TY  - JOUR
AU  - Milovanović, Stoja
AU  - Đuriš, Jelena
AU  - Dapčević, Aleksandra
AU  - Lučić-Škorić, Marija
AU  - Medarević, Đorđe
AU  - Pavlović, Stefan
AU  - Ibrić, Svetlana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3782
AB  - This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.
PB  - Springer Science and Business Media B.V.
T2  - Journal of Polymer Research
T1  - Preparation of floating polymer-valsartan delivery systems using supercritical CO2
VL  - 28
IS  - 3
DO  - 10.1007/s10965-021-02440-1
ER  - 

@article{
author = "Milovanović, Stoja and Đuriš, Jelena and Dapčević, Aleksandra and Lučić-Škorić, Marija and Medarević, Đorđe and Pavlović, Stefan and Ibrić, Svetlana",
year = "2021",
abstract = "This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.",
publisher = "Springer Science and Business Media B.V.",
journal = "Journal of Polymer Research",
title = "Preparation of floating polymer-valsartan delivery systems using supercritical CO2",
volume = "28",
number = "3",
doi = "10.1007/s10965-021-02440-1"
}

Milovanović, S., Đuriš, J., Dapčević, A., Lučić-Škorić, M., Medarević, Đ., Pavlović, S.,& Ibrić, S.. (2021). Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research
Springer Science and Business Media B.V.., 28(3).
https://doi.org/10.1007/s10965-021-02440-1

Milovanović S, Đuriš J, Dapčević A, Lučić-Škorić M, Medarević Đ, Pavlović S, Ibrić S. Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research. 2021;28(3).
doi:10.1007/s10965-021-02440-1 .

Milovanović, Stoja, Đuriš, Jelena, Dapčević, Aleksandra, Lučić-Škorić, Marija, Medarević, Đorđe, Pavlović, Stefan, Ibrić, Svetlana, "Preparation of floating polymer-valsartan delivery systems using supercritical CO2" in Journal of Polymer Research, 28, no. 3 (2021),
https://doi.org/10.1007/s10965-021-02440-1 . .

TY  - CONF
AU  - Đuriš, Jelena
AU  - Milovanović, Stoja
AU  - Medarević, Đorđe
AU  - Dobričić, Vladimir
AU  - Ibrić, Svetlana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5483
AB  - Formulation of solid dispersions is one of the most feasible strategies for overcoming the poor
drugs’ solubility – one of the major issues affecting drug bioavailability and therapeutic outcomes.
Since traditional methods used for preparation of solid dispersions often require usage of organic
solvents, it is of great importance to seek for more environment-friendly methods. It has been
demonstrated that supercritical (sc) CO2 may be effectively utilized for dispersion of drugs into the
suitable carrier (polymer), thus obtaining solid dispersions with the improved drug dissolution rate.
The aim of the presented study was to investigate the potential of scCO2 for preparation of poorly
soluble antihypertensive drugs (carvedilol and valsartan) solid dispersions in the conventional
pharmaceutical polymers (polyvinilypyrolidone-PVP and hypromellose-HPMC). Prepared solid
dispersions were characterized by scanning electron microscopy, differential scanning calorimetry
and Fourier-transform infrared spectroscopy; their porosity and density were determined and drug
dissolution rate was assessed and compared to the results obtained from solid dispersions prepared
by the traditional solvent casting method. Selected samples were tested for their tableting properties
as well. It has been demonstrated that scCO2 may be successfully applied for preparation of
carvedilol or valsartan solid dispersions with the improved drug dissolution rate. Further
characterization revealed the nature of interactions between the drugs and selected polymers. Due
to the low density (and high porosity), some of the prepared solid dispersions may be used for
further development of the floating dosage forms. It has also been demonstrated that some of the
prepared dispersions have excellent compressibility and compactibility, which is of great
importance for further development of solid dosage forms. The obtained results provide framework
for further development of environment-friendly methods in pharmaceutical development and
production.
PB  - Materials Research Society of Serbia
PB  - International Institute for the Science of Sintering
C3  - Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, September 2-6, 2019, Herceg Novi, Montenegro
T1  - Supercritical CO2 utilization in preparation of poorly soluble drugs solid dispersions
SP  - 71
EP  - 71
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5483
ER  - 

@conference{
author = "Đuriš, Jelena and Milovanović, Stoja and Medarević, Đorđe and Dobričić, Vladimir and Ibrić, Svetlana",
year = "2019",
abstract = "Formulation of solid dispersions is one of the most feasible strategies for overcoming the poor
drugs’ solubility – one of the major issues affecting drug bioavailability and therapeutic outcomes.
Since traditional methods used for preparation of solid dispersions often require usage of organic
solvents, it is of great importance to seek for more environment-friendly methods. It has been
demonstrated that supercritical (sc) CO2 may be effectively utilized for dispersion of drugs into the
suitable carrier (polymer), thus obtaining solid dispersions with the improved drug dissolution rate.
The aim of the presented study was to investigate the potential of scCO2 for preparation of poorly
soluble antihypertensive drugs (carvedilol and valsartan) solid dispersions in the conventional
pharmaceutical polymers (polyvinilypyrolidone-PVP and hypromellose-HPMC). Prepared solid
dispersions were characterized by scanning electron microscopy, differential scanning calorimetry
and Fourier-transform infrared spectroscopy; their porosity and density were determined and drug
dissolution rate was assessed and compared to the results obtained from solid dispersions prepared
by the traditional solvent casting method. Selected samples were tested for their tableting properties
as well. It has been demonstrated that scCO2 may be successfully applied for preparation of
carvedilol or valsartan solid dispersions with the improved drug dissolution rate. Further
characterization revealed the nature of interactions between the drugs and selected polymers. Due
to the low density (and high porosity), some of the prepared solid dispersions may be used for
further development of the floating dosage forms. It has also been demonstrated that some of the
prepared dispersions have excellent compressibility and compactibility, which is of great
importance for further development of solid dosage forms. The obtained results provide framework
for further development of environment-friendly methods in pharmaceutical development and
production.",
publisher = "Materials Research Society of Serbia, International Institute for the Science of Sintering",
journal = "Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, September 2-6, 2019, Herceg Novi, Montenegro",
title = "Supercritical CO2 utilization in preparation of poorly soluble drugs solid dispersions",
pages = "71-71",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5483"
}

Đuriš, J., Milovanović, S., Medarević, Đ., Dobričić, V.,& Ibrić, S.. (2019). Supercritical CO2 utilization in preparation of poorly soluble drugs solid dispersions. in Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, September 2-6, 2019, Herceg Novi, Montenegro
Materials Research Society of Serbia., 71-71.
https://hdl.handle.net/21.15107/rcub_farfar_5483

Đuriš J, Milovanović S, Medarević Đ, Dobričić V, Ibrić S. Supercritical CO2 utilization in preparation of poorly soluble drugs solid dispersions. in Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, September 2-6, 2019, Herceg Novi, Montenegro. 2019;:71-71.
https://hdl.handle.net/21.15107/rcub_farfar_5483 .

Đuriš, Jelena, Milovanović, Stoja, Medarević, Đorđe, Dobričić, Vladimir, Ibrić, Svetlana, "Supercritical CO2 utilization in preparation of poorly soluble drugs solid dispersions" in Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, September 2-6, 2019, Herceg Novi, Montenegro (2019):71-71,
https://hdl.handle.net/21.15107/rcub_farfar_5483 .

TY  - JOUR
AU  - Đuriš, Jelena
AU  - Milovanović, Stoja
AU  - Medarević, Đorđe
AU  - Dobričić, Vladimir
AU  - Dapcević, Aleksandra
AU  - Ibrić, Svetlana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3324
AB  - Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO2 assisted method, solid dispersions of CARV with the selected (co) polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus (R) and Eudragit (R)) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated delta(p) values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions
VL  - 554
SP  - 190
EP  - 200
DO  - 10.1016/j.ijpharm.2018.11.015
ER  - 

@article{
author = "Đuriš, Jelena and Milovanović, Stoja and Medarević, Đorđe and Dobričić, Vladimir and Dapcević, Aleksandra and Ibrić, Svetlana",
year = "2019",
abstract = "Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO2 assisted method, solid dispersions of CARV with the selected (co) polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus (R) and Eudragit (R)) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated delta(p) values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions",
volume = "554",
pages = "190-200",
doi = "10.1016/j.ijpharm.2018.11.015"
}

Đuriš, J., Milovanović, S., Medarević, Đ., Dobričić, V., Dapcević, A.,& Ibrić, S.. (2019). Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 554, 190-200.
https://doi.org/10.1016/j.ijpharm.2018.11.015

Đuriš J, Milovanović S, Medarević Đ, Dobričić V, Dapcević A, Ibrić S. Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions. in International Journal of Pharmaceutics. 2019;554:190-200.
doi:10.1016/j.ijpharm.2018.11.015 .

Đuriš, Jelena, Milovanović, Stoja, Medarević, Đorđe, Dobričić, Vladimir, Dapcević, Aleksandra, Ibrić, Svetlana, "Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions" in International Journal of Pharmaceutics, 554 (2019):190-200,
https://doi.org/10.1016/j.ijpharm.2018.11.015 . .