TY  - JOUR
AU  - Milovanović, S
AU  - Đuriš, Jelena
AU  - Dapcević, Aleksandra
AU  - Medarević, Đorđe
AU  - Ibrić, Svetlana
AU  - Zizović, I
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3252
AB  - The present work is aimed towards designing advanced materials by means of sustainable processes. In that sense, the utilization of supercritical CO 2 (scCO 2 ) for processing of pharmaceutical polymers (Soluplus ® , Eudragit ® , and hydroxypropyl methylcellulose acetate succinate), alone and with an addition of cardiovascular drug Carvedilol, was explored. Employed single-step static scCO 2 process (pressure of 30 MPa and temperature of 100 °C for 2 h) enabled fabrication of solvent-free polymeric foams and Carvedilol solid dispersions with controlled microstructure and average pore diameter of 101–257 μm suitable for application in the pharmaceutical industry. ScCO 2 did not remain in the foams after processing or affected the polymer composition, while Carvedilol formed hydrogen bonds with the polymers. Carvedilol was molecularly dispersed in the fabricated solid dispersions and its transition from the crystalline to amorphous form was complete. Korsmeyer-Peppas model was successfully used for the mathematical description of Carvedilol dissolution from solid dispersions. The dissolution rate of Carvedilol in acidic medium was significantly enhanced by its dispersion in tested polymers using the proposed high-pressure method.
PB  - Elsevier Ltd
T2  - Polymer Testing
T1  - Soluplus ® , Eudragit ® , HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO 2 process
VL  - 76
SP  - 54
EP  - 64
DO  - 10.1016/j.polymertesting.2019.03.001
ER  - 

@article{
author = "Milovanović, S and Đuriš, Jelena and Dapcević, Aleksandra and Medarević, Đorđe and Ibrić, Svetlana and Zizović, I",
year = "2019",
abstract = "The present work is aimed towards designing advanced materials by means of sustainable processes. In that sense, the utilization of supercritical CO 2 (scCO 2 ) for processing of pharmaceutical polymers (Soluplus ® , Eudragit ® , and hydroxypropyl methylcellulose acetate succinate), alone and with an addition of cardiovascular drug Carvedilol, was explored. Employed single-step static scCO 2 process (pressure of 30 MPa and temperature of 100 °C for 2 h) enabled fabrication of solvent-free polymeric foams and Carvedilol solid dispersions with controlled microstructure and average pore diameter of 101–257 μm suitable for application in the pharmaceutical industry. ScCO 2 did not remain in the foams after processing or affected the polymer composition, while Carvedilol formed hydrogen bonds with the polymers. Carvedilol was molecularly dispersed in the fabricated solid dispersions and its transition from the crystalline to amorphous form was complete. Korsmeyer-Peppas model was successfully used for the mathematical description of Carvedilol dissolution from solid dispersions. The dissolution rate of Carvedilol in acidic medium was significantly enhanced by its dispersion in tested polymers using the proposed high-pressure method.",
publisher = "Elsevier Ltd",
journal = "Polymer Testing",
title = "Soluplus ® , Eudragit ® , HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO 2 process",
volume = "76",
pages = "54-64",
doi = "10.1016/j.polymertesting.2019.03.001"
}

Milovanović, S., Đuriš, J., Dapcević, A., Medarević, Đ., Ibrić, S.,& Zizović, I.. (2019). Soluplus ® , Eudragit ® , HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO 2 process. in Polymer Testing
Elsevier Ltd., 76, 54-64.
https://doi.org/10.1016/j.polymertesting.2019.03.001

Milovanović S, Đuriš J, Dapcević A, Medarević Đ, Ibrić S, Zizović I. Soluplus ® , Eudragit ® , HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO 2 process. in Polymer Testing. 2019;76:54-64.
doi:10.1016/j.polymertesting.2019.03.001 .

Milovanović, S, Đuriš, Jelena, Dapcević, Aleksandra, Medarević, Đorđe, Ibrić, Svetlana, Zizović, I, "Soluplus ® , Eudragit ® , HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO 2 process" in Polymer Testing, 76 (2019):54-64,
https://doi.org/10.1016/j.polymertesting.2019.03.001 . .

TY  - JOUR
AU  - Stepanović-Petrović, Radica
AU  - Tokić-Vujošević, Zorana
AU  - Milovanović, S
AU  - Ceković, Z
AU  - Tomić, Maja
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/476
AB  - The transformation of isosorbide-5-mononitrate (CAS 16051-77-7, IS-5-MN) to the corresponding keto derivative and its ketoxime (oxime-nitrate derivative of isosorbide) is described. The effects of IS-5-MN and the new oxime-nitrate (ON) on the endothelial and smooth muscle cells of isolated rings of the rat superior mesenteric artery were examined. After contraction induced by phenylephrine, IS-5-MN (10(-8)-10(-4) mol/1) caused a concentration-dependent relaxation. Removal of the vascular endothelium strongly potentiated this effect. On the other hand, the new ON (10(-8)-10(-4) mol/1) was a more potent relaxant than the parent drug, but its effect was not dependent on the vascular endothelium. The inhibitory effect of the artery without endothelium to the new ON was more pronounced than that to IS-5-MN. The mechanism of the relaxant effect of the new compound consisted in the liberation of nitric-oxide (NO) which activated guanylate cyclase (GC), upon which accumulation of cyclic guanosine monophosphate (cGMP) occurred, which was the second messenger leading to relaxation. Tolerance to the frequent applications of the new compound was not observed, moreover a slight increase of the effect was detected in comparison with IS-5-MN for which tolerance was observed to a great extent. Clinically, the new ON could be favorable in all types of angina in comparison with the classical IS-5-MN.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Arzneimittelforschung - Drug Research
T1  - Comparison of the relaxant effects of a new oxime-nitrate derived from isosorbide-5-mononitrate and the parent drug
VL  - 54
IS  - 4
SP  - 195
EP  - 202
DO  - 10.1055/s-0031-1296959
UR  - https://hdl.handle.net/21.15107/rcub_farfar_476
ER  - 

@article{
author = "Stepanović-Petrović, Radica and Tokić-Vujošević, Zorana and Milovanović, S and Ceković, Z and Tomić, Maja",
year = "2004",
abstract = "The transformation of isosorbide-5-mononitrate (CAS 16051-77-7, IS-5-MN) to the corresponding keto derivative and its ketoxime (oxime-nitrate derivative of isosorbide) is described. The effects of IS-5-MN and the new oxime-nitrate (ON) on the endothelial and smooth muscle cells of isolated rings of the rat superior mesenteric artery were examined. After contraction induced by phenylephrine, IS-5-MN (10(-8)-10(-4) mol/1) caused a concentration-dependent relaxation. Removal of the vascular endothelium strongly potentiated this effect. On the other hand, the new ON (10(-8)-10(-4) mol/1) was a more potent relaxant than the parent drug, but its effect was not dependent on the vascular endothelium. The inhibitory effect of the artery without endothelium to the new ON was more pronounced than that to IS-5-MN. The mechanism of the relaxant effect of the new compound consisted in the liberation of nitric-oxide (NO) which activated guanylate cyclase (GC), upon which accumulation of cyclic guanosine monophosphate (cGMP) occurred, which was the second messenger leading to relaxation. Tolerance to the frequent applications of the new compound was not observed, moreover a slight increase of the effect was detected in comparison with IS-5-MN for which tolerance was observed to a great extent. Clinically, the new ON could be favorable in all types of angina in comparison with the classical IS-5-MN.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Arzneimittelforschung - Drug Research",
title = "Comparison of the relaxant effects of a new oxime-nitrate derived from isosorbide-5-mononitrate and the parent drug",
volume = "54",
number = "4",
pages = "195-202",
doi = "10.1055/s-0031-1296959",
url = "https://hdl.handle.net/21.15107/rcub_farfar_476"
}

Stepanović-Petrović, R., Tokić-Vujošević, Z., Milovanović, S., Ceković, Z.,& Tomić, M.. (2004). Comparison of the relaxant effects of a new oxime-nitrate derived from isosorbide-5-mononitrate and the parent drug. in Arzneimittelforschung - Drug Research
Georg Thieme Verlag Kg, Stuttgart., 54(4), 195-202.
https://doi.org/10.1055/s-0031-1296959
https://hdl.handle.net/21.15107/rcub_farfar_476

Stepanović-Petrović R, Tokić-Vujošević Z, Milovanović S, Ceković Z, Tomić M. Comparison of the relaxant effects of a new oxime-nitrate derived from isosorbide-5-mononitrate and the parent drug. in Arzneimittelforschung - Drug Research. 2004;54(4):195-202.
doi:10.1055/s-0031-1296959
https://hdl.handle.net/21.15107/rcub_farfar_476 .

Stepanović-Petrović, Radica, Tokić-Vujošević, Zorana, Milovanović, S, Ceković, Z, Tomić, Maja, "Comparison of the relaxant effects of a new oxime-nitrate derived from isosorbide-5-mononitrate and the parent drug" in Arzneimittelforschung - Drug Research, 54, no. 4 (2004):195-202,
https://doi.org/10.1055/s-0031-1296959 .,
https://hdl.handle.net/21.15107/rcub_farfar_476 .

TY  - JOUR
AU  - Milovanović, Lj
AU  - Kapetanović, Vera
AU  - Popović, Gordana
AU  - Aleksić, Mara
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/199
AB  - Fleroxacin belongs to the third generation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. This generation members are of broader spectrum and greater activity compared to nalidixin and oxicilin acid (1-3). The polarographic behaviour of fleroxacin fas not been studied so far. The extensive polarographic study of fleroxacin was done through the wide pH range from 2.48 to 10.00 (Britton Robinson buffer) by dc and dpp polarography. The waves obtained in this pH range show a different degree of reversibility; being much more irreversible in acid medium than in slightly acid medium, neutral or slightly alkaline medium (almost the same an value was obtained at pH 5 and 8). Since the polarographic wave at pH 8 was better developed and its limiting current better separated from the supporting electrolyte current, this pH was used in analytical purposes. Very good analytical respons was obtained at pH being approximately 9, in BR, TRIS and borate buffers. The regression equation obtained in borate buffer was y = 5.428 + 4.5360x (r = 0.9993). Determination of fleroxacin in Quinodis tablets was performed by dpp in borate buffer, pH 8.50. The statistical parameters obtained (SD = 3.07 and RSD = 0.8%) show good reproducibility.
PB  - APB Algemene Pharmaceutische Bond
T2  - Journal de Pharmacie de Belgique
T1  - Polarographic behaviour of fleroxacin and its determination in tablets
VL  - 53
IS  - 3
SP  - 224
UR  - https://hdl.handle.net/21.15107/rcub_farfar_199
ER  - 

@article{
author = "Milovanović, Lj and Kapetanović, Vera and Popović, Gordana and Aleksić, Mara",
year = "1998",
abstract = "Fleroxacin belongs to the third generation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. This generation members are of broader spectrum and greater activity compared to nalidixin and oxicilin acid (1-3). The polarographic behaviour of fleroxacin fas not been studied so far. The extensive polarographic study of fleroxacin was done through the wide pH range from 2.48 to 10.00 (Britton Robinson buffer) by dc and dpp polarography. The waves obtained in this pH range show a different degree of reversibility; being much more irreversible in acid medium than in slightly acid medium, neutral or slightly alkaline medium (almost the same an value was obtained at pH 5 and 8). Since the polarographic wave at pH 8 was better developed and its limiting current better separated from the supporting electrolyte current, this pH was used in analytical purposes. Very good analytical respons was obtained at pH being approximately 9, in BR, TRIS and borate buffers. The regression equation obtained in borate buffer was y = 5.428 + 4.5360x (r = 0.9993). Determination of fleroxacin in Quinodis tablets was performed by dpp in borate buffer, pH 8.50. The statistical parameters obtained (SD = 3.07 and RSD = 0.8%) show good reproducibility.",
publisher = "APB Algemene Pharmaceutische Bond",
journal = "Journal de Pharmacie de Belgique",
title = "Polarographic behaviour of fleroxacin and its determination in tablets",
volume = "53",
number = "3",
pages = "224",
url = "https://hdl.handle.net/21.15107/rcub_farfar_199"
}

Milovanović, L., Kapetanović, V., Popović, G.,& Aleksić, M.. (1998). Polarographic behaviour of fleroxacin and its determination in tablets. in Journal de Pharmacie de Belgique
APB Algemene Pharmaceutische Bond., 53(3), 224.
https://hdl.handle.net/21.15107/rcub_farfar_199

Milovanović L, Kapetanović V, Popović G, Aleksić M. Polarographic behaviour of fleroxacin and its determination in tablets. in Journal de Pharmacie de Belgique. 1998;53(3):224.
https://hdl.handle.net/21.15107/rcub_farfar_199 .

Milovanović, Lj, Kapetanović, Vera, Popović, Gordana, Aleksić, Mara, "Polarographic behaviour of fleroxacin and its determination in tablets" in Journal de Pharmacie de Belgique, 53, no. 3 (1998):224,
https://hdl.handle.net/21.15107/rcub_farfar_199 .

TY  - JOUR
AU  - Popović, Gordana
AU  - Kapetanović, Vera
AU  - Milovanović, Lj
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/201
AB  - Fleroxacin belongs to the third genegation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. In aqueous medium fleroxacin undergoes to complex acid-base equilibrium due to its zwitter ioninc nature and two ionizable functional groups of similar acidity. The corresponding ionization constants were determined by potentiometry and spectrophotometry. On the basis of the knowledge of distribution and spectral characteristics of ionic species of fleroxacin the spectrophotometric method for determination of fleroxacin was developed. The assay was carried out in acidic media (0.1 M HCl) at a wavelenght of 286 nm. A calibration graph was obtained for fleroxacin concentrations 2-8 μg/ml with correlation coefficient a 0.9999. The method is simple and rapid, and was successfully applied to the determination of fleroxacin in commercial tablets.
T2  - Journal de Pharmacie de Belgique
T1  - Spectrophotometric determination of fleroxacin in tablets
VL  - 53
IS  - 3
SP  - 242
UR  - https://hdl.handle.net/21.15107/rcub_farfar_201
ER  - 

@article{
author = "Popović, Gordana and Kapetanović, Vera and Milovanović, Lj",
year = "1998",
abstract = "Fleroxacin belongs to the third genegation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. In aqueous medium fleroxacin undergoes to complex acid-base equilibrium due to its zwitter ioninc nature and two ionizable functional groups of similar acidity. The corresponding ionization constants were determined by potentiometry and spectrophotometry. On the basis of the knowledge of distribution and spectral characteristics of ionic species of fleroxacin the spectrophotometric method for determination of fleroxacin was developed. The assay was carried out in acidic media (0.1 M HCl) at a wavelenght of 286 nm. A calibration graph was obtained for fleroxacin concentrations 2-8 μg/ml with correlation coefficient a 0.9999. The method is simple and rapid, and was successfully applied to the determination of fleroxacin in commercial tablets.",
journal = "Journal de Pharmacie de Belgique",
title = "Spectrophotometric determination of fleroxacin in tablets",
volume = "53",
number = "3",
pages = "242",
url = "https://hdl.handle.net/21.15107/rcub_farfar_201"
}

Popović, G., Kapetanović, V.,& Milovanović, L.. (1998). Spectrophotometric determination of fleroxacin in tablets. in Journal de Pharmacie de Belgique, 53(3), 242.
https://hdl.handle.net/21.15107/rcub_farfar_201

Popović G, Kapetanović V, Milovanović L. Spectrophotometric determination of fleroxacin in tablets. in Journal de Pharmacie de Belgique. 1998;53(3):242.
https://hdl.handle.net/21.15107/rcub_farfar_201 .

Popović, Gordana, Kapetanović, Vera, Milovanović, Lj, "Spectrophotometric determination of fleroxacin in tablets" in Journal de Pharmacie de Belgique, 53, no. 3 (1998):242,
https://hdl.handle.net/21.15107/rcub_farfar_201 .