TY  - JOUR
AU  - Tulić, Lidija
AU  - Ćurčić, Marijana
AU  - Stojnić, Jelena
AU  - Bulat, Zorica
AU  - Protić, Isidora
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3632
AB  - Introduction/Objective The aim was to assess the effect of oxidative stress parameters on sperm count, motility, and morphology of spermatozoa, and the influence of different semen parameters on the outcome of in vitro fertilization (IVF) procedure – the number of fertilized oocytes, fertilization, and pregnancy rate of female partners. Method In 52 male patients superoxide dismutase (SOD), malondialdehyde (MDA), and sulfhydryl (-SH) groups were determined in serum, before beginning the IVF cycle. Semen samples were collected after 2–3 days of sexual abstinence. Results Patients were divided into two groups, the normozoospermic, and those with pathological sperm findings. The second group was divided into oligozoospermic, asthenozoospermic, and teratozoospermic groups. SOD activity was lower, while MDA and-SH groups, while not significantly, was higher in groups with sperm parameter disorders. Fertilization rate was significantly lower in the group of asthenozoospermia and teratozoospermia (p = 0.034), as well as delivery rate (p = 0.020). The group with oligozoospermia had significantly lower delivery rate (p = 0.013). Conclusion Our study found higher fertilization and delivery rate in men with normozoospermia. However, no significant correlation between OS markers and semen parameters was found.
AB  - Увод/Циљ Циљ рада била је процена утицаја параметара оксидативног стреса на број, покретљивост и морфологију сперматозоида, као и утицаја различитих параметара спер-мограма на исход поступка in vitro фертилизације, број фер-тилисаних ооцита, стопе фертилизације и порођаја.Методе Код 52 мушка партнера одређиване су вредности супероксид-дисмутазе, малондиалдехидаи сулфидрила(-SHгрупа) у серуму, пре започињања поступка in vitro ферти-лизације. Узорци семена сакупљани су после два-три дана апстиненције. Резултати Болесници су били подељени у две групе: гру-па са нормозооспермијом и група са патолошким налазом спермограма. Друга група је затим подељена на подгрупе: олигозооспермија, астенозооспермија и тератозооспер-мија. Активност супероксид-дисмутазе била је нижа, док су вредности малондиалдехидаи -SH група биле више у гру-пама са поремећеним параметрима спермограма, али не статистички значајно. Стопа фертилизације била је значајно нижа у групи са астенозооспермијом и тератозооспермијом (p = 0,034), а такође и стопа порођаја (p = 0,020). Група са олигозооспермијом имала је значајно нижу стопу порођаја (p = 0,013).Закључак У овој студији пронађене су више стопе ферти-лизације и порођаја у групи са нормозооспермијом. Није било значајне корелације између параметара оксидативног стреса и спермограма.
PB  - Serbia Medical Society
T2  - Srpski Arhiv za Celokupno Lekarstvo
T1  - Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization
T1  - Корелација маркера оксидативног стреса и параметара спермограма  са исходом вантелесне оплодње
VL  - 148
IS  - 5-6
SP  - 310
EP  - 314
DO  - 10.2298/SARH190409010T
ER  - 

@article{
author = "Tulić, Lidija and Ćurčić, Marijana and Stojnić, Jelena and Bulat, Zorica and Protić, Isidora",
year = "2020",
abstract = "Introduction/Objective The aim was to assess the effect of oxidative stress parameters on sperm count, motility, and morphology of spermatozoa, and the influence of different semen parameters on the outcome of in vitro fertilization (IVF) procedure – the number of fertilized oocytes, fertilization, and pregnancy rate of female partners. Method In 52 male patients superoxide dismutase (SOD), malondialdehyde (MDA), and sulfhydryl (-SH) groups were determined in serum, before beginning the IVF cycle. Semen samples were collected after 2–3 days of sexual abstinence. Results Patients were divided into two groups, the normozoospermic, and those with pathological sperm findings. The second group was divided into oligozoospermic, asthenozoospermic, and teratozoospermic groups. SOD activity was lower, while MDA and-SH groups, while not significantly, was higher in groups with sperm parameter disorders. Fertilization rate was significantly lower in the group of asthenozoospermia and teratozoospermia (p = 0.034), as well as delivery rate (p = 0.020). The group with oligozoospermia had significantly lower delivery rate (p = 0.013). Conclusion Our study found higher fertilization and delivery rate in men with normozoospermia. However, no significant correlation between OS markers and semen parameters was found., Увод/Циљ Циљ рада била је процена утицаја параметара оксидативног стреса на број, покретљивост и морфологију сперматозоида, као и утицаја различитих параметара спер-мограма на исход поступка in vitro фертилизације, број фер-тилисаних ооцита, стопе фертилизације и порођаја.Методе Код 52 мушка партнера одређиване су вредности супероксид-дисмутазе, малондиалдехидаи сулфидрила(-SHгрупа) у серуму, пре започињања поступка in vitro ферти-лизације. Узорци семена сакупљани су после два-три дана апстиненције. Резултати Болесници су били подељени у две групе: гру-па са нормозооспермијом и група са патолошким налазом спермограма. Друга група је затим подељена на подгрупе: олигозооспермија, астенозооспермија и тератозооспер-мија. Активност супероксид-дисмутазе била је нижа, док су вредности малондиалдехидаи -SH група биле више у гру-пама са поремећеним параметрима спермограма, али не статистички значајно. Стопа фертилизације била је значајно нижа у групи са астенозооспермијом и тератозооспермијом (p = 0,034), а такође и стопа порођаја (p = 0,020). Група са олигозооспермијом имала је значајно нижу стопу порођаја (p = 0,013).Закључак У овој студији пронађене су више стопе ферти-лизације и порођаја у групи са нормозооспермијом. Није било значајне корелације између параметара оксидативног стреса и спермограма.",
publisher = "Serbia Medical Society",
journal = "Srpski Arhiv za Celokupno Lekarstvo",
title = "Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization, Корелација маркера оксидативног стреса и параметара спермограма  са исходом вантелесне оплодње",
volume = "148",
number = "5-6",
pages = "310-314",
doi = "10.2298/SARH190409010T"
}

Tulić, L., Ćurčić, M., Stojnić, J., Bulat, Z.,& Protić, I.. (2020). Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization. in Srpski Arhiv za Celokupno Lekarstvo
Serbia Medical Society., 148(5-6), 310-314.
https://doi.org/10.2298/SARH190409010T

Tulić L, Ćurčić M, Stojnić J, Bulat Z, Protić I. Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization. in Srpski Arhiv za Celokupno Lekarstvo. 2020;148(5-6):310-314.
doi:10.2298/SARH190409010T .

Tulić, Lidija, Ćurčić, Marijana, Stojnić, Jelena, Bulat, Zorica, Protić, Isidora, "Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization" in Srpski Arhiv za Celokupno Lekarstvo, 148, no. 5-6 (2020):310-314,
https://doi.org/10.2298/SARH190409010T . .

TY  - JOUR
AU  - Tulić, Lidija
AU  - Vidaković, Snežana
AU  - Tulić, Ivan
AU  - Ćurčić, Marijana
AU  - Stojnić, Jelena
AU  - Jeremić, Katarina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3009
AB  - Background: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. Methods: This prospective study included 82 patients who under went IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation. Results: Patients were divided into two groups depending on the protocol of stimulation. The mean total and mature oocytes number and number of fertilized oocytes were higher in GnRH agonist group. There was no significant difference in biochemical pregnancy, miscarriage and live -birth rate in both groups. Mean serum SOD was significantly lower, while mean serum MDA and SH groups were significantly higher after ovarian stimulation. Delivery rate was higher in patients without OS while miscarriage rate was higher in patients with OS. Conclusions: Our study confirmed that there is a difference in the concentration of oxidative stress parameters before and after ovarian stimulation. IVF outcome is better in patients without OS after ovarian stimulation. However, the protocol of ovarian stimulation is neither associated with a change in oxidative stress parameters nor with the outcome of ART procedures.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF
VL  - 36
IS  - 2
SP  - 163
EP  - 170
DO  - 10.1515/jomb-2017-0001
ER  - 

@article{
author = "Tulić, Lidija and Vidaković, Snežana and Tulić, Ivan and Ćurčić, Marijana and Stojnić, Jelena and Jeremić, Katarina",
year = "2017",
abstract = "Background: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. Methods: This prospective study included 82 patients who under went IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation. Results: Patients were divided into two groups depending on the protocol of stimulation. The mean total and mature oocytes number and number of fertilized oocytes were higher in GnRH agonist group. There was no significant difference in biochemical pregnancy, miscarriage and live -birth rate in both groups. Mean serum SOD was significantly lower, while mean serum MDA and SH groups were significantly higher after ovarian stimulation. Delivery rate was higher in patients without OS while miscarriage rate was higher in patients with OS. Conclusions: Our study confirmed that there is a difference in the concentration of oxidative stress parameters before and after ovarian stimulation. IVF outcome is better in patients without OS after ovarian stimulation. However, the protocol of ovarian stimulation is neither associated with a change in oxidative stress parameters nor with the outcome of ART procedures.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF",
volume = "36",
number = "2",
pages = "163-170",
doi = "10.1515/jomb-2017-0001"
}

Tulić, L., Vidaković, S., Tulić, I., Ćurčić, M., Stojnić, J.,& Jeremić, K.. (2017). Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(2), 163-170.
https://doi.org/10.1515/jomb-2017-0001

Tulić L, Vidaković S, Tulić I, Ćurčić M, Stojnić J, Jeremić K. Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF. in Journal of Medical Biochemistry. 2017;36(2):163-170.
doi:10.1515/jomb-2017-0001 .

Tulić, Lidija, Vidaković, Snežana, Tulić, Ivan, Ćurčić, Marijana, Stojnić, Jelena, Jeremić, Katarina, "Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF" in Journal of Medical Biochemistry, 36, no. 2 (2017):163-170,
https://doi.org/10.1515/jomb-2017-0001 . .