Kerkez, Mirko

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  • Kerkez, Mirko (5)
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Author's Bibliography

Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies

Đorđević, Vladimir; Wallace, David; Schweitzer, Amie; Boricić, Novica; Knežević, Đorđe; Matić, Slavko; Grubor, Nikola; Kerkez, Mirko; Radenković, Dejan; Bulat, Zorica; Antonijević, Biljana; Matović, Vesna; Buha, Aleksandra

(Pergamon-Elsevier Science Ltd, Oxford, 2019)

TY  - JOUR
AU  - Đorđević, Vladimir
AU  - Wallace, David
AU  - Schweitzer, Amie
AU  - Boricić, Novica
AU  - Knežević, Đorđe
AU  - Matić, Slavko
AU  - Grubor, Nikola
AU  - Kerkez, Mirko
AU  - Radenković, Dejan
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Matović, Vesna
AU  - Buha, Aleksandra
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3346
AB  - Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Environment International
T1  - Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies
VL  - 128
SP  - 353
EP  - 361
DO  - 10.1016/j.envint.2019.04.048
ER  - 
@article{
author = "Đorđević, Vladimir and Wallace, David and Schweitzer, Amie and Boricić, Novica and Knežević, Đorđe and Matić, Slavko and Grubor, Nikola and Kerkez, Mirko and Radenković, Dejan and Bulat, Zorica and Antonijević, Biljana and Matović, Vesna and Buha, Aleksandra",
year = "2019",
abstract = "Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Environment International",
title = "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies",
volume = "128",
pages = "353-361",
doi = "10.1016/j.envint.2019.04.048"
}
Đorđević, V., Wallace, D., Schweitzer, A., Boricić, N., Knežević, Đ., Matić, S., Grubor, N., Kerkez, M., Radenković, D., Bulat, Z., Antonijević, B., Matović, V.,& Buha, A.. (2019). Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. in Environment International
Pergamon-Elsevier Science Ltd, Oxford., 128, 353-361.
https://doi.org/10.1016/j.envint.2019.04.048
Đorđević V, Wallace D, Schweitzer A, Boricić N, Knežević Đ, Matić S, Grubor N, Kerkez M, Radenković D, Bulat Z, Antonijević B, Matović V, Buha A. Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. in Environment International. 2019;128:353-361.
doi:10.1016/j.envint.2019.04.048 .
Đorđević, Vladimir, Wallace, David, Schweitzer, Amie, Boricić, Novica, Knežević, Đorđe, Matić, Slavko, Grubor, Nikola, Kerkez, Mirko, Radenković, Dejan, Bulat, Zorica, Antonijević, Biljana, Matović, Vesna, Buha, Aleksandra, "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies" in Environment International, 128 (2019):353-361,
https://doi.org/10.1016/j.envint.2019.04.048 . .
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Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report

Đorđević, Vladimir; Buha, Aleksandra; Radojković, Željko; Zarić, Nemanja; Ostojić, Slavenko; Lekić, Nebojša; Ninić, Aleksandar; Ćulafić, Milica; Mihaljević, Biljana; Antić, Darko; Vuković, Vojin; Kerkez, Mirko

(Most Art doo, Beograd, 2016)

TY  - JOUR
AU  - Đorđević, Vladimir
AU  - Buha, Aleksandra
AU  - Radojković, Željko
AU  - Zarić, Nemanja
AU  - Ostojić, Slavenko
AU  - Lekić, Nebojša
AU  - Ninić, Aleksandar
AU  - Ćulafić, Milica
AU  - Mihaljević, Biljana
AU  - Antić, Darko
AU  - Vuković, Vojin
AU  - Kerkez, Mirko
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2556
AB  - Following solid organ transplantation, the patient's management includes the provision of immunosuppressive therapy to the recipient. All kidney transplant recipients require lifelong immunosuppression. Regardless the improving survival following solid organ transplantation, post-transplant complications such as the development of malignancy due to immunosuppression remain to be an issue. One of the most common malignancies encountered in the post-solid organ transplant is lymphoproliferative disorder likely developed as a consequence of immunosuppression. We report a case of plasma cell type lymphoma in the ileocecal region of a 45-year-old male kidney transplant patient who was on a tacrolimus-based regimen for ten years. Although literature data indicate differently localized lymphoma as an adverse reaction to the long term use of tacrolimus, to our knowledge, this is the first described case of lymphoma in the ileocecal region. Serious adverse drug reactions and potential toxicity of tacrolimus emphasize the importance of finding the optimal balance between effective drug concentration and the risk associated with its use.
AB  - Nakon transplantacije organa, pacijenti primaoci organa se stavljaju na režim imunosupresivne terapije, a u primalaca bubrega ta terapija je doživotna. Bez obzira na poboljšanje preživljavanja nakon transplantacije organa, brojne su komplikacije koje se mogu javiti nakon transplantacije, a razvoj maligniteta usled imunosupresije nastavlja da bude značajan problem. Jedan od najčešćih tipova maligniteta koji se sreće kod ovakvih pacijenata je limfoproliferativni poremećaj koji se verovatno razvija kao posledica pomenute imunosupresije. Opisan je slučaj limfoma u ileocekalnoj regiji u 45-godišnjeg muškarca sa transplantiranim bubregom, koji je bio na imunosupresivnoj terapiji zasnovanoj na takrolimusu, tokom 10 godina. Literaturni podaci ukazuju na drugačiju lokalizaciju limfoma kao neželjene reakcije nakon dugoročnog korišćenja takrolimusa, pa je prema našim saznanjima, ovo jedinstven slučaj razvoja limfoma u ileocekalnoj regiji. Ozbiljne neželjene reakcije i toksični potencijal takrolimusa naglašavaju značaj pronalaženja optimalnog balansa između efektivne koncentracije leka i rizika vezanih za njegovu upotrebu.
PB  - Most Art doo, Beograd
T2  - MD - Medical data
T1  - Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report
T1  - Razvoj Hodžkinovog limfoma u ileocekalnoj regiji pacijenta sa transplantiranim bubregom na dugoročnoj imunosupresivnoj terapiji - prikaz slučaja
VL  - 8
IS  - 4
SP  - 265
EP  - 269
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2556
ER  - 
@article{
author = "Đorđević, Vladimir and Buha, Aleksandra and Radojković, Željko and Zarić, Nemanja and Ostojić, Slavenko and Lekić, Nebojša and Ninić, Aleksandar and Ćulafić, Milica and Mihaljević, Biljana and Antić, Darko and Vuković, Vojin and Kerkez, Mirko",
year = "2016",
abstract = "Following solid organ transplantation, the patient's management includes the provision of immunosuppressive therapy to the recipient. All kidney transplant recipients require lifelong immunosuppression. Regardless the improving survival following solid organ transplantation, post-transplant complications such as the development of malignancy due to immunosuppression remain to be an issue. One of the most common malignancies encountered in the post-solid organ transplant is lymphoproliferative disorder likely developed as a consequence of immunosuppression. We report a case of plasma cell type lymphoma in the ileocecal region of a 45-year-old male kidney transplant patient who was on a tacrolimus-based regimen for ten years. Although literature data indicate differently localized lymphoma as an adverse reaction to the long term use of tacrolimus, to our knowledge, this is the first described case of lymphoma in the ileocecal region. Serious adverse drug reactions and potential toxicity of tacrolimus emphasize the importance of finding the optimal balance between effective drug concentration and the risk associated with its use., Nakon transplantacije organa, pacijenti primaoci organa se stavljaju na režim imunosupresivne terapije, a u primalaca bubrega ta terapija je doživotna. Bez obzira na poboljšanje preživljavanja nakon transplantacije organa, brojne su komplikacije koje se mogu javiti nakon transplantacije, a razvoj maligniteta usled imunosupresije nastavlja da bude značajan problem. Jedan od najčešćih tipova maligniteta koji se sreće kod ovakvih pacijenata je limfoproliferativni poremećaj koji se verovatno razvija kao posledica pomenute imunosupresije. Opisan je slučaj limfoma u ileocekalnoj regiji u 45-godišnjeg muškarca sa transplantiranim bubregom, koji je bio na imunosupresivnoj terapiji zasnovanoj na takrolimusu, tokom 10 godina. Literaturni podaci ukazuju na drugačiju lokalizaciju limfoma kao neželjene reakcije nakon dugoročnog korišćenja takrolimusa, pa je prema našim saznanjima, ovo jedinstven slučaj razvoja limfoma u ileocekalnoj regiji. Ozbiljne neželjene reakcije i toksični potencijal takrolimusa naglašavaju značaj pronalaženja optimalnog balansa između efektivne koncentracije leka i rizika vezanih za njegovu upotrebu.",
publisher = "Most Art doo, Beograd",
journal = "MD - Medical data",
title = "Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report, Razvoj Hodžkinovog limfoma u ileocekalnoj regiji pacijenta sa transplantiranim bubregom na dugoročnoj imunosupresivnoj terapiji - prikaz slučaja",
volume = "8",
number = "4",
pages = "265-269",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2556"
}
Đorđević, V., Buha, A., Radojković, Ž., Zarić, N., Ostojić, S., Lekić, N., Ninić, A., Ćulafić, M., Mihaljević, B., Antić, D., Vuković, V.,& Kerkez, M.. (2016). Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report. in MD - Medical data
Most Art doo, Beograd., 8(4), 265-269.
https://hdl.handle.net/21.15107/rcub_farfar_2556
Đorđević V, Buha A, Radojković Ž, Zarić N, Ostojić S, Lekić N, Ninić A, Ćulafić M, Mihaljević B, Antić D, Vuković V, Kerkez M. Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report. in MD - Medical data. 2016;8(4):265-269.
https://hdl.handle.net/21.15107/rcub_farfar_2556 .
Đorđević, Vladimir, Buha, Aleksandra, Radojković, Željko, Zarić, Nemanja, Ostojić, Slavenko, Lekić, Nebojša, Ninić, Aleksandar, Ćulafić, Milica, Mihaljević, Biljana, Antić, Darko, Vuković, Vojin, Kerkez, Mirko, "Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report" in MD - Medical data, 8, no. 4 (2016):265-269,
https://hdl.handle.net/21.15107/rcub_farfar_2556 .

Cadmium in human pancreatic cancer - preliminary report

Đorđević, Vladimir; Knežević, D.; Matić, S.; Kerkez, Mirko; Zarić, N.; Grubor, Nikica; Bidzić, N.; Boricić, Novica; Boricić, I.; Matović, Vesna; Buha, Aleksandra

(Elsevier Ireland Ltd, Clare, 2016)

TY  - CONF
AU  - Đorđević, Vladimir
AU  - Knežević, D.
AU  - Matić, S.
AU  - Kerkez, Mirko
AU  - Zarić, N.
AU  - Grubor, Nikica
AU  - Bidzić, N.
AU  - Boricić, Novica
AU  - Boricić, I.
AU  - Matović, Vesna
AU  - Buha, Aleksandra
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2666
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Cadmium in human pancreatic cancer - preliminary report
VL  - 258
IS  - Supplement
SP  - S92
EP  - S93
DO  - 10.1016/j.toxlet.2016.06.1406
ER  - 
@conference{
author = "Đorđević, Vladimir and Knežević, D. and Matić, S. and Kerkez, Mirko and Zarić, N. and Grubor, Nikica and Bidzić, N. and Boricić, Novica and Boricić, I. and Matović, Vesna and Buha, Aleksandra",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Cadmium in human pancreatic cancer - preliminary report",
volume = "258",
number = "Supplement",
pages = "S92-S93",
doi = "10.1016/j.toxlet.2016.06.1406"
}
Đorđević, V., Knežević, D., Matić, S., Kerkez, M., Zarić, N., Grubor, N., Bidzić, N., Boricić, N., Boricić, I., Matović, V.,& Buha, A.. (2016). Cadmium in human pancreatic cancer - preliminary report. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 258(Supplement), S92-S93.
https://doi.org/10.1016/j.toxlet.2016.06.1406
Đorđević V, Knežević D, Matić S, Kerkez M, Zarić N, Grubor N, Bidzić N, Boricić N, Boricić I, Matović V, Buha A. Cadmium in human pancreatic cancer - preliminary report. in Toxicology Letters. 2016;258(Supplement):S92-S93.
doi:10.1016/j.toxlet.2016.06.1406 .
Đorđević, Vladimir, Knežević, D., Matić, S., Kerkez, Mirko, Zarić, N., Grubor, Nikica, Bidzić, N., Boricić, Novica, Boricić, I., Matović, Vesna, Buha, Aleksandra, "Cadmium in human pancreatic cancer - preliminary report" in Toxicology Letters, 258, no. Supplement (2016):S92-S93,
https://doi.org/10.1016/j.toxlet.2016.06.1406 . .
1
1

Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population

Đuričić, Ivana; Kotur-Stevuljević, Jelena; Miljković, Milica; Kerkez, Mirko; Đorđević, Vladimir; Đurasić, Ljubomir; Šobajić, Slađana

(Društvo medicinskih biohemičara Srbije, Beograd i Versita, 2015)

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Miljković, Milica
AU  - Kerkez, Mirko
AU  - Đorđević, Vladimir
AU  - Đurasić, Ljubomir
AU  - Šobajić, Slađana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2431
AB  - Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p  lt  0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p  lt  0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population
VL  - 34
IS  - 3
SP  - 304
EP  - 313
DO  - 10.2478/jomb-2014-0039
ER  - 
@article{
author = "Đuričić, Ivana and Kotur-Stevuljević, Jelena and Miljković, Milica and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Šobajić, Slađana",
year = "2015",
abstract = "Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p  lt  0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p  lt  0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population",
volume = "34",
number = "3",
pages = "304-313",
doi = "10.2478/jomb-2014-0039"
}
Đuričić, I., Kotur-Stevuljević, J., Miljković, M., Kerkez, M., Đorđević, V., Đurasić, L.,& Šobajić, S.. (2015). Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(3), 304-313.
https://doi.org/10.2478/jomb-2014-0039
Đuričić I, Kotur-Stevuljević J, Miljković M, Kerkez M, Đorđević V, Đurasić L, Šobajić S. Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry. 2015;34(3):304-313.
doi:10.2478/jomb-2014-0039 .
Đuričić, Ivana, Kotur-Stevuljević, Jelena, Miljković, Milica, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Šobajić, Slađana, "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population" in Journal of Medical Biochemistry, 34, no. 3 (2015):304-313,
https://doi.org/10.2478/jomb-2014-0039 . .
8
8
9

Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity

Miljković, Milica; Đuričić, Ivana; Kotur-Stevuljević, Jelena; Šobajić, Slađana; Spasojević-Kalimanovska, Vesna; Jelić-Ivanović, Zorana; Kerkez, Mirko; Đorđević, Vladimir; Đurasić, Ljubomir; Spasić, Slavica

(Vup Food Research Inst, Bratislava, 2015)

TY  - JOUR
AU  - Miljković, Milica
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Šobajić, Slađana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Kerkez, Mirko
AU  - Đorđević, Vladimir
AU  - Đurasić, Ljubomir
AU  - Spasić, Slavica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2312
AB  - Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p  lt  0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p  lt  0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.
PB  - Vup Food Research Inst, Bratislava
T2  - Journal of Food and Nutrition Research
T1  - Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity
VL  - 54
IS  - 4
SP  - 314
EP  - 322
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2312
ER  - 
@article{
author = "Miljković, Milica and Đuričić, Ivana and Kotur-Stevuljević, Jelena and Šobajić, Slađana and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Spasić, Slavica",
year = "2015",
abstract = "Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p  lt  0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p  lt  0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.",
publisher = "Vup Food Research Inst, Bratislava",
journal = "Journal of Food and Nutrition Research",
title = "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity",
volume = "54",
number = "4",
pages = "314-322",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2312"
}
Miljković, M., Đuričić, I., Kotur-Stevuljević, J., Šobajić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Kerkez, M., Đorđević, V., Đurasić, L.,& Spasić, S.. (2015). Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research
Vup Food Research Inst, Bratislava., 54(4), 314-322.
https://hdl.handle.net/21.15107/rcub_farfar_2312
Miljković M, Đuričić I, Kotur-Stevuljević J, Šobajić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Kerkez M, Đorđević V, Đurasić L, Spasić S. Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research. 2015;54(4):314-322.
https://hdl.handle.net/21.15107/rcub_farfar_2312 .
Miljković, Milica, Đuričić, Ivana, Kotur-Stevuljević, Jelena, Šobajić, Slađana, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Spasić, Slavica, "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity" in Journal of Food and Nutrition Research, 54, no. 4 (2015):314-322,
https://hdl.handle.net/21.15107/rcub_farfar_2312 .
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