TY  - CONF
AU  - Popović, Kosana
AU  - Antonijević-Nikolić, Mirjana
AU  - Đuričić-Milanković, Jelena
AU  - Ranković, Dragan
AU  - Milutinović, Bojana
AU  - Dražić, Branka
AU  - Tanasković, Slađana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5412
AB  - The stinging nettle (Urtica dioica L.) belongs to the Urticaceae family and represents a perennial plant. Stinging nettle is abundant species occurring in various types of forest, road verges and grassland sites. In many countries is used as both medicine and food. Stinging nettle is a weed and its seeds, leaves and even roots are used for medicinal purpose. Thanks to its high content of nutrients and bioactive compounds like poly phenols, vitamins and minerals, nettle possesses a great nutritional value and a large number of pharmacological effects, including anti-proliferative, anti-inflammatory, antioxidant, analgesic, immunostimulatory, anti-infectious, hypotensive, antiulcer activities and cardiovascular disease prevention. It is a reservoir of minerals (especially iron), vitamin C and pro-vitamin A.
Last decades the popularity of herbal medicine is rapidly increasing all over the world. However, heavy metal toxicity in plant materials has a great impact and importance on herbal plants and consequently affects the quality of herbal raw materials, herbal extracts, the safety and marketability of drugs. This paper presents determination of content seven heavy metals (Cu, Fe, Mn, Ni, Zn, Cd and Pb) in leaves samples Urtica dioica L. collected from five localities in Republic of Serbia. The sample preparation procedure involved dry digestion in triplicate and dissolution of the ash in 6M HCl and then in 0.1 M HNO3. All elements were analyzed using an inductively coupled plasma-optical emission spectrometry (ICP-OES). The contents of Ni, Cu, Zn, Mn and Fe in the leaves were found to be in the ranges of 0.54±0.00 to 1.87±0.10 ˂ 2.12±0.69-12.79±0.53 ˂ 18.18±0.46-28.48±1.37 ˂ 30.63±1.45-68.44±5.11, and 109.75±4.01-244.41±13.50 mg/kg dry weight, respectively. Value of toxic heavy metal Pb in two samples is 0.37±0.0 mg/kg dry weight, whiles content Cd has been below the detection limit. The content of heavy metals in samples were used to calculate target hazard quotients values (THQ) and hazard index (HI).
PB  - University of East Sarajevo,  Faculty of technology
C3  - VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina
T1  - Determination of heavy metal contents in stinging nettle from different localities in Serbia
SP  - 419
EP  - 425
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5412
ER  - 

@conference{
author = "Popović, Kosana and Antonijević-Nikolić, Mirjana and Đuričić-Milanković, Jelena and Ranković, Dragan and Milutinović, Bojana and Dražić, Branka and Tanasković, Slađana",
year = "2023",
abstract = "The stinging nettle (Urtica dioica L.) belongs to the Urticaceae family and represents a perennial plant. Stinging nettle is abundant species occurring in various types of forest, road verges and grassland sites. In many countries is used as both medicine and food. Stinging nettle is a weed and its seeds, leaves and even roots are used for medicinal purpose. Thanks to its high content of nutrients and bioactive compounds like poly phenols, vitamins and minerals, nettle possesses a great nutritional value and a large number of pharmacological effects, including anti-proliferative, anti-inflammatory, antioxidant, analgesic, immunostimulatory, anti-infectious, hypotensive, antiulcer activities and cardiovascular disease prevention. It is a reservoir of minerals (especially iron), vitamin C and pro-vitamin A.
Last decades the popularity of herbal medicine is rapidly increasing all over the world. However, heavy metal toxicity in plant materials has a great impact and importance on herbal plants and consequently affects the quality of herbal raw materials, herbal extracts, the safety and marketability of drugs. This paper presents determination of content seven heavy metals (Cu, Fe, Mn, Ni, Zn, Cd and Pb) in leaves samples Urtica dioica L. collected from five localities in Republic of Serbia. The sample preparation procedure involved dry digestion in triplicate and dissolution of the ash in 6M HCl and then in 0.1 M HNO3. All elements were analyzed using an inductively coupled plasma-optical emission spectrometry (ICP-OES). The contents of Ni, Cu, Zn, Mn and Fe in the leaves were found to be in the ranges of 0.54±0.00 to 1.87±0.10 ˂ 2.12±0.69-12.79±0.53 ˂ 18.18±0.46-28.48±1.37 ˂ 30.63±1.45-68.44±5.11, and 109.75±4.01-244.41±13.50 mg/kg dry weight, respectively. Value of toxic heavy metal Pb in two samples is 0.37±0.0 mg/kg dry weight, whiles content Cd has been below the detection limit. The content of heavy metals in samples were used to calculate target hazard quotients values (THQ) and hazard index (HI).",
publisher = "University of East Sarajevo,  Faculty of technology",
journal = "VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina",
title = "Determination of heavy metal contents in stinging nettle from different localities in Serbia",
pages = "419-425",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5412"
}

Popović, K., Antonijević-Nikolić, M., Đuričić-Milanković, J., Ranković, D., Milutinović, B., Dražić, B.,& Tanasković, S.. (2023). Determination of heavy metal contents in stinging nettle from different localities in Serbia. in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina
University of East Sarajevo,  Faculty of technology., 419-425.
https://hdl.handle.net/21.15107/rcub_farfar_5412

Popović K, Antonijević-Nikolić M, Đuričić-Milanković J, Ranković D, Milutinović B, Dražić B, Tanasković S. Determination of heavy metal contents in stinging nettle from different localities in Serbia. in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina. 2023;:419-425.
https://hdl.handle.net/21.15107/rcub_farfar_5412 .

Popović, Kosana, Antonijević-Nikolić, Mirjana, Đuričić-Milanković, Jelena, Ranković, Dragan, Milutinović, Bojana, Dražić, Branka, Tanasković, Slađana, "Determination of heavy metal contents in stinging nettle from different localities in Serbia" in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina (2023):419-425,
https://hdl.handle.net/21.15107/rcub_farfar_5412 .

TY  - CONF
AU  - Dražić, Branka
AU  - Antonijević-Nikolić, Mirjana
AU  - Martinović-Cincović, Milena
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5334
AB  - The aim of this study was to investigate thermal behavior of the new complex with formula
[Cu(ala)cyc](ClO4)2∙2.5H2O. The complex was isolated and previously characterized by: elemental
analysis (C, H, N), molar conductivity, UV/Vis and FTIR spectroscopy and magnetic measurements
at room temperature. The sixcoordinate octahedral geometry around Cu(II) complexes was
proposed. The experimental data suggested that the tetradentate ligand cyclam was coordinated to
metals through four N donors and the amino carboxylate ligand coordinated via carboxylate ion.
Investigate of thermal stability can be crucial in confirming the structure as well as in assessing the
applicability of new compounds. The thermal properties of these complex have been investigated
by thermogravimetric (TG) and differential thermal analysis (DTA). Therefore, TG-DTA analysis
indicates that investigated complex decomposes exothermally in a single step in the range of 310 -
PB  - University in Banjaluka, Faculty of Technology
C3  - XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts
T1  - Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand
SP  - 25
EP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5334
ER  - 

@conference{
author = "Dražić, Branka and Antonijević-Nikolić, Mirjana and Martinović-Cincović, Milena and Tanasković, Slađana",
year = "2022",
abstract = "The aim of this study was to investigate thermal behavior of the new complex with formula
[Cu(ala)cyc](ClO4)2∙2.5H2O. The complex was isolated and previously characterized by: elemental
analysis (C, H, N), molar conductivity, UV/Vis and FTIR spectroscopy and magnetic measurements
at room temperature. The sixcoordinate octahedral geometry around Cu(II) complexes was
proposed. The experimental data suggested that the tetradentate ligand cyclam was coordinated to
metals through four N donors and the amino carboxylate ligand coordinated via carboxylate ion.
Investigate of thermal stability can be crucial in confirming the structure as well as in assessing the
applicability of new compounds. The thermal properties of these complex have been investigated
by thermogravimetric (TG) and differential thermal analysis (DTA). Therefore, TG-DTA analysis
indicates that investigated complex decomposes exothermally in a single step in the range of 310 -",
publisher = "University in Banjaluka, Faculty of Technology",
journal = "XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts",
title = "Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand",
pages = "25-25",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5334"
}

Dražić, B., Antonijević-Nikolić, M., Martinović-Cincović, M.,& Tanasković, S.. (2022). Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand. in XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts
University in Banjaluka, Faculty of Technology., 25-25.
https://hdl.handle.net/21.15107/rcub_farfar_5334

Dražić B, Antonijević-Nikolić M, Martinović-Cincović M, Tanasković S. Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand. in XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts. 2022;:25-25.
https://hdl.handle.net/21.15107/rcub_farfar_5334 .

Dražić, Branka, Antonijević-Nikolić, Mirjana, Martinović-Cincović, Milena, Tanasković, Slađana, "Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand" in XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts (2022):25-25,
https://hdl.handle.net/21.15107/rcub_farfar_5334 .

TY  - CONF
AU  - Antonijević Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4374
AB  - Two new bridged dinuclear Cu(II) compounds of tpmc (N,N',N'',N'''-tetrakis(2-pyridylmethyl)-
1,4,8,11-tetraazacyclotetradecane) and co-ligands L-leucine or L-isoleucine have been synthesized
and characterized. The complexes were prepared in the reaction [Cutpmc](ClO4)4∙6H2O and
aminocarboxylates. The complexes were characterized by elemental analysis (C, H, and N), molar
electrical conductivity and spectral methods (UV/vis and FTIR). The analytical data of the complexes
show the formation of binuclear complexes with the proposed formula [Cu2(L)tpmc](ClO4)4, L=L-
leucine (1) and L=L-isoleucine (2). The spectroscopic data suggested that the tpmc is coordinated to
Cu(II) through eight N donors and amino carboxylate ligands via their carboxylate ion moieties.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
T1  - New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands
VL  - II
SP  - 519
EP  - 522
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4374
ER  - 

@conference{
author = "Antonijević Nikolić, Mirjana and Dražić, Branka and Tanasković, Slađana",
year = "2022",
abstract = "Two new bridged dinuclear Cu(II) compounds of tpmc (N,N',N'',N'''-tetrakis(2-pyridylmethyl)-
1,4,8,11-tetraazacyclotetradecane) and co-ligands L-leucine or L-isoleucine have been synthesized
and characterized. The complexes were prepared in the reaction [Cutpmc](ClO4)4∙6H2O and
aminocarboxylates. The complexes were characterized by elemental analysis (C, H, and N), molar
electrical conductivity and spectral methods (UV/vis and FTIR). The analytical data of the complexes
show the formation of binuclear complexes with the proposed formula [Cu2(L)tpmc](ClO4)4, L=L-
leucine (1) and L=L-isoleucine (2). The spectroscopic data suggested that the tpmc is coordinated to
Cu(II) through eight N donors and amino carboxylate ligands via their carboxylate ion moieties.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)",
title = "New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands",
volume = "II",
pages = "519-522",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4374"
}

Antonijević Nikolić, M., Dražić, B.,& Tanasković, S.. (2022). New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
Society of Physical Chemists of Serbia., II, 519-522.
https://hdl.handle.net/21.15107/rcub_farfar_4374

Antonijević Nikolić M, Dražić B, Tanasković S. New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;II:519-522.
https://hdl.handle.net/21.15107/rcub_farfar_4374 .

Antonijević Nikolić, Mirjana, Dražić, Branka, Tanasković, Slađana, "New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), II (2022):519-522,
https://hdl.handle.net/21.15107/rcub_farfar_4374 .

TY  - CONF
AU  - Popović, Kosana
AU  - Antonijević Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4373
AB  - The chemical components in tea have received great interest because they are related to health. In this
study the content of five heavy metals including Cu, Fe, Mn, Zn and Ni were determined by atomic
absorption spectrometry on samples of herbal teas: Quercus cortex, Gentianae radix, Althaeae radix,
Uvae ursi folium and Glycyrrhizae radix collected from Šabac's market, Serbia. Based on the obtained
content of the metals in the analyzed herbal teas, estimated daily intake (EDI) was determined. Both
target hazard quotient (THQ) and hazard index (HI) were employed to assess the potential health risk
of studied metals in teas. The herbal tea samples analysed contain essential heavy metals (Cu, Fe,
Mn, Zn) and probably essential in trace (Ni) and could contribute to the daily dietary requirements.
The THQ from 7.76·10−4 to 5.75·10-1 and HI from 0.1059 to 0.6151 values for tea samples were lower
than 1, suggesting that consumption of tea would not cause significant health risks for consumers.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
T1  - The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia
VL  - II
SP  - 489
EP  - 492
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4373
ER  - 

@conference{
author = "Popović, Kosana and Antonijević Nikolić, Mirjana and Dražić, Branka and Tanasković, Slađana",
year = "2022",
abstract = "The chemical components in tea have received great interest because they are related to health. In this
study the content of five heavy metals including Cu, Fe, Mn, Zn and Ni were determined by atomic
absorption spectrometry on samples of herbal teas: Quercus cortex, Gentianae radix, Althaeae radix,
Uvae ursi folium and Glycyrrhizae radix collected from Šabac's market, Serbia. Based on the obtained
content of the metals in the analyzed herbal teas, estimated daily intake (EDI) was determined. Both
target hazard quotient (THQ) and hazard index (HI) were employed to assess the potential health risk
of studied metals in teas. The herbal tea samples analysed contain essential heavy metals (Cu, Fe,
Mn, Zn) and probably essential in trace (Ni) and could contribute to the daily dietary requirements.
The THQ from 7.76·10−4 to 5.75·10-1 and HI from 0.1059 to 0.6151 values for tea samples were lower
than 1, suggesting that consumption of tea would not cause significant health risks for consumers.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)",
title = "The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia",
volume = "II",
pages = "489-492",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4373"
}

Popović, K., Antonijević Nikolić, M., Dražić, B.,& Tanasković, S.. (2022). The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
Society of Physical Chemists of Serbia., II, 489-492.
https://hdl.handle.net/21.15107/rcub_farfar_4373

Popović K, Antonijević Nikolić M, Dražić B, Tanasković S. The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;II:489-492.
https://hdl.handle.net/21.15107/rcub_farfar_4373 .

Popović, Kosana, Antonijević Nikolić, Mirjana, Dražić, Branka, Tanasković, Slađana, "The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), II (2022):489-492,
https://hdl.handle.net/21.15107/rcub_farfar_4373 .

TY  - JOUR
AU  - Popović, Kosana
AU  - Antonijević-Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Jovanović, Dragoljub
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4295
AB  - Chemical components of teas have received great interest because they are related to health. In this work, data on the determination of foreign matter, loss on drying/water content, total ash and ash insoluble in hydrochloric acid are presented. The content of seven heavy metals including Cu, Fe, Mn, Zn, Ni, Cd and Pb were determined by atomic absorption spectrometry in samples of several herbal teas: Matricariae flos, Thymi herba, Menthae piperitae folium, Betulae folium, Quercus cortex, Gentianae radix, Frangulae cortex, Althaeae radix, Uvae ursi folium and Glycyrrhizae radix collected from Šabac’s market, Serbia. The sample preparation procedure involved dry digestion and dissolution of the ash in 6M HCl and then in 0.1 M HNO3. Herbal teas showed the concentration of heavy metals Cu, Fe, Mn, Zn and Ni in the range: 2.9 ± 0.1 – 22.2 ± 0.9 mg/kg, 118.5 ± 1.1 – 755.5 ± 2.5 mg/kg, 19.0 ± 5.8 – 561.0 ± 1.9 mg/kg, 6.5 ± 0.4 – 242.5 ± 1.4 mg/kg and 2.5 ± 0.1 – 10 ± 1.1 mg/kg, respectively. The level of copper in all samples was uniform. The highest content of Fe was in Thymi herba, while Mn and Zn were at maximum in Betulae folium. The levels of toxic heavy metals Cd and Pb were below the detection limit. The obtained values were compared with data available from literature. The herbal tea samples analyzed contained essential heavy metals (Cu, Fe, Mn, Zn) and probably essential in trace (Ni), and could obey the daily dietary requirements. Noncancer health risk assessment detected that the herbal teas of Betulae folium and Frangulae cortex can manifest some health risk to consumers.
PB  - Springer
T2  - Pharmaceutical Chemistry Journal
T1  - Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals
VL  - 56
IS  - 6
SP  - 827
EP  - 837
DO  - 10.1007/s11094-022-02716-w
ER  - 

@article{
author = "Popović, Kosana and Antonijević-Nikolić, Mirjana and Dražić, Branka and Jovanović, Dragoljub and Tanasković, Slađana",
year = "2022",
abstract = "Chemical components of teas have received great interest because they are related to health. In this work, data on the determination of foreign matter, loss on drying/water content, total ash and ash insoluble in hydrochloric acid are presented. The content of seven heavy metals including Cu, Fe, Mn, Zn, Ni, Cd and Pb were determined by atomic absorption spectrometry in samples of several herbal teas: Matricariae flos, Thymi herba, Menthae piperitae folium, Betulae folium, Quercus cortex, Gentianae radix, Frangulae cortex, Althaeae radix, Uvae ursi folium and Glycyrrhizae radix collected from Šabac’s market, Serbia. The sample preparation procedure involved dry digestion and dissolution of the ash in 6M HCl and then in 0.1 M HNO3. Herbal teas showed the concentration of heavy metals Cu, Fe, Mn, Zn and Ni in the range: 2.9 ± 0.1 – 22.2 ± 0.9 mg/kg, 118.5 ± 1.1 – 755.5 ± 2.5 mg/kg, 19.0 ± 5.8 – 561.0 ± 1.9 mg/kg, 6.5 ± 0.4 – 242.5 ± 1.4 mg/kg and 2.5 ± 0.1 – 10 ± 1.1 mg/kg, respectively. The level of copper in all samples was uniform. The highest content of Fe was in Thymi herba, while Mn and Zn were at maximum in Betulae folium. The levels of toxic heavy metals Cd and Pb were below the detection limit. The obtained values were compared with data available from literature. The herbal tea samples analyzed contained essential heavy metals (Cu, Fe, Mn, Zn) and probably essential in trace (Ni), and could obey the daily dietary requirements. Noncancer health risk assessment detected that the herbal teas of Betulae folium and Frangulae cortex can manifest some health risk to consumers.",
publisher = "Springer",
journal = "Pharmaceutical Chemistry Journal",
title = "Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals",
volume = "56",
number = "6",
pages = "827-837",
doi = "10.1007/s11094-022-02716-w"
}

Popović, K., Antonijević-Nikolić, M., Dražić, B., Jovanović, D.,& Tanasković, S.. (2022). Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals. in Pharmaceutical Chemistry Journal
Springer., 56(6), 827-837.
https://doi.org/10.1007/s11094-022-02716-w

Popović K, Antonijević-Nikolić M, Dražić B, Jovanović D, Tanasković S. Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals. in Pharmaceutical Chemistry Journal. 2022;56(6):827-837.
doi:10.1007/s11094-022-02716-w .

Popović, Kosana, Antonijević-Nikolić, Mirjana, Dražić, Branka, Jovanović, Dragoljub, Tanasković, Slađana, "Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals" in Pharmaceutical Chemistry Journal, 56, no. 6 (2022):827-837,
https://doi.org/10.1007/s11094-022-02716-w . .

TY  - JOUR
AU  - Antonijević Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Antić-Stanković, Jelena
AU  - Tanasković, Slađana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4379
AB  - New carboxylate complexes of the tetraazamacrocyclic ligand
N,N',N'',N'''-tetrakis(2-pyridilmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc)
with Ni(II) and Zn(II) as central ions were prepared. In mixed-ligand com-
plexes (endo,endo)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate dianion (C9H8O42-
)
is also coordinated to metal ions. The complexes were characterized by ele-
mental analysis (C, H, N), FTIR and UV–Vis spectroscopy, molar conductivity
determination and magnetic susceptibility measurement at room temperature.
The analytical data of the complexes show the formation of binuclear
[Ni2(C9H8O4)tpmc](ClO4)2·4H2O and tetranuclear [Zn4(C9H8O4)(tpmc)2](ClO4)6·
·CH3CN·KClO 4·4H2O complexes. In tetranuclear Zn(II) complex bicyclic
dicarboxylate ligand is most likely to be bridge coordinated, and in binuclear
Ni(II) complex it is coordinated in a combined bridged manner with chelate
rings formation. In both complexes macrocyclic ligand was exo coordinated,
out of cyclam ring and adopts a boat conformation. The Zn(II) complex is one
of the rare tetranuclear Zn(II)-tpmc complexes with carboxylate ion bridging
two Zn2tpmc units. The complexes were tested for antibacterial activity against
Gram-positive bacteria Staphylococcus aureus (ATCC 25923) and Bacillus
subtilis (ATCC 6633), Gram-negative bacterium Escherichia coli (ATCC
25922), and yeast Candida albicans (ATCC 10231), and were screened for
antiproliferative activity against human cervix adenocarcinoma (HeLa) and
human myelogenous leukemia (K562) cell lines.
AB  - Синтетисани су нови карбоксилато комплекси са тетраазамакроцикличним ли-
гандом N,N',N'',N'''-тетракис(2-пиридилметил)-1,4,8,11-тетраазациклотетрадеканом
(tpmc) и Ni(II) и Zn(II) као централним јонима. У мешовитолигандним комплексима
(endo,endo)-бицикло-[2.2.1]-хепт-5-ен-2,3-дикарбоксилато дианјон (C9H8O4
2-
) је такође
везан за метални јон. Комплекси су окарактерисани елементалном анализом (C, H, N),
FTIR и UV/Vis спектроскопијом, као и мерењем моларне проводљивости и магнетне
сусцептибилности на собној температури. На основу добијених резултата претпос-
тављена је бинуклеарна структура [Ni2(C9H8O4)tpmc](ClO4) 2·4H2O комплекса, односно,
тетрануклеарна [Zn4(C9H8O4 )(tpmc) 2](ClO4)6·CH3CN·KClO4 ·4H2O комплекса. У тетра-
нуклеарном Zn(II) комплексу, бициклични дикарбоксилато лиганд је највероватније
мостно везан, док је у бинуклеарном Ni(II) комплексу мешовити мостно-хелатни начин
координације. Други начини мостног везивања дикарбоксилата не могу бити у потпуности искључени. У оба комплекса макроциклични лиганд је егзо координован, изван
цикламовог прстена и заузима конформацију лађе. Добијени Zn(II) кoмплекс је један од
ретких тетрануклеарних Zn(II)–tpmc комплекса са карбоксилато лигандом у мосту
између две Zn2tpmc јединице. Добијени комплекси су тестирани на антибактеријску
активност према Грам-позитивним бактеријама Staphylococcus aureus (ATCC 25923) и
Bacillus subtilis (ATCC 6633), Грам-негативној бактерији Escherichia coli (ATCC 25922) и
квасцу Candida albicans (ATCC 10231). Испитивана је њихова антипролиферативна
активност на хуманим малигним ћелијским линијама: цервикалног аденокарцинома
(HeLa) и мијелогене леукемије (K562).
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity
T1  - Nови мешовитолигандни макроциклични комплекси Ni(II) и Zn(II) са мостовним (endo,endo)-бицикло-[2.2.1]-хепт-5-ен-2,3-дикарбоксилатом: синтеза, карактеризација, антимикробна и цитотоксична активност
VL  - 84
IS  - 9
SP  - 961
EP  - 973
DO  - https://doi.org/10.2298/JSC181216028A
ER  - 

@article{
author = "Antonijević Nikolić, Mirjana and Dražić, Branka and Antić-Stanković, Jelena and Tanasković, Slađana",
year = "2019",
abstract = "New carboxylate complexes of the tetraazamacrocyclic ligand
N,N',N'',N'''-tetrakis(2-pyridilmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc)
with Ni(II) and Zn(II) as central ions were prepared. In mixed-ligand com-
plexes (endo,endo)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate dianion (C9H8O42-
)
is also coordinated to metal ions. The complexes were characterized by ele-
mental analysis (C, H, N), FTIR and UV–Vis spectroscopy, molar conductivity
determination and magnetic susceptibility measurement at room temperature.
The analytical data of the complexes show the formation of binuclear
[Ni2(C9H8O4)tpmc](ClO4)2·4H2O and tetranuclear [Zn4(C9H8O4)(tpmc)2](ClO4)6·
·CH3CN·KClO 4·4H2O complexes. In tetranuclear Zn(II) complex bicyclic
dicarboxylate ligand is most likely to be bridge coordinated, and in binuclear
Ni(II) complex it is coordinated in a combined bridged manner with chelate
rings formation. In both complexes macrocyclic ligand was exo coordinated,
out of cyclam ring and adopts a boat conformation. The Zn(II) complex is one
of the rare tetranuclear Zn(II)-tpmc complexes with carboxylate ion bridging
two Zn2tpmc units. The complexes were tested for antibacterial activity against
Gram-positive bacteria Staphylococcus aureus (ATCC 25923) and Bacillus
subtilis (ATCC 6633), Gram-negative bacterium Escherichia coli (ATCC
25922), and yeast Candida albicans (ATCC 10231), and were screened for
antiproliferative activity against human cervix adenocarcinoma (HeLa) and
human myelogenous leukemia (K562) cell lines., Синтетисани су нови карбоксилато комплекси са тетраазамакроцикличним ли-
гандом N,N',N'',N'''-тетракис(2-пиридилметил)-1,4,8,11-тетраазациклотетрадеканом
(tpmc) и Ni(II) и Zn(II) као централним јонима. У мешовитолигандним комплексима
(endo,endo)-бицикло-[2.2.1]-хепт-5-ен-2,3-дикарбоксилато дианјон (C9H8O4
2-
) је такође
везан за метални јон. Комплекси су окарактерисани елементалном анализом (C, H, N),
FTIR и UV/Vis спектроскопијом, као и мерењем моларне проводљивости и магнетне
сусцептибилности на собној температури. На основу добијених резултата претпос-
тављена је бинуклеарна структура [Ni2(C9H8O4)tpmc](ClO4) 2·4H2O комплекса, односно,
тетрануклеарна [Zn4(C9H8O4 )(tpmc) 2](ClO4)6·CH3CN·KClO4 ·4H2O комплекса. У тетра-
нуклеарном Zn(II) комплексу, бициклични дикарбоксилато лиганд је највероватније
мостно везан, док је у бинуклеарном Ni(II) комплексу мешовити мостно-хелатни начин
координације. Други начини мостног везивања дикарбоксилата не могу бити у потпуности искључени. У оба комплекса макроциклични лиганд је егзо координован, изван
цикламовог прстена и заузима конформацију лађе. Добијени Zn(II) кoмплекс је један од
ретких тетрануклеарних Zn(II)–tpmc комплекса са карбоксилато лигандом у мосту
између две Zn2tpmc јединице. Добијени комплекси су тестирани на антибактеријску
активност према Грам-позитивним бактеријама Staphylococcus aureus (ATCC 25923) и
Bacillus subtilis (ATCC 6633), Грам-негативној бактерији Escherichia coli (ATCC 25922) и
квасцу Candida albicans (ATCC 10231). Испитивана је њихова антипролиферативна
активност на хуманим малигним ћелијским линијама: цервикалног аденокарцинома
(HeLa) и мијелогене леукемије (K562).",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity, Nови мешовитолигандни макроциклични комплекси Ni(II) и Zn(II) са мостовним (endo,endo)-бицикло-[2.2.1]-хепт-5-ен-2,3-дикарбоксилатом: синтеза, карактеризација, антимикробна и цитотоксична активност",
volume = "84",
number = "9",
pages = "961-973",
doi = "https://doi.org/10.2298/JSC181216028A"
}

Antonijević Nikolić, M., Dražić, B., Antić-Stanković, J.,& Tanasković, S.. (2019). New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 84(9), 961-973.
https://doi.org/https://doi.org/10.2298/JSC181216028A

Antonijević Nikolić M, Dražić B, Antić-Stanković J, Tanasković S. New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity. in Journal of the Serbian Chemical Society. 2019;84(9):961-973.
doi:https://doi.org/10.2298/JSC181216028A .

Antonijević Nikolić, Mirjana, Dražić, Branka, Antić-Stanković, Jelena, Tanasković, Slađana, "New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity" in Journal of the Serbian Chemical Society, 84, no. 9 (2019):961-973,
https://doi.org/https://doi.org/10.2298/JSC181216028A . .

TY  - JOUR
AU  - Popović, Gordana
AU  - Dražić, Branka
AU  - Pfendt, Lidija
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/196
PB  - Govi-Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Acid-base equilibria in homogeneous and heterogeneous systems of clonazepam and nitrazepam
VL  - 53
IS  - 9
SP  - 647
EP  - 649
UR  - https://hdl.handle.net/21.15107/rcub_farfar_196
ER  - 

@article{
author = "Popović, Gordana and Dražić, Branka and Pfendt, Lidija",
year = "1998",
publisher = "Govi-Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Acid-base equilibria in homogeneous and heterogeneous systems of clonazepam and nitrazepam",
volume = "53",
number = "9",
pages = "647-649",
url = "https://hdl.handle.net/21.15107/rcub_farfar_196"
}

Popović, G., Dražić, B.,& Pfendt, L.. (1998). Acid-base equilibria in homogeneous and heterogeneous systems of clonazepam and nitrazepam. in Pharmazie
Govi-Verlag Gmbh, Eschborn., 53(9), 647-649.
https://hdl.handle.net/21.15107/rcub_farfar_196

Popović G, Dražić B, Pfendt L. Acid-base equilibria in homogeneous and heterogeneous systems of clonazepam and nitrazepam. in Pharmazie. 1998;53(9):647-649.
https://hdl.handle.net/21.15107/rcub_farfar_196 .

Popović, Gordana, Dražić, Branka, Pfendt, Lidija, "Acid-base equilibria in homogeneous and heterogeneous systems of clonazepam and nitrazepam" in Pharmazie, 53, no. 9 (1998):647-649,
https://hdl.handle.net/21.15107/rcub_farfar_196 .