Milinković Budinčić, Jelena

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Chitosan/sodium lauryl ether sulfate microcapsules as carriers for vitamin E: in vitro release study

Milinković Budinčić, Jelena; Đekić, Ljiljana; Petrović, Lidija; Fraj, Jadranka; Ćirić, Ana

(Hungarian Society for Pharmaceutical Sciences, 2018) 

TY  - CONF
AU  - Milinković Budinčić, Jelena
AU  - Đekić, Ljiljana
AU  - Petrović, Lidija
AU  - Fraj, Jadranka
AU  - Ćirić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5369
AB  - INTRODUCTION: The important current focus
in production of cosmetics is usage of vitamin E
(E), a natural antioxidant protective for tissues
from UV radiation, delays photoaging and provide
moisturizing effect. Encapsulation is needed
for its protection from high temperature, oxygen,
and light, during storage, and also for a potential
ability to control its release and delivery. Preparation
of microcapsules of desired characteristics
depends on various factors (size and nature of the
core substance, wall material, techniques and parameters
of encapsulation) [1, 2]. The study aimed
to evaluate chitosan/sodium lauryl ether sulfate
(Ch/SLES) microcapsules with E as a delivery system
for skin care.
MATERIALS AND METHODS: Microcapsules
were prepared by complex coacervation. Initially,
a 20% O/W emulsion with E (10% solution
in medium-chain triglycerides), stabilized with
the mixture of Ch (0.1 %) and SLES [3], was obtained
by Ultra Turrax T25 homogenization. The
emulsion, without or with a crosslinker, formaldehyde
(FA) or glutaraldehyde (GA), was spray
dried. The in vitro release profile of E from the microcapsule
samples (0.1 g) was studied in 100 g of
ethanol 80%, under continuous stirring at room
temperature. The dissolved E in supernatant aliquots
(2 ml) was analyzed during 90 min, by the
Halo DB-20S UV-VIS spectrophotometer.
RESULTS: The obtained release profiles were
analyzed by fi tt ing in different mathematical
models and in all samples correlate the best with
Korsmeyer-Peppas model. The diffusion exponent
n values (0.05-0.23) indicated non-Fickian
diffusion. We assumed that release of E was
based on a combination of rinsing from the surface
of the microcapsules [4] and diffusion
through the capsule wall. For microparticles with
GA, n was the lowest, the release was rapid and
the amount of release of the substance was higher
(i.e., more pronounced rinsing process), compared
with FA and microcapsules without the
crosslinker, where release of E was more controlled
by diffusion.
CONCLUSION: E vitamin release from Ch/
SLES microcapsules followed Korsmeyer-Peppas
kinetics. The selection of the crosslinker influenced
their surface properties, the surface amount and permeability of the capsule wall for E vitamine
diffusion.
PB  - Hungarian Society for Pharmaceutical Sciences
C3  - Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts
T1  - Chitosan/sodium lauryl ether sulfate microcapsules as carriers for vitamin E: in vitro release study
VL  - 88
IS  - 043
SP  - 173
EP  - 174
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5369
ER  - 
@conference{
author = "Milinković Budinčić, Jelena and Đekić, Ljiljana and Petrović, Lidija and Fraj, Jadranka and Ćirić, Ana",
year = "2018",
abstract = "INTRODUCTION: The important current focus
in production of cosmetics is usage of vitamin E
(E), a natural antioxidant protective for tissues
from UV radiation, delays photoaging and provide
moisturizing effect. Encapsulation is needed
for its protection from high temperature, oxygen,
and light, during storage, and also for a potential
ability to control its release and delivery. Preparation
of microcapsules of desired characteristics
depends on various factors (size and nature of the
core substance, wall material, techniques and parameters
of encapsulation) [1, 2]. The study aimed
to evaluate chitosan/sodium lauryl ether sulfate
(Ch/SLES) microcapsules with E as a delivery system
for skin care.
MATERIALS AND METHODS: Microcapsules
were prepared by complex coacervation. Initially,
a 20% O/W emulsion with E (10% solution
in medium-chain triglycerides), stabilized with
the mixture of Ch (0.1 %) and SLES [3], was obtained
by Ultra Turrax T25 homogenization. The
emulsion, without or with a crosslinker, formaldehyde
(FA) or glutaraldehyde (GA), was spray
dried. The in vitro release profile of E from the microcapsule
samples (0.1 g) was studied in 100 g of
ethanol 80%, under continuous stirring at room
temperature. The dissolved E in supernatant aliquots
(2 ml) was analyzed during 90 min, by the
Halo DB-20S UV-VIS spectrophotometer.
RESULTS: The obtained release profiles were
analyzed by fi tt ing in different mathematical
models and in all samples correlate the best with
Korsmeyer-Peppas model. The diffusion exponent
n values (0.05-0.23) indicated non-Fickian
diffusion. We assumed that release of E was
based on a combination of rinsing from the surface
of the microcapsules [4] and diffusion
through the capsule wall. For microparticles with
GA, n was the lowest, the release was rapid and
the amount of release of the substance was higher
(i.e., more pronounced rinsing process), compared
with FA and microcapsules without the
crosslinker, where release of E was more controlled
by diffusion.
CONCLUSION: E vitamin release from Ch/
SLES microcapsules followed Korsmeyer-Peppas
kinetics. The selection of the crosslinker influenced
their surface properties, the surface amount and permeability of the capsule wall for E vitamine
diffusion.",
publisher = "Hungarian Society for Pharmaceutical Sciences",
journal = "Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts",
title = "Chitosan/sodium lauryl ether sulfate microcapsules as carriers for vitamin E: in vitro release study",
volume = "88",
number = "043",
pages = "173-174",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5369"
}
Milinković Budinčić, J., Đekić, L., Petrović, L., Fraj, J.,& Ćirić, A.. (2018). Chitosan/sodium lauryl ether sulfate microcapsules as carriers for vitamin E: in vitro release study. in Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts
Hungarian Society for Pharmaceutical Sciences., 88(043), 173-174.
https://hdl.handle.net/21.15107/rcub_farfar_5369
Milinković Budinčić J, Đekić L, Petrović L, Fraj J, Ćirić A. Chitosan/sodium lauryl ether sulfate microcapsules as carriers for vitamin E: in vitro release study. in Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts. 2018;88(043):173-174.
https://hdl.handle.net/21.15107/rcub_farfar_5369 .
Milinković Budinčić, Jelena, Đekić, Ljiljana, Petrović, Lidija, Fraj, Jadranka, Ćirić, Ana, "Chitosan/sodium lauryl ether sulfate microcapsules as carriers for vitamin E: in vitro release study" in Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts, 88, no. 043 (2018):173-174,
https://hdl.handle.net/21.15107/rcub_farfar_5369 .