TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Janković, Radmila
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5614
AB  - Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.
PB  - Elsevier Inc.
T2  - Environmental Research
T1  - Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
VL  - 252
IS  - 1
DO  - 10.1016/j.envres.2024.118680
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Savić, Miroslav and Batinić, Bojan and Janković, Radmila and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.",
publisher = "Elsevier Inc.",
journal = "Environmental Research",
title = "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach",
volume = "252",
number = "1",
doi = "10.1016/j.envres.2024.118680"
}

Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Kotur-Stevuljević, J., Ivanišević, J., Savić, M., Batinić, B., Janković, R., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research
Elsevier Inc.., 252(1).
https://doi.org/10.1016/j.envres.2024.118680

Živančević K, Baralić K, Vukelić D, Marić Đ, Kotur-Stevuljević J, Ivanišević J, Savić M, Batinić B, Janković R, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research. 2024;252(1).
doi:10.1016/j.envres.2024.118680 .

Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Savić, Miroslav, Batinić, Bojan, Janković, Radmila, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach" in Environmental Research, 252, no. 1 (2024),
https://doi.org/10.1016/j.envres.2024.118680 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Grahovac, Lazar
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5516
AB  - Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.
PB  - MDPI
T2  - Antioxidants
T1  - Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies
VL  - 13
IS  - 2
DO  - 10.3390/antiox13020147
ER  - 

@article{
author = "Baralić, Katarina and Živanović, Jovana and Marić, Đurđica and Božić, Dragica and Grahovac, Lazar and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies",
volume = "13",
number = "2",
doi = "10.3390/antiox13020147"
}

Baralić, K., Živanović, J., Marić, Đ., Božić, D., Grahovac, L., Antonijević-Miljaković, E., Ćurčić, M., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants
MDPI., 13(2).
https://doi.org/10.3390/antiox13020147

Baralić K, Živanović J, Marić Đ, Božić D, Grahovac L, Antonijević-Miljaković E, Ćurčić M, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants. 2024;13(2).
doi:10.3390/antiox13020147 .

Baralić, Katarina, Živanović, Jovana, Marić, Đurđica, Božić, Dragica, Grahovac, Lazar, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies" in Antioxidants, 13, no. 2 (2024),
https://doi.org/10.3390/antiox13020147 . .

TY  - JOUR
AU  - Radović, Biljana
AU  - Baralić, Katarina
AU  - Ćurčić, Marijana
AU  - Marić, Đurđica
AU  - Živanović, Jovana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5530
AB  - The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.
PB  - Elsevier V. B.
T2  - Science of the Total Environment
T1  - Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms
VL  - 917
SP  - 170437
DO  - 10.1016/j.scitotenv.2024.170437
ER  - 

@article{
author = "Radović, Biljana and Baralić, Katarina and Ćurčić, Marijana and Marić, Đurđica and Živanović, Jovana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2024",
abstract = "The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.",
publisher = "Elsevier V. B.",
journal = "Science of the Total Environment",
title = "Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms",
volume = "917",
pages = "170437",
doi = "10.1016/j.scitotenv.2024.170437"
}

Radović, B., Baralić, K., Ćurčić, M., Marić, Đ., Živanović, J., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2024). Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms. in Science of the Total Environment
Elsevier V. B.., 917, 170437.
https://doi.org/10.1016/j.scitotenv.2024.170437

Radović B, Baralić K, Ćurčić M, Marić Đ, Živanović J, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Bulat Z, Antonijević B. Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms. in Science of the Total Environment. 2024;917:170437.
doi:10.1016/j.scitotenv.2024.170437 .

Radović, Biljana, Baralić, Katarina, Ćurčić, Marijana, Marić, Đurđica, Živanović, Jovana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms" in Science of the Total Environment, 917 (2024):170437,
https://doi.org/10.1016/j.scitotenv.2024.170437 . .

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Panieri, Emiliano
AU  - Saso, Luciano
AU  - Buha-Đorđević, Aleksandra
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5313
AB  - The understanding that humans are exposed to a low level of toxic metals and metalloids in their lifetime has resulted in a shift in scientific and regulatory perspectives from the traditional evaluation of single metal toxicity to complex mixtures, relevant to real-life exposure. Therefore, the aim of this study was to examine the impact of real-life, 90-days exposure to mixture of toxic metal(oid)s, Cd, Pb, Ni, Cr, As and Hg, on the nuclear factor erythroid 2–related factor 2 and hemoxygenase-1 (Nrf2/HO-1) signalling and redox status by assessing total sulfhydryl groups (SH), glutathione (GSH), superoxide dismutase activity (SOD), malondialdehyde (MDA), and ischemia modified albumin (IMA) in the liver and kidney of Wistar rats. Animals (20 males and 20 females) were randomized in 2 control and 6 treated groups that received by oral gavage mixture of metal(oid)s solutions in doses that reflect blood metal(oid) levels determined in previous human biomonitoring study as benchmark dose (F/M _BMD), median (F/M _MED), and 95th percentile (F/M _95). Our results have shown that metal(oid)s mixture impaired the activation of the Nrf2/HO-1 pathway in the kidney and liver of male rats and kidney of female rats, followed by depletion of GSH levels in males. Additionally, in males elevated levels of IMA in the liver were observed, while in both genders increased MDA levels were observed in the kidney. Interestingly, the effects were more pronounced in male than in female rats. This study is among the first that examined hepato-renal toxic mechanisms of real-life metal mixture exposure, while our results might be of immense importance for assessing the risk of exposure to mixtures of toxic substances.
PB  - Elsevier B.V.
T2  - Science of the Total Environment
T1  - Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status
VL  - 908
DO  - 10.1016/j.scitotenv.2023.168352
ER  - 

@article{
author = "Vukelić, Dragana and Baralić, Katarina and Marić, Đurđica and Đukić-Ćosić, Danijela and Bulat, Zorica and Panieri, Emiliano and Saso, Luciano and Buha-Đorđević, Aleksandra",
year = "2024",
abstract = "The understanding that humans are exposed to a low level of toxic metals and metalloids in their lifetime has resulted in a shift in scientific and regulatory perspectives from the traditional evaluation of single metal toxicity to complex mixtures, relevant to real-life exposure. Therefore, the aim of this study was to examine the impact of real-life, 90-days exposure to mixture of toxic metal(oid)s, Cd, Pb, Ni, Cr, As and Hg, on the nuclear factor erythroid 2–related factor 2 and hemoxygenase-1 (Nrf2/HO-1) signalling and redox status by assessing total sulfhydryl groups (SH), glutathione (GSH), superoxide dismutase activity (SOD), malondialdehyde (MDA), and ischemia modified albumin (IMA) in the liver and kidney of Wistar rats. Animals (20 males and 20 females) were randomized in 2 control and 6 treated groups that received by oral gavage mixture of metal(oid)s solutions in doses that reflect blood metal(oid) levels determined in previous human biomonitoring study as benchmark dose (F/M _BMD), median (F/M _MED), and 95th percentile (F/M _95). Our results have shown that metal(oid)s mixture impaired the activation of the Nrf2/HO-1 pathway in the kidney and liver of male rats and kidney of female rats, followed by depletion of GSH levels in males. Additionally, in males elevated levels of IMA in the liver were observed, while in both genders increased MDA levels were observed in the kidney. Interestingly, the effects were more pronounced in male than in female rats. This study is among the first that examined hepato-renal toxic mechanisms of real-life metal mixture exposure, while our results might be of immense importance for assessing the risk of exposure to mixtures of toxic substances.",
publisher = "Elsevier B.V.",
journal = "Science of the Total Environment",
title = "Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status",
volume = "908",
doi = "10.1016/j.scitotenv.2023.168352"
}

Vukelić, D., Baralić, K., Marić, Đ., Đukić-Ćosić, D., Bulat, Z., Panieri, E., Saso, L.,& Buha-Đorđević, A.. (2024). Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status. in Science of the Total Environment
Elsevier B.V.., 908.
https://doi.org/10.1016/j.scitotenv.2023.168352

Vukelić D, Baralić K, Marić Đ, Đukić-Ćosić D, Bulat Z, Panieri E, Saso L, Buha-Đorđević A. Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status. in Science of the Total Environment. 2024;908.
doi:10.1016/j.scitotenv.2023.168352 .

Vukelić, Dragana, Baralić, Katarina, Marić, Đurđica, Đukić-Ćosić, Danijela, Bulat, Zorica, Panieri, Emiliano, Saso, Luciano, Buha-Đorđević, Aleksandra, "Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status" in Science of the Total Environment, 908 (2024),
https://doi.org/10.1016/j.scitotenv.2023.168352 . .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5552
AB  - Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ...
AB  - Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji
T1  - Possibilities and challenges of applying artificial intelligence in toxicology
SP  - 159
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5552
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ..., Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji, Possibilities and challenges of applying artificial intelligence in toxicology",
pages = "159-160",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5552"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):159-160,
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5514
AB  - Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ...
AB  - In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Komparativna toksikogenomska baza podataka: Nove mogućnosti
T1  - The Comparative Toxicogenomic Database: New possibilities
SP  - 157
EP  - 158
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5514
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ..., In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Komparativna toksikogenomska baza podataka: Nove mogućnosti, The Comparative Toxicogenomic Database: New possibilities",
pages = "157-158",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5514"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Komparativna toksikogenomska baza podataka: Nove mogućnosti" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):157-158,
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Manić, Luka
AU  - Grahovac, Lazar
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5513
AB  - In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ...
AB  - In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode
T1  - Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method
SP  - 154
EP  - 156
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5513
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živanović, Jovana and Živančević, Katarina and Marić, Đurđica and Vukelić, Dragana and Manić, Luka and Grahovac, Lazar and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ..., In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode, Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method",
pages = "154-156",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5513"
}

Božić, D., Baralić, K., Živanović, J., Živančević, K., Marić, Đ., Vukelić, D., Manić, L., Grahovac, L., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513

Božić D, Baralić K, Živanović J, Živančević K, Marić Đ, Vukelić D, Manić L, Grahovac L, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

Božić, Dragica, Baralić, Katarina, Živanović, Jovana, Živančević, Katarina, Marić, Đurđica, Vukelić, Dragana, Manić, Luka, Grahovac, Lazar, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):154-156,
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

TY  - CONF
AU  - Bonderović, Vera
AU  - Manić, Luka
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Stojilković, Nikola
AU  - Jorgovanović, Dragica
AU  - Grahovac, Lazar
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5510
AB  - Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ...
AB  - In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama
T1  - Informed mom, healthy baby - How to live safely with chemicals
SP  - 117
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5510
ER  - 

@conference{
author = "Bonderović, Vera and Manić, Luka and Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Stojilković, Nikola and Jorgovanović, Dragica and Grahovac, Lazar and Anđelković, Milena and Repić, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ..., In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama, Informed mom, healthy baby - How to live safely with chemicals",
pages = "117-118",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5510"
}

Bonderović, V., Manić, L., Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Stojilković, N., Jorgovanović, D., Grahovac, L., Anđelković, M., Repić, A., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2023). Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510

Bonderović V, Manić L, Živančević K, Baralić K, Vukelić D, Marić Đ, Stojilković N, Jorgovanović D, Grahovac L, Anđelković M, Repić A, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B, Buha-Đorđević A. Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

Bonderović, Vera, Manić, Luka, Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Stojilković, Nikola, Jorgovanović, Dragica, Grahovac, Lazar, Anđelković, Milena, Repić, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):117-118,
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

TY  - CONF
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Milovanović, Vesna
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Lukić, Vera
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5508
AB  - Endokrini ometači, u koje se između ostalih ubrajaju i toksični metali poput kadmijuma (Cd), se dovode u vezu sa sve češćom pojavom neplodnosti i poremećajima reproduktivnog zdravlja. Kako je jedan od najznačajnijih mehanizama toksičnosti Cd njegova interakcija sa bioelementima, dalje ispitivanje ovog mehanizma moglo bi da doprinese rasvetljavanju mehanizama toksičnosti ovog metala u testisima, kao i uloge izloženosti ovom metalu u reproduktivnom zdravlju.
AB  - Endocrine disruptors, which include, but are not limited to, toxic metals such as Cd, have been linked to the increasing incidence of infertility and reproductive health disorders. As one of the most important mechanisms of Cd toxicity is its interaction with bioelements, further investigation of this mechanism could contribute to a better understanding of mechanisms of endocrine-disrupting Cd activities in testes and its role in human reproductive health.
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova
T1  - Effect of cadmium intoxication on the bioelements levels in testicular tissue of rats
SP  - 103
EP  - 104
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5508
ER  - 

@conference{
author = "Marić, Đurđica and Vukelić, Dragana and Milovanović, Vesna and Bulat, Zorica and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Lukić, Vera and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Endokrini ometači, u koje se između ostalih ubrajaju i toksični metali poput kadmijuma (Cd), se dovode u vezu sa sve češćom pojavom neplodnosti i poremećajima reproduktivnog zdravlja. Kako je jedan od najznačajnijih mehanizama toksičnosti Cd njegova interakcija sa bioelementima, dalje ispitivanje ovog mehanizma moglo bi da doprinese rasvetljavanju mehanizama toksičnosti ovog metala u testisima, kao i uloge izloženosti ovom metalu u reproduktivnom zdravlju., Endocrine disruptors, which include, but are not limited to, toxic metals such as Cd, have been linked to the increasing incidence of infertility and reproductive health disorders. As one of the most important mechanisms of Cd toxicity is its interaction with bioelements, further investigation of this mechanism could contribute to a better understanding of mechanisms of endocrine-disrupting Cd activities in testes and its role in human reproductive health.",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova, Effect of cadmium intoxication on the bioelements levels in testicular tissue of rats",
pages = "103-104",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5508"
}

Marić, Đ., Vukelić, D., Milovanović, V., Bulat, Z., Ćurčić, M., Đukić-Ćosić, D., Lukić, V., Antonijević, B.,& Buha-Đorđević, A.. (2023). Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 103-104.
https://hdl.handle.net/21.15107/rcub_farfar_5508

Marić Đ, Vukelić D, Milovanović V, Bulat Z, Ćurčić M, Đukić-Ćosić D, Lukić V, Antonijević B, Buha-Đorđević A. Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:103-104.
https://hdl.handle.net/21.15107/rcub_farfar_5508 .

Marić, Đurđica, Vukelić, Dragana, Milovanović, Vesna, Bulat, Zorica, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Lukić, Vera, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):103-104,
https://hdl.handle.net/21.15107/rcub_farfar_5508 .

TY  - CONF
AU  - Živančević, Katarina
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5170
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
T1  - Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor
VL  - 384
IS  - S1
SP  - S78
EP  - S78
DO  - 10.1016/S0378-4274(23)00454-X
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5170
ER  - 

@conference{
author = "Živančević, Katarina and Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Marić, Đurđica and Vukelić, Dragana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia",
title = "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor",
volume = "384",
number = "S1",
pages = "S78-S78",
doi = "10.1016/S0378-4274(23)00454-X",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5170"
}

Živančević, K., Živanović, J., Baralić, K., Božić, D., Marić, Đ., Vukelić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
Elsevier., 384(S1), S78-S78.
https://doi.org/10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170

Živančević K, Živanović J, Baralić K, Božić D, Marić Đ, Vukelić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia. 2023;384(S1):S78-S78.
doi:10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

Živančević, Katarina, Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Marić, Đurđica, Vukelić, Dragana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor" in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia, 384, no. S1 (2023):S78-S78,
https://doi.org/10.1016/S0378-4274(23)00454-X .,
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

TY  - CONF
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Janković, Radmila
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5424
AB  - Izloženost olovu (Pb), kadmijumu (Cd), živi (Hg) i arsenu (As) iz životne sredine, kako pojedinačno tako
i njihovim smešama jedan je od faktora za razvoj brojnih zdravstvenih poremećaja, među kojima su i
štetni efekti na nivou centralnog nervnog sistema. ...
AB  - Lead (Pb), cadmium (Cd), mercury (Hg) and arsenic (As) are top ranked toxic metal(oid)s on the list of
the most important environmental pollutants from the aspect of public health. Literature data show
that exposure to individual metals, as well as their mixtures, is one of the factors for numerous health
disorders development, including adverse effects on the central nervous system. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine
T1  - Neurotoxicity of lead, cadmium, mercury and arsenic low dosed mixtures relevant to environmental exposure
SP  - 37
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5424
ER  - 

@conference{
author = "Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Savić, Miroslav and Batinić, Bojan and Janković, Radmila and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Izloženost olovu (Pb), kadmijumu (Cd), živi (Hg) i arsenu (As) iz životne sredine, kako pojedinačno tako
i njihovim smešama jedan je od faktora za razvoj brojnih zdravstvenih poremećaja, među kojima su i
štetni efekti na nivou centralnog nervnog sistema. ..., Lead (Pb), cadmium (Cd), mercury (Hg) and arsenic (As) are top ranked toxic metal(oid)s on the list of
the most important environmental pollutants from the aspect of public health. Literature data show
that exposure to individual metals, as well as their mixtures, is one of the factors for numerous health
disorders development, including adverse effects on the central nervous system. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine, Neurotoxicity of lead, cadmium, mercury and arsenic low dosed mixtures relevant to environmental exposure",
pages = "37-38",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5424"
}

Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Kotur-Stevuljević, J., Ivanišević, J., Savić, M., Batinić, B., Janković, R., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5424

Živančević K, Baralić K, Vukelić D, Marić Đ, Kotur-Stevuljević J, Ivanišević J, Savić M, Batinić B, Janković R, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5424 .

Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Savić, Miroslav, Batinić, Bojan, Janković, Radmila, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):37-38,
https://hdl.handle.net/21.15107/rcub_farfar_5424 .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Mandić-Rajčević, Stefan
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4299
AB  - Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response relationship has been established for such an effect. The present study aimed to examine blood Pb levels (BLLs) in relation to serum levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and insulin in 435 nonoccupationally exposed Serbian subjects (218 women, 217 men, 18–94 years of age, mean age 48). In addition, benchmark dose (BMD) values were calculated for these endocrine endpoints using the PROAST 70.1 software. An explicit dose-response dependency between BLL and TSH, fT3, fT4, testosterone, and insulin serum levels was evident from BMD modelling. The results support the positive association between BLLs and serum insulin levels, with observed dose-response and calculated BMD values of 1.49 and 0.74 μg Pb/dL in males and females, respectively. Collectively, our findings reported potential endocrine-disrupting effects of Pb at the environmental exposure levels experienced by current Serbian population. They also strengthen the notion that the blood Pb threshold level for an endocrine effect is low.
PB  - Elsevier Ltd
T2  - Environmental Pollution
T1  - Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans
VL  - 316
DO  - 10.1016/j.envpol.2022.120428
ER  - 

@article{
author = "Javorac, Dragana and Baralić, Katarina and Marić, Đurđica and Mandić-Rajčević, Stefan and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response relationship has been established for such an effect. The present study aimed to examine blood Pb levels (BLLs) in relation to serum levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and insulin in 435 nonoccupationally exposed Serbian subjects (218 women, 217 men, 18–94 years of age, mean age 48). In addition, benchmark dose (BMD) values were calculated for these endocrine endpoints using the PROAST 70.1 software. An explicit dose-response dependency between BLL and TSH, fT3, fT4, testosterone, and insulin serum levels was evident from BMD modelling. The results support the positive association between BLLs and serum insulin levels, with observed dose-response and calculated BMD values of 1.49 and 0.74 μg Pb/dL in males and females, respectively. Collectively, our findings reported potential endocrine-disrupting effects of Pb at the environmental exposure levels experienced by current Serbian population. They also strengthen the notion that the blood Pb threshold level for an endocrine effect is low.",
publisher = "Elsevier Ltd",
journal = "Environmental Pollution",
title = "Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans",
volume = "316",
doi = "10.1016/j.envpol.2022.120428"
}

Javorac, D., Baralić, K., Marić, Đ., Mandić-Rajčević, S., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans. in Environmental Pollution
Elsevier Ltd., 316.
https://doi.org/10.1016/j.envpol.2022.120428

Javorac D, Baralić K, Marić Đ, Mandić-Rajčević S, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans. in Environmental Pollution. 2023;316.
doi:10.1016/j.envpol.2022.120428 .

Javorac, Dragana, Baralić, Katarina, Marić, Đurđica, Mandić-Rajčević, Stefan, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans" in Environmental Pollution, 316 (2023),
https://doi.org/10.1016/j.envpol.2022.120428 . .

TY  - CONF
AU  - Vukelić, Dragana
AU  - Petrović, Bojana
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5486
AB  - Zagađenje vazduha predstavlja ekološki faktor rizika koji je povezan sa 1% svih slučajeva razvoja karcinoma i 2% svih smrtnih slučajeva usled razvoja karcinoma u Evropi. Postoji veliki broj podataka koji ukazuju na vezu između zagađenja vazduha, posebno suspendovanih čestica (PM), i pojave karcinoma pluća. ...
AB  - Air pollution represents environmental risk factor linked to 1% of all cancer incidences and 2% of all cancer deaths in Europe. There is a strong body of data linking outdoor (ambient) air pollution, particularly particulate matter (PM), with lung cancer incidence.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?
T1  - Exposure to outdoor air pollution and cancer development: Is air pollution responsible for more than lung cancer?
SP  - 59
EP  - 60
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5486
ER  - 

@conference{
author = "Vukelić, Dragana and Petrović, Bojana and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Zagađenje vazduha predstavlja ekološki faktor rizika koji je povezan sa 1% svih slučajeva razvoja karcinoma i 2% svih smrtnih slučajeva usled razvoja karcinoma u Evropi. Postoji veliki broj podataka koji ukazuju na vezu između zagađenja vazduha, posebno suspendovanih čestica (PM), i pojave karcinoma pluća. ..., Air pollution represents environmental risk factor linked to 1% of all cancer incidences and 2% of all cancer deaths in Europe. There is a strong body of data linking outdoor (ambient) air pollution, particularly particulate matter (PM), with lung cancer incidence.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?, Exposure to outdoor air pollution and cancer development: Is air pollution responsible for more than lung cancer?",
pages = "59-60",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5486"
}

Vukelić, D., Petrović, B., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2023). Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 59-60.
https://hdl.handle.net/21.15107/rcub_farfar_5486

Vukelić D, Petrović B, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:59-60.
https://hdl.handle.net/21.15107/rcub_farfar_5486 .

Vukelić, Dragana, Petrović, Bojana, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):59-60,
https://hdl.handle.net/21.15107/rcub_farfar_5486 .

TY  - CONF
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Mandić-Rajčević, Stefan
AU  - Žarković, Miloš
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5426
AB  - Uticaj toksičnog metala nikla (Ni) na funkciju štitaste žlezde još uvek nije dovoljno istražen.
Stoga je cilj ove studije bio da se ispita potencijal Ni da poremeti funkciju štitaste žlezde ispitivanjem
odnosa između koncentracije Ni u krvi i nivoa hormona u serumu (TSH, T4, T3, fT4, fT3), kao i parametara
tiroidne homeostaze (SPINA-GT i SPINA-GD) korišćenjem korelacione analize i Benchmark (BMD) koncepta. ...
AB  - Nickel (Ni) is one of the well-known toxic metals whose effect on thyroid function has not been suffi-
ciently investigated yet. The aim of this study was to analyse the potential of Ni to disrupt thyroid func-
tion by exploring the relationship between blood Ni concentration and serum hormone levels (TSH,
T4, T3, fT4, fT3), as well as the parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) by using
correlation analysis and Benchmark (BMD) concept ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Veza između izloženosti niklu i poremećaja funkcije štitaste žlezde - rezultati studije humanog biomonitoringa
T1  - The relationship between nickel exposure and thyroid dysfunction - results of a human biomonitoring study
SP  - 63
EP  - 64
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5426
ER  - 

@conference{
author = "Marić, Đurđica and Baralić, Katarina and Vukelić, Dragana and Mandić-Rajčević, Stefan and Žarković, Miloš and Antonijević, Biljana and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Uticaj toksičnog metala nikla (Ni) na funkciju štitaste žlezde još uvek nije dovoljno istražen.
Stoga je cilj ove studije bio da se ispita potencijal Ni da poremeti funkciju štitaste žlezde ispitivanjem
odnosa između koncentracije Ni u krvi i nivoa hormona u serumu (TSH, T4, T3, fT4, fT3), kao i parametara
tiroidne homeostaze (SPINA-GT i SPINA-GD) korišćenjem korelacione analize i Benchmark (BMD) koncepta. ..., Nickel (Ni) is one of the well-known toxic metals whose effect on thyroid function has not been suffi-
ciently investigated yet. The aim of this study was to analyse the potential of Ni to disrupt thyroid func-
tion by exploring the relationship between blood Ni concentration and serum hormone levels (TSH,
T4, T3, fT4, fT3), as well as the parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) by using
correlation analysis and Benchmark (BMD) concept ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Veza između izloženosti niklu i poremećaja funkcije štitaste žlezde - rezultati studije humanog biomonitoringa, The relationship between nickel exposure and thyroid dysfunction - results of a human biomonitoring study",
pages = "63-64",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5426"
}

Marić, Đ., Baralić, K., Vukelić, D., Mandić-Rajčević, S., Žarković, M., Antonijević, B., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Veza između izloženosti niklu i poremećaja funkcije štitaste žlezde - rezultati studije humanog biomonitoringa. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 63-64.
https://hdl.handle.net/21.15107/rcub_farfar_5426

Marić Đ, Baralić K, Vukelić D, Mandić-Rajčević S, Žarković M, Antonijević B, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Veza između izloženosti niklu i poremećaja funkcije štitaste žlezde - rezultati studije humanog biomonitoringa. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:63-64.
https://hdl.handle.net/21.15107/rcub_farfar_5426 .

Marić, Đurđica, Baralić, Katarina, Vukelić, Dragana, Mandić-Rajčević, Stefan, Žarković, Miloš, Antonijević, Biljana, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Veza između izloženosti niklu i poremećaja funkcije štitaste žlezde - rezultati studije humanog biomonitoringa" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):63-64,
https://hdl.handle.net/21.15107/rcub_farfar_5426 .

TY  - CONF
AU  - Vukelić, Dragana
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5423
AB  - Novija saznanja ukazuju da niska izloženost olovu (Pb), koja se u današnje vreme sreće, predstavlja rizik
po zdravlje ljudi. Jedan od najznačajnijih mehanizama toksičnosti Pb je oksidativni stres koji nastaje
usled osobine Pb da indukuje stvaranje slobodnih kiseoničnih i azotovih radikala i suprimira antioksidativnu zaštitu. ...
AB  - Recent findings indicate that low-dose lead (Pb) exposure, which is encountered today, represents a
risk to human health. One of the most important mechanisms of Pb toxicity is oxidative stress, which
occurs due to Pb ability to induce the formation of free oxygen and nitrogen radicals and suppress
antioxidant protection. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje
T1  - Oxidative stress induced by low doses of lead: a Subacute toxicity study in Wistar rats and Benchmark modeling
SP  - 57
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5423
ER  - 

@conference{
author = "Vukelić, Dragana and Anđelković, Milena and Repić, Aleksandra and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Novija saznanja ukazuju da niska izloženost olovu (Pb), koja se u današnje vreme sreće, predstavlja rizik
po zdravlje ljudi. Jedan od najznačajnijih mehanizama toksičnosti Pb je oksidativni stres koji nastaje
usled osobine Pb da indukuje stvaranje slobodnih kiseoničnih i azotovih radikala i suprimira antioksidativnu zaštitu. ..., Recent findings indicate that low-dose lead (Pb) exposure, which is encountered today, represents a
risk to human health. One of the most important mechanisms of Pb toxicity is oxidative stress, which
occurs due to Pb ability to induce the formation of free oxygen and nitrogen radicals and suppress
antioxidant protection. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje, Oxidative stress induced by low doses of lead: a Subacute toxicity study in Wistar rats and Benchmark modeling",
pages = "57-58",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5423"
}

Vukelić, D., Anđelković, M., Repić, A., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Kotur-Stevuljević, J., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2023). Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 57-58.
https://hdl.handle.net/21.15107/rcub_farfar_5423

Vukelić D, Anđelković M, Repić A, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Kotur-Stevuljević J, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:57-58.
https://hdl.handle.net/21.15107/rcub_farfar_5423 .

Vukelić, Dragana, Anđelković, Milena, Repić, Aleksandra, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):57-58,
https://hdl.handle.net/21.15107/rcub_farfar_5423 .

TY  - CONF
AU  - Stojilković, Nikola
AU  - Stojković, Miodrag
AU  - Ćurčić, Marijana
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Stojanović, Aleksandra
AU  - Zdravković, Aleksandra
AU  - Stojadinović, Tina
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5428
AB  - Jedan od najvećih izazova u toksikologiji je procena toksičnosti hemijskim smešama, odnosno procena
rizika po zdravlje ljudi usled celoživotnog izlaganja složenim smešama različitih supstanci. Studije bio-
monitoringa su nesumnjivo pokazale prisustvo preko stotinu hemikalija u ljudskom telu. ...
AB  - One of the biggest challenges in toxicology is the evaluation of the toxicity of chemical mixtures, as
well as the risk to human health due to lifelong exposure to complex mixtures of different substances.
Biomonitoring studies have undoubtedly shown the presence of over a hundred chemicals in the
human body. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova
T1  - Effect of lead and polychlorinated-biphenyls mixture on sperm cells and serum level of testosterone in rats
SP  - 65
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5428
ER  - 

@conference{
author = "Stojilković, Nikola and Stojković, Miodrag and Ćurčić, Marijana and Vukelić, Dragana and Buha-Đorđević, Aleksandra and Stojanović, Aleksandra and Zdravković, Aleksandra and Stojadinović, Tina and Marić, Đurđica and Baralić, Katarina and Antonijević, Biljana",
year = "2023",
abstract = "Jedan od najvećih izazova u toksikologiji je procena toksičnosti hemijskim smešama, odnosno procena
rizika po zdravlje ljudi usled celoživotnog izlaganja složenim smešama različitih supstanci. Studije bio-
monitoringa su nesumnjivo pokazale prisustvo preko stotinu hemikalija u ljudskom telu. ..., One of the biggest challenges in toxicology is the evaluation of the toxicity of chemical mixtures, as
well as the risk to human health due to lifelong exposure to complex mixtures of different substances.
Biomonitoring studies have undoubtedly shown the presence of over a hundred chemicals in the
human body. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova, Effect of lead and polychlorinated-biphenyls mixture on sperm cells and serum level of testosterone in rats",
pages = "65-66",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5428"
}

Stojilković, N., Stojković, M., Ćurčić, M., Vukelić, D., Buha-Đorđević, A., Stojanović, A., Zdravković, A., Stojadinović, T., Marić, Đ., Baralić, K.,& Antonijević, B.. (2023). Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 65-66.
https://hdl.handle.net/21.15107/rcub_farfar_5428

Stojilković N, Stojković M, Ćurčić M, Vukelić D, Buha-Đorđević A, Stojanović A, Zdravković A, Stojadinović T, Marić Đ, Baralić K, Antonijević B. Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:65-66.
https://hdl.handle.net/21.15107/rcub_farfar_5428 .

Stojilković, Nikola, Stojković, Miodrag, Ćurčić, Marijana, Vukelić, Dragana, Buha-Đorđević, Aleksandra, Stojanović, Aleksandra, Zdravković, Aleksandra, Stojadinović, Tina, Marić, Đurđica, Baralić, Katarina, Antonijević, Biljana, "Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):65-66,
https://hdl.handle.net/21.15107/rcub_farfar_5428 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5168
AB  - Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ...
AB  - Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19
T1  - In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease
SP  - 37
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5168
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ..., Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19, In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease",
pages = "37-38",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5168"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):37-38,
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5429
AB  - Sobzirom na to da su ljudi u svakodnevnom životu konstantno izloženi smešama hemikalija koje deluju
putem zajedničkih mehanizama, važno je proceniti da li su ovi „koktel efekti“ izraženiji u poređenju sa
dejstvom pojedinačnih hemikalija. ...
AB  - Due to the fact that in daily life humans are constantly exposed to mixtures of chemicals acting by
a common mechanism of action, it is important to assess whether these "cocktail effects" are more
pronounced compared to the effects of single chemicals. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova
T1  - Assessment of lead and polychlorinated biphenyls mixture toxic effects on redox status in rat kidneys
SP  - 67
EP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5429
ER  - 

@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Baralić, Katarina and Marić, Đurđica and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Sobzirom na to da su ljudi u svakodnevnom životu konstantno izloženi smešama hemikalija koje deluju
putem zajedničkih mehanizama, važno je proceniti da li su ovi „koktel efekti“ izraženiji u poređenju sa
dejstvom pojedinačnih hemikalija. ..., Due to the fact that in daily life humans are constantly exposed to mixtures of chemicals acting by
a common mechanism of action, it is important to assess whether these "cocktail effects" are more
pronounced compared to the effects of single chemicals. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova, Assessment of lead and polychlorinated biphenyls mixture toxic effects on redox status in rat kidneys",
pages = "67-68",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5429"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukelić, D., Baralić, K., Marić, Đ., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 67-68.
https://hdl.handle.net/21.15107/rcub_farfar_5429

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Vukelić D, Baralić K, Marić Đ, Đukić-Ćosić D, Bulat Z, Antonijević B. Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:67-68.
https://hdl.handle.net/21.15107/rcub_farfar_5429 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Baralić, Katarina, Marić, Đurđica, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):67-68,
https://hdl.handle.net/21.15107/rcub_farfar_5429 .

TY  - JOUR
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Mandić-Rajčević, Stefan
AU  - Žarković, Miloš
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5144
AB  - Introduction: Nickel (Ni) is one of the well-known toxic metals found in the environment. However, its influence on thyroid function is not explored enough. Hence, the aim of this study was to analyse the potential of Ni to disrupt thyroid function by exploring the relationship between blood Ni concentration and serum hormone levels (TSH, T4, T3, fT4 and fT3), as well as the parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) by using correlation analysis and Benchmark (BMD) concept. Methods: Ni concentration was measured by ICP-MS method, while CLIA was used for serum hormone determination. SPINA Thyr software was used to calculate SPINA-GT and SPINA-GD parameters. BMD analysis was performed by PROAST software (70.1). The limitations of this study are the small sample size and the uneven distribution of healthy and unhealthy subjects, limited confounding factors, as well as the age of the subjects that could have influenced the obtained results. Results and discussion: The highest median value for blood Ni concentration was observed for the male population and amounted 8,278 µg/L. Accordingly, the statistically significant correlation was observed only in the male population, for Ni-fT4 and Ni-SPINA-GT pairs. The existence of a dose-response relationship was established between Ni and all the measured parameters of thyroid functions in entire population and in both sexes. However, the narrowest BMD intervals were obtained only in men, for Ni - SPINA-GT pair (1.36-60.9 µg/L) and Ni - fT3 pair (0.397-66.8 µg/L), indicating that even 78.68 and 83.25% of men in our study might be in 10% higher risk of Ni-induced SPINA-GT and fT3 alterations, respectively. Due to the relationship established between Ni and the SPINA-GT parameter, it can be concluded that Ni has an influence on the secretory function of the thyroid gland in men. Although the further research is required, these findings suggest possible role of Ni in thyroid function disturbances. Copyright
PB  - Frontiers Media SA
T2  - Frontiers in Endocrinology
T1  - Nickel as a potential disruptor of thyroid function: benchmark modelling of human data
VL  - 14
DO  - 10.3389/fendo.2023.1145153
ER  - 

@article{
author = "Marić, Đurđica and Baralić, Katarina and Javorac, Dragana and Mandić-Rajčević, Stefan and Žarković, Miloš and Antonijević, Biljana and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Introduction: Nickel (Ni) is one of the well-known toxic metals found in the environment. However, its influence on thyroid function is not explored enough. Hence, the aim of this study was to analyse the potential of Ni to disrupt thyroid function by exploring the relationship between blood Ni concentration and serum hormone levels (TSH, T4, T3, fT4 and fT3), as well as the parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) by using correlation analysis and Benchmark (BMD) concept. Methods: Ni concentration was measured by ICP-MS method, while CLIA was used for serum hormone determination. SPINA Thyr software was used to calculate SPINA-GT and SPINA-GD parameters. BMD analysis was performed by PROAST software (70.1). The limitations of this study are the small sample size and the uneven distribution of healthy and unhealthy subjects, limited confounding factors, as well as the age of the subjects that could have influenced the obtained results. Results and discussion: The highest median value for blood Ni concentration was observed for the male population and amounted 8,278 µg/L. Accordingly, the statistically significant correlation was observed only in the male population, for Ni-fT4 and Ni-SPINA-GT pairs. The existence of a dose-response relationship was established between Ni and all the measured parameters of thyroid functions in entire population and in both sexes. However, the narrowest BMD intervals were obtained only in men, for Ni - SPINA-GT pair (1.36-60.9 µg/L) and Ni - fT3 pair (0.397-66.8 µg/L), indicating that even 78.68 and 83.25% of men in our study might be in 10% higher risk of Ni-induced SPINA-GT and fT3 alterations, respectively. Due to the relationship established between Ni and the SPINA-GT parameter, it can be concluded that Ni has an influence on the secretory function of the thyroid gland in men. Although the further research is required, these findings suggest possible role of Ni in thyroid function disturbances. Copyright",
publisher = "Frontiers Media SA",
journal = "Frontiers in Endocrinology",
title = "Nickel as a potential disruptor of thyroid function: benchmark modelling of human data",
volume = "14",
doi = "10.3389/fendo.2023.1145153"
}

Marić, Đ., Baralić, K., Javorac, D., Mandić-Rajčević, S., Žarković, M., Antonijević, B., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Nickel as a potential disruptor of thyroid function: benchmark modelling of human data. in Frontiers in Endocrinology
Frontiers Media SA., 14.
https://doi.org/10.3389/fendo.2023.1145153

Marić Đ, Baralić K, Javorac D, Mandić-Rajčević S, Žarković M, Antonijević B, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Nickel as a potential disruptor of thyroid function: benchmark modelling of human data. in Frontiers in Endocrinology. 2023;14.
doi:10.3389/fendo.2023.1145153 .

Marić, Đurđica, Baralić, Katarina, Javorac, Dragana, Mandić-Rajčević, Stefan, Žarković, Miloš, Antonijević, Biljana, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Nickel as a potential disruptor of thyroid function: benchmark modelling of human data" in Frontiers in Endocrinology, 14 (2023),
https://doi.org/10.3389/fendo.2023.1145153 . .

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Đukić-Ćosić, Danijela
AU  - Marić, Đurđica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5175
AB  - Considering that combined exposure to toxic metals and organic pollutants may induce various adverse effects on human health, it is important to elucidate the mechanisms of toxicity that occur after lowdose exposure to these chemicals in a real-life scenario. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats
VL  - 384
IS  - S1
SP  - S223
EP  - S223
DO  - 10.1016/S0378-4274(23)00790-7
ER  - 

@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Baralić, Katarina and Vukelić, Dragana and Đukić-Ćosić, Danijela and Marić, Đurđica and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Considering that combined exposure to toxic metals and organic pollutants may induce various adverse effects on human health, it is important to elucidate the mechanisms of toxicity that occur after lowdose exposure to these chemicals in a real-life scenario. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats",
volume = "384",
number = "S1",
pages = "S223-S223",
doi = "10.1016/S0378-4274(23)00790-7"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Baralić, K., Vukelić, D., Đukić-Ćosić, D., Marić, Đ., Bulat, Z.,& Antonijević, B.. (2023). Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats. in Toxicology Letters
Elsevier., 384(S1), S223-S223.
https://doi.org/10.1016/S0378-4274(23)00790-7

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Baralić K, Vukelić D, Đukić-Ćosić D, Marić Đ, Bulat Z, Antonijević B. Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats. in Toxicology Letters. 2023;384(S1):S223-S223.
doi:10.1016/S0378-4274(23)00790-7 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Baralić, Katarina, Vukelić, Dragana, Đukić-Ćosić, Danijela, Marić, Đurđica, Bulat, Zorica, Antonijević, Biljana, "Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats" in Toxicology Letters, 384, no. S1 (2023):S223-S223,
https://doi.org/10.1016/S0378-4274(23)00790-7 . .

TY  - CONF
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5174
AB  - Toxic metal(oid)s are being frequently referred to as endocrine-disrupting chemicals (EDCs), and as they are prevalent in nature, they may be linked to the current reproductive issues confronting the female population. [1,2]  ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data
VL  - 384
IS  - S1
SP  - S145
EP  - S145
DO  - 10.1016/S0378-4274(23)00609-4
ER  - 

@conference{
author = "Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Antonijević, Biljana and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Toxic metal(oid)s are being frequently referred to as endocrine-disrupting chemicals (EDCs), and as they are prevalent in nature, they may be linked to the current reproductive issues confronting the female population. [1,2]  ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data",
volume = "384",
number = "S1",
pages = "S145-S145",
doi = "10.1016/S0378-4274(23)00609-4"
}

Baralić, K., Vukelić, D., Marić, Đ., Antonijević, B., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data. in Toxicology Letters
Elsevier., 384(S1), S145-S145.
https://doi.org/10.1016/S0378-4274(23)00609-4

Baralić K, Vukelić D, Marić Đ, Antonijević B, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data. in Toxicology Letters. 2023;384(S1):S145-S145.
doi:10.1016/S0378-4274(23)00609-4 .

Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Antonijević, Biljana, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data" in Toxicology Letters, 384, no. S1 (2023):S145-S145,
https://doi.org/10.1016/S0378-4274(23)00609-4 . .

TY  - CONF
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5173
AB  - Infertility and other reproductive health issues have emerged as one of the world’s foremost challenges in recent decades. Globally, around 15% of couples suffer from infertility, and male partners are shown to be responsible for about 20–30% of infertility cases. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - The effect of real-life toxic metal(oid)s mixture on the redox status in testicular tissues of rats
VL  - 384
IS  - S1
SP  - S144
EP  - S144
DO  - 10.1016/S0378-4274(23)00607-0
ER  - 

@conference{
author = "Marić, Đurđica and Baralić, Katarina and Vukelić, Dragana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Infertility and other reproductive health issues have emerged as one of the world’s foremost challenges in recent decades. Globally, around 15% of couples suffer from infertility, and male partners are shown to be responsible for about 20–30% of infertility cases. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "The effect of real-life toxic metal(oid)s mixture on the redox status in testicular tissues of rats",
volume = "384",
number = "S1",
pages = "S144-S144",
doi = "10.1016/S0378-4274(23)00607-0"
}

Marić, Đ., Baralić, K., Vukelić, D., Đukić-Ćosić, D., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2023). The effect of real-life toxic metal(oid)s mixture on the redox status in testicular tissues of rats. in Toxicology Letters
Elsevier., 384(S1), S144-S144.
https://doi.org/10.1016/S0378-4274(23)00607-0

Marić Đ, Baralić K, Vukelić D, Đukić-Ćosić D, Bulat Z, Antonijević B, Buha-Đorđević A. The effect of real-life toxic metal(oid)s mixture on the redox status in testicular tissues of rats. in Toxicology Letters. 2023;384(S1):S144-S144.
doi:10.1016/S0378-4274(23)00607-0 .

Marić, Đurđica, Baralić, Katarina, Vukelić, Dragana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "The effect of real-life toxic metal(oid)s mixture on the redox status in testicular tissues of rats" in Toxicology Letters, 384, no. S1 (2023):S144-S144,
https://doi.org/10.1016/S0378-4274(23)00607-0 . .

TY  - CONF
AU  - Živanović, Jovana
AU  - Šljivić, Jovana
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5171
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation
VL  - 384
IS  - S1
SP  - S114
EP  - S114
DO  - 10.1016/S0378-4274(23)00534-9
ER  - 

@conference{
author = "Živanović, Jovana and Šljivić, Jovana and Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation",
volume = "384",
number = "S1",
pages = "S114-S114",
doi = "10.1016/S0378-4274(23)00534-9"
}

Živanović, J., Šljivić, J., Božić, D., Baralić, K., Živančević, K., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation. in Toxicology Letters
Elsevier., 384(S1), S114-S114.
https://doi.org/10.1016/S0378-4274(23)00534-9

Živanović J, Šljivić J, Božić D, Baralić K, Živančević K, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation. in Toxicology Letters. 2023;384(S1):S114-S114.
doi:10.1016/S0378-4274(23)00534-9 .

Živanović, Jovana, Šljivić, Jovana, Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation" in Toxicology Letters, 384, no. S1 (2023):S114-S114,
https://doi.org/10.1016/S0378-4274(23)00534-9 . .

TY  - JOUR
AU  - Stojilković, Nikola
AU  - Radović, Biljana
AU  - Vukelić, Dragana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5142
AB  - Toxicological research is mostly limited to considering the effects of a single substance, even though the real exposure of people is reflected in their daily exposure to many different chemical substances in low-doses. This in silico toxicogenomic study aims to provide evidence for the selected environmental (organo)metals (lead, cadmium, methyl mercury) + polychlorinated biphenyls mixture involvement in the possible alteration of thyroid, and male reproductive system function, and furthermore to predict the possible toxic mechanisms of the environmental cocktail. The Comparative Toxicogenomic Database, GeneMANIA online software, and ToppGene Suite portal were used as the main tools for toxicogenomic data mining and gene ontology analysis. The results show that 35 annotated common genes between selected chemicals and endocrine system diseases can interact on the co-expression level. Our study highlighted the disruption of the cytokines, the cell's response to oxidative stress, and the influence of the transcription factors as the potential core of toxicological mechanisms of the discussed mixture's effects. The connected toxicological effects of the tested mixture were abnormal sperm cells, a disrupted level of testosterone, and thyroid hormones. The core mechanisms of these effects were inflammation, oxidative stress, disruption of androgen receptor signaling, and the alteration of the FOXO3-Keap-1/NRF2-HMOX1-NQO1 pathway signaling most likely controlled by the co-expression of overlapped genes among used chemicals. This in silico research can be used as a potential core for the determination of biomarkers that can be monitored in future further in vitro and in vivo experiments.
PB  - Elsevier
T2  - Environmental Research
T1  - Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining
DO  - 10.1016/j.envres.2023.117274
ER  - 

@article{
author = "Stojilković, Nikola and Radović, Biljana and Vukelić, Dragana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Baralić, Katarina and Marić, Đurđica and Bulat, Zorica and Đukić-Ćosić, Danijela and Antonijević, Biljana",
year = "2023",
abstract = "Toxicological research is mostly limited to considering the effects of a single substance, even though the real exposure of people is reflected in their daily exposure to many different chemical substances in low-doses. This in silico toxicogenomic study aims to provide evidence for the selected environmental (organo)metals (lead, cadmium, methyl mercury) + polychlorinated biphenyls mixture involvement in the possible alteration of thyroid, and male reproductive system function, and furthermore to predict the possible toxic mechanisms of the environmental cocktail. The Comparative Toxicogenomic Database, GeneMANIA online software, and ToppGene Suite portal were used as the main tools for toxicogenomic data mining and gene ontology analysis. The results show that 35 annotated common genes between selected chemicals and endocrine system diseases can interact on the co-expression level. Our study highlighted the disruption of the cytokines, the cell's response to oxidative stress, and the influence of the transcription factors as the potential core of toxicological mechanisms of the discussed mixture's effects. The connected toxicological effects of the tested mixture were abnormal sperm cells, a disrupted level of testosterone, and thyroid hormones. The core mechanisms of these effects were inflammation, oxidative stress, disruption of androgen receptor signaling, and the alteration of the FOXO3-Keap-1/NRF2-HMOX1-NQO1 pathway signaling most likely controlled by the co-expression of overlapped genes among used chemicals. This in silico research can be used as a potential core for the determination of biomarkers that can be monitored in future further in vitro and in vivo experiments.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining",
doi = "10.1016/j.envres.2023.117274"
}

Stojilković, N., Radović, B., Vukelić, D., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Baralić, K., Marić, Đ., Bulat, Z., Đukić-Ćosić, D.,& Antonijević, B.. (2023). Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining. in Environmental Research
Elsevier..
https://doi.org/10.1016/j.envres.2023.117274

Stojilković N, Radović B, Vukelić D, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Baralić K, Marić Đ, Bulat Z, Đukić-Ćosić D, Antonijević B. Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining. in Environmental Research. 2023;.
doi:10.1016/j.envres.2023.117274 .

Stojilković, Nikola, Radović, Biljana, Vukelić, Dragana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Baralić, Katarina, Marić, Đurđica, Bulat, Zorica, Đukić-Ćosić, Danijela, Antonijević, Biljana, "Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining" in Environmental Research (2023),
https://doi.org/10.1016/j.envres.2023.117274 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Anđelković, Milena
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4915
AB  - The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats after the 28- and 90-day exposure to dose levels calculated on the basis of the previously conducted human study. Experimental groups included: 2 controls (28- and 90-day), treated groups - doses based on: median– F2 (28) and F2(90) and 95th percentile concentrations in the general human population – F3(28) and F3(90); calculated lower Benchmark dose confidence limit (BMDL) for effects on hormone levels – F1(28) and F1(90) and a group given the doses calculated on the basis of the reference values from the literature (F4(28)). Blood and ovarian samples were collected for sex hormones and ovary redox status analysis. After 28-day exposure, changes were present both in prooxidants and antioxidants. However, after the 90-day exposure redox status imbalance was majorly caused by the disturbance of antioxidants. Changes in some parameters were observed even after exposure to the lowest doses. After 28-day exposure, the strongest dose-response relationship was found between hormones: LH and FSH and toxic metal(oid)s and, after 90-day exposure, between investigated redox status parameters: sulfhydryl groups, ischemia-modified albumin and nuclear factor erythroid 2–related factor 2 (Nrf2) and toxic metal(oid)s. Low obtained BMDLs and narrow Benchmark intervals for toxic metal(oid)s and some of the parameters might confirm the “no-threshold” paradigm. This study indicates possible detrimental effects of prolonged exposure to real-life mixtures of toxic metal(oid) on female reproductive function.
PB  - Elsevier B.V.
T2  - Science of the Total Environment
T1  - Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different
VL  - 895
DO  - 10.1016/j.scitotenv.2023.165181
ER  - 

@article{
author = "Baralić, Katarina and Marić, Đurđica and Vukelić, Dragana and Antonijević-Miljaković, Evica and Anđelković, Milena and Antonijević, Biljana and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats after the 28- and 90-day exposure to dose levels calculated on the basis of the previously conducted human study. Experimental groups included: 2 controls (28- and 90-day), treated groups - doses based on: median– F2 (28) and F2(90) and 95th percentile concentrations in the general human population – F3(28) and F3(90); calculated lower Benchmark dose confidence limit (BMDL) for effects on hormone levels – F1(28) and F1(90) and a group given the doses calculated on the basis of the reference values from the literature (F4(28)). Blood and ovarian samples were collected for sex hormones and ovary redox status analysis. After 28-day exposure, changes were present both in prooxidants and antioxidants. However, after the 90-day exposure redox status imbalance was majorly caused by the disturbance of antioxidants. Changes in some parameters were observed even after exposure to the lowest doses. After 28-day exposure, the strongest dose-response relationship was found between hormones: LH and FSH and toxic metal(oid)s and, after 90-day exposure, between investigated redox status parameters: sulfhydryl groups, ischemia-modified albumin and nuclear factor erythroid 2–related factor 2 (Nrf2) and toxic metal(oid)s. Low obtained BMDLs and narrow Benchmark intervals for toxic metal(oid)s and some of the parameters might confirm the “no-threshold” paradigm. This study indicates possible detrimental effects of prolonged exposure to real-life mixtures of toxic metal(oid) on female reproductive function.",
publisher = "Elsevier B.V.",
journal = "Science of the Total Environment",
title = "Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different",
volume = "895",
doi = "10.1016/j.scitotenv.2023.165181"
}

Baralić, K., Marić, Đ., Vukelić, D., Antonijević-Miljaković, E., Anđelković, M., Antonijević, B., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different. in Science of the Total Environment
Elsevier B.V.., 895.
https://doi.org/10.1016/j.scitotenv.2023.165181

Baralić K, Marić Đ, Vukelić D, Antonijević-Miljaković E, Anđelković M, Antonijević B, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different. in Science of the Total Environment. 2023;895.
doi:10.1016/j.scitotenv.2023.165181 .

Baralić, Katarina, Marić, Đurđica, Vukelić, Dragana, Antonijević-Miljaković, Evica, Anđelković, Milena, Antonijević, Biljana, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different" in Science of the Total Environment, 895 (2023),
https://doi.org/10.1016/j.scitotenv.2023.165181 . .