TY  - JOUR
AU  - Stulić, Miloš
AU  - Ćulafić, Đorđe
AU  - Obrenović, Radmila
AU  - Janković, Goran
AU  - Alempijević, Tamara
AU  - Stojković-Lalošević, Milica
AU  - Dostanić, Nataša
AU  - Vezmar-Kovačević, Sandra
AU  - Ćulafić, Milica
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3068
AB  - Background: Data suggest cystatin C (CysC) levels and hepatic artery resistive index (HARI) correspond to the progression of chronic liver disease. We aimed to evaluate the clinical significance of these parameters in assessment of fibrosis in patients with liver cirrhosis. Methods: The cross-sectional study included 63 patients with liver cirrhosis. A control group consisted of 30 age- and gender-matched healthy persons. Results: We confirmed significantly higher values of CysC in patients with cirrhosis compared to control group (p = 0.036). Average value of HARI in the examined group was increased (0.72 +/- 0.06) and there was the statistically significant difference compared to controls (0.66 +/- 0.03) (p  lt  0.001). We found statistically significant correlation between HARI and CysC in the study group. Analyzing the possibility of distinguishing healthy subjects from patients with fibrosis, we have found that the area under the curve is far greater in the HARI index than CysC. Comparison of CysC among Child-Pugh stages and correlation with a model for end-stage liver disease (MELD) score showed statistically significant results. Conclusion: We confirmed HARI is a more accurate parameter than CysC in discriminating healthy subjects from patients with fibrosis, while CysC could be a better indicator of the stage of liver cirrhosis.
PB  - MDPI, Basel
T2  - Medicina-Lithuania
T1  - The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis
VL  - 54
IS  - 3
DO  - 10.3390/medicina54030037
ER  - 

@article{
author = "Stulić, Miloš and Ćulafić, Đorđe and Obrenović, Radmila and Janković, Goran and Alempijević, Tamara and Stojković-Lalošević, Milica and Dostanić, Nataša and Vezmar-Kovačević, Sandra and Ćulafić, Milica",
year = "2018",
abstract = "Background: Data suggest cystatin C (CysC) levels and hepatic artery resistive index (HARI) correspond to the progression of chronic liver disease. We aimed to evaluate the clinical significance of these parameters in assessment of fibrosis in patients with liver cirrhosis. Methods: The cross-sectional study included 63 patients with liver cirrhosis. A control group consisted of 30 age- and gender-matched healthy persons. Results: We confirmed significantly higher values of CysC in patients with cirrhosis compared to control group (p = 0.036). Average value of HARI in the examined group was increased (0.72 +/- 0.06) and there was the statistically significant difference compared to controls (0.66 +/- 0.03) (p  lt  0.001). We found statistically significant correlation between HARI and CysC in the study group. Analyzing the possibility of distinguishing healthy subjects from patients with fibrosis, we have found that the area under the curve is far greater in the HARI index than CysC. Comparison of CysC among Child-Pugh stages and correlation with a model for end-stage liver disease (MELD) score showed statistically significant results. Conclusion: We confirmed HARI is a more accurate parameter than CysC in discriminating healthy subjects from patients with fibrosis, while CysC could be a better indicator of the stage of liver cirrhosis.",
publisher = "MDPI, Basel",
journal = "Medicina-Lithuania",
title = "The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis",
volume = "54",
number = "3",
doi = "10.3390/medicina54030037"
}

Stulić, M., Ćulafić, Đ., Obrenović, R., Janković, G., Alempijević, T., Stojković-Lalošević, M., Dostanić, N., Vezmar-Kovačević, S.,& Ćulafić, M.. (2018). The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis. in Medicina-Lithuania
MDPI, Basel., 54(3).
https://doi.org/10.3390/medicina54030037

Stulić M, Ćulafić Đ, Obrenović R, Janković G, Alempijević T, Stojković-Lalošević M, Dostanić N, Vezmar-Kovačević S, Ćulafić M. The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis. in Medicina-Lithuania. 2018;54(3).
doi:10.3390/medicina54030037 .

Stulić, Miloš, Ćulafić, Đorđe, Obrenović, Radmila, Janković, Goran, Alempijević, Tamara, Stojković-Lalošević, Milica, Dostanić, Nataša, Vezmar-Kovačević, Sandra, Ćulafić, Milica, "The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis" in Medicina-Lithuania, 54, no. 3 (2018),
https://doi.org/10.3390/medicina54030037 . .