TY  - JOUR
AU  - Medarević, Đorđe
AU  - Čežek, Maša
AU  - Knežević, Aleksandar
AU  - Turković, Erna
AU  - Barudžija, Tanja
AU  - Samardžić, Stevan
AU  - Maksimović, Zoran
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5733
AB  - A lack of strategies for the utilization of harvest residues (HRs) has led to serious environmental problems due to an accumulation of these residues or their burning in the field. In this study, wheat and corn HRs were used as feedstock for the production of microcrystalline cellulose (MCC) by treatment with 2–8% sodium hydroxide, 10% hydrogen peroxide and further hydrolysis with 1–2 M hydrochloric acid. The changes in the FT-IR spectra and PXRD diffractograms after chemical treatment confirmed the removal of most of the lignin, hemicellulose and amorphous fraction of cellulose. A higher degree of crystallinity was observed for MCC obtained from corn HRs, which was attributed to a more efficient removal of lignin and hemicellulose by a higher sodium hydroxide concentration, which facilitates the dissolution of amorphous cellulose during acid hydrolysis. MCC obtained from HRs exhibited lower bulk density and poorer flow properties but similar or better tableting properties compared to commercial MCC (CeolusTM PH101). The lower ejection and detachment stress suggests that MCC isolated from HRs requires less lubricant compared to commercial MCC. This study showed that MCC isolated from wheat and corn HRs exhibits comparable tableting behaviour like commercial sample, further supporting this type of agricultural waste utilization.
PB  - MDPI
T2  - Pharmaceutics
T1  - From Field to Pharmacy: Isolation, Characterization and Tableting Behaviour of Microcrystalline Cellulose from Wheat and Corn Harvest Residues
VL  - 16
IS  - 8
SP  - 1090
DO  - 10.3390/pharmaceutics16081090
ER  - 

@article{
author = "Medarević, Đorđe and Čežek, Maša and Knežević, Aleksandar and Turković, Erna and Barudžija, Tanja and Samardžić, Stevan and Maksimović, Zoran",
year = "2024",
abstract = "A lack of strategies for the utilization of harvest residues (HRs) has led to serious environmental problems due to an accumulation of these residues or their burning in the field. In this study, wheat and corn HRs were used as feedstock for the production of microcrystalline cellulose (MCC) by treatment with 2–8% sodium hydroxide, 10% hydrogen peroxide and further hydrolysis with 1–2 M hydrochloric acid. The changes in the FT-IR spectra and PXRD diffractograms after chemical treatment confirmed the removal of most of the lignin, hemicellulose and amorphous fraction of cellulose. A higher degree of crystallinity was observed for MCC obtained from corn HRs, which was attributed to a more efficient removal of lignin and hemicellulose by a higher sodium hydroxide concentration, which facilitates the dissolution of amorphous cellulose during acid hydrolysis. MCC obtained from HRs exhibited lower bulk density and poorer flow properties but similar or better tableting properties compared to commercial MCC (CeolusTM PH101). The lower ejection and detachment stress suggests that MCC isolated from HRs requires less lubricant compared to commercial MCC. This study showed that MCC isolated from wheat and corn HRs exhibits comparable tableting behaviour like commercial sample, further supporting this type of agricultural waste utilization.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "From Field to Pharmacy: Isolation, Characterization and Tableting Behaviour of Microcrystalline Cellulose from Wheat and Corn Harvest Residues",
volume = "16",
number = "8",
pages = "1090",
doi = "10.3390/pharmaceutics16081090"
}

Medarević, Đ., Čežek, M., Knežević, A., Turković, E., Barudžija, T., Samardžić, S.,& Maksimović, Z.. (2024). From Field to Pharmacy: Isolation, Characterization and Tableting Behaviour of Microcrystalline Cellulose from Wheat and Corn Harvest Residues. in Pharmaceutics
MDPI., 16(8), 1090.
https://doi.org/10.3390/pharmaceutics16081090

Medarević Đ, Čežek M, Knežević A, Turković E, Barudžija T, Samardžić S, Maksimović Z. From Field to Pharmacy: Isolation, Characterization and Tableting Behaviour of Microcrystalline Cellulose from Wheat and Corn Harvest Residues. in Pharmaceutics. 2024;16(8):1090.
doi:10.3390/pharmaceutics16081090 .

Medarević, Đorđe, Čežek, Maša, Knežević, Aleksandar, Turković, Erna, Barudžija, Tanja, Samardžić, Stevan, Maksimović, Zoran, "From Field to Pharmacy: Isolation, Characterization and Tableting Behaviour of Microcrystalline Cellulose from Wheat and Corn Harvest Residues" in Pharmaceutics, 16, no. 8 (2024):1090,
https://doi.org/10.3390/pharmaceutics16081090 . .

TY  - CONF
AU  - Medarević, Đorđe
AU  - Turković, Erna
AU  - Čežek, Maša
AU  - Ibrić, Svetlana
AU  - Maksimović, Zoran
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5606
AB  - INTRODUCTION
Crop residues (CRs) represent a resource that is available in
virtually unlimited quantities, but still the largest part
remains unused. Unfortunately, CRs are usually burned in
the field, which causes air pollution, contributes to global
warming by emitting greenhouse gasses, hinders nutrient
recycling, and negatively affects soil microbes through
overheating and carbon loss [1]. One of the most important
value-added components that can be isolated from CRs is
microcrystalline cellulose (MCC), a common excipient in
tablet formulation. In this study, a comparative evaluation
of tableting properties of MCC obtained from wheat and
corn CRs by different chemical treatment was performed. ...
PB  - International Association for Pharmaceutical Technology (APV), Mainz, Germany
PB  - International Society of Drug Delivery Sciences and Technology (APGI), Lille, France
PB  - Italian Society of Technology and Legislation (S.I.T.E.L.F), Milan, Italy
C3  - 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria
T1  - Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5606
ER  - 

@conference{
author = "Medarević, Đorđe and Turković, Erna and Čežek, Maša and Ibrić, Svetlana and Maksimović, Zoran",
year = "2024",
abstract = "INTRODUCTION
Crop residues (CRs) represent a resource that is available in
virtually unlimited quantities, but still the largest part
remains unused. Unfortunately, CRs are usually burned in
the field, which causes air pollution, contributes to global
warming by emitting greenhouse gasses, hinders nutrient
recycling, and negatively affects soil microbes through
overheating and carbon loss [1]. One of the most important
value-added components that can be isolated from CRs is
microcrystalline cellulose (MCC), a common excipient in
tablet formulation. In this study, a comparative evaluation
of tableting properties of MCC obtained from wheat and
corn CRs by different chemical treatment was performed. ...",
publisher = "International Association for Pharmaceutical Technology (APV), Mainz, Germany, International Society of Drug Delivery Sciences and Technology (APGI), Lille, France, Italian Society of Technology and Legislation (S.I.T.E.L.F), Milan, Italy",
journal = "14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria",
title = "Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5606"
}

Medarević, Đ., Turković, E., Čežek, M., Ibrić, S.,& Maksimović, Z.. (2024). Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues. in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria
International Association for Pharmaceutical Technology (APV), Mainz, Germany..
https://hdl.handle.net/21.15107/rcub_farfar_5606

Medarević Đ, Turković E, Čežek M, Ibrić S, Maksimović Z. Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues. in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria. 2024;.
https://hdl.handle.net/21.15107/rcub_farfar_5606 .

Medarević, Đorđe, Turković, Erna, Čežek, Maša, Ibrić, Svetlana, Maksimović, Zoran, "Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues" in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria (2024),
https://hdl.handle.net/21.15107/rcub_farfar_5606 .

TY  - CONF
AU  - Medarević, Đorđe
AU  - Čežek, Maša
AU  - Knežević, Aleksandar
AU  - Pešić, Nikola
AU  - Ibrić, Svetlana
AU  - Maksimović, Zoran
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5070
AB  - Crop residues (CR) are usually burned in the field,
which causes air pollution, contributes to global warming,
hinders nutrient recycling, and negatively affects soil
microbes through overheating and carbon loss. There is
growing interest in developing processes for isolation of
value added components with application in different
industries from CR as feedstock. In this study, different
procedures for isolation of microcrystalline cellulose
(MCC) from wheat, corn and sunflower CR were
evaluated, with further testing of functional characteristics
of MCC, which are relevant for tablets production.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - Functional characterization of microcrystalline cellulose obtained from the crop residues
VL  - 69
IS  - Suppl 1
SP  - 185
EP  - 186
DO  - 10.33320/maced.pharm.bull.2023.69.03.091
ER  - 

@conference{
author = "Medarević, Đorđe and Čežek, Maša and Knežević, Aleksandar and Pešić, Nikola and Ibrić, Svetlana and Maksimović, Zoran",
year = "2023",
abstract = "Crop residues (CR) are usually burned in the field,
which causes air pollution, contributes to global warming,
hinders nutrient recycling, and negatively affects soil
microbes through overheating and carbon loss. There is
growing interest in developing processes for isolation of
value added components with application in different
industries from CR as feedstock. In this study, different
procedures for isolation of microcrystalline cellulose
(MCC) from wheat, corn and sunflower CR were
evaluated, with further testing of functional characteristics
of MCC, which are relevant for tablets production.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Functional characterization of microcrystalline cellulose obtained from the crop residues",
volume = "69",
number = "Suppl 1",
pages = "185-186",
doi = "10.33320/maced.pharm.bull.2023.69.03.091"
}

Medarević, Đ., Čežek, M., Knežević, A., Pešić, N., Ibrić, S.,& Maksimović, Z.. (2023). Functional characterization of microcrystalline cellulose obtained from the crop residues. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 185-186.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.091

Medarević Đ, Čežek M, Knežević A, Pešić N, Ibrić S, Maksimović Z. Functional characterization of microcrystalline cellulose obtained from the crop residues. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):185-186.
doi:10.33320/maced.pharm.bull.2023.69.03.091 .

Medarević, Đorđe, Čežek, Maša, Knežević, Aleksandar, Pešić, Nikola, Ibrić, Svetlana, Maksimović, Zoran, "Functional characterization of microcrystalline cellulose obtained from the crop residues" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):185-186,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.091 . .

TY  - CONF
AU  - Čežek, Maša
AU  - Nikić, Sonja
AU  - Neškov, Lea
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4780
AB  - Због своје лаке доступности, ниске цене и недовољне искоришћености, жетвени остаци представљају атрактивну сировину за добијање микрокристалне целулозе (MCC), најчешће коришћеног ексципијенса у формулацији таблета.
AB  - Due to its easy availability and underutilization, crop residues are attractive raw material for obtaining microcrystalline cellulose (MCC), the most commonly used tablet excipient.
T1  - Карактеризација микрокристалне целулозе добијене из жетвених остатака
T1  - Characterization of microcrystalline cellulose obtained from harvest residues
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4780
ER  - 

@conference{
author = "Čežek, Maša and Nikić, Sonja and Neškov, Lea",
year = "2023",
abstract = "Због своје лаке доступности, ниске цене и недовољне искоришћености, жетвени остаци представљају атрактивну сировину за добијање микрокристалне целулозе (MCC), најчешће коришћеног ексципијенса у формулацији таблета., Due to its easy availability and underutilization, crop residues are attractive raw material for obtaining microcrystalline cellulose (MCC), the most commonly used tablet excipient.",
title = "Карактеризација микрокристалне целулозе добијене из жетвених остатака, Characterization of microcrystalline cellulose obtained from harvest residues",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4780"
}

Čežek, M., Nikić, S.,& Neškov, L.. (2023). Карактеризација микрокристалне целулозе добијене из жетвених остатака. .
https://hdl.handle.net/21.15107/rcub_farfar_4780

Čežek M, Nikić S, Neškov L. Карактеризација микрокристалне целулозе добијене из жетвених остатака. 2023;.
https://hdl.handle.net/21.15107/rcub_farfar_4780 .

Čežek, Maša, Nikić, Sonja, Neškov, Lea, "Карактеризација микрокристалне целулозе добијене из жетвених остатака" (2023),
https://hdl.handle.net/21.15107/rcub_farfar_4780 .