and Marić, Đurđica and Božić, Dragica and Grahovac, Lazar and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies",
volume = "13",
number = "2",
doi = "10.3390/antiox13020147"
}

Baralić, K., Živanović, J., Marić, Đ., Božić, D., Grahovac, L., Antonijević-Miljaković, E., Ćurčić, M., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants
MDPI., 13(2).
https://doi.org/10.3390/antiox13020147

Baralić K, Živanović J, Marić Đ, Božić D, Grahovac L, Antonijević-Miljaković E, Ćurčić M, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants. 2024;13(2).
doi:10.3390/antiox13020147 .

Baralić, Katarina, Živanović, Jovana, Marić, Đurđica, Božić, Dragica, Grahovac, Lazar, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies" in Antioxidants, 13, no. 2 (2024),
https://doi.org/10.3390/antiox13020147 . .

TY  - JOUR
AU  - Božić, Dragica
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5531
AB  - Cancer is a leading cause of death worldwide, for which finding the optimal therapy remains an ongoing challenge. Drug resistance, toxic side effects, and a lack of specificity pose significant difficulties in traditional cancer treatments, leading to suboptimal clinical outcomes and high mortality rates among cancer patients. The need for alternative therapies is crucial, especially for those resistant to conventional methods like chemotherapy and radiotherapy or for patients where surgery is not possible. Over the past decade, a novel approach known as bacteria-mediated cancer therapy has emerged, offering potential solutions to the limitations of conventional treatments. An increasing number of in vitro and in vivo studies suggest that the subtype of highly virulent Pseudomonas aeruginosa bacterium called Pseudomonas aeruginosa mannose-sensitive-hemagglutinin (PA-MSHA) can successfully inhibit the progression of various cancer types, such as breast, lung, and bladder cancer, as well as hepatocellular carcinoma. PA-MSHA inhibits the growth and proliferation of tumor cells and induces their apoptosis. Proposed mechanisms of action include cell-cycle arrest and activation of pro-apoptotic pathways regulated by caspase-9 and caspase-3. Moreover, clinical studies have shown that PA-MSHA improved the effectiveness of chemotherapy and promoted the activation of the immune response in cancer patients without causing severe side effects. Reported adverse reactions were fever, skin irritation, and pain, attributed to the overactivation of the immune response. This review aims to summarize the current knowledge obtained from in vitro, in vivo, and clinical studies available at PubMed, Google Scholar, and ClinicalTrials.gov regarding the use of PA-MSHA in cancer treatment in order to further elucidate its pharmacological and toxicological properties.
PB  - MDPI
T2  - Cancers
T1  - Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects
VL  - 16
IS  - 3
DO  - 10.3390/cancers16030524
ER  - 

@article{
author = "Božić, Dragica and Živanović, Jovana and Živančević, Katarina and Baralić, Katarina and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Cancer is a leading cause of death worldwide, for which finding the optimal therapy remains an ongoing challenge. Drug resistance, toxic side effects, and a lack of specificity pose significant difficulties in traditional cancer treatments, leading to suboptimal clinical outcomes and high mortality rates among cancer patients. The need for alternative therapies is crucial, especially for those resistant to conventional methods like chemotherapy and radiotherapy or for patients where surgery is not possible. Over the past decade, a novel approach known as bacteria-mediated cancer therapy has emerged, offering potential solutions to the limitations of conventional treatments. An increasing number of in vitro and in vivo studies suggest that the subtype of highly virulent Pseudomonas aeruginosa bacterium called Pseudomonas aeruginosa mannose-sensitive-hemagglutinin (PA-MSHA) can successfully inhibit the progression of various cancer types, such as breast, lung, and bladder cancer, as well as hepatocellular carcinoma. PA-MSHA inhibits the growth and proliferation of tumor cells and induces their apoptosis. Proposed mechanisms of action include cell-cycle arrest and activation of pro-apoptotic pathways regulated by caspase-9 and caspase-3. Moreover, clinical studies have shown that PA-MSHA improved the effectiveness of chemotherapy and promoted the activation of the immune response in cancer patients without causing severe side effects. Reported adverse reactions were fever, skin irritation, and pain, attributed to the overactivation of the immune response. This review aims to summarize the current knowledge obtained from in vitro, in vivo, and clinical studies available at PubMed, Google Scholar, and ClinicalTrials.gov regarding the use of PA-MSHA in cancer treatment in order to further elucidate its pharmacological and toxicological properties.",
publisher = "MDPI",
journal = "Cancers",
title = "Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects",
volume = "16",
number = "3",
doi = "10.3390/cancers16030524"
}

Božić, D., Živanović, J., Živančević, K., Baralić, K.,& Đukić-Ćosić, D.. (2024). Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects. in Cancers
MDPI., 16(3).
https://doi.org/10.3390/cancers16030524

Božić D, Živanović J, Živančević K, Baralić K, Đukić-Ćosić D. Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects. in Cancers. 2024;16(3).
doi:10.3390/cancers16030524 .

Božić, Dragica, Živanović, Jovana, Živančević, Katarina, Baralić, Katarina, Đukić-Ćosić, Danijela, "Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects" in Cancers, 16, no. 3 (2024),
https://doi.org/10.3390/cancers16030524 . .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5552
AB  - Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ...
AB  - Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji
T1  - Possibilities and challenges of applying artificial intelligence in toxicology
SP  - 159
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5552
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ..., Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji, Possibilities and challenges of applying artificial intelligence in toxicology",
pages = "159-160",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5552"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):159-160,
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5514
AB  - Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ...
AB  - In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Komparativna toksikogenomska baza podataka: Nove mogućnosti
T1  - The Comparative Toxicogenomic Database: New possibilities
SP  - 157
EP  - 158
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5514
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ..., In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Komparativna toksikogenomska baza podataka: Nove mogućnosti, The Comparative Toxicogenomic Database: New possibilities",
pages = "157-158",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5514"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Komparativna toksikogenomska baza podataka: Nove mogućnosti" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):157-158,
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Manić, Luka
AU  - Grahovac, Lazar
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5513
AB  - In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ...
AB  - In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode
T1  - Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method
SP  - 154
EP  - 156
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5513
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živanović, Jovana and Živančević, Katarina and Marić, Đurđica and Vukelić, Dragana and Manić, Luka and Grahovac, Lazar and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ..., In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode, Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method",
pages = "154-156",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5513"
}

Božić, D., Baralić, K., Živanović, J., Živančević, K., Marić, Đ., Vukelić, D., Manić, L., Grahovac, L., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513

Božić D, Baralić K, Živanović J, Živančević K, Marić Đ, Vukelić D, Manić L, Grahovac L, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

Božić, Dragica, Baralić, Katarina, Živanović, Jovana, Živančević, Katarina, Marić, Đurđica, Vukelić, Dragana, Manić, Luka, Grahovac, Lazar, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):154-156,
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

TY  - CONF
AU  - Živančević, Katarina
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5170
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
T1  - Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor
VL  - 384
IS  - S1
SP  - S78
EP  - S78
DO  - 10.1016/S0378-4274(23)00454-X
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5170
ER  - 

@conference{
author = "Živančević, Katarina and Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Marić, Đurđica and Vukelić, Dragana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia",
title = "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor",
volume = "384",
number = "S1",
pages = "S78-S78",
doi = "10.1016/S0378-4274(23)00454-X",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5170"
}

Živančević, K., Živanović, J., Baralić, K., Božić, D., Marić, Đ., Vukelić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
Elsevier., 384(S1), S78-S78.
https://doi.org/10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170

Živančević K, Živanović J, Baralić K, Božić D, Marić Đ, Vukelić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia. 2023;384(S1):S78-S78.
doi:10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

Živančević, Katarina, Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Marić, Đurđica, Vukelić, Dragana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor" in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia, 384, no. S1 (2023):S78-S78,
https://doi.org/10.1016/S0378-4274(23)00454-X .,
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Zhang, Yi
AU  - Yang, Li
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5425
AB  - Sulforafan (SFN) je imunomodulator poreklom iz kupusastog povrća čija su antioksidativna i antikancerogena svojstva prepoznata sredinom prošlog veka. Međutim, njegov toksikološki profil i potencijal da izazove štetne efekte su nedovoljno razjašnjeni. Cilj ove studije bio je predviđanje toksičnog potencijala SFN kombinovanjem bioinformatičkih analiza. ...
AB  - Sulforaphane (SFN) is an immunomodulator from cruciferous vegetables whose anti-oxidative and anti-carcinogenic properties were recognized in the middle of the last century. However, its toxicological profile remains insufficiently elucidated. The aim of the study was to predict the toxicity of SFN by combining bioinformatic analyses. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza
T1  - Predicting toxic effects of an immunomodulator, sulforaphane: Bioinformatic analsis
SP  - 61
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5425
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Zhang, Yi and Yang, Li and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforafan (SFN) je imunomodulator poreklom iz kupusastog povrća čija su antioksidativna i antikancerogena svojstva prepoznata sredinom prošlog veka. Međutim, njegov toksikološki profil i potencijal da izazove štetne efekte su nedovoljno razjašnjeni. Cilj ove studije bio je predviđanje toksičnog potencijala SFN kombinovanjem bioinformatičkih analiza. ..., Sulforaphane (SFN) is an immunomodulator from cruciferous vegetables whose anti-oxidative and anti-carcinogenic properties were recognized in the middle of the last century. However, its toxicological profile remains insufficiently elucidated. The aim of the study was to predict the toxicity of SFN by combining bioinformatic analyses. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza, Predicting toxic effects of an immunomodulator, sulforaphane: Bioinformatic analsis",
pages = "61-62",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5425"
}

Božić, D., Baralić, K., Živančević, K., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B., Zhang, Y., Yang, L.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 61-62.
https://hdl.handle.net/21.15107/rcub_farfar_5425

Božić D, Baralić K, Živančević K, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Zhang Y, Yang L, Đukić-Ćosić D. Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:61-62.
https://hdl.handle.net/21.15107/rcub_farfar_5425 .

Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Zhang, Yi, Yang, Li, Đukić-Ćosić, Danijela, "Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):61-62,
https://hdl.handle.net/21.15107/rcub_farfar_5425 .

TY  - CONF
AU  - Baralić, Katarina
AU  - Pavić, Aleksandar
AU  - Javorac, Dragana
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Radaković, Nataša
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5422
AB  - Široka upotreba bis(2-etilheksil) ftalata (DEHP), dibutil ftalata (DBP) i bisfenola A (BPA) otvara niz mogućnosti
za kombinovanu izloženost ljudi ovim toksičnim jedinjenjima u svakodnevnom životu i brojne štetne
ishode, uključujući hepatotoksičnost.  ...
AB  - The extensive usage of bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A
(BPA) creates a lot of opportunities for combined human exposure to these hazardous compounds in
everyday life and a variety of negative outcomes, including hepatotoxicity. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela
T1  - Three lines of evidence of the hepatotoxicity of a mixture containing phthalates and bisphenol a: In silico and two in vivo models
SP  - 55
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5422
ER  - 

@conference{
author = "Baralić, Katarina and Pavić, Aleksandar and Javorac, Dragana and Živančević, Katarina and Božić, Dragica and Radaković, Nataša and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Široka upotreba bis(2-etilheksil) ftalata (DEHP), dibutil ftalata (DBP) i bisfenola A (BPA) otvara niz mogućnosti
za kombinovanu izloženost ljudi ovim toksičnim jedinjenjima u svakodnevnom životu i brojne štetne
ishode, uključujući hepatotoksičnost.  ..., The extensive usage of bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A
(BPA) creates a lot of opportunities for combined human exposure to these hazardous compounds in
everyday life and a variety of negative outcomes, including hepatotoxicity. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela, Three lines of evidence of the hepatotoxicity of a mixture containing phthalates and bisphenol a: In silico and two in vivo models",
pages = "55-56",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5422"
}

Baralić, K., Pavić, A., Javorac, D., Živančević, K., Božić, D., Radaković, N., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 55-56.
https://hdl.handle.net/21.15107/rcub_farfar_5422

Baralić K, Pavić A, Javorac D, Živančević K, Božić D, Radaković N, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:55-56.
https://hdl.handle.net/21.15107/rcub_farfar_5422 .

Baralić, Katarina, Pavić, Aleksandar, Javorac, Dragana, Živančević, Katarina, Božić, Dragica, Radaković, Nataša, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):55-56,
https://hdl.handle.net/21.15107/rcub_farfar_5422 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5168
AB  - Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ...
AB  - Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19
T1  - In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease
SP  - 37
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5168
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ..., Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19, In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease",
pages = "37-38",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5168"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):37-38,
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

TY  - CONF
AU  - Baralić, Katarina
AU  - Božović, Predrag
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Živanović, Jovana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5176
AB  - Chemical exposure can occur through a variety of means (ingestion, inhalation, or skin contact), by food and water consumption, polluted air, use of consumer products, etc. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining
VL  - 384
IS  - S1
SP  - S224
EP  - S225
DO  - 10.1016/S0378-4274(23)00793-2
ER  - 

@conference{
author = "Baralić, Katarina and Božović, Predrag and Božić, Dragica and Živančević, Katarina and Živanović, Jovana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Chemical exposure can occur through a variety of means (ingestion, inhalation, or skin contact), by food and water consumption, polluted air, use of consumer products, etc. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining",
volume = "384",
number = "S1",
pages = "S224-S225",
doi = "10.1016/S0378-4274(23)00793-2"
}

Baralić, K., Božović, P., Božić, D., Živančević, K., Živanović, J.,& Đukić-Ćosić, D.. (2023). Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining. in Toxicology Letters
Elsevier., 384(S1), S224-S225.
https://doi.org/10.1016/S0378-4274(23)00793-2

Baralić K, Božović P, Božić D, Živančević K, Živanović J, Đukić-Ćosić D. Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining. in Toxicology Letters. 2023;384(S1):S224-S225.
doi:10.1016/S0378-4274(23)00793-2 .

Baralić, Katarina, Božović, Predrag, Božić, Dragica, Živančević, Katarina, Živanović, Jovana, Đukić-Ćosić, Danijela, "Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining" in Toxicology Letters, 384, no. S1 (2023):S224-S225,
https://doi.org/10.1016/S0378-4274(23)00793-2 . .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5172
AB  - Sulforaphane (SFN) is a compound found in cruciferous vegetables which have been studied as a molecule with the potential in disease prevention and treatment. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis
VL  - 384
IS  - S1
SP  - S115
EP  - S115
DO  - 10.1016/S0378-4274(23)00536-2
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živanović, Jovana and Živančević, Katarina and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforaphane (SFN) is a compound found in cruciferous vegetables which have been studied as a molecule with the potential in disease prevention and treatment. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis",
volume = "384",
number = "S1",
pages = "S115-S115",
doi = "10.1016/S0378-4274(23)00536-2"
}

Božić, D., Baralić, K., Živanović, J., Živančević, K.,& Đukić-Ćosić, D.. (2023). Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis. in Toxicology Letters
Elsevier., 384(S1), S115-S115.
https://doi.org/10.1016/S0378-4274(23)00536-2

Božić D, Baralić K, Živanović J, Živančević K, Đukić-Ćosić D. Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis. in Toxicology Letters. 2023;384(S1):S115-S115.
doi:10.1016/S0378-4274(23)00536-2 .

Božić, Dragica, Baralić, Katarina, Živanović, Jovana, Živančević, Katarina, Đukić-Ćosić, Danijela, "Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis" in Toxicology Letters, 384, no. S1 (2023):S115-S115,
https://doi.org/10.1016/S0378-4274(23)00536-2 . .

TY  - CONF
AU  - Živanović, Jovana
AU  - Šljivić, Jovana
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5171
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation
VL  - 384
IS  - S1
SP  - S114
EP  - S114
DO  - 10.1016/S0378-4274(23)00534-9
ER  - 

@conference{
author = "Živanović, Jovana and Šljivić, Jovana and Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation",
volume = "384",
number = "S1",
pages = "S114-S114",
doi = "10.1016/S0378-4274(23)00534-9"
}

Živanović, J., Šljivić, J., Božić, D., Baralić, K., Živančević, K., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation. in Toxicology Letters
Elsevier., 384(S1), S114-S114.
https://doi.org/10.1016/S0378-4274(23)00534-9

Živanović J, Šljivić J, Božić D, Baralić K, Živančević K, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation. in Toxicology Letters. 2023;384(S1):S114-S114.
doi:10.1016/S0378-4274(23)00534-9 .

Živanović, Jovana, Šljivić, Jovana, Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation" in Toxicology Letters, 384, no. S1 (2023):S114-S114,
https://doi.org/10.1016/S0378-4274(23)00534-9 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4651
AB  - Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal carcinoma (CRC) advancement. Sulforaphane (SFN), isothiocyanate from cruciferous vegetables, diminishes chemical carcinogenesis susceptibility, but has been shown to act as a friend or a foe depending on various factors. By conducting the mechanistic toxicogenomic data mining approach, this research aimed to determine if SFN can alleviate toxic-metal and/or phthalate/BPA mixture-induced CRC at the gene level. Comparative Toxicogenomics Database, ToppGene Suite portal, Cytoscape software, InteractiVenn and Gene Expression Omnibus (GEO) database (GEO2R tool) was used. Among the mutual genes for all the investigated substances, SFN had a protective impact only through PTGS2. Other proposed protective SFN-targets included ABCA1, ALDH2, BMP2, DPYD, MYC, SLCO2A1, and SOD2, only in the case of phthalates/BPA exposure. The only additional gene relevant for SFN protection against the toxic metal mixture-induced CRC was ABCB1. Additionally, the majority of the top 15 molecular pathways extracted for SFN impact on phthalate and BPA mixture-linked CRC development were directly linked with cancer development, which was not the case with the toxic metal mixture. The current research has indicated that SFN is a more effective chemoprotective agent against CRC induced by phthalates/BPA mixture than by toxic-metal mixture. It has also presented the value of computational methods as a simple tool for directing further research, selecting appropriate biomarkers and exploring the mechanisms of toxicity.
PB  - Academic Press Inc.
T2  - Environmental Research
T1  - Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study
VL  - 227
DO  - 10.1016/j.envres.2023.115818
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Marić, Đurđica and Božić, Dragica and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal carcinoma (CRC) advancement. Sulforaphane (SFN), isothiocyanate from cruciferous vegetables, diminishes chemical carcinogenesis susceptibility, but has been shown to act as a friend or a foe depending on various factors. By conducting the mechanistic toxicogenomic data mining approach, this research aimed to determine if SFN can alleviate toxic-metal and/or phthalate/BPA mixture-induced CRC at the gene level. Comparative Toxicogenomics Database, ToppGene Suite portal, Cytoscape software, InteractiVenn and Gene Expression Omnibus (GEO) database (GEO2R tool) was used. Among the mutual genes for all the investigated substances, SFN had a protective impact only through PTGS2. Other proposed protective SFN-targets included ABCA1, ALDH2, BMP2, DPYD, MYC, SLCO2A1, and SOD2, only in the case of phthalates/BPA exposure. The only additional gene relevant for SFN protection against the toxic metal mixture-induced CRC was ABCB1. Additionally, the majority of the top 15 molecular pathways extracted for SFN impact on phthalate and BPA mixture-linked CRC development were directly linked with cancer development, which was not the case with the toxic metal mixture. The current research has indicated that SFN is a more effective chemoprotective agent against CRC induced by phthalates/BPA mixture than by toxic-metal mixture. It has also presented the value of computational methods as a simple tool for directing further research, selecting appropriate biomarkers and exploring the mechanisms of toxicity.",
publisher = "Academic Press Inc.",
journal = "Environmental Research",
title = "Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study",
volume = "227",
doi = "10.1016/j.envres.2023.115818"
}

Baralić, K., Živančević, K., Marić, Đ., Božić, D., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. in Environmental Research
Academic Press Inc.., 227.
https://doi.org/10.1016/j.envres.2023.115818

Baralić K, Živančević K, Marić Đ, Božić D, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. in Environmental Research. 2023;227.
doi:10.1016/j.envres.2023.115818 .

Baralić, Katarina, Živančević, Katarina, Marić, Đurđica, Božić, Dragica, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study" in Environmental Research, 227 (2023),
https://doi.org/10.1016/j.envres.2023.115818 . .

TY  - JOUR
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4425
AB  - Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained scientific popularity due to its antioxidant and anti-cancer properties. However, its toxicity profile and potential to cause adverse effects remain largely unidentified. Thus, this study aimed to generate SFN-triggered adverse outcome pathway (AOP) by looking at the relationship between SFN-chemical structure and its toxicity, as well as SFN-gene interactions. Quantitative structure-activity relationship (QSAR) analysis identified 2 toxophores (Derek Nexus software) that have the potential to cause chromosomal damage and skin sensitization in mammals or mutagenicity in bacteria. Data extracted from Comparative Toxicogenomics Database (CTD) linked SFN with previously proposed outcomes via gene interactions. The total of 11 and 146 genes connected SFN with chromosomal damage and skin diseases, respectively. However, network analysis (NetworkAnalyst tool) revealed that these genes function in wider networks containing 490 and 1986 nodes, respectively. The over-representation analysis (ExpressAnalyst tool) pointed out crucial biological pathways regulated by SFN-interfering genes. These pathways are uploaded to AOP-helpFinder tool which found the 2321 connections between 19 enriched pathways and SFN which were further considered as key events. Two major, interconnected AOPs were generated: first starting from disruption of biological pathways involved in cell cycle and cell proliferation leading to increased apoptosis, and the second one connecting activated immune system signaling pathways to inflammation and apoptosis. In both cases, chromosomal damage and/or skin diseases such as dermatitis or psoriasis appear as adverse outcomes.
PB  - Elsevier
T2  - Biomedicine and Pharmacotherapy
T1  - Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells
VL  - 160
DO  - 10.1016/j.biopha.2023.114316
ER  - 

@article{
author = "Božić, Dragica and Živančević, Katarina and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained scientific popularity due to its antioxidant and anti-cancer properties. However, its toxicity profile and potential to cause adverse effects remain largely unidentified. Thus, this study aimed to generate SFN-triggered adverse outcome pathway (AOP) by looking at the relationship between SFN-chemical structure and its toxicity, as well as SFN-gene interactions. Quantitative structure-activity relationship (QSAR) analysis identified 2 toxophores (Derek Nexus software) that have the potential to cause chromosomal damage and skin sensitization in mammals or mutagenicity in bacteria. Data extracted from Comparative Toxicogenomics Database (CTD) linked SFN with previously proposed outcomes via gene interactions. The total of 11 and 146 genes connected SFN with chromosomal damage and skin diseases, respectively. However, network analysis (NetworkAnalyst tool) revealed that these genes function in wider networks containing 490 and 1986 nodes, respectively. The over-representation analysis (ExpressAnalyst tool) pointed out crucial biological pathways regulated by SFN-interfering genes. These pathways are uploaded to AOP-helpFinder tool which found the 2321 connections between 19 enriched pathways and SFN which were further considered as key events. Two major, interconnected AOPs were generated: first starting from disruption of biological pathways involved in cell cycle and cell proliferation leading to increased apoptosis, and the second one connecting activated immune system signaling pathways to inflammation and apoptosis. In both cases, chromosomal damage and/or skin diseases such as dermatitis or psoriasis appear as adverse outcomes.",
publisher = "Elsevier",
journal = "Biomedicine and Pharmacotherapy",
title = "Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells",
volume = "160",
doi = "10.1016/j.biopha.2023.114316"
}

Božić, D., Živančević, K., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. in Biomedicine and Pharmacotherapy
Elsevier., 160.
https://doi.org/10.1016/j.biopha.2023.114316

Božić D, Živančević K, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. in Biomedicine and Pharmacotherapy. 2023;160.
doi:10.1016/j.biopha.2023.114316 .

Božić, Dragica, Živančević, Katarina, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells" in Biomedicine and Pharmacotherapy, 160 (2023),
https://doi.org/10.1016/j.biopha.2023.114316 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4371
AB  - Environmentally relevant toxic substances may affect human health, provoking numerous harmful effects on central nervous, respiratory, cardiovascular, endocrine and reproductive system, and even cause various types of carcinoma. These substances, to which general population is constantly and simultaneously exposed, enter human body via food and water, but also by inhalation and dermal contact, while accumulating evidence suggests that probiotic cultures are able to efficiently adsorb and/or degrade them. Cell wall of probiotic bacteria/fungi, which contains structures such as exopolysaccharide, teichoic acid, protein and peptidoglycan components, is considered the main place of toxic substances adsorption. Moreover, probiotics are able to induce metabolism and degradation of various toxic substances, making them less toxic and more suitable for elimination. Other probable in vivo protective effects have also been suggested, including decreased intestinal absorption and increased excretion of toxic substances, prevented gut microbial dysbiosis, increase in the intestinal mucus secretion, decreased production of reactive oxygen species, reduction of inflammation, etc. Having all of this in mind, this review aims to summarize the state-of-the-art knowledge regarding the potential protective effects of different probiotic strains against environmentally relevant toxic substances (mycotoxins, polycyclic aromatic hydrocarbons, pesticides, perfluoroalkyl and polyfluoroalkyl substances, phthalates, bisphenol A and toxic metals)
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge
VL  - 172
DO  - 10.1016/j.fct.2022.113582
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Environmentally relevant toxic substances may affect human health, provoking numerous harmful effects on central nervous, respiratory, cardiovascular, endocrine and reproductive system, and even cause various types of carcinoma. These substances, to which general population is constantly and simultaneously exposed, enter human body via food and water, but also by inhalation and dermal contact, while accumulating evidence suggests that probiotic cultures are able to efficiently adsorb and/or degrade them. Cell wall of probiotic bacteria/fungi, which contains structures such as exopolysaccharide, teichoic acid, protein and peptidoglycan components, is considered the main place of toxic substances adsorption. Moreover, probiotics are able to induce metabolism and degradation of various toxic substances, making them less toxic and more suitable for elimination. Other probable in vivo protective effects have also been suggested, including decreased intestinal absorption and increased excretion of toxic substances, prevented gut microbial dysbiosis, increase in the intestinal mucus secretion, decreased production of reactive oxygen species, reduction of inflammation, etc. Having all of this in mind, this review aims to summarize the state-of-the-art knowledge regarding the potential protective effects of different probiotic strains against environmentally relevant toxic substances (mycotoxins, polycyclic aromatic hydrocarbons, pesticides, perfluoroalkyl and polyfluoroalkyl substances, phthalates, bisphenol A and toxic metals)",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge",
volume = "172",
doi = "10.1016/j.fct.2022.113582"
}

Baralić, K., Živančević, K., Božić, D.,& Đukić-Ćosić, D.. (2023). Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge. in Food and Chemical Toxicology
Elsevier Ltd., 172.
https://doi.org/10.1016/j.fct.2022.113582

Baralić K, Živančević K, Božić D, Đukić-Ćosić D. Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge. in Food and Chemical Toxicology. 2023;172.
doi:10.1016/j.fct.2022.113582 .

Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Đukić-Ćosić, Danijela, "Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge" in Food and Chemical Toxicology, 172 (2023),
https://doi.org/10.1016/j.fct.2022.113582 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Pavić, Aleksandar
AU  - Javorac, Dragana
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Radaković, Nataša
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4334
AB  - Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative Toxicogenomics Database (CTD), ShinyGO, ToppCluster and Cytoscape were used for bioinformatic analysis. In vivo subacute study was performed on rats - five groups (n = 6): (1) Control: corn oil, (2) DEHP: 50 mg/kg b.w./day, (3) DBP: 50 mg/kg b.w./day, (4) BPA: 25 mg/kg b.w./day, (5) MIX: DEHP + DBP + BPA. Zebrafish embryos were exposed to the investigated substances in different doses, singularly and combined (binary and ternary mixtures). Liver injury was linked to 75 DEHP, DBP, and BPA genes, mostly connected to inflammation/oxidative stress. In rats, significant alterations in redox status/bioelements and pathohistology were most notable or exclusively present in MIX (probable additive effects). BPA decreased liver area (LA) index in dose-dependent manner. DEHP (< 2 µg/mL) and DBP (≤ 5 µg/mL) reduced LA values, while their higher doses increased LA index. The effect of DBP in binary mixtures led to a lethal outcome at the two highest concentrations, while the hepatotoxicity of DEHP/DBP/BPA mixture was dictated by BPA (confirmed by the benchmark dose analysis).
PB  - Elsevier B.V.
T2  - Journal of Hazardous Materials
T1  - Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A
VL  - 445
DO  - 10.1016/j.jhazmat.2022.130404
ER  - 

@article{
author = "Baralić, Katarina and Pavić, Aleksandar and Javorac, Dragana and Živančević, Katarina and Božić, Dragica and Radaković, Nataša and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative Toxicogenomics Database (CTD), ShinyGO, ToppCluster and Cytoscape were used for bioinformatic analysis. In vivo subacute study was performed on rats - five groups (n = 6): (1) Control: corn oil, (2) DEHP: 50 mg/kg b.w./day, (3) DBP: 50 mg/kg b.w./day, (4) BPA: 25 mg/kg b.w./day, (5) MIX: DEHP + DBP + BPA. Zebrafish embryos were exposed to the investigated substances in different doses, singularly and combined (binary and ternary mixtures). Liver injury was linked to 75 DEHP, DBP, and BPA genes, mostly connected to inflammation/oxidative stress. In rats, significant alterations in redox status/bioelements and pathohistology were most notable or exclusively present in MIX (probable additive effects). BPA decreased liver area (LA) index in dose-dependent manner. DEHP (< 2 µg/mL) and DBP (≤ 5 µg/mL) reduced LA values, while their higher doses increased LA index. The effect of DBP in binary mixtures led to a lethal outcome at the two highest concentrations, while the hepatotoxicity of DEHP/DBP/BPA mixture was dictated by BPA (confirmed by the benchmark dose analysis).",
publisher = "Elsevier B.V.",
journal = "Journal of Hazardous Materials",
title = "Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A",
volume = "445",
doi = "10.1016/j.jhazmat.2022.130404"
}

Baralić, K., Pavić, A., Javorac, D., Živančević, K., Božić, D., Radaković, N., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A. in Journal of Hazardous Materials
Elsevier B.V.., 445.
https://doi.org/10.1016/j.jhazmat.2022.130404

Baralić K, Pavić A, Javorac D, Živančević K, Božić D, Radaković N, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A. in Journal of Hazardous Materials. 2023;445.
doi:10.1016/j.jhazmat.2022.130404 .

Baralić, Katarina, Pavić, Aleksandar, Javorac, Dragana, Živančević, Katarina, Božić, Dragica, Radaković, Nataša, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A" in Journal of Hazardous Materials, 445 (2023),
https://doi.org/10.1016/j.jhazmat.2022.130404 . .

TY  - CONF
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4632
AB  - Alternative form of cancer treatment includes targeting natural compounds such as
sulfur-rich dietary phytochemical sulforaphane (SFN). However, data on SFN safety,
interactions on the protein level and target of SFN in human organism are limited (1). The
aim of this study was to elucidate the target interactions of SFN in human body in order to
rationalize possible side-effects and predict off-targets by using in silico approach. STITCH
database (http://stitch.embl.de) was used to obtain the information about chemical–protein
interactions, while Metascape (https://metascape.org/) highlighted protein-protein
interaction enrichment (PPIE).
SwissTargetPrediction (http://www.swisstargetprediction.ch/) indicated the target
molecule classes of SFN in human. Human genes that had the strongest interaction with SFN
were NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1 and
GSTM1. PPIE analysis singled out fluid shear stress and atherosclerosis, NRF2 pathway and
chemical carcinogenesis - reactive oxygen species (ROS) as the most significant interactions.
The most represented class of SFN targeted molecules in human organism were enzymes
(26.7%). Epidermal growth factor receptor erbB1, macrophage migration inhibitory factor,
nitric oxide synthase (inducible) showed the highest probability target rate. In our previous
study (2), we pointed out that the genome of cancer patients could affect SFN safety. The
current study provides a set of target genes, emphasizes the importance of oxidative stress in
the suggested genetic interactions and predicts classes of target molecules, which should
further be examined.
AB  - Alternativni oblik lečenja raka uključuje upotrebu prirodnih jedinjenja kao što je
fitohemikalija bogata sumporom, sulforafan (SFN). Međutim, podaci o interakcijama SFN na
nivou proteina i ciljnih mesta dejstva SFN u ljudskom organizmu su ograničeni (1). Cilj ove
studije bio je da se ukaže na ciljne interakcije SFN kod ljudi kako bi se racionalizovali mogući
neželjeni efekti i predvidela nova ciljna mesta toksičnosti korišćenjem in silico pristupa.
STITCH baza podataka (http://stitch.embl.de) korišć ena je za dobijanje informacija o
interakcijama između hemikalija i proteina, dok je Metascape (https://metascape.org/)
izdvojio protein-protein interakcije (PPIE).
SwissTargetPrediction (http://vvv.svisstargetprediction.ch/) ukazao je na ciljana
mesta dejstva SFN kod ljudi. Izdvojeni su geni koji kod ljudi imaju najjaču interakciju sa SFN:
NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1, GSTM1.
Ateroskleroza, NRF2 signalni put i hemijska karcinogeneza - reaktivne vrste kiseonika (ROS)
označeni su kao najznačajnije protein-protein interakcije. Najzastupljenija klasa SFN ciljanih
molekula u ljudskom organizmu bili su enzimi (26,7%). Receptor epidermalnog faktora rasta
erbB1, faktor inhibitora migracije makrofaga i sintaza azot oksida (inducibilna) pokazali su
najveć u stopu verovatnoć e ciljnog mesta dejstva. U našoj prethodnoj studiji (2) istakli smo
da bi genom pacijenata obolelih od raka mogao uticati na bezbednost primene SFN. Međutim,
ova studija daje dodatni set ciljnih gena i naglašava važnost oksidativnog stresa u
predloženim interakcijama između gena, kao i predviđenim klasama ciljnih molekula na koje
deluje SFN i koje bi trebalo dalje ispitati.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes
T1  - Predviđanje štetnih efekata sulforafana in silico ispitivanjem njegovog ciljanog dejstva na gene, protein‐protein interakcije i klase molekula
VL  - 72
IS  - 4 suplement
SP  - S591
EP  - S592
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4632
ER  - 

@conference{
author = "Živančević, Katarina and Baralić, Katarina and Božić, Dragica and Javorac, Dragana and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "Alternative form of cancer treatment includes targeting natural compounds such as
sulfur-rich dietary phytochemical sulforaphane (SFN). However, data on SFN safety,
interactions on the protein level and target of SFN in human organism are limited (1). The
aim of this study was to elucidate the target interactions of SFN in human body in order to
rationalize possible side-effects and predict off-targets by using in silico approach. STITCH
database (http://stitch.embl.de) was used to obtain the information about chemical–protein
interactions, while Metascape (https://metascape.org/) highlighted protein-protein
interaction enrichment (PPIE).
SwissTargetPrediction (http://www.swisstargetprediction.ch/) indicated the target
molecule classes of SFN in human. Human genes that had the strongest interaction with SFN
were NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1 and
GSTM1. PPIE analysis singled out fluid shear stress and atherosclerosis, NRF2 pathway and
chemical carcinogenesis - reactive oxygen species (ROS) as the most significant interactions.
The most represented class of SFN targeted molecules in human organism were enzymes
(26.7%). Epidermal growth factor receptor erbB1, macrophage migration inhibitory factor,
nitric oxide synthase (inducible) showed the highest probability target rate. In our previous
study (2), we pointed out that the genome of cancer patients could affect SFN safety. The
current study provides a set of target genes, emphasizes the importance of oxidative stress in
the suggested genetic interactions and predicts classes of target molecules, which should
further be examined., Alternativni oblik lečenja raka uključuje upotrebu prirodnih jedinjenja kao što je
fitohemikalija bogata sumporom, sulforafan (SFN). Međutim, podaci o interakcijama SFN na
nivou proteina i ciljnih mesta dejstva SFN u ljudskom organizmu su ograničeni (1). Cilj ove
studije bio je da se ukaže na ciljne interakcije SFN kod ljudi kako bi se racionalizovali mogući
neželjeni efekti i predvidela nova ciljna mesta toksičnosti korišćenjem in silico pristupa.
STITCH baza podataka (http://stitch.embl.de) korišć ena je za dobijanje informacija o
interakcijama između hemikalija i proteina, dok je Metascape (https://metascape.org/)
izdvojio protein-protein interakcije (PPIE).
SwissTargetPrediction (http://vvv.svisstargetprediction.ch/) ukazao je na ciljana
mesta dejstva SFN kod ljudi. Izdvojeni su geni koji kod ljudi imaju najjaču interakciju sa SFN:
NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1, GSTM1.
Ateroskleroza, NRF2 signalni put i hemijska karcinogeneza - reaktivne vrste kiseonika (ROS)
označeni su kao najznačajnije protein-protein interakcije. Najzastupljenija klasa SFN ciljanih
molekula u ljudskom organizmu bili su enzimi (26,7%). Receptor epidermalnog faktora rasta
erbB1, faktor inhibitora migracije makrofaga i sintaza azot oksida (inducibilna) pokazali su
najveć u stopu verovatnoć e ciljnog mesta dejstva. U našoj prethodnoj studiji (2) istakli smo
da bi genom pacijenata obolelih od raka mogao uticati na bezbednost primene SFN. Međutim,
ova studija daje dodatni set ciljnih gena i naglašava važnost oksidativnog stresa u
predloženim interakcijama između gena, kao i predviđenim klasama ciljnih molekula na koje
deluje SFN i koje bi trebalo dalje ispitati.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes, Predviđanje štetnih efekata sulforafana in silico ispitivanjem njegovog ciljanog dejstva na gene, protein‐protein interakcije i klase molekula",
volume = "72",
number = "4 suplement",
pages = "S591-S592",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4632"
}

Živančević, K., Baralić, K., Božić, D., Javorac, D., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S591-S592.
https://hdl.handle.net/21.15107/rcub_farfar_4632

Živančević K, Baralić K, Božić D, Javorac D, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes. in Arhiv za farmaciju. 2022;72(4 suplement):S591-S592.
https://hdl.handle.net/21.15107/rcub_farfar_4632 .

Živančević, Katarina, Baralić, Katarina, Božić, Dragica, Javorac, Dragana, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S591-S592,
https://hdl.handle.net/21.15107/rcub_farfar_4632 .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Filipović, Teodora
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4201
AB  - Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality.
AB  - COVID-19 (engl. coronavirus disease 2019) respiratorna je bolest prouzročena infekcijom SARS-CoV-2 virusom (engl. severe acute respiratory
syndrome coronavirus 2). Pretpostavlja se da postoji utjecaj atmosferskih čimbenika, uključujući i onečišćenje zraka, na prenošenje koronavirusa,
njegovu težinu i stopu smrtnosti. Stoga je cilj ovoga in silico istraživanja bio utvrditi odnos između ključnih onečišćivača zraka [sumporova
dioksida (SO2), ugljikova monoksida (CO), lebdećih čestica (PMx), dušikova dioksida (NO2), ozona (O3)] i komplikacija COVID-a 19
korištenjem: (i) komparativne toksikogenomičke baze podataka (engl. Comparative Toxicogenomic Database, CTD) za dobivanje gena, međusobno
povezanih s onečišćivačima zraka i komplikacijama COVID-a 19, (ii) GeneMANIA servera za konstruiranje mreže između dobivenih i
srodnih gena, (iii) ToppGene Suite za izdvajanje najvažnijih bioloških procesa/molekularnih puteva i (iv) DisGeNET baze podataka za
traženje najvažnijih parova gen-bolest. Za SO2, CO, PMx, NO2 odnosno O3 utvrđena je interakcija sa 6, 6, 18, 9, odnosno 12 gena povezanih
s komplikacijama COVID-a 19. Četiri su zajednička (IL10, IL6, IL1B i TNF) i u najvećem postotku (77,64 %) sudjeluju u fizičkim
interakcijama. Vezivanje citokina i signalni put posredovan citokinima izdvojeni su kao najvažnija molekularna funkcija i biološki proces.
Druge molekularne funkcije i biološki procesi uglavnom su bili povezani s aktivnošću citokina i upalom, što bi se moglo dovesti u vezu s
citokinskom olujom i posljedičnim komplikacijama COVID-a 19. Utvrđena je veza između različitih bolesti i ispitivanih gena, posebice
između CEBPA i akutne mijelogene leukemije (AML) te između TNFRSF1A i sindroma periodične vrućice povezanoga s TNF receptorom.
To upozorava na moguće komplikacije u osoba zaraženih koronavirusom koje boluju od tih bolesti, poglavito kada su dodatno potaknute
poremećajem funkcije spomenutih gena.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis
T1  - Zajednički utjecaj ključnih onečišćivača zraka na težinu COVID-a 19 – predviđanje zasnovano na analizi toksikogenomičkih
podataka
VL  - 73
IS  - 2
SP  - 119
EP  - 125
DO  - 10.2478/aiht-2022-73-3631
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Filipović, Teodora and Božić, Dragica and Živančević, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Ćurčić, Marijana",
year = "2022",
abstract = "Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality., COVID-19 (engl. coronavirus disease 2019) respiratorna je bolest prouzročena infekcijom SARS-CoV-2 virusom (engl. severe acute respiratory
syndrome coronavirus 2). Pretpostavlja se da postoji utjecaj atmosferskih čimbenika, uključujući i onečišćenje zraka, na prenošenje koronavirusa,
njegovu težinu i stopu smrtnosti. Stoga je cilj ovoga in silico istraživanja bio utvrditi odnos između ključnih onečišćivača zraka [sumporova
dioksida (SO2), ugljikova monoksida (CO), lebdećih čestica (PMx), dušikova dioksida (NO2), ozona (O3)] i komplikacija COVID-a 19
korištenjem: (i) komparativne toksikogenomičke baze podataka (engl. Comparative Toxicogenomic Database, CTD) za dobivanje gena, međusobno
povezanih s onečišćivačima zraka i komplikacijama COVID-a 19, (ii) GeneMANIA servera za konstruiranje mreže između dobivenih i
srodnih gena, (iii) ToppGene Suite za izdvajanje najvažnijih bioloških procesa/molekularnih puteva i (iv) DisGeNET baze podataka za
traženje najvažnijih parova gen-bolest. Za SO2, CO, PMx, NO2 odnosno O3 utvrđena je interakcija sa 6, 6, 18, 9, odnosno 12 gena povezanih
s komplikacijama COVID-a 19. Četiri su zajednička (IL10, IL6, IL1B i TNF) i u najvećem postotku (77,64 %) sudjeluju u fizičkim
interakcijama. Vezivanje citokina i signalni put posredovan citokinima izdvojeni su kao najvažnija molekularna funkcija i biološki proces.
Druge molekularne funkcije i biološki procesi uglavnom su bili povezani s aktivnošću citokina i upalom, što bi se moglo dovesti u vezu s
citokinskom olujom i posljedičnim komplikacijama COVID-a 19. Utvrđena je veza između različitih bolesti i ispitivanih gena, posebice
između CEBPA i akutne mijelogene leukemije (AML) te između TNFRSF1A i sindroma periodične vrućice povezanoga s TNF receptorom.
To upozorava na moguće komplikacije u osoba zaraženih koronavirusom koje boluju od tih bolesti, poglavito kada su dodatno potaknute
poremećajem funkcije spomenutih gena.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis, Zajednički utjecaj ključnih onečišćivača zraka na težinu COVID-a 19 – predviđanje zasnovano na analizi toksikogenomičkih
podataka",
volume = "73",
number = "2",
pages = "119-125",
doi = "10.2478/aiht-2022-73-3631"
}

Đukić-Ćosić, D., Baralić, K., Filipović, T., Božić, D., Živančević, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Ćurčić, M.. (2022). Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Sciendo., 73(2), 119-125.
https://doi.org/10.2478/aiht-2022-73-3631

Đukić-Ćosić D, Baralić K, Filipović T, Božić D, Živančević K, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Ćurčić M. Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2022;73(2):119-125.
doi:10.2478/aiht-2022-73-3631 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Filipović, Teodora, Božić, Dragica, Živančević, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Ćurčić, Marijana, "Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 73, no. 2 (2022):119-125,
https://doi.org/10.2478/aiht-2022-73-3631 . .

TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Bulat, Petar
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4052
AB  - We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening
VL  - 161
DO  - 10.1016/j.fct.2022.112839
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Božić, Dragica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Bulat, Petar and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening",
volume = "161",
doi = "10.1016/j.fct.2022.112839"
}

Živančević, K., Baralić, K., Božić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B., Bulat, P.,& Đukić-Ćosić, D.. (2022). Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. in Food and Chemical Toxicology
Elsevier Ltd., 161.
https://doi.org/10.1016/j.fct.2022.112839

Živančević K, Baralić K, Božić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Bulat P, Đukić-Ćosić D. Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. in Food and Chemical Toxicology. 2022;161.
doi:10.1016/j.fct.2022.112839 .

Živančević, Katarina, Baralić, Katarina, Božić, Dragica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Bulat, Petar, Đukić-Ćosić, Danijela, "Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening" in Food and Chemical Toxicology, 161 (2022),
https://doi.org/10.1016/j.fct.2022.112839 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Jennen, Danyel
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4026
AB  - This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www. disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in 67, 65 and 116 pathways, respectively. Among these, 53 genes/proteins and 42 pathways were common to all three substances. 31 genes/proteins had matching interactions for all three investigated substances, while more than half of these genes/proteins (56.49%) were in co-expression. 7 of the common genes/proteins (6 relevant to humans: CCL2, IL6, LPL, PPARG, SERPINE1, and TNF) were identified in all the investigated obesity comorbidities, while PPARG and LPL were most closely linked to obesity. These genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP, DBP and BPA mixture obesogenic properties. Analysis reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD.
PB  - Tech Science Press
T2  - Biocell
T1  - Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach
VL  - 46
IS  - 2
SP  - 519
EP  - 533
DO  - 10.32604/biocell.2022.018271
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Jennen, Danyel and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www. disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in 67, 65 and 116 pathways, respectively. Among these, 53 genes/proteins and 42 pathways were common to all three substances. 31 genes/proteins had matching interactions for all three investigated substances, while more than half of these genes/proteins (56.49%) were in co-expression. 7 of the common genes/proteins (6 relevant to humans: CCL2, IL6, LPL, PPARG, SERPINE1, and TNF) were identified in all the investigated obesity comorbidities, while PPARG and LPL were most closely linked to obesity. These genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP, DBP and BPA mixture obesogenic properties. Analysis reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD.",
publisher = "Tech Science Press",
journal = "Biocell",
title = "Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach",
volume = "46",
number = "2",
pages = "519-533",
doi = "10.32604/biocell.2022.018271"
}

Baralić, K., Živančević, K., Božić, D., Jennen, D., Buha-Đorđević, A., Antonijević-Miljaković, E.,& Đukić-Ćosić, D.. (2022). Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach. in Biocell
Tech Science Press., 46(2), 519-533.
https://doi.org/10.32604/biocell.2022.018271

Baralić K, Živančević K, Božić D, Jennen D, Buha-Đorđević A, Antonijević-Miljaković E, Đukić-Ćosić D. Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach. in Biocell. 2022;46(2):519-533.
doi:10.32604/biocell.2022.018271 .

Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Jennen, Danyel, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, "Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach" in Biocell, 46, no. 2 (2022):519-533,
https://doi.org/10.32604/biocell.2022.018271 . .

TY  - JOUR
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Zhang, Yi
AU  - Yang, Li
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4018
AB  - Colorectal cancer (CRC) is a significant global health burden that ranks as the third most diagnosed and second most common cause of cancer related deaths worldwide. New therapeutic strategies include chemoprevention and use of molecules which could prevent, suppress or reverse CRC progression such as sulforaphane (SFN). However, evidences about its safety in CRC patients are still lacking. The aim of this in silico investigation was to predict SFN-induced adverse effects in CRC patients by computational analysis. The study showed that 334 genes were consistently dysregulated in CRC (223 downregulated and 111 upregulated), while 38 were recognized as significant and might be used as predictive biomarkers for overall survival and metastasis (TCGA, GEO, R studio). Among them, SFN interacted with 86 genes, out of which 11 were marked as significant (correlate with overall prognosis and metastasis). Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD). Pathway enrichment analysis revealed that SFN stimulated Transcriptional activation of RUNX2, AURKA activation by TPX2, IL-10 signaling, while inhibited Differentiation of White and Brown Adipocyte process, an underlying pathway which inactivation led to obesity (Cytoscape ClueGo + CluePedia, DAVID). Thus, genome signature of CRC patients could serve as important factor when addressing the risk-to-benefit profile of SFN. Patients with colon cancer and increased expression of TIMP1, CCL20, SPP1, AURKA, CEP55, NEK2, SOX9 and CDK1, or downregulation of CRYAB, PLCE1, MMP28, BMP2 and PLAC8 may not be ideal candidates for SFN chemoprevention.
PB  - Elsevier Masson s.r.l.
T2  - Biomedicine and Pharmacotherapy
T1  - Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation
VL  - 146
DO  - 10.1016/j.biopha.2021.112598
ER  - 

@article{
author = "Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Antonijević, Biljana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Zhang, Yi and Yang, Li and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "Colorectal cancer (CRC) is a significant global health burden that ranks as the third most diagnosed and second most common cause of cancer related deaths worldwide. New therapeutic strategies include chemoprevention and use of molecules which could prevent, suppress or reverse CRC progression such as sulforaphane (SFN). However, evidences about its safety in CRC patients are still lacking. The aim of this in silico investigation was to predict SFN-induced adverse effects in CRC patients by computational analysis. The study showed that 334 genes were consistently dysregulated in CRC (223 downregulated and 111 upregulated), while 38 were recognized as significant and might be used as predictive biomarkers for overall survival and metastasis (TCGA, GEO, R studio). Among them, SFN interacted with 86 genes, out of which 11 were marked as significant (correlate with overall prognosis and metastasis). Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD). Pathway enrichment analysis revealed that SFN stimulated Transcriptional activation of RUNX2, AURKA activation by TPX2, IL-10 signaling, while inhibited Differentiation of White and Brown Adipocyte process, an underlying pathway which inactivation led to obesity (Cytoscape ClueGo + CluePedia, DAVID). Thus, genome signature of CRC patients could serve as important factor when addressing the risk-to-benefit profile of SFN. Patients with colon cancer and increased expression of TIMP1, CCL20, SPP1, AURKA, CEP55, NEK2, SOX9 and CDK1, or downregulation of CRYAB, PLCE1, MMP28, BMP2 and PLAC8 may not be ideal candidates for SFN chemoprevention.",
publisher = "Elsevier Masson s.r.l.",
journal = "Biomedicine and Pharmacotherapy",
title = "Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation",
volume = "146",
doi = "10.1016/j.biopha.2021.112598"
}

Božić, D., Baralić, K., Živančević, K., Antonijević-Miljaković, E., Ćurčić, M., Antonijević, B., Buha-Đorđević, A., Bulat, Z., Zhang, Y., Yang, L.,& Đukić-Ćosić, D.. (2022). Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation. in Biomedicine and Pharmacotherapy
Elsevier Masson s.r.l.., 146.
https://doi.org/10.1016/j.biopha.2021.112598

Božić D, Baralić K, Živančević K, Antonijević-Miljaković E, Ćurčić M, Antonijević B, Buha-Đorđević A, Bulat Z, Zhang Y, Yang L, Đukić-Ćosić D. Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation. in Biomedicine and Pharmacotherapy. 2022;146.
doi:10.1016/j.biopha.2021.112598 .

Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Antonijević, Biljana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Zhang, Yi, Yang, Li, Đukić-Ćosić, Danijela, "Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation" in Biomedicine and Pharmacotherapy, 146 (2022),
https://doi.org/10.1016/j.biopha.2021.112598 . .

TY  - CONF
AU  - Jorgovanović, Sonja
AU  - Božić, Dragica
AU  - Jorgovanović, Slaviša
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4628
AB  - The rapid global growth of drugs production and consumption undoubtedly leads to
contamination of the environment with pharmaceutical substances, as well as the products
of their decomposition and metabolism. Therefore, the ecosystem is exposed to
pharmaceutical waste, what may result in various unwanted effects, such as the
development of microorganism’s resistance to antibiotics. A brief review of the European
Union regulations, as well as the United States of America and Australia amadments,
revealed the diversity of approaches and regulatory measures adopted with the purpose of
proper hazardous waste handling. However, none of proposed systems show enviable
results. We conducted the research in the period of March-May 2020, to find out how citizens
of Bor municipality handle the pharmaceutical waste. A total of 226 responses were collected
by surveying patients, in person and in electronic form. The obtained results were analyzed
using the statistical software SPSS 21.0. The presented results show that the awareness of
the potential toxicity of pharmaceutical waste is developed in more than a third of
respondents (37.5%), but also low level of knowleadge about the proper way of disposing
generated waste. Over 36% of men and 42% of women throw away their medicines together
with other household waste, while 9% of men and 11% of women take them to pharmacies.
The legal regulations and accompanying guidelines, together with appropriate media
campaign, would contribute to a better understanding of the given problem and the adoption
of new citizens habits when it comes to hazardous waste handling.
AB  - Brz rast proizvodnje i potrošnje lekova na globalnom nivou, nesumnjivo dovodi do
kontaminacije životne sredine farmaceutskim supstancama, njihovim metabolitima, kao i
proizvodima njihove dodatne razgradnje u životnoj sredini. Posledično, živi svet biva izložen
uticaju farmaceutskog otpada usled čega dolazi do ispoljavanja različitih neželjenih efekata,
kao, na primer, razvoja rezistencije mikroorganizama na antibiotike. Kratkim pregledom
regulative zemalja članica Evropske unije, Sjedinjenih Američkih Država i Australije, uočena
je različitost pristupa i regulatornih mera donetih u cilju pravilnog rukovanja otpadom,
između ostalih i farmaceutskim otpadom, pri čemu ni jedan sistem ne pokazuje zavidne
rezultate. Istraživanjem rađenim u periodu mart-maj 2020. godine pokušali smo da dođemo
do saznanja koliko je razvijena svest građana opštine Bor, o postojanju farmaceutskog
otpada kao posebne kategorije koja može da ugrozi zdravlje ljudi ali i životnu sredinu.
Anketiranjem pacijenata, kako ličnim kontaktom, tako i u elektronskoj formi prikupljeno je
ukupno 226 odgovora, a dobijeni rezultati analizirani su pomoću statističkog softvera SPSS
21.0. Dobijeni rezultati pokazuju da je svest o štetnosti farmaceutskog otpada razvijena kod
više od trećine ispitanika (37,5%), ali i postojanje niskog stepena informisanosti o pravilnom
načinu zbrinjavanja generisanog otpada. Zbog toga, preko 36% muškaraca i 42% žena lekove
baca u komunalni otpad., dok ih 9% muškaraca i 11% žena odnosi u apoteke. Dopuna
zakonske regulative kao i pratećih pravilnika, propraćena odgovarajućom medijskom
kampanjom doprinela bi boljem razumevanju datog problema i usvajanju novih navika kod
građana u načinu rukovanja neiskorišćenim lekovima iz domaćinstva.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment
T1  - Svest stanovništva opštine Bor o uticaju farmaceutskog otpada na zdravlje ljudi i životnu sredinu
VL  - 72
IS  - 4 suplement
SP  - S579
EP  - S580
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4628
ER  - 

@conference{
author = "Jorgovanović, Sonja and Božić, Dragica and Jorgovanović, Slaviša and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "The rapid global growth of drugs production and consumption undoubtedly leads to
contamination of the environment with pharmaceutical substances, as well as the products
of their decomposition and metabolism. Therefore, the ecosystem is exposed to
pharmaceutical waste, what may result in various unwanted effects, such as the
development of microorganism’s resistance to antibiotics. A brief review of the European
Union regulations, as well as the United States of America and Australia amadments,
revealed the diversity of approaches and regulatory measures adopted with the purpose of
proper hazardous waste handling. However, none of proposed systems show enviable
results. We conducted the research in the period of March-May 2020, to find out how citizens
of Bor municipality handle the pharmaceutical waste. A total of 226 responses were collected
by surveying patients, in person and in electronic form. The obtained results were analyzed
using the statistical software SPSS 21.0. The presented results show that the awareness of
the potential toxicity of pharmaceutical waste is developed in more than a third of
respondents (37.5%), but also low level of knowleadge about the proper way of disposing
generated waste. Over 36% of men and 42% of women throw away their medicines together
with other household waste, while 9% of men and 11% of women take them to pharmacies.
The legal regulations and accompanying guidelines, together with appropriate media
campaign, would contribute to a better understanding of the given problem and the adoption
of new citizens habits when it comes to hazardous waste handling., Brz rast proizvodnje i potrošnje lekova na globalnom nivou, nesumnjivo dovodi do
kontaminacije životne sredine farmaceutskim supstancama, njihovim metabolitima, kao i
proizvodima njihove dodatne razgradnje u životnoj sredini. Posledično, živi svet biva izložen
uticaju farmaceutskog otpada usled čega dolazi do ispoljavanja različitih neželjenih efekata,
kao, na primer, razvoja rezistencije mikroorganizama na antibiotike. Kratkim pregledom
regulative zemalja članica Evropske unije, Sjedinjenih Američkih Država i Australije, uočena
je različitost pristupa i regulatornih mera donetih u cilju pravilnog rukovanja otpadom,
između ostalih i farmaceutskim otpadom, pri čemu ni jedan sistem ne pokazuje zavidne
rezultate. Istraživanjem rađenim u periodu mart-maj 2020. godine pokušali smo da dođemo
do saznanja koliko je razvijena svest građana opštine Bor, o postojanju farmaceutskog
otpada kao posebne kategorije koja može da ugrozi zdravlje ljudi ali i životnu sredinu.
Anketiranjem pacijenata, kako ličnim kontaktom, tako i u elektronskoj formi prikupljeno je
ukupno 226 odgovora, a dobijeni rezultati analizirani su pomoću statističkog softvera SPSS
21.0. Dobijeni rezultati pokazuju da je svest o štetnosti farmaceutskog otpada razvijena kod
više od trećine ispitanika (37,5%), ali i postojanje niskog stepena informisanosti o pravilnom
načinu zbrinjavanja generisanog otpada. Zbog toga, preko 36% muškaraca i 42% žena lekove
baca u komunalni otpad., dok ih 9% muškaraca i 11% žena odnosi u apoteke. Dopuna
zakonske regulative kao i pratećih pravilnika, propraćena odgovarajućom medijskom
kampanjom doprinela bi boljem razumevanju datog problema i usvajanju novih navika kod
građana u načinu rukovanja neiskorišćenim lekovima iz domaćinstva.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment, Svest stanovništva opštine Bor o uticaju farmaceutskog otpada na zdravlje ljudi i životnu sredinu",
volume = "72",
number = "4 suplement",
pages = "S579-S580",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4628"
}

Jorgovanović, S., Božić, D., Jorgovanović, S., Ćurčić, M., Buha-Đorđević, A., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Bulat, Z.,& Antonijević, B.. (2022). Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S579-S580.
https://hdl.handle.net/21.15107/rcub_farfar_4628

Jorgovanović S, Božić D, Jorgovanović S, Ćurčić M, Buha-Đorđević A, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Bulat Z, Antonijević B. Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment. in Arhiv za farmaciju. 2022;72(4 suplement):S579-S580.
https://hdl.handle.net/21.15107/rcub_farfar_4628 .

Jorgovanović, Sonja, Božić, Dragica, Jorgovanović, Slaviša, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Bulat, Zorica, Antonijević, Biljana, "Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S579-S580,
https://hdl.handle.net/21.15107/rcub_farfar_4628 .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Janković, Saša
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Durgo, Ksenija
AU  - Vučinić, Slavica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4626
AB  - Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd.
AB  - Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats
T1  - Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova
VL  - 72
IS  - 4 suplement
SP  - S575
EP  - S576
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4626
ER  - 

@conference{
author = "Ćurčić, Marijana and Janković, Saša and Buha-Đorđević, Aleksandra and Milovanović, Vesna and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Durgo, Ksenija and Vučinić, Slavica and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd., Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats, Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova",
volume = "72",
number = "4 suplement",
pages = "S575-S576",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4626"
}

Ćurčić, M., Janković, S., Buha-Đorđević, A., Milovanović, V., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Živančević, K., Božić, D., Durgo, K., Vučinić, S., Bulat, Z.,& Antonijević, B.. (2022). Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S575-S576.
https://hdl.handle.net/21.15107/rcub_farfar_4626

Ćurčić M, Janković S, Buha-Đorđević A, Milovanović V, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Živančević K, Božić D, Durgo K, Vučinić S, Bulat Z, Antonijević B. Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju. 2022;72(4 suplement):S575-S576.
https://hdl.handle.net/21.15107/rcub_farfar_4626 .

Ćurčić, Marijana, Janković, Saša, Buha-Đorđević, Aleksandra, Milovanović, Vesna, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Durgo, Ksenija, Vučinić, Slavica, Bulat, Zorica, Antonijević, Biljana, "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S575-S576,
https://hdl.handle.net/21.15107/rcub_farfar_4626 .

TY  - CONF
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4495
AB  - The aim of this study was to: (1) examine subacute toxicity of bis (2-ethylhexyl)
phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) mixture in rats and
compare it with individual substance effects; (2) investigate the mechanisms of toxicity on
critical target organ, testes (in vivo/in silico study); (3) examine multibiotic ability to mitigate
mixture toxicity. Male rats were divided into groups (n = 6): (1) Control; (2) P (probiotic
(8.78*10 8 CFU/kg bw/day)); (3) DEHP (50 mg/kg bw/day); (4) DBP (50 mg/kg bw/day); (5)
BPA (25 mg/kg bw/day); and (6) MIX (50 mg/kg bw/day DEHP + 50 mg/kg bw/day DBP +
25 mg/kg bw/day BPA) (7) MIX + P. In silico toxicogenomic analysis was performed by
Comparative Toxicogenomic Database (CTD), Citoscape software and ToppGene Suite portal.
MIX led to significant changes in tissue structure (liver, kidney, spleen and testis),
biochemical parameters and testosterone level of rats compared to the control group and
individual substances. In silico analysis revealed 20 genes associated with DEHP/DBP/BPA
and male reproductive system disorders, while the most probable mechanisms included
metabolism, aryl hydrocarbon receptor pathway, apoptosis, and oxidative stress. Oxidative
stress was confirmed in vivo, and changes in parameters in testicular tissue homogenates
were most pronounced or present only in MIX group. Probiotic annulled/mitigated changes
in biochemical, hematological, and oxidative stress parameters, relative liver mass, food
consumption, and organ pathohistology. Hence, the obtained results indicate the possibility
of future considerations of protective probiotic effects against phthalates and BPA mixture
toxicity.
AB  - Cilj ove studije bio je: (1) ispitati subakutnu toksičnost smeše bis (2-etilheksil) ftalata
(DEHP), dibutil ftalata (DBP), bisfenola A (BPA) na pacovima i uporediti je sa efektima
pojedinačnih supstanci; (2) istražiti mehanizme toksičnosti na kritičnom ciljnom organu,
testisima (in vivo/in silico studija); (3) ispitati sposobnost višekomponentnog probiotika da
ublaži toksičnost smeše. Mužjaci pacova podeljeni su u grupe (n = 6): (1) Kontrola; (2) P
(probiotik (8.78 * 108 CFU/kg/day)); (3) DEHP (50 mg/kg t.m/dan); (4) DBP (50 mg/kg
t.m/dan); (5) BPA (25 mg/kg t.m/dan); i (6) MIX (50 mg/kg t.m/dan DEHP + 50 mg/kg
t.m/dan DBP + 25 mg/kg t.m/dan BPA) (7) MIX + P. In silico toksikogenomička analiza
sprovedena je Komparativnom toksikogenomičkom bazom podataka (CTD), Citoscape
softverom i ToppGene Suite portalom. Smeša je dovela do značajnih promena u strukturi
tkiva (jetra, bubreg, slezina i testis), biohemijskim parametrima i nivou testosterona pacova
u poređenju sa kontrolnom grupom i pojedinačnim supstancama. In silico analizom
otkriveno je 20 gena povezanih sa smešom DEHP/DBP/BPA i poremećajima muškog
reproduktivnog sistema, dok su najverovatniji mehanizmi uključili metabolizam,
molekularni put povezan sa receptorom za aromatične ugljovodinike, apoptozu i oksidativni
stres. Oksidativni stres potvrđen je in vivo, a promene u parametrima u homogenatu tkiva
testisa bile su najizraženije ili prisutne samo u MIX grupi. Probiotik je otklonio ili ublažio
promene u biohemijskim, hematološkim, i parametrima oksidativnog stresa, kao i relativnoj
masi jetre, unosu hrane i patohistološkim nalazima izazvanim smešom ispitivanih supstanci.
Dobijeni rezultati ukazuju na mogućnost budućih razmatranja protektivnih efekata
probiotika protiv toksičnosti smeše ftalata i BPA.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects
T1  - Subakutna toksičnost smeše ftalata i bisfenola a: procena protektivnog dejstva probiotika
VL  - 72
IS  - 4 suplement
SP  - S207
EP  - S208
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4495
ER  - 

@conference{
author = "Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Javorac, Dragana and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "The aim of this study was to: (1) examine subacute toxicity of bis (2-ethylhexyl)
phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) mixture in rats and
compare it with individual substance effects; (2) investigate the mechanisms of toxicity on
critical target organ, testes (in vivo/in silico study); (3) examine multibiotic ability to mitigate
mixture toxicity. Male rats were divided into groups (n = 6): (1) Control; (2) P (probiotic
(8.78*10 8 CFU/kg bw/day)); (3) DEHP (50 mg/kg bw/day); (4) DBP (50 mg/kg bw/day); (5)
BPA (25 mg/kg bw/day); and (6) MIX (50 mg/kg bw/day DEHP + 50 mg/kg bw/day DBP +
25 mg/kg bw/day BPA) (7) MIX + P. In silico toxicogenomic analysis was performed by
Comparative Toxicogenomic Database (CTD), Citoscape software and ToppGene Suite portal.
MIX led to significant changes in tissue structure (liver, kidney, spleen and testis),
biochemical parameters and testosterone level of rats compared to the control group and
individual substances. In silico analysis revealed 20 genes associated with DEHP/DBP/BPA
and male reproductive system disorders, while the most probable mechanisms included
metabolism, aryl hydrocarbon receptor pathway, apoptosis, and oxidative stress. Oxidative
stress was confirmed in vivo, and changes in parameters in testicular tissue homogenates
were most pronounced or present only in MIX group. Probiotic annulled/mitigated changes
in biochemical, hematological, and oxidative stress parameters, relative liver mass, food
consumption, and organ pathohistology. Hence, the obtained results indicate the possibility
of future considerations of protective probiotic effects against phthalates and BPA mixture
toxicity., Cilj ove studije bio je: (1) ispitati subakutnu toksičnost smeše bis (2-etilheksil) ftalata
(DEHP), dibutil ftalata (DBP), bisfenola A (BPA) na pacovima i uporediti je sa efektima
pojedinačnih supstanci; (2) istražiti mehanizme toksičnosti na kritičnom ciljnom organu,
testisima (in vivo/in silico studija); (3) ispitati sposobnost višekomponentnog probiotika da
ublaži toksičnost smeše. Mužjaci pacova podeljeni su u grupe (n = 6): (1) Kontrola; (2) P
(probiotik (8.78 * 108 CFU/kg/day)); (3) DEHP (50 mg/kg t.m/dan); (4) DBP (50 mg/kg
t.m/dan); (5) BPA (25 mg/kg t.m/dan); i (6) MIX (50 mg/kg t.m/dan DEHP + 50 mg/kg
t.m/dan DBP + 25 mg/kg t.m/dan BPA) (7) MIX + P. In silico toksikogenomička analiza
sprovedena je Komparativnom toksikogenomičkom bazom podataka (CTD), Citoscape
softverom i ToppGene Suite portalom. Smeša je dovela do značajnih promena u strukturi
tkiva (jetra, bubreg, slezina i testis), biohemijskim parametrima i nivou testosterona pacova
u poređenju sa kontrolnom grupom i pojedinačnim supstancama. In silico analizom
otkriveno je 20 gena povezanih sa smešom DEHP/DBP/BPA i poremećajima muškog
reproduktivnog sistema, dok su najverovatniji mehanizmi uključili metabolizam,
molekularni put povezan sa receptorom za aromatične ugljovodinike, apoptozu i oksidativni
stres. Oksidativni stres potvrđen je in vivo, a promene u parametrima u homogenatu tkiva
testisa bile su najizraženije ili prisutne samo u MIX grupi. Probiotik je otklonio ili ublažio
promene u biohemijskim, hematološkim, i parametrima oksidativnog stresa, kao i relativnoj
masi jetre, unosu hrane i patohistološkim nalazima izazvanim smešom ispitivanih supstanci.
Dobijeni rezultati ukazuju na mogućnost budućih razmatranja protektivnih efekata
probiotika protiv toksičnosti smeše ftalata i BPA.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects, Subakutna toksičnost smeše ftalata i bisfenola a: procena protektivnog dejstva probiotika",
volume = "72",
number = "4 suplement",
pages = "S207-S208",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4495"
}

Baralić, K., Božić, D., Živančević, K., Javorac, D., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S207-S208.
https://hdl.handle.net/21.15107/rcub_farfar_4495

Baralić K, Božić D, Živančević K, Javorac D, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects. in Arhiv za farmaciju. 2022;72(4 suplement):S207-S208.
https://hdl.handle.net/21.15107/rcub_farfar_4495 .

Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Javorac, Dragana, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S207-S208,
https://hdl.handle.net/21.15107/rcub_farfar_4495 .

TY  - CONF
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Tavrić, J
AU  - Plankoš, A
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4350
PB  - Elsevier B.V.
C3  - Toxicology Letters
T1  - Mechanistic studies of sulforaphane induced toxicity: in silico approach
VL  - 368
IS  - Supplement
SP  - S87
EP  - S87
DO  - 10.1016/j.toxlet.2022.07.252
ER  - 

@conference{
author = "Božić, Dragica and Živančević, Katarina and Baralić, Katarina and Tavrić, J and Plankoš, A and Ćurčić, Marijana and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
publisher = "Elsevier B.V.",
journal = "Toxicology Letters",
title = "Mechanistic studies of sulforaphane induced toxicity: in silico approach",
volume = "368",
number = "Supplement",
pages = "S87-S87",
doi = "10.1016/j.toxlet.2022.07.252"
}

Božić, D., Živančević, K., Baralić, K., Tavrić, J., Plankoš, A., Ćurčić, M., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Mechanistic studies of sulforaphane induced toxicity: in silico approach. in Toxicology Letters
Elsevier B.V.., 368(Supplement), S87-S87.
https://doi.org/10.1016/j.toxlet.2022.07.252

Božić D, Živančević K, Baralić K, Tavrić J, Plankoš A, Ćurčić M, Antonijević B, Đukić-Ćosić D. Mechanistic studies of sulforaphane induced toxicity: in silico approach. in Toxicology Letters. 2022;368(Supplement):S87-S87.
doi:10.1016/j.toxlet.2022.07.252 .

Božić, Dragica, Živančević, Katarina, Baralić, Katarina, Tavrić, J, Plankoš, A, Ćurčić, Marijana, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Mechanistic studies of sulforaphane induced toxicity: in silico approach" in Toxicology Letters, 368, no. Supplement (2022):S87-S87,
https://doi.org/10.1016/j.toxlet.2022.07.252 . .