TY  - JOUR
AU  - Milovanović, Vesna
AU  - Buha, Aleksandra
AU  - Matović, Vesna
AU  - Ćurčić, Marijana
AU  - Vučinić, Slavica
AU  - Nakano, Takeshi
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3176
AB  - Fully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals were given by oral gavage 31.25-500 mg BDE-209/kg b.w./day for 28 days, and relative kidney weight, serum urea and creatinine, and oxidative stress parameters in the kidney were determined. Benchmark-dose approach was used for dose response modeling. Serum creatinine was increased, while results obtained for serum urea were inconclusive. Relative kidney weight was not affected by BDE-209. Kidney reduced glutathione was elevated, while superoxide dismutase activity was not changed after BDE-209 treatment. Also, levels of thiobarbituric acid reactive substances (TBARS) were increased and total -SH groups were decreased, which indicated oxidative imbalance. The critical effect dose (CED)/CEDL ratios for the effects on TBARS and total -SH groups indicated estimated CEDs for these markers can be used in risk assessment of BDE-209. Our study results have shown that a relatively low dose of BDE-209 affects kidney function and that oxidative stress is one of the mechanisms of its nephrotoxicity.
PB  - Springer Heidelberg, Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats
VL  - 25
IS  - 8
SP  - 7223
EP  - 7230
DO  - 10.1007/s11356-015-5921-5
ER  - 

@article{
author = "Milovanović, Vesna and Buha, Aleksandra and Matović, Vesna and Ćurčić, Marijana and Vučinić, Slavica and Nakano, Takeshi and Antonijević, Biljana",
year = "2018",
abstract = "Fully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals were given by oral gavage 31.25-500 mg BDE-209/kg b.w./day for 28 days, and relative kidney weight, serum urea and creatinine, and oxidative stress parameters in the kidney were determined. Benchmark-dose approach was used for dose response modeling. Serum creatinine was increased, while results obtained for serum urea were inconclusive. Relative kidney weight was not affected by BDE-209. Kidney reduced glutathione was elevated, while superoxide dismutase activity was not changed after BDE-209 treatment. Also, levels of thiobarbituric acid reactive substances (TBARS) were increased and total -SH groups were decreased, which indicated oxidative imbalance. The critical effect dose (CED)/CEDL ratios for the effects on TBARS and total -SH groups indicated estimated CEDs for these markers can be used in risk assessment of BDE-209. Our study results have shown that a relatively low dose of BDE-209 affects kidney function and that oxidative stress is one of the mechanisms of its nephrotoxicity.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats",
volume = "25",
number = "8",
pages = "7223-7230",
doi = "10.1007/s11356-015-5921-5"
}

Milovanović, V., Buha, A., Matović, V., Ćurčić, M., Vučinić, S., Nakano, T.,& Antonijević, B.. (2018). Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats. in Environmental Science and Pollution Research
Springer Heidelberg, Heidelberg., 25(8), 7223-7230.
https://doi.org/10.1007/s11356-015-5921-5

Milovanović V, Buha A, Matović V, Ćurčić M, Vučinić S, Nakano T, Antonijević B. Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats. in Environmental Science and Pollution Research. 2018;25(8):7223-7230.
doi:10.1007/s11356-015-5921-5 .

Milovanović, Vesna, Buha, Aleksandra, Matović, Vesna, Ćurčić, Marijana, Vučinić, Slavica, Nakano, Takeshi, Antonijević, Biljana, "Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats" in Environmental Science and Pollution Research, 25, no. 8 (2018):7223-7230,
https://doi.org/10.1007/s11356-015-5921-5 . .