TY  - JOUR
AU  - Milović, Sanja
AU  - Stanković, Ivan
AU  - Nikolić, Dejan
AU  - Radović, Jelena
AU  - Kolundžić, Marina
AU  - Nikolić, Vesna
AU  - Stanojković, Tatjana
AU  - Petović, Slavica
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3468
AB  - Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).
PB  - Wiley
T2  - Chemistry and Biodiversity
T1  - Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro
VL  - 16
IS  - 10
SP  - 1
EP  - 11
DO  - 10.1002/cbdv.201900327
ER  - 

@article{
author = "Milović, Sanja and Stanković, Ivan and Nikolić, Dejan and Radović, Jelena and Kolundžić, Marina and Nikolić, Vesna and Stanojković, Tatjana and Petović, Slavica and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).",
publisher = "Wiley",
journal = "Chemistry and Biodiversity",
title = "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro",
volume = "16",
number = "10",
pages = "1-11",
doi = "10.1002/cbdv.201900327"
}

Milović, S., Stanković, I., Nikolić, D., Radović, J., Kolundžić, M., Nikolić, V., Stanojković, T., Petović, S.,& Kundaković-Vasović, T.. (2019). Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity
Wiley., 16(10), 1-11.
https://doi.org/10.1002/cbdv.201900327

Milović S, Stanković I, Nikolić D, Radović J, Kolundžić M, Nikolić V, Stanojković T, Petović S, Kundaković-Vasović T. Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity. 2019;16(10):1-11.
doi:10.1002/cbdv.201900327 .

Milović, Sanja, Stanković, Ivan, Nikolić, Dejan, Radović, Jelena, Kolundžić, Marina, Nikolić, Vesna, Stanojković, Tatjana, Petović, Slavica, Kundaković-Vasović, Tatjana, "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro" in Chemistry and Biodiversity, 16, no. 10 (2019):1-11,
https://doi.org/10.1002/cbdv.201900327 . .

TY  - JOUR
AU  - Milović, Sanja
AU  - Stanković, Ivan
AU  - Nikolić, Dejan
AU  - Radović, Jelena
AU  - Kolundžić, Marina
AU  - Nikolić, Vesna
AU  - Stanojković, Tatjana
AU  - Petović, Slavica
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3463
AB  - Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).
PB  - Wiley
T2  - Chemistry and Biodiversity
T1  - Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro
VL  - 16
IS  - 10
SP  - 1
EP  - 11
DO  - 10.1002/cbdv.201900327
ER  - 

@article{
author = "Milović, Sanja and Stanković, Ivan and Nikolić, Dejan and Radović, Jelena and Kolundžić, Marina and Nikolić, Vesna and Stanojković, Tatjana and Petović, Slavica and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).",
publisher = "Wiley",
journal = "Chemistry and Biodiversity",
title = "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro",
volume = "16",
number = "10",
pages = "1-11",
doi = "10.1002/cbdv.201900327"
}

Milović, S., Stanković, I., Nikolić, D., Radović, J., Kolundžić, M., Nikolić, V., Stanojković, T., Petović, S.,& Kundaković-Vasović, T.. (2019). Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity
Wiley., 16(10), 1-11.
https://doi.org/10.1002/cbdv.201900327

Milović S, Stanković I, Nikolić D, Radović J, Kolundžić M, Nikolić V, Stanojković T, Petović S, Kundaković-Vasović T. Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity. 2019;16(10):1-11.
doi:10.1002/cbdv.201900327 .

Milović, Sanja, Stanković, Ivan, Nikolić, Dejan, Radović, Jelena, Kolundžić, Marina, Nikolić, Vesna, Stanojković, Tatjana, Petović, Slavica, Kundaković-Vasović, Tatjana, "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro" in Chemistry and Biodiversity, 16, no. 10 (2019):1-11,
https://doi.org/10.1002/cbdv.201900327 . .

TY  - CONF
AU  - Milutinović, Violeta
AU  - Petrović, Silvana
AU  - Niketić, Marjan
AU  - Krunić, Aleksej
AU  - Nikolić, Dejan
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5260
AB  - The genus Hieracium L. is autochthonous in Eurasia, North Africa and North America and the
vast majority of the taxa are distributed in Europe. Hieracium naegelianum Pančić, belonging
to monotypic subendemic section H. sect. Naegeliana Zahn ex Szeląg, is a small, caespitose
plant, with long rhizome. It inhabits subalpine and alpine orosubmediterranean screes and
mainly is endemic for the mountains in W Balkan, with a single population in S Apennines.
Hieracium scheppigianum Freyn is a hybridogenous apomictic species probably originated
from H. gymnocephalum Griseb. ex Pant. (H. sect. Pannosa /Zahn (Zahn) and H. bupleuroides
C.C. Gmelin, s. l. (H. sect. Drepanoidea Monnier). The species can be found only on screes,
rocky places or rocky pastures in subalpine and alpine zone in Dinarides. The underground
parts of H. naegelianum and H. scheppigianum were collected on Mt Durmitor, Republic of
Montenegro. Dried and powered plant material was macerated with dichloromethane and
methanol, successively. Both solvents were evaporated under reduced pressure and dried
methanol extracts were used for further investigation. Using LC-MS method, sesquiterpene
lactone glycoside of guaianolide type, crepiside E, and six phenolic acids, i.e. chlorogenic acid
and five dicaffeoylquinic acids (cynarin, 3,5-, 1,5-, 3,4- and 4,5-dicaffeoylquinic acids) were
identified and quantified in both dried methanol extracts. Crepiside E was the most abundant
compound (116.58 and 126.88 mg/g), while among phenolic acids, 3,5-dicaffeoylquinic
acid (72.86 and 62.01 mg/g) was dominant in both investigated extracts. Radical scavenging
activity was estimated using colorimetric DPPH and OH radical assays, and both extracts
showed prominent and concentration dependent activity with SC50DPPH of 25.25 and
29.38 μg/mL and SC50OH of 16.09 and 17.50 μg/mL, respectively. This is the first report on
secondary metabolites and antiradical potential of underground parts of H. naegelianum and
H. scheppigianum
PB  - University of Zagreb, Faculty of Agriculture, Zagreb, Croatia
PB  - Centre of Excellence for Biodiversity and Molecular Plant Breeding (CroP-BioDiv), Zagreb, Croatia
C3  - 10th Conference on Medicinal and Aromatic Plants of Southeast European Countries (10th CMAPSEEC): Book of Abstracts
T1  - Phytochemical analysis and antiradical potential of methanol extracts of Hieracium naegelianum Pančić and H. scheppigianum Freyn underground parts
SP  - 113
EP  - 113
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5260
ER  - 

@conference{
author = "Milutinović, Violeta and Petrović, Silvana and Niketić, Marjan and Krunić, Aleksej and Nikolić, Dejan",
year = "2018",
abstract = "The genus Hieracium L. is autochthonous in Eurasia, North Africa and North America and the
vast majority of the taxa are distributed in Europe. Hieracium naegelianum Pančić, belonging
to monotypic subendemic section H. sect. Naegeliana Zahn ex Szeląg, is a small, caespitose
plant, with long rhizome. It inhabits subalpine and alpine orosubmediterranean screes and
mainly is endemic for the mountains in W Balkan, with a single population in S Apennines.
Hieracium scheppigianum Freyn is a hybridogenous apomictic species probably originated
from H. gymnocephalum Griseb. ex Pant. (H. sect. Pannosa /Zahn (Zahn) and H. bupleuroides
C.C. Gmelin, s. l. (H. sect. Drepanoidea Monnier). The species can be found only on screes,
rocky places or rocky pastures in subalpine and alpine zone in Dinarides. The underground
parts of H. naegelianum and H. scheppigianum were collected on Mt Durmitor, Republic of
Montenegro. Dried and powered plant material was macerated with dichloromethane and
methanol, successively. Both solvents were evaporated under reduced pressure and dried
methanol extracts were used for further investigation. Using LC-MS method, sesquiterpene
lactone glycoside of guaianolide type, crepiside E, and six phenolic acids, i.e. chlorogenic acid
and five dicaffeoylquinic acids (cynarin, 3,5-, 1,5-, 3,4- and 4,5-dicaffeoylquinic acids) were
identified and quantified in both dried methanol extracts. Crepiside E was the most abundant
compound (116.58 and 126.88 mg/g), while among phenolic acids, 3,5-dicaffeoylquinic
acid (72.86 and 62.01 mg/g) was dominant in both investigated extracts. Radical scavenging
activity was estimated using colorimetric DPPH and OH radical assays, and both extracts
showed prominent and concentration dependent activity with SC50DPPH of 25.25 and
29.38 μg/mL and SC50OH of 16.09 and 17.50 μg/mL, respectively. This is the first report on
secondary metabolites and antiradical potential of underground parts of H. naegelianum and
H. scheppigianum",
publisher = "University of Zagreb, Faculty of Agriculture, Zagreb, Croatia, Centre of Excellence for Biodiversity and Molecular Plant Breeding (CroP-BioDiv), Zagreb, Croatia",
journal = "10th Conference on Medicinal and Aromatic Plants of Southeast European Countries (10th CMAPSEEC): Book of Abstracts",
title = "Phytochemical analysis and antiradical potential of methanol extracts of Hieracium naegelianum Pančić and H. scheppigianum Freyn underground parts",
pages = "113-113",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5260"
}

Milutinović, V., Petrović, S., Niketić, M., Krunić, A.,& Nikolić, D.. (2018). Phytochemical analysis and antiradical potential of methanol extracts of Hieracium naegelianum Pančić and H. scheppigianum Freyn underground parts. in 10th Conference on Medicinal and Aromatic Plants of Southeast European Countries (10th CMAPSEEC): Book of Abstracts
University of Zagreb, Faculty of Agriculture, Zagreb, Croatia., 113-113.
https://hdl.handle.net/21.15107/rcub_farfar_5260

Milutinović V, Petrović S, Niketić M, Krunić A, Nikolić D. Phytochemical analysis and antiradical potential of methanol extracts of Hieracium naegelianum Pančić and H. scheppigianum Freyn underground parts. in 10th Conference on Medicinal and Aromatic Plants of Southeast European Countries (10th CMAPSEEC): Book of Abstracts. 2018;:113-113.
https://hdl.handle.net/21.15107/rcub_farfar_5260 .

Milutinović, Violeta, Petrović, Silvana, Niketić, Marjan, Krunić, Aleksej, Nikolić, Dejan, "Phytochemical analysis and antiradical potential of methanol extracts of Hieracium naegelianum Pančić and H. scheppigianum Freyn underground parts" in 10th Conference on Medicinal and Aromatic Plants of Southeast European Countries (10th CMAPSEEC): Book of Abstracts (2018):113-113,
https://hdl.handle.net/21.15107/rcub_farfar_5260 .

TY  - JOUR
AU  - Milutinović, Violeta
AU  - Niketić, Marjan
AU  - Ušjak, Ljuboš
AU  - Nikolić, Dejan
AU  - Krunić, Aleksej
AU  - Zidorn, Christian
AU  - Petrović, Silvana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3127
AB  - IntroductionHieracium s. str. represents one of the largest and most complex genera of flowering plants. As molecular genetics seems unlikely to disentangle intricate relationships within this reticulate species complex, analysis of flavonoids and phenolic acids, known as good chemosystematic markers, promise to be more reliable. Data about pharmacological activity of Hieracium species are scarce. ObjectiveEvaluation of the chemosystematic significance of flavonoids and phenolic acids of methanol extracts of aerial flowering parts of 28 Hieracium species from the Balkans. Additionally, investigation of antioxidant potentials of the extracts. MethodsComparative qualitative and quantitative analysis of flavonoids and phenolic acids was performed by LC-MS. Multivariate statistical data analysis included non-metric multidimensional scaling (nMDS), unweighted pair-group arithmetic averages (UPGMA) and principal component analysis (PCA). Antioxidant activity was evaluated using three colorimetric tests. ResultsDominant phenolics in almost all species were luteolin type flavonoids, followed by phenolic acids. Although the investigated Hieracium species share many compounds, the current classification of the genus was supported by nMDS and UPGMA analyses with a good resolution to the group level. Hieracium naegelianum was clearly separated from the other investigated species. Spatial and ecological distances of the samples were likely to influence unexpected differentiation of some groups within H. sect. Pannosa. The vast majority of dominant compounds significantly contributed to differences between taxa. The antioxidant potential of the extracts was satisfactory and in accordance with their phenolics composition. ConclusionsComparative LC-MS analysis demonstrated that flavonoids and phenolic acids are good indicators of chemosystematic relationships within Hieracium, particularly between non-hybrid species and groups from the same location. Copyright
PB  - Wiley, Hoboken
T2  - Phytochemical Analysis
T1  - Methanol Extracts of 28 Hieracium Species from the Balkan Peninsula - Comparative LC-MS Analysis, Chemosystematic Evaluation of their Flavonoid and Phenolic Acid Profiles and Antioxidant Potentials
VL  - 29
IS  - 1
SP  - 30
EP  - 47
DO  - 10.1002/pca.2712
ER  - 

@article{
author = "Milutinović, Violeta and Niketić, Marjan and Ušjak, Ljuboš and Nikolić, Dejan and Krunić, Aleksej and Zidorn, Christian and Petrović, Silvana",
year = "2018",
abstract = "IntroductionHieracium s. str. represents one of the largest and most complex genera of flowering plants. As molecular genetics seems unlikely to disentangle intricate relationships within this reticulate species complex, analysis of flavonoids and phenolic acids, known as good chemosystematic markers, promise to be more reliable. Data about pharmacological activity of Hieracium species are scarce. ObjectiveEvaluation of the chemosystematic significance of flavonoids and phenolic acids of methanol extracts of aerial flowering parts of 28 Hieracium species from the Balkans. Additionally, investigation of antioxidant potentials of the extracts. MethodsComparative qualitative and quantitative analysis of flavonoids and phenolic acids was performed by LC-MS. Multivariate statistical data analysis included non-metric multidimensional scaling (nMDS), unweighted pair-group arithmetic averages (UPGMA) and principal component analysis (PCA). Antioxidant activity was evaluated using three colorimetric tests. ResultsDominant phenolics in almost all species were luteolin type flavonoids, followed by phenolic acids. Although the investigated Hieracium species share many compounds, the current classification of the genus was supported by nMDS and UPGMA analyses with a good resolution to the group level. Hieracium naegelianum was clearly separated from the other investigated species. Spatial and ecological distances of the samples were likely to influence unexpected differentiation of some groups within H. sect. Pannosa. The vast majority of dominant compounds significantly contributed to differences between taxa. The antioxidant potential of the extracts was satisfactory and in accordance with their phenolics composition. ConclusionsComparative LC-MS analysis demonstrated that flavonoids and phenolic acids are good indicators of chemosystematic relationships within Hieracium, particularly between non-hybrid species and groups from the same location. Copyright",
publisher = "Wiley, Hoboken",
journal = "Phytochemical Analysis",
title = "Methanol Extracts of 28 Hieracium Species from the Balkan Peninsula - Comparative LC-MS Analysis, Chemosystematic Evaluation of their Flavonoid and Phenolic Acid Profiles and Antioxidant Potentials",
volume = "29",
number = "1",
pages = "30-47",
doi = "10.1002/pca.2712"
}

Milutinović, V., Niketić, M., Ušjak, L., Nikolić, D., Krunić, A., Zidorn, C.,& Petrović, S.. (2018). Methanol Extracts of 28 Hieracium Species from the Balkan Peninsula - Comparative LC-MS Analysis, Chemosystematic Evaluation of their Flavonoid and Phenolic Acid Profiles and Antioxidant Potentials. in Phytochemical Analysis
Wiley, Hoboken., 29(1), 30-47.
https://doi.org/10.1002/pca.2712

Milutinović V, Niketić M, Ušjak L, Nikolić D, Krunić A, Zidorn C, Petrović S. Methanol Extracts of 28 Hieracium Species from the Balkan Peninsula - Comparative LC-MS Analysis, Chemosystematic Evaluation of their Flavonoid and Phenolic Acid Profiles and Antioxidant Potentials. in Phytochemical Analysis. 2018;29(1):30-47.
doi:10.1002/pca.2712 .

Milutinović, Violeta, Niketić, Marjan, Ušjak, Ljuboš, Nikolić, Dejan, Krunić, Aleksej, Zidorn, Christian, Petrović, Silvana, "Methanol Extracts of 28 Hieracium Species from the Balkan Peninsula - Comparative LC-MS Analysis, Chemosystematic Evaluation of their Flavonoid and Phenolic Acid Profiles and Antioxidant Potentials" in Phytochemical Analysis, 29, no. 1 (2018):30-47,
https://doi.org/10.1002/pca.2712 . .

TY  - JOUR
AU  - Milutinović, Violeta
AU  - Niketić, Marjan
AU  - Krunić, Aleksej
AU  - Nikolić, Dejan
AU  - Petković, Miloš
AU  - Ušjak, Ljuboš
AU  - Petrović, Silvana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3077
AB  - Four sesquiterpene lactones (SLs), including three undescribed proline-SL conjugates, the guaianolides calophyllamine A and 8-epiixerisamine A, and the eudesmanolide calophyllamine B, were isolated from the methanol extract of Hieracium calophyllum R. Uechtr. (Compositae) flowering heads. Another known guaianolide, crepiside E, was detected in Hieracium L. species for the first time. Their structures were elucidated using extensive 1D and 2D NMR spectroscopy in combination with HRMS. The isolated SLs were used as external standards for qualitative and quantitative LC-MS analysis of the dry methanol extracts of the flowering aerial parts of 28 Hieracium species from the Balkan Peninsula. Guaianolides were the dominant SLs in 27 species studied. The chemosystematic significance of detected SLs was evaluated using multivariate statistics (PCA, nMDS and UPGMA). Differentiation between the main groups was well supported. All four compounds significantly and equally contributed to the differences between the species. In addition, the eudesmanolide calophyllamine B could be a significant chemosystematic marker for H. sect. Villosa (Griseb.) Gremli s.l. and Glauciformia (Freyn) Zahn-Italica (Fr.) Av. Touv.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Sesquiterpene lactones from the methanol extracts of twenty-eight Hieracium species from the Balkan Peninsula and their chemosystematic significance
VL  - 154
SP  - 19
EP  - 30
DO  - 10.1016/j.phytochem.2018.06.008
ER  - 

@article{
author = "Milutinović, Violeta and Niketić, Marjan and Krunić, Aleksej and Nikolić, Dejan and Petković, Miloš and Ušjak, Ljuboš and Petrović, Silvana",
year = "2018",
abstract = "Four sesquiterpene lactones (SLs), including three undescribed proline-SL conjugates, the guaianolides calophyllamine A and 8-epiixerisamine A, and the eudesmanolide calophyllamine B, were isolated from the methanol extract of Hieracium calophyllum R. Uechtr. (Compositae) flowering heads. Another known guaianolide, crepiside E, was detected in Hieracium L. species for the first time. Their structures were elucidated using extensive 1D and 2D NMR spectroscopy in combination with HRMS. The isolated SLs were used as external standards for qualitative and quantitative LC-MS analysis of the dry methanol extracts of the flowering aerial parts of 28 Hieracium species from the Balkan Peninsula. Guaianolides were the dominant SLs in 27 species studied. The chemosystematic significance of detected SLs was evaluated using multivariate statistics (PCA, nMDS and UPGMA). Differentiation between the main groups was well supported. All four compounds significantly and equally contributed to the differences between the species. In addition, the eudesmanolide calophyllamine B could be a significant chemosystematic marker for H. sect. Villosa (Griseb.) Gremli s.l. and Glauciformia (Freyn) Zahn-Italica (Fr.) Av. Touv.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Sesquiterpene lactones from the methanol extracts of twenty-eight Hieracium species from the Balkan Peninsula and their chemosystematic significance",
volume = "154",
pages = "19-30",
doi = "10.1016/j.phytochem.2018.06.008"
}

Milutinović, V., Niketić, M., Krunić, A., Nikolić, D., Petković, M., Ušjak, L.,& Petrović, S.. (2018). Sesquiterpene lactones from the methanol extracts of twenty-eight Hieracium species from the Balkan Peninsula and their chemosystematic significance. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 154, 19-30.
https://doi.org/10.1016/j.phytochem.2018.06.008

Milutinović V, Niketić M, Krunić A, Nikolić D, Petković M, Ušjak L, Petrović S. Sesquiterpene lactones from the methanol extracts of twenty-eight Hieracium species from the Balkan Peninsula and their chemosystematic significance. in Phytochemistry. 2018;154:19-30.
doi:10.1016/j.phytochem.2018.06.008 .

Milutinović, Violeta, Niketić, Marjan, Krunić, Aleksej, Nikolić, Dejan, Petković, Miloš, Ušjak, Ljuboš, Petrović, Silvana, "Sesquiterpene lactones from the methanol extracts of twenty-eight Hieracium species from the Balkan Peninsula and their chemosystematic significance" in Phytochemistry, 154 (2018):19-30,
https://doi.org/10.1016/j.phytochem.2018.06.008 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Petrović, Silvana
AU  - Milenković, Marina
AU  - Stanojković, Tatjana
AU  - Nikolić, Dejan
AU  - Krunić, Aleksej
AU  - Niketić, Marjan
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2330
AB  - The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffeliiGriseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5g/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5g/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2M, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5M, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2M). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 lt 11.0g/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50=22.32 +/- 1.32 vs. 18.67 +/- 0.75M).
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Chemistry & Biodiversity
T1  - Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites
VL  - 12
IS  - 10
SP  - 1585
EP  - 1594
DO  - 10.1002/cbdv.201400400
ER  - 

@article{
author = "Pavlović, Ivan and Petrović, Silvana and Milenković, Marina and Stanojković, Tatjana and Nikolić, Dejan and Krunić, Aleksej and Niketić, Marjan",
year = "2015",
abstract = "The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffeliiGriseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5g/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5g/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2M, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5M, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2M). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 lt 11.0g/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50=22.32 +/- 1.32 vs. 18.67 +/- 0.75M).",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites",
volume = "12",
number = "10",
pages = "1585-1594",
doi = "10.1002/cbdv.201400400"
}

Pavlović, I., Petrović, S., Milenković, M., Stanojković, T., Nikolić, D., Krunić, A.,& Niketić, M.. (2015). Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites. in Chemistry & Biodiversity
Wiley-VCH Verlag GMBH, Weinheim., 12(10), 1585-1594.
https://doi.org/10.1002/cbdv.201400400

Pavlović I, Petrović S, Milenković M, Stanojković T, Nikolić D, Krunić A, Niketić M. Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites. in Chemistry & Biodiversity. 2015;12(10):1585-1594.
doi:10.1002/cbdv.201400400 .

Pavlović, Ivan, Petrović, Silvana, Milenković, Marina, Stanojković, Tatjana, Nikolić, Dejan, Krunić, Aleksej, Niketić, Marjan, "Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites" in Chemistry & Biodiversity, 12, no. 10 (2015):1585-1594,
https://doi.org/10.1002/cbdv.201400400 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Krunić, Aleksej
AU  - Nikolić, Dejan
AU  - Radenković, Mirjana
AU  - Branković, Suzana
AU  - Niketić, Marjan
AU  - Petrović, Silvana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2077
AB  - Plants from the genus Ferula L. (Apiaceae) were used for various purposes in traditional medicine of different nations throughout the history. Ferula heuffelii GRISEB. ex HEUFFEL is a perennial species endemic for Balkan peninsula. Ten compounds which belong to classes of prenyl-furocoumarin-, prenyl-dihydrofurochromone-, prenyl-benzoyl-and prenyl-benzoylfuranone-type sesquiterpenoids, as well as sesquiterpene coumarins and phenylpropanoids, were, for the first time, isolated from the CHCl3 extract of the underground parts of this plant and identified. Furthermore, extract and three isolated compounds, i.e., latifolone (1), dshamirone (4), and (2S*, 3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro7- hydroxy-2,3-dimethylfuro[3,2-c] coumarin (6) were, for the first time, evaluated for their in vitro antispasmodic activities in three experimental models: spontaneous contraction, and ACh- and KCl-induced contraction of an isolated rat ileum. The extract (0.1-1.3 mg/ml) and compound 6 (1 - 10 mu g/ml) exhibited dose-dependent effect in all three models. Compound 1 (1-6 mu g/ml) affected spontaneous contractions and those induced by KCl, while compound 4 (8 mu g/ml) displayed only moderate activity with ACh-induced contractions. It can be concluded that tested compounds contribute to exhibited antispasmodic activity of crude extract. Additionally, extract (0.1-1.3 mg/ml) was tested for in vitro relaxant activity on an isolated rat trachea, and relaxed the KCl-induced contractions in a dose-dependent manner.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Chemistry & Biodiversity
T1  - Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity
VL  - 11
IS  - 9
SP  - 1417
EP  - 1427
DO  - 10.1002/cbdv.201400094
ER  - 

@article{
author = "Pavlović, Ivan and Krunić, Aleksej and Nikolić, Dejan and Radenković, Mirjana and Branković, Suzana and Niketić, Marjan and Petrović, Silvana",
year = "2014",
abstract = "Plants from the genus Ferula L. (Apiaceae) were used for various purposes in traditional medicine of different nations throughout the history. Ferula heuffelii GRISEB. ex HEUFFEL is a perennial species endemic for Balkan peninsula. Ten compounds which belong to classes of prenyl-furocoumarin-, prenyl-dihydrofurochromone-, prenyl-benzoyl-and prenyl-benzoylfuranone-type sesquiterpenoids, as well as sesquiterpene coumarins and phenylpropanoids, were, for the first time, isolated from the CHCl3 extract of the underground parts of this plant and identified. Furthermore, extract and three isolated compounds, i.e., latifolone (1), dshamirone (4), and (2S*, 3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro7- hydroxy-2,3-dimethylfuro[3,2-c] coumarin (6) were, for the first time, evaluated for their in vitro antispasmodic activities in three experimental models: spontaneous contraction, and ACh- and KCl-induced contraction of an isolated rat ileum. The extract (0.1-1.3 mg/ml) and compound 6 (1 - 10 mu g/ml) exhibited dose-dependent effect in all three models. Compound 1 (1-6 mu g/ml) affected spontaneous contractions and those induced by KCl, while compound 4 (8 mu g/ml) displayed only moderate activity with ACh-induced contractions. It can be concluded that tested compounds contribute to exhibited antispasmodic activity of crude extract. Additionally, extract (0.1-1.3 mg/ml) was tested for in vitro relaxant activity on an isolated rat trachea, and relaxed the KCl-induced contractions in a dose-dependent manner.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity",
volume = "11",
number = "9",
pages = "1417-1427",
doi = "10.1002/cbdv.201400094"
}

Pavlović, I., Krunić, A., Nikolić, D., Radenković, M., Branković, S., Niketić, M.,& Petrović, S.. (2014). Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity. in Chemistry & Biodiversity
Wiley-VCH Verlag GMBH, Weinheim., 11(9), 1417-1427.
https://doi.org/10.1002/cbdv.201400094

Pavlović I, Krunić A, Nikolić D, Radenković M, Branković S, Niketić M, Petrović S. Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity. in Chemistry & Biodiversity. 2014;11(9):1417-1427.
doi:10.1002/cbdv.201400094 .

Pavlović, Ivan, Krunić, Aleksej, Nikolić, Dejan, Radenković, Mirjana, Branković, Suzana, Niketić, Marjan, Petrović, Silvana, "Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity" in Chemistry & Biodiversity, 11, no. 9 (2014):1417-1427,
https://doi.org/10.1002/cbdv.201400094 . .

TY  - JOUR
AU  - Stanojković, Tatjana
AU  - Kolundžija, Branka
AU  - Ćirić, Ana D.
AU  - Soković, Marina
AU  - Nikolić, Dejan
AU  - Kundaković, Tatjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1975
AB  - Methanolic extract of Satureja kitaibelii Wierzb. ex Heuff. (Lamiaceae) and its major compond rosmarinic acid possessed strong antimicrobial activity against tested bacteria and fungi, and antitumour activity against malignant cells, but without antiproliferative effect on healthy cell line MRC5. Minimal inhibitory concentration (MIC) of methanolic extract was ranged between 0.0125-1.25 mg/ml, while minimal bactericidal concentration (MBC) was of 0.2-5.0 mg/ml and fungicidal (MFC) was 0.15-2.5 mg/ml. The rosmarinic acid exhibited better antimicrobial activity then methanol extract. The most sensitive species to rosmarinic acid were Bacillus cereus and Candida kruzei, while Micrococcus flavus, Trichoderma viride and Aspergillus niger were the most resistant. The methanol extract exhibited strong activity against Fem-x human malignant melanoma cells with an IC50 39.66 +/- 2.71 mu g/ml, and moderate activity against other cancer cell lines (IC50 from 138.06 +/- 0.16 mu g/ml against estrogen-dependant breast cancer cell lines MDA-MB-361 to 173.15 +/- 0.02 against a human epithelial cervical cancer cells HeLa). Rosmarinic acid arrested G2/M phase cell cycle in Fem-x cells, against which both methanol extract and rosmarinic acid possessed the best cytotoxic activity.
PB  - Inst Materials Physics, Bucharest
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae)
VL  - 8
IS  - 2
SP  - 845
EP  - 854
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1021
ER  - 

@article{
author = "Stanojković, Tatjana and Kolundžija, Branka and Ćirić, Ana D. and Soković, Marina and Nikolić, Dejan and Kundaković, Tatjana",
year = "2013",
abstract = "Methanolic extract of Satureja kitaibelii Wierzb. ex Heuff. (Lamiaceae) and its major compond rosmarinic acid possessed strong antimicrobial activity against tested bacteria and fungi, and antitumour activity against malignant cells, but without antiproliferative effect on healthy cell line MRC5. Minimal inhibitory concentration (MIC) of methanolic extract was ranged between 0.0125-1.25 mg/ml, while minimal bactericidal concentration (MBC) was of 0.2-5.0 mg/ml and fungicidal (MFC) was 0.15-2.5 mg/ml. The rosmarinic acid exhibited better antimicrobial activity then methanol extract. The most sensitive species to rosmarinic acid were Bacillus cereus and Candida kruzei, while Micrococcus flavus, Trichoderma viride and Aspergillus niger were the most resistant. The methanol extract exhibited strong activity against Fem-x human malignant melanoma cells with an IC50 39.66 +/- 2.71 mu g/ml, and moderate activity against other cancer cell lines (IC50 from 138.06 +/- 0.16 mu g/ml against estrogen-dependant breast cancer cell lines MDA-MB-361 to 173.15 +/- 0.02 against a human epithelial cervical cancer cells HeLa). Rosmarinic acid arrested G2/M phase cell cycle in Fem-x cells, against which both methanol extract and rosmarinic acid possessed the best cytotoxic activity.",
publisher = "Inst Materials Physics, Bucharest",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae)",
volume = "8",
number = "2",
pages = "845-854",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1021"
}

Stanojković, T., Kolundžija, B., Ćirić, A. D., Soković, M., Nikolić, D.,& Kundaković, T.. (2013). Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae). in Digest Journal of Nanomaterials and Biostructures
Inst Materials Physics, Bucharest., 8(2), 845-854.
https://hdl.handle.net/21.15107/rcub_ibiss_1021

Stanojković T, Kolundžija B, Ćirić AD, Soković M, Nikolić D, Kundaković T. Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae). in Digest Journal of Nanomaterials and Biostructures. 2013;8(2):845-854.
https://hdl.handle.net/21.15107/rcub_ibiss_1021 .

Stanojković, Tatjana, Kolundžija, Branka, Ćirić, Ana D., Soković, Marina, Nikolić, Dejan, Kundaković, Tatjana, "Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae)" in Digest Journal of Nanomaterials and Biostructures, 8, no. 2 (2013):845-854,
https://hdl.handle.net/21.15107/rcub_ibiss_1021 .

TY  - CONF
AU  - Pavlović, Ivan
AU  - Petrović, Silvana
AU  - Milenković, Marina
AU  - Nikolić, Dejan
AU  - Niketić, Marjan
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1283
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - Antimicrobial, anti-inflammatory and anti-ulcer activities of Ferula heuffelii root extracts
VL  - 75
IS  - 9
SP  - 1039
EP  - 1039
DO  - 10.1055/s-0029-1234844
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1283
ER  - 

@conference{
author = "Pavlović, Ivan and Petrović, Silvana and Milenković, Marina and Nikolić, Dejan and Niketić, Marjan",
year = "2009",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Antimicrobial, anti-inflammatory and anti-ulcer activities of Ferula heuffelii root extracts",
volume = "75",
number = "9",
pages = "1039-1039",
doi = "10.1055/s-0029-1234844",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1283"
}

Pavlović, I., Petrović, S., Milenković, M., Nikolić, D.,& Niketić, M.. (2009). Antimicrobial, anti-inflammatory and anti-ulcer activities of Ferula heuffelii root extracts. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 75(9), 1039-1039.
https://doi.org/10.1055/s-0029-1234844
https://hdl.handle.net/21.15107/rcub_farfar_1283

Pavlović I, Petrović S, Milenković M, Nikolić D, Niketić M. Antimicrobial, anti-inflammatory and anti-ulcer activities of Ferula heuffelii root extracts. in Planta Medica. 2009;75(9):1039-1039.
doi:10.1055/s-0029-1234844
https://hdl.handle.net/21.15107/rcub_farfar_1283 .

Pavlović, Ivan, Petrović, Silvana, Milenković, Marina, Nikolić, Dejan, Niketić, Marjan, "Antimicrobial, anti-inflammatory and anti-ulcer activities of Ferula heuffelii root extracts" in Planta Medica, 75, no. 9 (2009):1039-1039,
https://doi.org/10.1055/s-0029-1234844 .,
https://hdl.handle.net/21.15107/rcub_farfar_1283 .

TY  - JOUR
AU  - Cvetanović, Suzana D.
AU  - Nikolić, Dejan M.
AU  - Đorđević, Brižita
AU  - Miletić, Ivanka
AU  - Stanković, Ivan
AU  - Vidović, Bojana
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1145
AB  - In this paper the parameters of quality and nutrition value of cow, goat and sheep cheese in brine were investigated. The samples of cheese were produced on the Pirot territory. The dynamic of changes of this parameters was investigated throughout storage of cheeses. Investigation of chemical composition (dry matter, fat, total nitrogen, salt, calcium and ash), as well as pH and titrimetric acidity of cheeses in brine were analyzed through 6 months: after production, and 30, 60, 120 and 180 days of storage. The obtained results are according to general characteristics of white cheese in brine: sour-bitter taste, soft appearance, and high content of fat in dry matter. After detailed chemical analyses white cheeses in brine, it might be concluded that analyzed cheese samples have significant nutritive value after 6 months of production. It could be concluded that the most intensive dynamic of chemical changes is first month after their production.
AB  - U radu su ispitani hemijski parametri kvaliteta i nutritivne vrednosti belih sireva u salamuri od kravljeg, kozijeg i ovčijeg mleka, proizvedenih na teritoriji pirotskog okruga kao i dinamika promene ovih parametara tokom perioda zrenja i čuvanja. Ispitivanje hemijskog sastava (suve materije, masti, ukupnih azotnih materija, NaCl, kalcijuma, pepela) i kiselosti (pH i titraciona kiselost) analiziranih belih sireva u salamuri vršeno je tokom 6 meseci zrenja i to po sledećoj dinamici: nakon proizvodnje, 30, 60, 120 i 180-og dana nakon proizvodnje. Dobijeni rezultati su u skladu sa opštim karakteristikama belih sireva u salamuri: kiselo-slani ukus, meka konzistencija i visok sadržaj masti u suvoj materiji. Nakon detaljne hemijske analize belih sireva u salamuri, koji su proizvedeni od kravljeg, ovčijeg i kozjeg mleka, može se zaključiti da ovi sirevi i nakon šest meseci imaju značajnu nutritivnu vrednost, a na osnovu praćenja dinamike promene hemijskog sastava analiziranih sireva tokom perioda zrenja, da je ona najintenzivnija tokom prvih 30 dana zrenja.
PB  - Univerzitet u Novom Sadu - Tehnološki fakultet, Novi Sad i Savez hemičara i tehnologa, Beograd
T2  - Prehrambena industrija - mleko i mlečni proizvodi
T1  - Investigation of cheeses in brine from Pirot region
T1  - Ispitivanje belih sireva u salamuri sa teritorije pirotskog okruga
VL  - 19
IS  - 1-2
SP  - 88
EP  - 91
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1145
ER  - 

@article{
author = "Cvetanović, Suzana D. and Nikolić, Dejan M. and Đorđević, Brižita and Miletić, Ivanka and Stanković, Ivan and Vidović, Bojana",
year = "2008",
abstract = "In this paper the parameters of quality and nutrition value of cow, goat and sheep cheese in brine were investigated. The samples of cheese were produced on the Pirot territory. The dynamic of changes of this parameters was investigated throughout storage of cheeses. Investigation of chemical composition (dry matter, fat, total nitrogen, salt, calcium and ash), as well as pH and titrimetric acidity of cheeses in brine were analyzed through 6 months: after production, and 30, 60, 120 and 180 days of storage. The obtained results are according to general characteristics of white cheese in brine: sour-bitter taste, soft appearance, and high content of fat in dry matter. After detailed chemical analyses white cheeses in brine, it might be concluded that analyzed cheese samples have significant nutritive value after 6 months of production. It could be concluded that the most intensive dynamic of chemical changes is first month after their production., U radu su ispitani hemijski parametri kvaliteta i nutritivne vrednosti belih sireva u salamuri od kravljeg, kozijeg i ovčijeg mleka, proizvedenih na teritoriji pirotskog okruga kao i dinamika promene ovih parametara tokom perioda zrenja i čuvanja. Ispitivanje hemijskog sastava (suve materije, masti, ukupnih azotnih materija, NaCl, kalcijuma, pepela) i kiselosti (pH i titraciona kiselost) analiziranih belih sireva u salamuri vršeno je tokom 6 meseci zrenja i to po sledećoj dinamici: nakon proizvodnje, 30, 60, 120 i 180-og dana nakon proizvodnje. Dobijeni rezultati su u skladu sa opštim karakteristikama belih sireva u salamuri: kiselo-slani ukus, meka konzistencija i visok sadržaj masti u suvoj materiji. Nakon detaljne hemijske analize belih sireva u salamuri, koji su proizvedeni od kravljeg, ovčijeg i kozjeg mleka, može se zaključiti da ovi sirevi i nakon šest meseci imaju značajnu nutritivnu vrednost, a na osnovu praćenja dinamike promene hemijskog sastava analiziranih sireva tokom perioda zrenja, da je ona najintenzivnija tokom prvih 30 dana zrenja.",
publisher = "Univerzitet u Novom Sadu - Tehnološki fakultet, Novi Sad i Savez hemičara i tehnologa, Beograd",
journal = "Prehrambena industrija - mleko i mlečni proizvodi",
title = "Investigation of cheeses in brine from Pirot region, Ispitivanje belih sireva u salamuri sa teritorije pirotskog okruga",
volume = "19",
number = "1-2",
pages = "88-91",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1145"
}

Cvetanović, S. D., Nikolić, D. M., Đorđević, B., Miletić, I., Stanković, I.,& Vidović, B.. (2008). Investigation of cheeses in brine from Pirot region. in Prehrambena industrija - mleko i mlečni proizvodi
Univerzitet u Novom Sadu - Tehnološki fakultet, Novi Sad i Savez hemičara i tehnologa, Beograd., 19(1-2), 88-91.
https://hdl.handle.net/21.15107/rcub_farfar_1145

Cvetanović SD, Nikolić DM, Đorđević B, Miletić I, Stanković I, Vidović B. Investigation of cheeses in brine from Pirot region. in Prehrambena industrija - mleko i mlečni proizvodi. 2008;19(1-2):88-91.
https://hdl.handle.net/21.15107/rcub_farfar_1145 .

Cvetanović, Suzana D., Nikolić, Dejan M., Đorđević, Brižita, Miletić, Ivanka, Stanković, Ivan, Vidović, Bojana, "Investigation of cheeses in brine from Pirot region" in Prehrambena industrija - mleko i mlečni proizvodi, 19, no. 1-2 (2008):88-91,
https://hdl.handle.net/21.15107/rcub_farfar_1145 .