TY  - JOUR
AU  - Štulić, Miloš
AU  - Ćulafić, Đorđe
AU  - Boričić, Ivan
AU  - Stojković Lalošević, Milica
AU  - Pejić, Nina
AU  - Janković, Goran
AU  - Milovanović, Tamara
AU  - Ćulafić-Vojinović, Violeta
AU  - Vlaisavljević, Željko
AU  - Ćulafić, Milica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4827
AB  - Intrahepatic cholestasis of pregnancy (ICP) is a gestation-specific liver disorder, defined most often as the onset of pruritus, usually from the third trimester of pregnancy, associated with abnormal liver test results and/or increased total serum bile acids and spontaneous relief after delivery. The 21-year-old patient was admitted to our ward in the 11th week of pregnancy due to raised liver enzymes. The first onset of pruritus and jaundice appeared a month before hospitalization. Immunology tests and Toxoplasma gondii were negative. We excluded viral etiology, while alpha-1-antitrypsin, serum and urine copper levels, and thyroid hormones were within the reference values. The patient denied she had taken any medicines and herbal preparations before and during pregnancy. Total bile acids in the serum were significantly elevated (242 μmol/L). The abdominal ultrasound revealed a regular finding. Liver biopsy suggested a cholestatic liver disorder. After a presentation of all risks, the patient decided to stop the pregnancy. After a month, the hepatogram was within the reference values. Very rarely an ICP can occur in early pregnancy (first trimester), which calls for close monitoring. The risk of serious adverse fetal outcomes and spontaneous preterm delivery is proportional with increased levels of maternal serum bile acid.
PB  - MDPI
T2  - Medicina
T1  - Intrahepatic Cholestasis of Pregnancy: A Case Study of the Rare Onset in the First Trimester
VL  - 55
IS  - 8
DO  - 10.3390/medicina55080454
ER  - 

@article{
author = "Štulić, Miloš and Ćulafić, Đorđe and Boričić, Ivan and Stojković Lalošević, Milica and Pejić, Nina and Janković, Goran and Milovanović, Tamara and Ćulafić-Vojinović, Violeta and Vlaisavljević, Željko and Ćulafić, Milica",
year = "2019",
abstract = "Intrahepatic cholestasis of pregnancy (ICP) is a gestation-specific liver disorder, defined most often as the onset of pruritus, usually from the third trimester of pregnancy, associated with abnormal liver test results and/or increased total serum bile acids and spontaneous relief after delivery. The 21-year-old patient was admitted to our ward in the 11th week of pregnancy due to raised liver enzymes. The first onset of pruritus and jaundice appeared a month before hospitalization. Immunology tests and Toxoplasma gondii were negative. We excluded viral etiology, while alpha-1-antitrypsin, serum and urine copper levels, and thyroid hormones were within the reference values. The patient denied she had taken any medicines and herbal preparations before and during pregnancy. Total bile acids in the serum were significantly elevated (242 μmol/L). The abdominal ultrasound revealed a regular finding. Liver biopsy suggested a cholestatic liver disorder. After a presentation of all risks, the patient decided to stop the pregnancy. After a month, the hepatogram was within the reference values. Very rarely an ICP can occur in early pregnancy (first trimester), which calls for close monitoring. The risk of serious adverse fetal outcomes and spontaneous preterm delivery is proportional with increased levels of maternal serum bile acid.",
publisher = "MDPI",
journal = "Medicina",
title = "Intrahepatic Cholestasis of Pregnancy: A Case Study of the Rare Onset in the First Trimester",
volume = "55",
number = "8",
doi = "10.3390/medicina55080454"
}

Štulić, M., Ćulafić, Đ., Boričić, I., Stojković Lalošević, M., Pejić, N., Janković, G., Milovanović, T., Ćulafić-Vojinović, V., Vlaisavljević, Ž.,& Ćulafić, M.. (2019). Intrahepatic Cholestasis of Pregnancy: A Case Study of the Rare Onset in the First Trimester. in Medicina
MDPI., 55(8).
https://doi.org/10.3390/medicina55080454

Štulić M, Ćulafić Đ, Boričić I, Stojković Lalošević M, Pejić N, Janković G, Milovanović T, Ćulafić-Vojinović V, Vlaisavljević Ž, Ćulafić M. Intrahepatic Cholestasis of Pregnancy: A Case Study of the Rare Onset in the First Trimester. in Medicina. 2019;55(8).
doi:10.3390/medicina55080454 .

Štulić, Miloš, Ćulafić, Đorđe, Boričić, Ivan, Stojković Lalošević, Milica, Pejić, Nina, Janković, Goran, Milovanović, Tamara, Ćulafić-Vojinović, Violeta, Vlaisavljević, Željko, Ćulafić, Milica, "Intrahepatic Cholestasis of Pregnancy: A Case Study of the Rare Onset in the First Trimester" in Medicina, 55, no. 8 (2019),
https://doi.org/10.3390/medicina55080454 . .