TY  - JOUR
AU  - Đurđević, Predrag
AU  - Jakovljević, Ivan
AU  - Joksović, Ljubinka
AU  - Ivanović, Nevena
AU  - Jelikić-Stankov, Milena
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2104
AB  - The speciation of Cu2+, Ni2+ and Zn2+ ions in the presence of the fluoroquinolones (FQs) moxifloxacin, ofloxacin, levofloxacin and ciprofloxacin, in human blood plasma was studied under physiological conditions by computer simulation. The speciation was calculated using an updated model of human blood plasma including over 6,000 species with the aid of the program Hyss2009. The identity and stability of metal-FQ complexes were determined by potentiometric (310 K, 0.15 mol/L NaCl), spectrophotometric, spectrofluorimetric, ESI-MS and H-1-NMR measurements. In the case of Cu2+ ion the concentration of main low molecular weight (LMW) plasma complex (Cu(Cis) His) is very slightly influenced by all examined FQs. FQs show much higher influence on main plasma Ni2+ and Zn2+ complexes: (Ni(His)(2) and Zn(Cys) Cit, respectively. Levofloxacin exhibits the highest influence on the fraction of the main nickel complex, Ni(His)(2), even at a concentration level of 3 x 10(-5) mol/L. The same effect is seen on the main zinc complex, Zn(Cys) Cit. Calculated plasma mobilizing indexes indicate that ciprofloxacin possesses the highest mobilizing power from plasma proteins, toward copper ion, while levofloxacin is the most influential on nickel and zinc ions. The results obtained indicate that the drugs studied are safe in relation to mobilization of essential metal ions under physiological conditions. The observed effects were explained in terms of competitive equilibrium reactions between the FQs and the main LMW complexes of the metal ions.
PB  - MDPI, Basel
T2  - Molecules
T1  - The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma
VL  - 19
IS  - 8
SP  - 12194
EP  - 12223
DO  - 10.3390/molecules190812194
ER  - 

@article{
author = "Đurđević, Predrag and Jakovljević, Ivan and Joksović, Ljubinka and Ivanović, Nevena and Jelikić-Stankov, Milena",
year = "2014",
abstract = "The speciation of Cu2+, Ni2+ and Zn2+ ions in the presence of the fluoroquinolones (FQs) moxifloxacin, ofloxacin, levofloxacin and ciprofloxacin, in human blood plasma was studied under physiological conditions by computer simulation. The speciation was calculated using an updated model of human blood plasma including over 6,000 species with the aid of the program Hyss2009. The identity and stability of metal-FQ complexes were determined by potentiometric (310 K, 0.15 mol/L NaCl), spectrophotometric, spectrofluorimetric, ESI-MS and H-1-NMR measurements. In the case of Cu2+ ion the concentration of main low molecular weight (LMW) plasma complex (Cu(Cis) His) is very slightly influenced by all examined FQs. FQs show much higher influence on main plasma Ni2+ and Zn2+ complexes: (Ni(His)(2) and Zn(Cys) Cit, respectively. Levofloxacin exhibits the highest influence on the fraction of the main nickel complex, Ni(His)(2), even at a concentration level of 3 x 10(-5) mol/L. The same effect is seen on the main zinc complex, Zn(Cys) Cit. Calculated plasma mobilizing indexes indicate that ciprofloxacin possesses the highest mobilizing power from plasma proteins, toward copper ion, while levofloxacin is the most influential on nickel and zinc ions. The results obtained indicate that the drugs studied are safe in relation to mobilization of essential metal ions under physiological conditions. The observed effects were explained in terms of competitive equilibrium reactions between the FQs and the main LMW complexes of the metal ions.",
publisher = "MDPI, Basel",
journal = "Molecules",
title = "The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma",
volume = "19",
number = "8",
pages = "12194-12223",
doi = "10.3390/molecules190812194"
}

Đurđević, P., Jakovljević, I., Joksović, L., Ivanović, N.,& Jelikić-Stankov, M.. (2014). The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma. in Molecules
MDPI, Basel., 19(8), 12194-12223.
https://doi.org/10.3390/molecules190812194

Đurđević P, Jakovljević I, Joksović L, Ivanović N, Jelikić-Stankov M. The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma. in Molecules. 2014;19(8):12194-12223.
doi:10.3390/molecules190812194 .

Đurđević, Predrag, Jakovljević, Ivan, Joksović, Ljubinka, Ivanović, Nevena, Jelikić-Stankov, Milena, "The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma" in Molecules, 19, no. 8 (2014):12194-12223,
https://doi.org/10.3390/molecules190812194 . .

TY  - JOUR
AU  - Ćirić, Andrija
AU  - Ivanović, Nevena
AU  - Cvijović, Milica S.
AU  - Jelikić-Stankov, Milena
AU  - Joksović, Ljubinka
AU  - Đurđević, Predrag
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2216
AB  - In the present work, the rapid RP-HPLC method with UV (DAD) detection for simultaneous quantification of bioflavonoids: quercetin, apigenin, catechin, epicatechin, kaempferol, and luteolin in Brassica oleracea species samples (cauliflower, broccoli, and Brussels sprouts) was developed with the aid of LC-Simulator (ACD LabsA (R) suite) software. A series of extracts obtained with different extraction method were evaluated for antioxidant activity. The optimal conditions for separation and quantification were established after nine scouting runs entered to LC-Simulator software. The optimized separation was achieved on Hypersil GOLD aQ column with isocratic elution and mobile phase composition A:2 % acetic acid in water and B:acetonitrile in 91:9 (v/v %) ratio. The R (s) values were in the range from 2.6 to 8.00, indicating good selectivity of the method. The obtained results generally show good agreement with published data. Low detection limits (0.02-0.055 mu g/mL) were obtained with acceptable recoveries (90-109 %). Total time of analysis was less than 11 min; therefore, the proposed method represents significant improvement over existing methods. Extracts from Brassica vegetables, obtained using different extraction procedures, were studied for their radical scavenging effects. Scavenging of DPPH showed different kinetics at the beginning of the assay period and after 15 min from the initialization of reaction. Different kinetics suggested the presence of polymerized and/or less active antioxidants with different scavenging mechanisms for particular polyphenolic compounds.
PB  - Springer, New York
T2  - Food Analytical Methods
T1  - Chemometric-Assisted Optimization of RP-HPLC Method for Determination of Some Bioflavonoids in Brassica oleracea Species and Their Antioxidative Activity
VL  - 7
IS  - 7
SP  - 1387
EP  - 1399
DO  - 10.1007/s12161-013-9761-y
ER  - 

@article{
author = "Ćirić, Andrija and Ivanović, Nevena and Cvijović, Milica S. and Jelikić-Stankov, Milena and Joksović, Ljubinka and Đurđević, Predrag",
year = "2014",
abstract = "In the present work, the rapid RP-HPLC method with UV (DAD) detection for simultaneous quantification of bioflavonoids: quercetin, apigenin, catechin, epicatechin, kaempferol, and luteolin in Brassica oleracea species samples (cauliflower, broccoli, and Brussels sprouts) was developed with the aid of LC-Simulator (ACD LabsA (R) suite) software. A series of extracts obtained with different extraction method were evaluated for antioxidant activity. The optimal conditions for separation and quantification were established after nine scouting runs entered to LC-Simulator software. The optimized separation was achieved on Hypersil GOLD aQ column with isocratic elution and mobile phase composition A:2 % acetic acid in water and B:acetonitrile in 91:9 (v/v %) ratio. The R (s) values were in the range from 2.6 to 8.00, indicating good selectivity of the method. The obtained results generally show good agreement with published data. Low detection limits (0.02-0.055 mu g/mL) were obtained with acceptable recoveries (90-109 %). Total time of analysis was less than 11 min; therefore, the proposed method represents significant improvement over existing methods. Extracts from Brassica vegetables, obtained using different extraction procedures, were studied for their radical scavenging effects. Scavenging of DPPH showed different kinetics at the beginning of the assay period and after 15 min from the initialization of reaction. Different kinetics suggested the presence of polymerized and/or less active antioxidants with different scavenging mechanisms for particular polyphenolic compounds.",
publisher = "Springer, New York",
journal = "Food Analytical Methods",
title = "Chemometric-Assisted Optimization of RP-HPLC Method for Determination of Some Bioflavonoids in Brassica oleracea Species and Their Antioxidative Activity",
volume = "7",
number = "7",
pages = "1387-1399",
doi = "10.1007/s12161-013-9761-y"
}

Ćirić, A., Ivanović, N., Cvijović, M. S., Jelikić-Stankov, M., Joksović, L.,& Đurđević, P.. (2014). Chemometric-Assisted Optimization of RP-HPLC Method for Determination of Some Bioflavonoids in Brassica oleracea Species and Their Antioxidative Activity. in Food Analytical Methods
Springer, New York., 7(7), 1387-1399.
https://doi.org/10.1007/s12161-013-9761-y

Ćirić A, Ivanović N, Cvijović MS, Jelikić-Stankov M, Joksović L, Đurđević P. Chemometric-Assisted Optimization of RP-HPLC Method for Determination of Some Bioflavonoids in Brassica oleracea Species and Their Antioxidative Activity. in Food Analytical Methods. 2014;7(7):1387-1399.
doi:10.1007/s12161-013-9761-y .

Ćirić, Andrija, Ivanović, Nevena, Cvijović, Milica S., Jelikić-Stankov, Milena, Joksović, Ljubinka, Đurđević, Predrag, "Chemometric-Assisted Optimization of RP-HPLC Method for Determination of Some Bioflavonoids in Brassica oleracea Species and Their Antioxidative Activity" in Food Analytical Methods, 7, no. 7 (2014):1387-1399,
https://doi.org/10.1007/s12161-013-9761-y . .

TY  - JOUR
AU  - Marković, Violeta
AU  - Erić, Slavica
AU  - Juranić, Zorica
AU  - Stanojković, Tatjana
AU  - Joksović, Ljubinka
AU  - Ranković, Branislav
AU  - Kosanić, Marijana
AU  - Joksović, Milan D.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1500
AB  - A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Bioorganic Chemistry
T1  - Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
VL  - 39
IS  - 1-3
SP  - 18
EP  - 27
DO  - 10.1016/j.bioorg.2010.10.003
ER  - 

@article{
author = "Marković, Violeta and Erić, Slavica and Juranić, Zorica and Stanojković, Tatjana and Joksović, Ljubinka and Ranković, Branislav and Kosanić, Marijana and Joksović, Milan D.",
year = "2011",
abstract = "A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Bioorganic Chemistry",
title = "Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone",
volume = "39",
number = "1-3",
pages = "18-27",
doi = "10.1016/j.bioorg.2010.10.003"
}

Marković, V., Erić, S., Juranić, Z., Stanojković, T., Joksović, L., Ranković, B., Kosanić, M.,& Joksović, M. D.. (2011). Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone. in Bioorganic Chemistry
Academic Press Inc Elsevier Science, San Diego., 39(1-3), 18-27.
https://doi.org/10.1016/j.bioorg.2010.10.003

Marković V, Erić S, Juranić Z, Stanojković T, Joksović L, Ranković B, Kosanić M, Joksović MD. Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone. in Bioorganic Chemistry. 2011;39(1-3):18-27.
doi:10.1016/j.bioorg.2010.10.003 .

Marković, Violeta, Erić, Slavica, Juranić, Zorica, Stanojković, Tatjana, Joksović, Ljubinka, Ranković, Branislav, Kosanić, Marijana, Joksović, Milan D., "Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone" in Bioorganic Chemistry, 39, no. 1-3 (2011):18-27,
https://doi.org/10.1016/j.bioorg.2010.10.003 . .