TY  - JOUR
AU  - Perović-Blagojević, Iva
AU  - Eror, Tatjana
AU  - Pelivanović, Jovana
AU  - Jelić, Svetlana
AU  - Kotur-Stevuljević, Jelena
AU  - Ignjatović, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2987
AB  - Background: Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk. Methods: Fifty-four young women with PCOS (22 obese and 32 normal weight) were compared to 46 respective controls (17 obese and 29 normal weight). Anthropometric parameters, lipid status parameters, inflammation markers, concentrations of glucose, transaminases, sex and anterior pituitary hormones, sex hormone binding globulin (SHBG) and androgens were measured. Cardiovascular Risk Score (CVRS), indices for identifying Non-Alcoholic Fatty Liver Disease (NAFLD) and the Index of Central Obesity (ICO) were calculated. Results: Significantly higher CVRS values (p lt  0.05) were found in obese PCOS women compared to normal weight control and normal weight PCOS groups. Anthropometric parameters, lipid status parameters and fibrinogen (p lt  0.001, p lt  0.01) were higher in women with higher CVRS. The most significant CVRS predictors in all PCOS women were SHBG, androstenedione, follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulphate (DHEAS). ICO and all NAFLD indices exhibited significant positive correlation with CVRS and a model consisting of these indices provided good diagnostic accuracy (AUC> 0.8) in identifying patients with increased cardiovascular risk (CVR). Conclusions: Obesity is a higher risk for developing CVD than PCOS alone. Anthropometric parameters, lipid parameters, fibrinogen, NAFLD indices and ICO increase CVR in PCOS women. For the prediction of CVR in PCOS, we suggest a combination of NAFLD indices and ICO.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Women with Polycystic Ovary Syndrome and Risk of Cardiovascular Disease
VL  - 36
IS  - 3
SP  - 259
EP  - 269
DO  - 10.1515/jomb-2017-0020
ER  - 

@article{
author = "Perović-Blagojević, Iva and Eror, Tatjana and Pelivanović, Jovana and Jelić, Svetlana and Kotur-Stevuljević, Jelena and Ignjatović, Svetlana",
year = "2017",
abstract = "Background: Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk. Methods: Fifty-four young women with PCOS (22 obese and 32 normal weight) were compared to 46 respective controls (17 obese and 29 normal weight). Anthropometric parameters, lipid status parameters, inflammation markers, concentrations of glucose, transaminases, sex and anterior pituitary hormones, sex hormone binding globulin (SHBG) and androgens were measured. Cardiovascular Risk Score (CVRS), indices for identifying Non-Alcoholic Fatty Liver Disease (NAFLD) and the Index of Central Obesity (ICO) were calculated. Results: Significantly higher CVRS values (p lt  0.05) were found in obese PCOS women compared to normal weight control and normal weight PCOS groups. Anthropometric parameters, lipid status parameters and fibrinogen (p lt  0.001, p lt  0.01) were higher in women with higher CVRS. The most significant CVRS predictors in all PCOS women were SHBG, androstenedione, follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulphate (DHEAS). ICO and all NAFLD indices exhibited significant positive correlation with CVRS and a model consisting of these indices provided good diagnostic accuracy (AUC> 0.8) in identifying patients with increased cardiovascular risk (CVR). Conclusions: Obesity is a higher risk for developing CVD than PCOS alone. Anthropometric parameters, lipid parameters, fibrinogen, NAFLD indices and ICO increase CVR in PCOS women. For the prediction of CVR in PCOS, we suggest a combination of NAFLD indices and ICO.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Women with Polycystic Ovary Syndrome and Risk of Cardiovascular Disease",
volume = "36",
number = "3",
pages = "259-269",
doi = "10.1515/jomb-2017-0020"
}

Perović-Blagojević, I., Eror, T., Pelivanović, J., Jelić, S., Kotur-Stevuljević, J.,& Ignjatović, S.. (2017). Women with Polycystic Ovary Syndrome and Risk of Cardiovascular Disease. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(3), 259-269.
https://doi.org/10.1515/jomb-2017-0020

Perović-Blagojević I, Eror T, Pelivanović J, Jelić S, Kotur-Stevuljević J, Ignjatović S. Women with Polycystic Ovary Syndrome and Risk of Cardiovascular Disease. in Journal of Medical Biochemistry. 2017;36(3):259-269.
doi:10.1515/jomb-2017-0020 .

Perović-Blagojević, Iva, Eror, Tatjana, Pelivanović, Jovana, Jelić, Svetlana, Kotur-Stevuljević, Jelena, Ignjatović, Svetlana, "Women with Polycystic Ovary Syndrome and Risk of Cardiovascular Disease" in Journal of Medical Biochemistry, 36, no. 3 (2017):259-269,
https://doi.org/10.1515/jomb-2017-0020 . .