TY  - JOUR
AU  - Krivokapić, Jovana
AU  - Ivanović, Jasna
AU  - Đuriš, Jelena
AU  - Medarević, Đorđe
AU  - Potpara, Zorica
AU  - Maksimović, Zoran
AU  - Ibrić, Svetlana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3621
AB  - The objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to produce MCC from wheat straw, utilizing an acid hydrolysis method, either using only sulfuric acid or combination of sulfuric and hydrochloric acid. The tableting behavior of obtained MCC samples and mixtures of MCC with ibuprofen was studied using a dynamic powder compaction analyzer. It was observed that some of the obtained MCC samples showed better flowing properties than commercially available Vivapur® PH101 and also very high values of tensile strength, solid fraction and elastic recovery. This can be linked with its good compaction behavior, but on the other hand it can cause problems with the disintegration of the tablets. In mixtures with ibuprofen, MCC samples showed lower values of tensile strength, while on the other hand elastic recovery did not seem to be much affected, still exhibiting very high values. According to the obtained results, it can be concluded that MCC obtained from the agricultural waste could have satisfactory properties for tablet preparation by the direct compression method. Further studies are needed to optimize process conditions in order to achieve better physicochemical characteristics, especially in terms of elastic recovery.
PB  - Elsevier B.V.
T2  - Saudi Pharmaceutical Journal
T1  - Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press
VL  - 2
SP  - 710
EP  - 718
DO  - 10.1016/j.jsps.2020.04.013
ER  - 

@article{
author = "Krivokapić, Jovana and Ivanović, Jasna and Đuriš, Jelena and Medarević, Đorđe and Potpara, Zorica and Maksimović, Zoran and Ibrić, Svetlana",
year = "2020",
abstract = "The objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to produce MCC from wheat straw, utilizing an acid hydrolysis method, either using only sulfuric acid or combination of sulfuric and hydrochloric acid. The tableting behavior of obtained MCC samples and mixtures of MCC with ibuprofen was studied using a dynamic powder compaction analyzer. It was observed that some of the obtained MCC samples showed better flowing properties than commercially available Vivapur® PH101 and also very high values of tensile strength, solid fraction and elastic recovery. This can be linked with its good compaction behavior, but on the other hand it can cause problems with the disintegration of the tablets. In mixtures with ibuprofen, MCC samples showed lower values of tensile strength, while on the other hand elastic recovery did not seem to be much affected, still exhibiting very high values. According to the obtained results, it can be concluded that MCC obtained from the agricultural waste could have satisfactory properties for tablet preparation by the direct compression method. Further studies are needed to optimize process conditions in order to achieve better physicochemical characteristics, especially in terms of elastic recovery.",
publisher = "Elsevier B.V.",
journal = "Saudi Pharmaceutical Journal",
title = "Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press",
volume = "2",
pages = "710-718",
doi = "10.1016/j.jsps.2020.04.013"
}

Krivokapić, J., Ivanović, J., Đuriš, J., Medarević, Đ., Potpara, Z., Maksimović, Z.,& Ibrić, S.. (2020). Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press. in Saudi Pharmaceutical Journal
Elsevier B.V.., 2, 710-718.
https://doi.org/10.1016/j.jsps.2020.04.013

Krivokapić J, Ivanović J, Đuriš J, Medarević Đ, Potpara Z, Maksimović Z, Ibrić S. Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press. in Saudi Pharmaceutical Journal. 2020;2:710-718.
doi:10.1016/j.jsps.2020.04.013 .

Krivokapić, Jovana, Ivanović, Jasna, Đuriš, Jelena, Medarević, Đorđe, Potpara, Zorica, Maksimović, Zoran, Ibrić, Svetlana, "Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press" in Saudi Pharmaceutical Journal, 2 (2020):710-718,
https://doi.org/10.1016/j.jsps.2020.04.013 . .

TY  - JOUR
AU  - Vojinović, Tanja
AU  - Medarević, Đorđe
AU  - Vranić, Edina
AU  - Potpara, Zorica
AU  - Krstić, Marko
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3243
AB  - In this study solid dispersions of carbamazepine in the hydrophilic Kollidon (R) VA64 polymer, adsorbed onto Neusilin (R) UFL2 adsorption carrier have been employed to improve carbamazepine dissolution rate. In order to evaluate effects of changing in the proportions of all solid dispersion components on carbamazepine dissolution rate, D-optimal mixture experimental design was used in the formulation development. From all prepared solid dispersion formulations, significantly faster carbamazepine dissolution was observed compared to pure drug. Ternary solid dispersions containing carbamazepine, Kollidon (R) VA64 and Neusilin (R) UFL2 showed superior dissolution performances over binary ones, containing only carbamazepine and Neusilin (R) UFL2. Proportion of Kollidon (R) VA64 showed the most profound effect on the amount of carbamazepine dissolved after 10 and 30 min, whereby these parameters increase upon increasing in Kollidon (R) VA64 concentrations up to the middle values in the studied range of Kollidon (R) VA64 concentrations. Physicochemical characterization of the selected samples using differential scanning calorimetry, FT-IR spectroscopy, powder X-ray diffraction and polarizing light microscopy showed polymorphic transition of carbamazepine from more thermodynamically stable monoclinic form (form III) to less thermodynamically stable triclinic form (form I) in the case of ternary, but not of binary solid dispersion formulations. This polymorphic transition can be one of the factors responsible for improving of carbamazepine dissolution rate from studied solid dispersions. Ternary solid dispersions prepared with Kollidon (R) VA64 hydrophilic polymer and Neusilin (R) UFL2 adsorption carrier resulted in significantly improvement of carbamazepine dissolution rate, but formation of metastable polymorphic form of carbamazepine requires particular care to be taken in ensuring product long term stability.
PB  - Elsevier Science BV, Amsterdam
T2  - Science of the Total Environment
T1  - Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine
VL  - 26
IS  - 5
SP  - 725
EP  - 732
DO  - 10.1016/j.jsps.2018.02.017
ER  - 

@article{
author = "Vojinović, Tanja and Medarević, Đorđe and Vranić, Edina and Potpara, Zorica and Krstić, Marko and Đuriš, Jelena and Ibrić, Svetlana",
year = "2018",
abstract = "In this study solid dispersions of carbamazepine in the hydrophilic Kollidon (R) VA64 polymer, adsorbed onto Neusilin (R) UFL2 adsorption carrier have been employed to improve carbamazepine dissolution rate. In order to evaluate effects of changing in the proportions of all solid dispersion components on carbamazepine dissolution rate, D-optimal mixture experimental design was used in the formulation development. From all prepared solid dispersion formulations, significantly faster carbamazepine dissolution was observed compared to pure drug. Ternary solid dispersions containing carbamazepine, Kollidon (R) VA64 and Neusilin (R) UFL2 showed superior dissolution performances over binary ones, containing only carbamazepine and Neusilin (R) UFL2. Proportion of Kollidon (R) VA64 showed the most profound effect on the amount of carbamazepine dissolved after 10 and 30 min, whereby these parameters increase upon increasing in Kollidon (R) VA64 concentrations up to the middle values in the studied range of Kollidon (R) VA64 concentrations. Physicochemical characterization of the selected samples using differential scanning calorimetry, FT-IR spectroscopy, powder X-ray diffraction and polarizing light microscopy showed polymorphic transition of carbamazepine from more thermodynamically stable monoclinic form (form III) to less thermodynamically stable triclinic form (form I) in the case of ternary, but not of binary solid dispersion formulations. This polymorphic transition can be one of the factors responsible for improving of carbamazepine dissolution rate from studied solid dispersions. Ternary solid dispersions prepared with Kollidon (R) VA64 hydrophilic polymer and Neusilin (R) UFL2 adsorption carrier resulted in significantly improvement of carbamazepine dissolution rate, but formation of metastable polymorphic form of carbamazepine requires particular care to be taken in ensuring product long term stability.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Science of the Total Environment",
title = "Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine",
volume = "26",
number = "5",
pages = "725-732",
doi = "10.1016/j.jsps.2018.02.017"
}

Vojinović, T., Medarević, Đ., Vranić, E., Potpara, Z., Krstić, M., Đuriš, J.,& Ibrić, S.. (2018). Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine. in Science of the Total Environment
Elsevier Science BV, Amsterdam., 26(5), 725-732.
https://doi.org/10.1016/j.jsps.2018.02.017

Vojinović T, Medarević Đ, Vranić E, Potpara Z, Krstić M, Đuriš J, Ibrić S. Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine. in Science of the Total Environment. 2018;26(5):725-732.
doi:10.1016/j.jsps.2018.02.017 .

Vojinović, Tanja, Medarević, Đorđe, Vranić, Edina, Potpara, Zorica, Krstić, Marko, Đuriš, Jelena, Ibrić, Svetlana, "Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine" in Science of the Total Environment, 26, no. 5 (2018):725-732,
https://doi.org/10.1016/j.jsps.2018.02.017 . .