TY  - JOUR
AU  - Vasiljević, Dragana
AU  - Đuriš, Jelena
AU  - Jakimenko, Sergej
AU  - Ibrić, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2862
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3445
AB  - In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Dispersion Science and Technology
T1  - Application of the fractional factorial design in multiple W/O/W emulsions
VL  - 38
IS  - 12
SP  - 1732
EP  - 1737
DO  - 10.1080/01932691.2016.1278551
ER  - 

@article{
author = "Vasiljević, Dragana and Đuriš, Jelena and Jakimenko, Sergej and Ibrić, Svetlana",
year = "2017",
abstract = "In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Dispersion Science and Technology",
title = "Application of the fractional factorial design in multiple W/O/W emulsions",
volume = "38",
number = "12",
pages = "1732-1737",
doi = "10.1080/01932691.2016.1278551"
}

Vasiljević, D., Đuriš, J., Jakimenko, S.,& Ibrić, S.. (2017). Application of the fractional factorial design in multiple W/O/W emulsions. in Journal of Dispersion Science and Technology
Taylor & Francis Inc, Philadelphia., 38(12), 1732-1737.
https://doi.org/10.1080/01932691.2016.1278551

Vasiljević D, Đuriš J, Jakimenko S, Ibrić S. Application of the fractional factorial design in multiple W/O/W emulsions. in Journal of Dispersion Science and Technology. 2017;38(12):1732-1737.
doi:10.1080/01932691.2016.1278551 .

Vasiljević, Dragana, Đuriš, Jelena, Jakimenko, Sergej, Ibrić, Svetlana, "Application of the fractional factorial design in multiple W/O/W emulsions" in Journal of Dispersion Science and Technology, 38, no. 12 (2017):1732-1737,
https://doi.org/10.1080/01932691.2016.1278551 . .

TY  - JOUR
AU  - Vasiljević, Dragana
AU  - Đuriš, Jelena
AU  - Jakimenko, Sergej
AU  - Ibrić, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2862
AB  - In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Dispersion Science and Technology
T1  - Application of the fractional factorial design in multiple W/O/W emulsions
VL  - 38
IS  - 12
SP  - 1732
EP  - 1737
DO  - 10.1080/01932691.2016.1278551
ER  - 

@article{
author = "Vasiljević, Dragana and Đuriš, Jelena and Jakimenko, Sergej and Ibrić, Svetlana",
year = "2017",
abstract = "In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Dispersion Science and Technology",
title = "Application of the fractional factorial design in multiple W/O/W emulsions",
volume = "38",
number = "12",
pages = "1732-1737",
doi = "10.1080/01932691.2016.1278551"
}

Vasiljević, D., Đuriš, J., Jakimenko, S.,& Ibrić, S.. (2017). Application of the fractional factorial design in multiple W/O/W emulsions. in Journal of Dispersion Science and Technology
Taylor & Francis Inc, Philadelphia., 38(12), 1732-1737.
https://doi.org/10.1080/01932691.2016.1278551

Vasiljević D, Đuriš J, Jakimenko S, Ibrić S. Application of the fractional factorial design in multiple W/O/W emulsions. in Journal of Dispersion Science and Technology. 2017;38(12):1732-1737.
doi:10.1080/01932691.2016.1278551 .

Vasiljević, Dragana, Đuriš, Jelena, Jakimenko, Sergej, Ibrić, Svetlana, "Application of the fractional factorial design in multiple W/O/W emulsions" in Journal of Dispersion Science and Technology, 38, no. 12 (2017):1732-1737,
https://doi.org/10.1080/01932691.2016.1278551 . .