TY  - CONF
AU  - Popović-Nikolić, Marija
AU  - Mudrić, Jelena
AU  - Popović, Gordana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4683
AB  - The ionization constants (pKa) of ceftazidime, third generation cephalosporin, were determined by potentiometry. Ceftazidime is an ampholyte with four ionizable centers, three acidic centers (two carboxyl groups and amide group) and one basic center (aminothiazole). Potentiometric determinations were performed at 25 °C and constant ionic strength of 0.1 M (NaCl). Experimental data were analyzed by computer software Hyperquad and four pKa values were derived: pKa1 2.55; pKa2 3.94; pKa3 4.54 and pKa4 7.55. According to the obtained pKa values distribution diagram as a function of pH was constructed and distribution of the ceftazidime equilibrium forms was calculated at a pH values of biopharmaceutical significance (pH 1.2, 4.5, 6.8 and 7.4). In addition, based on the chemical structure of ceftazidime the order of ionization were suggested.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
T1  - The determination of the ionization profile of ceftazidime
VL  - II
SP  - 585
EP  - 588
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4683
ER  - 

@conference{
author = "Popović-Nikolić, Marija and Mudrić, Jelena and Popović, Gordana",
year = "2022",
abstract = "The ionization constants (pKa) of ceftazidime, third generation cephalosporin, were determined by potentiometry. Ceftazidime is an ampholyte with four ionizable centers, three acidic centers (two carboxyl groups and amide group) and one basic center (aminothiazole). Potentiometric determinations were performed at 25 °C and constant ionic strength of 0.1 M (NaCl). Experimental data were analyzed by computer software Hyperquad and four pKa values were derived: pKa1 2.55; pKa2 3.94; pKa3 4.54 and pKa4 7.55. According to the obtained pKa values distribution diagram as a function of pH was constructed and distribution of the ceftazidime equilibrium forms was calculated at a pH values of biopharmaceutical significance (pH 1.2, 4.5, 6.8 and 7.4). In addition, based on the chemical structure of ceftazidime the order of ionization were suggested.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)",
title = "The determination of the ionization profile of ceftazidime",
volume = "II",
pages = "585-588",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4683"
}

Popović-Nikolić, M., Mudrić, J.,& Popović, G.. (2022). The determination of the ionization profile of ceftazidime. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
Society of Physical Chemists of Serbia., II, 585-588.
https://hdl.handle.net/21.15107/rcub_farfar_4683

Popović-Nikolić M, Mudrić J, Popović G. The determination of the ionization profile of ceftazidime. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;II:585-588.
https://hdl.handle.net/21.15107/rcub_farfar_4683 .

Popović-Nikolić, Marija, Mudrić, Jelena, Popović, Gordana, "The determination of the ionization profile of ceftazidime" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), II (2022):585-588,
https://hdl.handle.net/21.15107/rcub_farfar_4683 .

TY  - JOUR
AU  - Gopčević, Kristina
AU  - Grujić, Slavica
AU  - Arsenijević, Jelena
AU  - Džamić, Ana
AU  - Veličković, Ivona
AU  - Izrael-Živković, Lidija
AU  - Medić, Ana
AU  - Mudrić, Jelena
AU  - Soković, Marina
AU  - Đurić, Ana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4342
AB  - The aim of the study was to investigate the biological activity and chemical composition of Satureja kitaibelii Wierzb. ex Heuff. LC–PDA/MS analyses for the aqueous extracts (A1-stem, leaves and flowers, A2-leaves and flowers) and ethyl-acetate extracts (E1-stem, leaves and flowers, E2-leaves and flowers) obtained by ultrasound-assisted extraction enabled the identification of thirty-four compounds. Quantitative analysis revealed that the aqueous extract obtained from leaves and flowers was the richest in total phenolic acids (65.36 mg/g) and flavonoids (21.17 mg/g). The total polyphenol content was the highest in the aqueous extract obtained from leaves and flowers (274 ± 2.4 mg Gallic Acid equivalents/g). The best antioxidant activity was observed for the same extract using the DPPH (SC50 20 ± 10 µg/mL), ABTS (2.834 ± 0.02 mg Ascorbic Acid/g), FRAP (1.922 ± 0.03 mmol Fe2+/mg), and total reducing power tests (16.4 ± 1.0 mg Ascorbic Acid/g). Both ethyl acetate extracts were the most active against strains of Bacillus cereus and Micrococcus flavus (MIC 1.70–1.99 mg/mL and 1.99–3.41 mg/mL, respectively). They were more efficient against Aspergillus ochraceus (MFC 0.86 mg/mL) and towards HeLa cell lines. All the obtained results implied the good potential of the investigated extracts to be used as effective preservatives and functional ingredients in food products and dietary supplements.
PB  - Nature Research
T2  - Scientific Reports
T1  - Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction
VL  - 12
IS  - 1
DO  - 10.1038/s41598-022-25668-3
ER  - 

@article{
author = "Gopčević, Kristina and Grujić, Slavica and Arsenijević, Jelena and Džamić, Ana and Veličković, Ivona and Izrael-Živković, Lidija and Medić, Ana and Mudrić, Jelena and Soković, Marina and Đurić, Ana",
year = "2022",
abstract = "The aim of the study was to investigate the biological activity and chemical composition of Satureja kitaibelii Wierzb. ex Heuff. LC–PDA/MS analyses for the aqueous extracts (A1-stem, leaves and flowers, A2-leaves and flowers) and ethyl-acetate extracts (E1-stem, leaves and flowers, E2-leaves and flowers) obtained by ultrasound-assisted extraction enabled the identification of thirty-four compounds. Quantitative analysis revealed that the aqueous extract obtained from leaves and flowers was the richest in total phenolic acids (65.36 mg/g) and flavonoids (21.17 mg/g). The total polyphenol content was the highest in the aqueous extract obtained from leaves and flowers (274 ± 2.4 mg Gallic Acid equivalents/g). The best antioxidant activity was observed for the same extract using the DPPH (SC50 20 ± 10 µg/mL), ABTS (2.834 ± 0.02 mg Ascorbic Acid/g), FRAP (1.922 ± 0.03 mmol Fe2+/mg), and total reducing power tests (16.4 ± 1.0 mg Ascorbic Acid/g). Both ethyl acetate extracts were the most active against strains of Bacillus cereus and Micrococcus flavus (MIC 1.70–1.99 mg/mL and 1.99–3.41 mg/mL, respectively). They were more efficient against Aspergillus ochraceus (MFC 0.86 mg/mL) and towards HeLa cell lines. All the obtained results implied the good potential of the investigated extracts to be used as effective preservatives and functional ingredients in food products and dietary supplements.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction",
volume = "12",
number = "1",
doi = "10.1038/s41598-022-25668-3"
}

Gopčević, K., Grujić, S., Arsenijević, J., Džamić, A., Veličković, I., Izrael-Živković, L., Medić, A., Mudrić, J., Soković, M.,& Đurić, A.. (2022). Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction. in Scientific Reports
Nature Research., 12(1).
https://doi.org/10.1038/s41598-022-25668-3

Gopčević K, Grujić S, Arsenijević J, Džamić A, Veličković I, Izrael-Živković L, Medić A, Mudrić J, Soković M, Đurić A. Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction. in Scientific Reports. 2022;12(1).
doi:10.1038/s41598-022-25668-3 .

Gopčević, Kristina, Grujić, Slavica, Arsenijević, Jelena, Džamić, Ana, Veličković, Ivona, Izrael-Živković, Lidija, Medić, Ana, Mudrić, Jelena, Soković, Marina, Đurić, Ana, "Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction" in Scientific Reports, 12, no. 1 (2022),
https://doi.org/10.1038/s41598-022-25668-3 . .

TY  - CONF
AU  - Mudrić, Jelena
AU  - Arsenijević, Jelena
AU  - Maksimović, Zoran
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5307
AB  - Rosmarinic acid is a dominant component in the extracts of
Satureja kitaibelii (Gopčević et al., 2019). It is reported that
rosmarinic acid has antioxidant, anti-inflammatory,
antibacterial, antiviral and antimutagenic activity (Petersen
et al., 2003). The aim of this study was to develop an
optimal model by using RSM (response surface
methodology) and ANN (artificial neural network)
approach which can describe the influence of ethanol
concentration, temperature and time on the extraction of
rosmarinic acid from aerial parts of S. kitaibelii.
PB  - International Association for Pharmaceutical Technology, Mainz, Germany
C3  - 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May
T1  - Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii
SP  - 1
EP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5307
ER  - 

@conference{
author = "Mudrić, Jelena and Arsenijević, Jelena and Maksimović, Zoran and Ibrić, Svetlana and Đuriš, Jelena",
year = "2021",
abstract = "Rosmarinic acid is a dominant component in the extracts of
Satureja kitaibelii (Gopčević et al., 2019). It is reported that
rosmarinic acid has antioxidant, anti-inflammatory,
antibacterial, antiviral and antimutagenic activity (Petersen
et al., 2003). The aim of this study was to develop an
optimal model by using RSM (response surface
methodology) and ANN (artificial neural network)
approach which can describe the influence of ethanol
concentration, temperature and time on the extraction of
rosmarinic acid from aerial parts of S. kitaibelii.",
publisher = "International Association for Pharmaceutical Technology, Mainz, Germany",
journal = "12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May",
title = "Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii",
pages = "1-2",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5307"
}

Mudrić, J., Arsenijević, J., Maksimović, Z., Ibrić, S.,& Đuriš, J.. (2021). Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May
International Association for Pharmaceutical Technology, Mainz, Germany., 1-2.
https://hdl.handle.net/21.15107/rcub_farfar_5307

Mudrić J, Arsenijević J, Maksimović Z, Ibrić S, Đuriš J. Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May. 2021;:1-2.
https://hdl.handle.net/21.15107/rcub_farfar_5307 .

Mudrić, Jelena, Arsenijević, Jelena, Maksimović, Zoran, Ibrić, Svetlana, Đuriš, Jelena, "Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii" in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May (2021):1-2,
https://hdl.handle.net/21.15107/rcub_farfar_5307 .

TY  - JOUR
AU  - Mudrić, Jelena
AU  - Šavikin, Katarina
AU  - Ðekić, Ljiljana
AU  - Pavlović, Stefan
AU  - Kurćubić, Ivana
AU  - Ibrić, Svetlana
AU  - Ðuriš, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4014
AB  - Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside. The aim of study was to encapsulate GRE in the lipid-based gastroretentive delivery system that could provide high yield and encapsulation efficiency, as well as the biphasic release of gentiopicroside from the tablets obtained by direct compression. Solid lipid microparticles (SLM) loaded with GRE were prepared by freeze-drying double (W/O/W) emulsions, which were obtained by a multiple emulsion–melt dispersion technique, with GRE as the inner water phase, Gelucire® 39/01 or 43/01, as lipid components, with or without the addition of porous silica (Sylysia® 350) in the outer water phase. Formulated SLM powders were examined by SEM and mercury intrusion porosimetry, as well as by determination of yield, encapsulation efficiency, and flow properties. Furthermore, in vitro dissolution of gentiopicroside, the size of the dispersed systems, mechanical properties, and mucoadhesion of tablets obtained by direct compression were investigated. The results have revealed that SLM with the macroporous structure were formulated, and, consequently, the powders floated immediately in the acidic medium. Formulation with porous silica (Sylysia® 350) and Gelucire® 43/01 as a solid lipid was characterized with the high yield end encapsulation efficiency. Furthermore, the mucoadhesive properties of tablets obtained by direct compression of that formulation, as well as the biphasic release of gentiopicroside, presence of nanoassociates in dissolution medium, and optimal mechanical properties indicated that a promising lipid-based gastroretentive system for GRE was developed.
PB  - MDPI
T2  - Pharmaceutics
T1  - Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique
VL  - 13
IS  - 12
DO  - 10.3390/pharmaceutics13122095
ER  - 

@article{
author = "Mudrić, Jelena and Šavikin, Katarina and Ðekić, Ljiljana and Pavlović, Stefan and Kurćubić, Ivana and Ibrić, Svetlana and Ðuriš, Jelena",
year = "2021",
abstract = "Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside. The aim of study was to encapsulate GRE in the lipid-based gastroretentive delivery system that could provide high yield and encapsulation efficiency, as well as the biphasic release of gentiopicroside from the tablets obtained by direct compression. Solid lipid microparticles (SLM) loaded with GRE were prepared by freeze-drying double (W/O/W) emulsions, which were obtained by a multiple emulsion–melt dispersion technique, with GRE as the inner water phase, Gelucire® 39/01 or 43/01, as lipid components, with or without the addition of porous silica (Sylysia® 350) in the outer water phase. Formulated SLM powders were examined by SEM and mercury intrusion porosimetry, as well as by determination of yield, encapsulation efficiency, and flow properties. Furthermore, in vitro dissolution of gentiopicroside, the size of the dispersed systems, mechanical properties, and mucoadhesion of tablets obtained by direct compression were investigated. The results have revealed that SLM with the macroporous structure were formulated, and, consequently, the powders floated immediately in the acidic medium. Formulation with porous silica (Sylysia® 350) and Gelucire® 43/01 as a solid lipid was characterized with the high yield end encapsulation efficiency. Furthermore, the mucoadhesive properties of tablets obtained by direct compression of that formulation, as well as the biphasic release of gentiopicroside, presence of nanoassociates in dissolution medium, and optimal mechanical properties indicated that a promising lipid-based gastroretentive system for GRE was developed.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique",
volume = "13",
number = "12",
doi = "10.3390/pharmaceutics13122095"
}

Mudrić, J., Šavikin, K., Ðekić, L., Pavlović, S., Kurćubić, I., Ibrić, S.,& Ðuriš, J.. (2021). Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique. in Pharmaceutics
MDPI., 13(12).
https://doi.org/10.3390/pharmaceutics13122095

Mudrić J, Šavikin K, Ðekić L, Pavlović S, Kurćubić I, Ibrić S, Ðuriš J. Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique. in Pharmaceutics. 2021;13(12).
doi:10.3390/pharmaceutics13122095 .

Mudrić, Jelena, Šavikin, Katarina, Ðekić, Ljiljana, Pavlović, Stefan, Kurćubić, Ivana, Ibrić, Svetlana, Ðuriš, Jelena, "Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique" in Pharmaceutics, 13, no. 12 (2021),
https://doi.org/10.3390/pharmaceutics13122095 . .

TY  - JOUR
AU  - Mudrić, Jelena
AU  - Arsenijević, Jelena
AU  - Maksimović, Zoran
AU  - Ibrić, Svetlana
AU  - Gopčević, Kristina
AU  - Đuriš, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3953
AB  - Aerial parts of Satureja kitaibelii are traditionally used as carminative, for treatment of respiratory and urinary  complaints, or as anti-inflammatory agent for skin and mucous membranes. The aim of the present study was to  formulate immediate-release capsules and tablets with high content (≥95%) of S. kitaibelii optimized dry extract  by direct compression. The influence of ethanol concentration (40–96%, v/v), temperature (25–80 ◦C) and time  (2–8 h) on the extraction yield, total phenolic content (TPC), as well as on the contents of rosmarinic acid (RA)  and clinopodic acid O (CAO) in the S. kitaibelii dry extract was investigated using the response surface meth-odology (RSM). The estimated optimal conditions for the extraction were: ethanol 46.4%, 61.6 ◦C, 2 h. Dry  extract of S. kitaibelii obtained under the optimal conditions (characterized by: yield 24.2%, TPC 170.4 mg gallic  acid equivalents/g, RA 10.7 mg/g and CAO 17.1 mg/g) was used to manufacture solid dosage forms. Three  formulations (F) were prepared: F1, hard capsules (99% dry extract, 1% magnesium stearate); F2, uncoated  tablets (99% dry extract, 1% magnesium stearate) and F3, uncoated tablets (95% dry extract, 4% sodium starch  glycolate, 1% magnesium stearate). Hard capsules (F1) with the uniform weight, adequate disintegration time  and dissolution rate were obtained. Regarding tablet formulations, F3 exhibited satisfactory tableting properties,  disintegration time and dissolution profile. Therefore, immediate-release capsules and tablets with a high content  of S.kitaibelii extract were formulated to accomplish the unmet need for convenient solid dosage forms that  contains high doses of herbal extracts.
PB  - Elsevier B.V.
T2  - Journal of Drug Delivery Science and Technology
T1  - Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii
VL  - 66
DO  - 10.1016/j.jddst.2021.102776
ER  - 

@article{
author = "Mudrić, Jelena and Arsenijević, Jelena and Maksimović, Zoran and Ibrić, Svetlana and Gopčević, Kristina and Đuriš, Jelena",
year = "2021",
abstract = "Aerial parts of Satureja kitaibelii are traditionally used as carminative, for treatment of respiratory and urinary  complaints, or as anti-inflammatory agent for skin and mucous membranes. The aim of the present study was to  formulate immediate-release capsules and tablets with high content (≥95%) of S. kitaibelii optimized dry extract  by direct compression. The influence of ethanol concentration (40–96%, v/v), temperature (25–80 ◦C) and time  (2–8 h) on the extraction yield, total phenolic content (TPC), as well as on the contents of rosmarinic acid (RA)  and clinopodic acid O (CAO) in the S. kitaibelii dry extract was investigated using the response surface meth-odology (RSM). The estimated optimal conditions for the extraction were: ethanol 46.4%, 61.6 ◦C, 2 h. Dry  extract of S. kitaibelii obtained under the optimal conditions (characterized by: yield 24.2%, TPC 170.4 mg gallic  acid equivalents/g, RA 10.7 mg/g and CAO 17.1 mg/g) was used to manufacture solid dosage forms. Three  formulations (F) were prepared: F1, hard capsules (99% dry extract, 1% magnesium stearate); F2, uncoated  tablets (99% dry extract, 1% magnesium stearate) and F3, uncoated tablets (95% dry extract, 4% sodium starch  glycolate, 1% magnesium stearate). Hard capsules (F1) with the uniform weight, adequate disintegration time  and dissolution rate were obtained. Regarding tablet formulations, F3 exhibited satisfactory tableting properties,  disintegration time and dissolution profile. Therefore, immediate-release capsules and tablets with a high content  of S.kitaibelii extract were formulated to accomplish the unmet need for convenient solid dosage forms that  contains high doses of herbal extracts.",
publisher = "Elsevier B.V.",
journal = "Journal of Drug Delivery Science and Technology",
title = "Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii",
volume = "66",
doi = "10.1016/j.jddst.2021.102776"
}

Mudrić, J., Arsenijević, J., Maksimović, Z., Ibrić, S., Gopčević, K.,& Đuriš, J.. (2021). Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii. in Journal of Drug Delivery Science and Technology
Elsevier B.V.., 66.
https://doi.org/10.1016/j.jddst.2021.102776

Mudrić J, Arsenijević J, Maksimović Z, Ibrić S, Gopčević K, Đuriš J. Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii. in Journal of Drug Delivery Science and Technology. 2021;66.
doi:10.1016/j.jddst.2021.102776 .

Mudrić, Jelena, Arsenijević, Jelena, Maksimović, Zoran, Ibrić, Svetlana, Gopčević, Kristina, Đuriš, Jelena, "Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii" in Journal of Drug Delivery Science and Technology, 66 (2021),
https://doi.org/10.1016/j.jddst.2021.102776 . .

TY  - JOUR
AU  - Mudrić, Jelena
AU  - Janković, Teodora
AU  - Šavikin, Katarina
AU  - Bigović, Dubravka
AU  - Đukić-Ćosić, Danijela
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3636
AB  - Perennial plant Gentiana lutea L. is used worldwide for the preparation of pharmaceutical and food products. Health benefits of G. lutea roots are associated with the presence of major bitter-tasting secoiridoid gentiopicroside and xanthone isogentisin. The aim was to optimize the heat-assisted extraction of gentipicroside (GP), isogentisin (ISG) and total phenolics (TP) from G. lutea roots and develop models with high accuracy and prediction capacity by response surface methodology (RSM) and artificial neural networks (ANN). Extracts were prepared according to central composite design. Significant independent variables which were previously identified by Plackett-Burman screening design were varied at five levels - temperature (20−80 °C), time (8−180 min), solid-to-solvent ratio (1:10−1:50) and ethanol concentration (10–70 %). Contents of GP, ISG (by HPLC-DAD) and TP (by Folin–Ciocalteu method) were analyzed. The optimal conditions for the extraction were temperature of 65 °C, time of 129.08 min, solid-to-solvent ratio of 1:40, and ethanol concentration 49.33 %. Under these conditions, experimentally obtained results for GP (18.03 mg/g dw), ISG (8.15 mg/g dw) and TP (17.46 mg of gallic acid equivalents/g dw) content were in agreement with the values predicted by RSM and ANN. Comparison of models through the coefficient of determination (R2) and the root mean square error (RMSE) showed that ANN approach was superior to RSM in predicting and modelling GP, ISG and TP content, simultaneously. Effective heat-assisted extraction method for the extraction of GP, ISG and TP from the roots of G. lutea was designed, and models with high accuracy and good prediction capacity were developed.
PB  - Elsevier B.V.
T2  - Industrial Crops and Products
T1  - Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots
VL  - 155
DO  - 10.1016/j.indcrop.2020.112767
ER  - 

@article{
author = "Mudrić, Jelena and Janković, Teodora and Šavikin, Katarina and Bigović, Dubravka and Đukić-Ćosić, Danijela and Ibrić, Svetlana and Đuriš, Jelena",
year = "2020",
abstract = "Perennial plant Gentiana lutea L. is used worldwide for the preparation of pharmaceutical and food products. Health benefits of G. lutea roots are associated with the presence of major bitter-tasting secoiridoid gentiopicroside and xanthone isogentisin. The aim was to optimize the heat-assisted extraction of gentipicroside (GP), isogentisin (ISG) and total phenolics (TP) from G. lutea roots and develop models with high accuracy and prediction capacity by response surface methodology (RSM) and artificial neural networks (ANN). Extracts were prepared according to central composite design. Significant independent variables which were previously identified by Plackett-Burman screening design were varied at five levels - temperature (20−80 °C), time (8−180 min), solid-to-solvent ratio (1:10−1:50) and ethanol concentration (10–70 %). Contents of GP, ISG (by HPLC-DAD) and TP (by Folin–Ciocalteu method) were analyzed. The optimal conditions for the extraction were temperature of 65 °C, time of 129.08 min, solid-to-solvent ratio of 1:40, and ethanol concentration 49.33 %. Under these conditions, experimentally obtained results for GP (18.03 mg/g dw), ISG (8.15 mg/g dw) and TP (17.46 mg of gallic acid equivalents/g dw) content were in agreement with the values predicted by RSM and ANN. Comparison of models through the coefficient of determination (R2) and the root mean square error (RMSE) showed that ANN approach was superior to RSM in predicting and modelling GP, ISG and TP content, simultaneously. Effective heat-assisted extraction method for the extraction of GP, ISG and TP from the roots of G. lutea was designed, and models with high accuracy and good prediction capacity were developed.",
publisher = "Elsevier B.V.",
journal = "Industrial Crops and Products",
title = "Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots",
volume = "155",
doi = "10.1016/j.indcrop.2020.112767"
}

Mudrić, J., Janković, T., Šavikin, K., Bigović, D., Đukić-Ćosić, D., Ibrić, S.,& Đuriš, J.. (2020). Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots. in Industrial Crops and Products
Elsevier B.V.., 155.
https://doi.org/10.1016/j.indcrop.2020.112767

Mudrić J, Janković T, Šavikin K, Bigović D, Đukić-Ćosić D, Ibrić S, Đuriš J. Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots. in Industrial Crops and Products. 2020;155.
doi:10.1016/j.indcrop.2020.112767 .

Mudrić, Jelena, Janković, Teodora, Šavikin, Katarina, Bigović, Dubravka, Đukić-Ćosić, Danijela, Ibrić, Svetlana, Đuriš, Jelena, "Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots" in Industrial Crops and Products, 155 (2020),
https://doi.org/10.1016/j.indcrop.2020.112767 . .

TY  - CONF
AU  - Mudrić, Jelena
AU  - Arsenijević, Jelena
AU  - Maksimović, Zoran
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5312
AB  - Tradicionalno se herba S.kitaibelii koristi za lečenje digestivnih poremećaja, urinarnih
problema i respiratornih bolesti. Formulisane su kapsule i tablete sa suvim etanolnim
ekstraktom S. kitaibelii (46,4% v/v; odnos droga/ekstrakt 4,13:1). Cilj je bio ispitati mehaničke i
biofarmaceutske karakteristike tvrdih kapsula i neobložnih tableta sa visokim sadržajem suvog
ekstrakta S.kitaibelii.
Pripremljene su 3 formulacije: tvrde kapsule (F1) i neobložene tablete (F2) istog sastava
(99% suvog ekstrakta, 1% magnezijum-stearata); i neobložene tablete F3 (95% suvog
ekstrakta, 4% natrijum-skrobglikolata, 1% magnezijum-stearata). Tablete su izrađene
direktnom kompresijom. Karakteristike formulacija procenjene su ispitivanjem tabletabilnosti,
raspadljivosti i ispitivanjem brzine rastvaranja bioaktivnih komponenti (ukupni polifenoli (TP),
rozmarinska kiselina (RA), klinopodinska kiselina (CAO)). ...
AB  - Traditionally, aerial parts of S. kitaibelii are used for treatment of digestive disorders, urinary
complaints or respiratory diseases. Tablets and capsules with the dry extract of S. kitaibelii
(46.4% v/v; DER 4.13:1) were formulated. The aim of this study was to investigate mechanical
and biopharmaceutical properties of hard capsules and uncoated tablets with high content of S.
kitaibelii dry extract.
Three formulations were prepared: hard capsules (F1) and uncoated tablets (F2) with the same
composition (99% dry extract, 1% magnesium stearate); and uncoated tablets (F3) (95% dry
extract, 4% sodium starch glycolate, 1% magnesium stearate). Tablets were manufactured by
direct compression. Properties of formulations were estimated by tesing of their tabletability,
desintegration time and dissolution profiles of bioactive compounds (total phenolics (TP),
rosmarinic acid (RA) and clinopodic acid O (CAO)). ...
PB  - Farmaceutska komora Crne Gore
PB  - Univerzitet Crne Gore, Medicinski fakultet, Studijski program - farmacija
C3  - Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, Budva, Bečići, 2019, Zbornik sažetaka
T1  - Ispitivanje mehaničkih i biofarmaceutskih osobina tableta i kapsula sa visokim sadržajem suvog ekstrakta Satureja kitaibelii Werzb. ex Heuff. (Lamiaceae)
T1  - Investigation of mechanical and biopharmaceutical properties of tablets and capsules with high content of Sature kitaibelii Wierzb. ex Heuff. (Lamiaceae) dry extract
SP  - 240
EP  - 241
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5312
ER  - 

@conference{
author = "Mudrić, Jelena and Arsenijević, Jelena and Maksimović, Zoran and Ibrić, Svetlana and Đuriš, Jelena",
year = "2019",
abstract = "Tradicionalno se herba S.kitaibelii koristi za lečenje digestivnih poremećaja, urinarnih
problema i respiratornih bolesti. Formulisane su kapsule i tablete sa suvim etanolnim
ekstraktom S. kitaibelii (46,4% v/v; odnos droga/ekstrakt 4,13:1). Cilj je bio ispitati mehaničke i
biofarmaceutske karakteristike tvrdih kapsula i neobložnih tableta sa visokim sadržajem suvog
ekstrakta S.kitaibelii.
Pripremljene su 3 formulacije: tvrde kapsule (F1) i neobložene tablete (F2) istog sastava
(99% suvog ekstrakta, 1% magnezijum-stearata); i neobložene tablete F3 (95% suvog
ekstrakta, 4% natrijum-skrobglikolata, 1% magnezijum-stearata). Tablete su izrađene
direktnom kompresijom. Karakteristike formulacija procenjene su ispitivanjem tabletabilnosti,
raspadljivosti i ispitivanjem brzine rastvaranja bioaktivnih komponenti (ukupni polifenoli (TP),
rozmarinska kiselina (RA), klinopodinska kiselina (CAO)). ..., Traditionally, aerial parts of S. kitaibelii are used for treatment of digestive disorders, urinary
complaints or respiratory diseases. Tablets and capsules with the dry extract of S. kitaibelii
(46.4% v/v; DER 4.13:1) were formulated. The aim of this study was to investigate mechanical
and biopharmaceutical properties of hard capsules and uncoated tablets with high content of S.
kitaibelii dry extract.
Three formulations were prepared: hard capsules (F1) and uncoated tablets (F2) with the same
composition (99% dry extract, 1% magnesium stearate); and uncoated tablets (F3) (95% dry
extract, 4% sodium starch glycolate, 1% magnesium stearate). Tablets were manufactured by
direct compression. Properties of formulations were estimated by tesing of their tabletability,
desintegration time and dissolution profiles of bioactive compounds (total phenolics (TP),
rosmarinic acid (RA) and clinopodic acid O (CAO)). ...",
publisher = "Farmaceutska komora Crne Gore, Univerzitet Crne Gore, Medicinski fakultet, Studijski program - farmacija",
journal = "Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, Budva, Bečići, 2019, Zbornik sažetaka",
title = "Ispitivanje mehaničkih i biofarmaceutskih osobina tableta i kapsula sa visokim sadržajem suvog ekstrakta Satureja kitaibelii Werzb. ex Heuff. (Lamiaceae), Investigation of mechanical and biopharmaceutical properties of tablets and capsules with high content of Sature kitaibelii Wierzb. ex Heuff. (Lamiaceae) dry extract",
pages = "240-241",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5312"
}

Mudrić, J., Arsenijević, J., Maksimović, Z., Ibrić, S.,& Đuriš, J.. (2019). Ispitivanje mehaničkih i biofarmaceutskih osobina tableta i kapsula sa visokim sadržajem suvog ekstrakta Satureja kitaibelii Werzb. ex Heuff. (Lamiaceae). in Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, Budva, Bečići, 2019, Zbornik sažetaka
Farmaceutska komora Crne Gore., 240-241.
https://hdl.handle.net/21.15107/rcub_farfar_5312

Mudrić J, Arsenijević J, Maksimović Z, Ibrić S, Đuriš J. Ispitivanje mehaničkih i biofarmaceutskih osobina tableta i kapsula sa visokim sadržajem suvog ekstrakta Satureja kitaibelii Werzb. ex Heuff. (Lamiaceae). in Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, Budva, Bečići, 2019, Zbornik sažetaka. 2019;:240-241.
https://hdl.handle.net/21.15107/rcub_farfar_5312 .

Mudrić, Jelena, Arsenijević, Jelena, Maksimović, Zoran, Ibrić, Svetlana, Đuriš, Jelena, "Ispitivanje mehaničkih i biofarmaceutskih osobina tableta i kapsula sa visokim sadržajem suvog ekstrakta Satureja kitaibelii Werzb. ex Heuff. (Lamiaceae)" in Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, Budva, Bečići, 2019, Zbornik sažetaka (2019):240-241,
https://hdl.handle.net/21.15107/rcub_farfar_5312 .

TY  - JOUR
AU  - Mudrić, Jelena
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3116
AB  - Biologically active compounds from plants have attracted great interest due to their affordability, effectiveness and low toxicity. Herbal extracts provide an infinite resource of raw materials for pharmaceutical, cosmetic and food industry. Unfortunately, use of the valuable natural compounds can be limited by their low bioavailability, volatilization of active compounds, sensitivity to the temperature, oxidation and UV light, in vivo instability, as well as unpleasant taste. One of the potential strategies to overcome these issues is microencapsulation of the biologically active ingredients. In this review, preparation, applications and limitations of the most popular techniques for microencapsulation, such as spray drying, fluid bed coating, encapsulation using supercritical fluids, freeze drying, ionic gelation, emulsification-solvent removal methods and formulation of liposomes, were discussed. Also, microparticles properties produced by presented microencapsulation methods were interpreted.
PB  - Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd
T2  - Lekovite sirovine
T1  - Microencapsulation methods for plants biologically active compounds: A review
IS  - 38
SP  - 62
EP  - 67
DO  - 10.5937/leksir1838062M
ER  - 

@article{
author = "Mudrić, Jelena and Ibrić, Svetlana and Đuriš, Jelena",
year = "2018",
abstract = "Biologically active compounds from plants have attracted great interest due to their affordability, effectiveness and low toxicity. Herbal extracts provide an infinite resource of raw materials for pharmaceutical, cosmetic and food industry. Unfortunately, use of the valuable natural compounds can be limited by their low bioavailability, volatilization of active compounds, sensitivity to the temperature, oxidation and UV light, in vivo instability, as well as unpleasant taste. One of the potential strategies to overcome these issues is microencapsulation of the biologically active ingredients. In this review, preparation, applications and limitations of the most popular techniques for microencapsulation, such as spray drying, fluid bed coating, encapsulation using supercritical fluids, freeze drying, ionic gelation, emulsification-solvent removal methods and formulation of liposomes, were discussed. Also, microparticles properties produced by presented microencapsulation methods were interpreted.",
publisher = "Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd",
journal = "Lekovite sirovine",
title = "Microencapsulation methods for plants biologically active compounds: A review",
number = "38",
pages = "62-67",
doi = "10.5937/leksir1838062M"
}

Mudrić, J., Ibrić, S.,& Đuriš, J.. (2018). Microencapsulation methods for plants biologically active compounds: A review. in Lekovite sirovine
Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd.(38), 62-67.
https://doi.org/10.5937/leksir1838062M

Mudrić J, Ibrić S, Đuriš J. Microencapsulation methods for plants biologically active compounds: A review. in Lekovite sirovine. 2018;(38):62-67.
doi:10.5937/leksir1838062M .

Mudrić, Jelena, Ibrić, Svetlana, Đuriš, Jelena, "Microencapsulation methods for plants biologically active compounds: A review" in Lekovite sirovine, no. 38 (2018):62-67,
https://doi.org/10.5937/leksir1838062M . .