TY  - JOUR
AU  - Đorđević, Vladimir
AU  - Wallace, David
AU  - Schweitzer, Amie
AU  - Boricić, Novica
AU  - Knežević, Đorđe
AU  - Matić, Slavko
AU  - Grubor, Nikola
AU  - Kerkez, Mirko
AU  - Radenković, Dejan
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Matović, Vesna
AU  - Buha, Aleksandra
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3346
AB  - Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Environment International
T1  - Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies
VL  - 128
SP  - 353
EP  - 361
DO  - 10.1016/j.envint.2019.04.048
ER  - 

@article{
author = "Đorđević, Vladimir and Wallace, David and Schweitzer, Amie and Boricić, Novica and Knežević, Đorđe and Matić, Slavko and Grubor, Nikola and Kerkez, Mirko and Radenković, Dejan and Bulat, Zorica and Antonijević, Biljana and Matović, Vesna and Buha, Aleksandra",
year = "2019",
abstract = "Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Environment International",
title = "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies",
volume = "128",
pages = "353-361",
doi = "10.1016/j.envint.2019.04.048"
}

Đorđević, V., Wallace, D., Schweitzer, A., Boricić, N., Knežević, Đ., Matić, S., Grubor, N., Kerkez, M., Radenković, D., Bulat, Z., Antonijević, B., Matović, V.,& Buha, A.. (2019). Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. in Environment International
Pergamon-Elsevier Science Ltd, Oxford., 128, 353-361.
https://doi.org/10.1016/j.envint.2019.04.048

Đorđević V, Wallace D, Schweitzer A, Boricić N, Knežević Đ, Matić S, Grubor N, Kerkez M, Radenković D, Bulat Z, Antonijević B, Matović V, Buha A. Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. in Environment International. 2019;128:353-361.
doi:10.1016/j.envint.2019.04.048 .

Đorđević, Vladimir, Wallace, David, Schweitzer, Amie, Boricić, Novica, Knežević, Đorđe, Matić, Slavko, Grubor, Nikola, Kerkez, Mirko, Radenković, Dejan, Bulat, Zorica, Antonijević, Biljana, Matović, Vesna, Buha, Aleksandra, "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies" in Environment International, 128 (2019):353-361,
https://doi.org/10.1016/j.envint.2019.04.048 . .