TY  - JOUR
AU  - Krstić, Marko
AU  - Milović, Mladen
AU  - Ibrić, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2701
AB  - In latest years, many natural and synthetic solid carriers attract increasing attention, due to theirs biocompatibility, acceptable ecological and toxicological properties, possible modification of physico-chemical properties, simple production, high stability and relatively low price. These carriers have similar chemical structure, mostly based on silicon-dioxide, magnesium aluminometasilicate and calcium phosphate, and differ from each other in structure porosity, specific surface area, size, volume and shape of pores, and possibility of surface functionalization. Ordered mesoporous materials like MCM - 41 and SBA - 15, as well as porous materials from Neusilin® and Sylysia® groups, represent the most common adsorbents evaluated in order to increase drug dissolution rate, and its bioavailability, and also in modifiedand targeted drug release formulations. Also, natural silica material, isolated from diatomites, diatom microshells, with its unique characteristics, represents relatively cheap solid carrier used in formulation of oral dosage forms and implants. Modern adsorbents are mostly used in formulations of solid dispersions with low water-soluble drugs, or as solid carriers for lipid formulations. In latest years, modern porous carriers are evaluated for possible surface functionalization in order to achieve prolonged or signal-initiated drug release.
AB  - Poslednjih godina veliki broj adsorpcionih nosača prirodnog i sintetskog porekla privlači sve više pažnje zbog svoje biokompatibilnosti, prihvatljivih ekoloških i toksikoloških osobina, velike mogućnosti za modifikaciju fizičkohemijskih osobina, jednostavnog dobijanja, visoke stabilnosti i relativno niske cene. Ovi nosači su slične hemijske strukture, najčešće na bazi silicijum-dioksida, magnezijum-aluminometasilikata i kalcijum-fosfata, a međusobno se razlikuju po poroznosti struktura, specifičnoj površini, veličini, zapremini i obliku pora kao i mogućnosti funkcionalizacije površine. Uređeni mezoporozni materijali kao što su MCM - 41 i SBA - 15, kao i porozni materijali iz grupe Neusilin®-a i Sylysia®-a predstavljaju najčešće ispitivane adsorbente sa ciljem da povećaju brzinu rastvaranja lekovite supstance, a samim tim i biološku raspoloživost, ali se koriste i u formulaciji preparata sa modifikovanim ili ciljanim oslobađanjem lekovite supstance u određeno tkivo. Takođe prirodni silika materijal jedinstvenih karakteristika, izolovan iz dijatomita, dijatomitne mikrokapsule, predstavlja relativno jeftin adsorbent za formulaciju nosača za peroralnu primenu lekovite supstance kao i primenu u obliku implanta. Savremeni adsorbenti najčešće se koriste u izradi čvrstih disperzija sa nisko rastvorljivom lekovitom supstancom, ili kao adsorbenti za različite lipidne formulacije. Jedna od mogućnosti primene savremenih nosača koja se poslednjih godina ispituje jeste i funkcionalizacija površine poroznih materijala u cilju postizanja usporenog ili signalinicirajućeg oslobađanja lekovite supstance.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Properties and potential application of modern adsorbents in formulation of solid drug delivery systems
T1  - Karakteristike i potencijalna primena savremenih adsorbenata u formulaciji nosača lekovitih supstanci
VL  - 66
IS  - 1
SP  - 1
EP  - 23
DO  - 10.5937/arhfarm1601001K
ER  - 

@article{
author = "Krstić, Marko and Milović, Mladen and Ibrić, Svetlana",
year = "2016",
abstract = "In latest years, many natural and synthetic solid carriers attract increasing attention, due to theirs biocompatibility, acceptable ecological and toxicological properties, possible modification of physico-chemical properties, simple production, high stability and relatively low price. These carriers have similar chemical structure, mostly based on silicon-dioxide, magnesium aluminometasilicate and calcium phosphate, and differ from each other in structure porosity, specific surface area, size, volume and shape of pores, and possibility of surface functionalization. Ordered mesoporous materials like MCM - 41 and SBA - 15, as well as porous materials from Neusilin® and Sylysia® groups, represent the most common adsorbents evaluated in order to increase drug dissolution rate, and its bioavailability, and also in modifiedand targeted drug release formulations. Also, natural silica material, isolated from diatomites, diatom microshells, with its unique characteristics, represents relatively cheap solid carrier used in formulation of oral dosage forms and implants. Modern adsorbents are mostly used in formulations of solid dispersions with low water-soluble drugs, or as solid carriers for lipid formulations. In latest years, modern porous carriers are evaluated for possible surface functionalization in order to achieve prolonged or signal-initiated drug release., Poslednjih godina veliki broj adsorpcionih nosača prirodnog i sintetskog porekla privlači sve više pažnje zbog svoje biokompatibilnosti, prihvatljivih ekoloških i toksikoloških osobina, velike mogućnosti za modifikaciju fizičkohemijskih osobina, jednostavnog dobijanja, visoke stabilnosti i relativno niske cene. Ovi nosači su slične hemijske strukture, najčešće na bazi silicijum-dioksida, magnezijum-aluminometasilikata i kalcijum-fosfata, a međusobno se razlikuju po poroznosti struktura, specifičnoj površini, veličini, zapremini i obliku pora kao i mogućnosti funkcionalizacije površine. Uređeni mezoporozni materijali kao što su MCM - 41 i SBA - 15, kao i porozni materijali iz grupe Neusilin®-a i Sylysia®-a predstavljaju najčešće ispitivane adsorbente sa ciljem da povećaju brzinu rastvaranja lekovite supstance, a samim tim i biološku raspoloživost, ali se koriste i u formulaciji preparata sa modifikovanim ili ciljanim oslobađanjem lekovite supstance u određeno tkivo. Takođe prirodni silika materijal jedinstvenih karakteristika, izolovan iz dijatomita, dijatomitne mikrokapsule, predstavlja relativno jeftin adsorbent za formulaciju nosača za peroralnu primenu lekovite supstance kao i primenu u obliku implanta. Savremeni adsorbenti najčešće se koriste u izradi čvrstih disperzija sa nisko rastvorljivom lekovitom supstancom, ili kao adsorbenti za različite lipidne formulacije. Jedna od mogućnosti primene savremenih nosača koja se poslednjih godina ispituje jeste i funkcionalizacija površine poroznih materijala u cilju postizanja usporenog ili signalinicirajućeg oslobađanja lekovite supstance.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Properties and potential application of modern adsorbents in formulation of solid drug delivery systems, Karakteristike i potencijalna primena savremenih adsorbenata u formulaciji nosača lekovitih supstanci",
volume = "66",
number = "1",
pages = "1-23",
doi = "10.5937/arhfarm1601001K"
}

Krstić, M., Milović, M.,& Ibrić, S.. (2016). Properties and potential application of modern adsorbents in formulation of solid drug delivery systems. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 66(1), 1-23.
https://doi.org/10.5937/arhfarm1601001K

Krstić M, Milović M, Ibrić S. Properties and potential application of modern adsorbents in formulation of solid drug delivery systems. in Arhiv za farmaciju. 2016;66(1):1-23.
doi:10.5937/arhfarm1601001K .

Krstić, Marko, Milović, Mladen, Ibrić, Svetlana, "Properties and potential application of modern adsorbents in formulation of solid drug delivery systems" in Arhiv za farmaciju, 66, no. 1 (2016):1-23,
https://doi.org/10.5937/arhfarm1601001K . .

TY  - JOUR
AU  - Milović, Mladen
AU  - Simović, Spomenka
AU  - Losić, Dušan
AU  - Dashevskiy, Andriy
AU  - Ibrić, Svetlana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2086
AB  - We report the application of diatom as a solid carrier for water insoluble drugs applied in oral drug delivery system based on the self-emulsifying drug delivery system (SEDDS) caprylocaproyl macrogol-8 glycerides/lecithin/propylene glycol/caprylic/capric triglyceride. Diatoms are fossilized skeletons of photosynthetic algae with complex 3-dimensional (3D), porous structure consisting of amorphous silica, obtained by purification of diatomaceous earth. Different solid samples of carbamazepine (CBZ) suspension in SEDDS, called solid self-emulsifying phospholipid suspension (SSEPS), were prepared using two methods: adsorption of CBZ dispersion in SEDDS by gentle mixing with diatoms in mortar with pestle (Method A) or dispersion of diatoms in ethanol solution of CBZ and SEDDS components, followed by ethanol evaporation (Method B). Release rate of CBZ from SSEPS was significantly higher in comparison to pure drug, physical mixture of diatoms and CBZ as well as solid dispersion of pure CBZ and diatoms obtained by ethanol evaporation. The dissolution of CBZ from SSEPS sample prepared using method B was faster than from the sample prepared by the method A. Higher dissolution for sample prepared by the method B can be attributed to the partial adsorption (deeper localization) of liquid material inside the pores of diatoms. Upon storage of the samples under accelerated conditions (40 degrees C and 70% RH) for 10 weeks no significant changes in CBZ crystallinity and dissolution was in case of SSEPS, contrary to solid dispersion with increased crystallinity, indicating that diatoms with adsorbed liquid CBZ-loaded SEPS can maintain initial CBZ characteristics.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Solid self-emulsifying phospholipid suspension (SSEPS) with diatom as a drug carrier
VL  - 63
SP  - 226
EP  - 232
DO  - 10.1016/j.ejps.2014.07.010
ER  - 

@article{
author = "Milović, Mladen and Simović, Spomenka and Losić, Dušan and Dashevskiy, Andriy and Ibrić, Svetlana",
year = "2014",
abstract = "We report the application of diatom as a solid carrier for water insoluble drugs applied in oral drug delivery system based on the self-emulsifying drug delivery system (SEDDS) caprylocaproyl macrogol-8 glycerides/lecithin/propylene glycol/caprylic/capric triglyceride. Diatoms are fossilized skeletons of photosynthetic algae with complex 3-dimensional (3D), porous structure consisting of amorphous silica, obtained by purification of diatomaceous earth. Different solid samples of carbamazepine (CBZ) suspension in SEDDS, called solid self-emulsifying phospholipid suspension (SSEPS), were prepared using two methods: adsorption of CBZ dispersion in SEDDS by gentle mixing with diatoms in mortar with pestle (Method A) or dispersion of diatoms in ethanol solution of CBZ and SEDDS components, followed by ethanol evaporation (Method B). Release rate of CBZ from SSEPS was significantly higher in comparison to pure drug, physical mixture of diatoms and CBZ as well as solid dispersion of pure CBZ and diatoms obtained by ethanol evaporation. The dissolution of CBZ from SSEPS sample prepared using method B was faster than from the sample prepared by the method A. Higher dissolution for sample prepared by the method B can be attributed to the partial adsorption (deeper localization) of liquid material inside the pores of diatoms. Upon storage of the samples under accelerated conditions (40 degrees C and 70% RH) for 10 weeks no significant changes in CBZ crystallinity and dissolution was in case of SSEPS, contrary to solid dispersion with increased crystallinity, indicating that diatoms with adsorbed liquid CBZ-loaded SEPS can maintain initial CBZ characteristics.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Solid self-emulsifying phospholipid suspension (SSEPS) with diatom as a drug carrier",
volume = "63",
pages = "226-232",
doi = "10.1016/j.ejps.2014.07.010"
}

Milović, M., Simović, S., Losić, D., Dashevskiy, A.,& Ibrić, S.. (2014). Solid self-emulsifying phospholipid suspension (SSEPS) with diatom as a drug carrier. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 63, 226-232.
https://doi.org/10.1016/j.ejps.2014.07.010

Milović M, Simović S, Losić D, Dashevskiy A, Ibrić S. Solid self-emulsifying phospholipid suspension (SSEPS) with diatom as a drug carrier. in European Journal of Pharmaceutical Sciences. 2014;63:226-232.
doi:10.1016/j.ejps.2014.07.010 .

Milović, Mladen, Simović, Spomenka, Losić, Dušan, Dashevskiy, Andriy, Ibrić, Svetlana, "Solid self-emulsifying phospholipid suspension (SSEPS) with diatom as a drug carrier" in European Journal of Pharmaceutical Sciences, 63 (2014):226-232,
https://doi.org/10.1016/j.ejps.2014.07.010 . .

TY  - JOUR
AU  - Milović, Mladen
AU  - Đuriš, Jelena
AU  - Vasiljević, Dragana
AU  - Đurić, Zorica
AU  - Ibrić, Svetlana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1769
AB  - In order to achieve fast release of ibuprofen, a slightly soluble model substance (0.52×10?4 mol/l), surfactant systems for oral use with different PEG-40 hydrogenated castor oil (C)/diethylene glycol monoethyl ether (T) ratios were investigated. Comparison between dissolution profiles for ibuprofen from formulated systems and from two commercial products, film tablets and soft capsules, is presented in this paper. Photon correlation spectroscopy has shown that after high dilution with water, the surfactant systems were able to form micellar solutions. The size of micelles varied from 14.8±0.075 nm to 16.2±0.021 nm with increasing C/T ratio from 1:2 to 2:1. Although increasing content of PEG-40 hydrogenated castor oil resulted in formation of larger micelles, the lower values of polydispersity index indicated that a more homogeneous distribution of micelle sizes was gained. Conductometric analysis had demonstrated that the system composing of C/T ratio 2:1 showed the most pronounced interaction between droplets, which can be seen as a high rise of electrical conductivity with increasing water content (wwater/wtotal) in the sample. No significant difference in percolation threshold between formulations with different C/T ratios was observed. Different surfactant systems were adsorbed on magnesium aluminometasilicate, as adsorbent with high specific active surface (≈300 m2/g), in order to investigate the potential influence of adsorbent on ibuprofen dissolution rate. Formulated systems, with or without adsorbent, were filled in hard gelatin capsules. The dissolution profiles of ibuprofen from different formulations were obtained in 30 min by dissolution apparatus with rotating baskets and compared with dissolution profiles of ibuprofen from commercial products. For formulations without adsorbent faster release of ibuprofen in the first minutes of the dissolution test, showed formulations with C/T ratio 2:1 and 1:1. Magnesium aluminometasilicate, as adsorbent with high specific surface area, significantly improved release rate of ibuprofen from formulation with C/T ratio 2:1. However, for the formulation with C/T ratio 1:1, significantly lower release of ibuprofen was observed. Formulations with other C/T ratios in terms of fast ibuprofen release did not give satisfying results. The obtained results show that in comparison to dissolution profile of ibuprofen from commercial products proper C/T ratio as well as magnesium aluminometasilicate, as adsorbent with high specific surface area, can significantly increase release of ibuprofen.
AB  - U radu je prikazana izrada različitih PEG-40 hidrogenizovano ricinusovo ulje (C)/dietil-englikolmonoetiletar (T) surfaktantnih sistema za peroralnu primenu, radi postizanja bržeg rastvaranja ibuprofena u odnosu na komercijalne preparate tipa film tableta i mekih želatinskih kapsula. Surfaktantni sistemi sa C/T odnosom 1:2, 2:1 i 1:1 okarakterisani su ispitivanjem promene električne provodljivosti sistema sa promenom sadržaja vode (% (mvode/ /mukupno)), kao i merenjem veličine prečnika kapi pri sadržaju vode od 95% (mvode/mukupno). Formulacije C/T odnosa 2:1 i 1:1 pokazale su brže rastvaranje ibuprofena u odnosu na komercijalni preparat. Izrađene formulacije C/T sistema sa ibuprofenom su zatim adsorbovane na magnezijum-aluminijum-metasilikatu, koji kao adsorbens velike specifične aktivne površine, znatno ubrzava rastvaranje ibuprofena pri C/T odnosu 2:1, dok pri drugim C/T odnosima, pozitivan uticaj adsorbensa na brzinu rastvaranja ibuprofena izostaje. Pravilnim odabirom odnosa lekovita supstanca/surfaktant/kosurfaktant/adsorbens, moguće je postići brzo rastvaranje teško rastvorljive lekovite supstance iz čvrstih farmaceutskih oblika.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Potential application of surfactant systems in formulation of dosage forms with slightly soluble substances
T1  - Potencijalna primena surfaktantnih sistema u formulaciji farmaceutskih oblika sa teško rastvorljivim lekovitim supstancama
VL  - 66
IS  - 5
SP  - 667
EP  - 676
DO  - 10.2298/HEMIND120130036M
ER  - 

@article{
author = "Milović, Mladen and Đuriš, Jelena and Vasiljević, Dragana and Đurić, Zorica and Ibrić, Svetlana",
year = "2012",
abstract = "In order to achieve fast release of ibuprofen, a slightly soluble model substance (0.52×10?4 mol/l), surfactant systems for oral use with different PEG-40 hydrogenated castor oil (C)/diethylene glycol monoethyl ether (T) ratios were investigated. Comparison between dissolution profiles for ibuprofen from formulated systems and from two commercial products, film tablets and soft capsules, is presented in this paper. Photon correlation spectroscopy has shown that after high dilution with water, the surfactant systems were able to form micellar solutions. The size of micelles varied from 14.8±0.075 nm to 16.2±0.021 nm with increasing C/T ratio from 1:2 to 2:1. Although increasing content of PEG-40 hydrogenated castor oil resulted in formation of larger micelles, the lower values of polydispersity index indicated that a more homogeneous distribution of micelle sizes was gained. Conductometric analysis had demonstrated that the system composing of C/T ratio 2:1 showed the most pronounced interaction between droplets, which can be seen as a high rise of electrical conductivity with increasing water content (wwater/wtotal) in the sample. No significant difference in percolation threshold between formulations with different C/T ratios was observed. Different surfactant systems were adsorbed on magnesium aluminometasilicate, as adsorbent with high specific active surface (≈300 m2/g), in order to investigate the potential influence of adsorbent on ibuprofen dissolution rate. Formulated systems, with or without adsorbent, were filled in hard gelatin capsules. The dissolution profiles of ibuprofen from different formulations were obtained in 30 min by dissolution apparatus with rotating baskets and compared with dissolution profiles of ibuprofen from commercial products. For formulations without adsorbent faster release of ibuprofen in the first minutes of the dissolution test, showed formulations with C/T ratio 2:1 and 1:1. Magnesium aluminometasilicate, as adsorbent with high specific surface area, significantly improved release rate of ibuprofen from formulation with C/T ratio 2:1. However, for the formulation with C/T ratio 1:1, significantly lower release of ibuprofen was observed. Formulations with other C/T ratios in terms of fast ibuprofen release did not give satisfying results. The obtained results show that in comparison to dissolution profile of ibuprofen from commercial products proper C/T ratio as well as magnesium aluminometasilicate, as adsorbent with high specific surface area, can significantly increase release of ibuprofen., U radu je prikazana izrada različitih PEG-40 hidrogenizovano ricinusovo ulje (C)/dietil-englikolmonoetiletar (T) surfaktantnih sistema za peroralnu primenu, radi postizanja bržeg rastvaranja ibuprofena u odnosu na komercijalne preparate tipa film tableta i mekih želatinskih kapsula. Surfaktantni sistemi sa C/T odnosom 1:2, 2:1 i 1:1 okarakterisani su ispitivanjem promene električne provodljivosti sistema sa promenom sadržaja vode (% (mvode/ /mukupno)), kao i merenjem veličine prečnika kapi pri sadržaju vode od 95% (mvode/mukupno). Formulacije C/T odnosa 2:1 i 1:1 pokazale su brže rastvaranje ibuprofena u odnosu na komercijalni preparat. Izrađene formulacije C/T sistema sa ibuprofenom su zatim adsorbovane na magnezijum-aluminijum-metasilikatu, koji kao adsorbens velike specifične aktivne površine, znatno ubrzava rastvaranje ibuprofena pri C/T odnosu 2:1, dok pri drugim C/T odnosima, pozitivan uticaj adsorbensa na brzinu rastvaranja ibuprofena izostaje. Pravilnim odabirom odnosa lekovita supstanca/surfaktant/kosurfaktant/adsorbens, moguće je postići brzo rastvaranje teško rastvorljive lekovite supstance iz čvrstih farmaceutskih oblika.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Potential application of surfactant systems in formulation of dosage forms with slightly soluble substances, Potencijalna primena surfaktantnih sistema u formulaciji farmaceutskih oblika sa teško rastvorljivim lekovitim supstancama",
volume = "66",
number = "5",
pages = "667-676",
doi = "10.2298/HEMIND120130036M"
}

Milović, M., Đuriš, J., Vasiljević, D., Đurić, Z.,& Ibrić, S.. (2012). Potential application of surfactant systems in formulation of dosage forms with slightly soluble substances. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 66(5), 667-676.
https://doi.org/10.2298/HEMIND120130036M

Milović M, Đuriš J, Vasiljević D, Đurić Z, Ibrić S. Potential application of surfactant systems in formulation of dosage forms with slightly soluble substances. in Hemijska industrija. 2012;66(5):667-676.
doi:10.2298/HEMIND120130036M .

Milović, Mladen, Đuriš, Jelena, Vasiljević, Dragana, Đurić, Zorica, Ibrić, Svetlana, "Potential application of surfactant systems in formulation of dosage forms with slightly soluble substances" in Hemijska industrija, 66, no. 5 (2012):667-676,
https://doi.org/10.2298/HEMIND120130036M . .

TY  - JOUR
AU  - Milović, Mladen
AU  - Đuriš, Jelena
AU  - Đekić, Ljiljana
AU  - Vasiljević, Dragana
AU  - Ibrić, Svetlana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1639
AB  - The purpose of this study was to investigate solid self-microemulsifying drug delivery system (SSMEDDS), as potential delivery system for poorly water soluble drug carbamazepine (CBZ). Self-microemulsifying drug delivery system (SMEDDS) was formulated using the surfactant polyoxyethylene 20 sorbitan monooleate [Polysorbate 80] (S), the cosurfactant PEG-40 hydrogenated castor oil [Cremophor (R) RH40]
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release
VL  - 436
IS  - 1-2
SP  - 58
EP  - 65
DO  - 10.1016/j.ijpharm.2012.06.032
ER  - 

@article{
author = "Milović, Mladen and Đuriš, Jelena and Đekić, Ljiljana and Vasiljević, Dragana and Ibrić, Svetlana",
year = "2012",
abstract = "The purpose of this study was to investigate solid self-microemulsifying drug delivery system (SSMEDDS), as potential delivery system for poorly water soluble drug carbamazepine (CBZ). Self-microemulsifying drug delivery system (SMEDDS) was formulated using the surfactant polyoxyethylene 20 sorbitan monooleate [Polysorbate 80] (S), the cosurfactant PEG-40 hydrogenated castor oil [Cremophor (R) RH40]",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release",
volume = "436",
number = "1-2",
pages = "58-65",
doi = "10.1016/j.ijpharm.2012.06.032"
}

Milović, M., Đuriš, J., Đekić, L., Vasiljević, D.,& Ibrić, S.. (2012). Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 436(1-2), 58-65.
https://doi.org/10.1016/j.ijpharm.2012.06.032

Milović M, Đuriš J, Đekić L, Vasiljević D, Ibrić S. Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release. in International Journal of Pharmaceutics. 2012;436(1-2):58-65.
doi:10.1016/j.ijpharm.2012.06.032 .

Milović, Mladen, Đuriš, Jelena, Đekić, Ljiljana, Vasiljević, Dragana, Ibrić, Svetlana, "Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release" in International Journal of Pharmaceutics, 436, no. 1-2 (2012):58-65,
https://doi.org/10.1016/j.ijpharm.2012.06.032 . .