TY  - JOUR
AU  - Končar, I.
AU  - Nikolić, D.
AU  - Milošević, Z.
AU  - Bogavac-Stanojević, Nataša
AU  - Ilić, N.
AU  - Dragaš, M.
AU  - Sladojević, M.
AU  - Marković, M.
AU  - Vujčić, A.
AU  - Filipović, N.
AU  - Davidović, L.
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4772
AB  - Objectives: The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods: Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively collected and analyzed. Anatomical, morphological, and biomechanical imaging markers like peak wall stress (PWS) and rupture risk equivalent diameter (RRED), comorbid conditions, and demographics were compared between the groups. Biomechanical features were assessed by analysis of Digital Imaging and Communication in Medicine images by A4clinics (Vascops), and anatomical features were assessed by 3Surgery (Trimensio). Binary and multiple logistic regression analysis were used and adjusted for confounders. Accuracy was assessed using receiving operative characteristic (ROC) curve analysis. Results: In a multivariable model, including gender and age as confounder variables, maximal aneurysm diameter [MAD, odds ratio (OR) = 1.063], relative intraluminal thrombus (rILT, OR = 1.039), and total aneurysm volume (TAV, OR = 1.006) continued to be significant predictors of AAA rupture with PWS (OR = 1.010) and RRED (OR = 1.031). Area under the ROC curve values and correct classification (cc) for the same parameters and the model that combines MAD, TAV, and rILT were measured: MAD (0.790, cc = 75%), PWS (0.713, cc = 73%), RRED (0.717, cc = 55%), TAV (0.756, cc = 79%), rILT (0.656, cc = 60%), and MAD + TAV + rILT (0.797, cc = 82%). Conclusion: Based on our results, in addition to MAD, other important predictors of rupture that might be used during aneurysm surveillance are TAV and rILT. Biomechanical parameters (PWS, RRED) as valuable predictors should be assessed in prospective clinical trials. Similar studies on AAA smaller than 55 mm in diameter, even difficult to organize, would be of even greater clinical value. 2023 Koncar, Nikolic, Milosevic, Bogavac-Stanojevic, Ilic, Dragas, Sladojevic, Markovic, Vujcic, Filipovic and Davidovic.
PB  - Frontiers Media S.A.
T2  - Frontiers in Surgery
T1  - Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study
VL  - 10
DO  - 10.3389/fsurg.2023.1095224
ER  - 

@article{
author = "Končar, I. and Nikolić, D. and Milošević, Z. and Bogavac-Stanojević, Nataša and Ilić, N. and Dragaš, M. and Sladojević, M. and Marković, M. and Vujčić, A. and Filipović, N. and Davidović, L.",
year = "2023",
abstract = "Objectives: The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods: Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively collected and analyzed. Anatomical, morphological, and biomechanical imaging markers like peak wall stress (PWS) and rupture risk equivalent diameter (RRED), comorbid conditions, and demographics were compared between the groups. Biomechanical features were assessed by analysis of Digital Imaging and Communication in Medicine images by A4clinics (Vascops), and anatomical features were assessed by 3Surgery (Trimensio). Binary and multiple logistic regression analysis were used and adjusted for confounders. Accuracy was assessed using receiving operative characteristic (ROC) curve analysis. Results: In a multivariable model, including gender and age as confounder variables, maximal aneurysm diameter [MAD, odds ratio (OR) = 1.063], relative intraluminal thrombus (rILT, OR = 1.039), and total aneurysm volume (TAV, OR = 1.006) continued to be significant predictors of AAA rupture with PWS (OR = 1.010) and RRED (OR = 1.031). Area under the ROC curve values and correct classification (cc) for the same parameters and the model that combines MAD, TAV, and rILT were measured: MAD (0.790, cc = 75%), PWS (0.713, cc = 73%), RRED (0.717, cc = 55%), TAV (0.756, cc = 79%), rILT (0.656, cc = 60%), and MAD + TAV + rILT (0.797, cc = 82%). Conclusion: Based on our results, in addition to MAD, other important predictors of rupture that might be used during aneurysm surveillance are TAV and rILT. Biomechanical parameters (PWS, RRED) as valuable predictors should be assessed in prospective clinical trials. Similar studies on AAA smaller than 55 mm in diameter, even difficult to organize, would be of even greater clinical value. 2023 Koncar, Nikolic, Milosevic, Bogavac-Stanojevic, Ilic, Dragas, Sladojevic, Markovic, Vujcic, Filipovic and Davidovic.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Surgery",
title = "Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study",
volume = "10",
doi = "10.3389/fsurg.2023.1095224"
}

Končar, I., Nikolić, D., Milošević, Z., Bogavac-Stanojević, N., Ilić, N., Dragaš, M., Sladojević, M., Marković, M., Vujčić, A., Filipović, N.,& Davidović, L.. (2023). Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study. in Frontiers in Surgery
Frontiers Media S.A.., 10.
https://doi.org/10.3389/fsurg.2023.1095224

Končar I, Nikolić D, Milošević Z, Bogavac-Stanojević N, Ilić N, Dragaš M, Sladojević M, Marković M, Vujčić A, Filipović N, Davidović L. Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study. in Frontiers in Surgery. 2023;10.
doi:10.3389/fsurg.2023.1095224 .

Končar, I., Nikolić, D., Milošević, Z., Bogavac-Stanojević, Nataša, Ilić, N., Dragaš, M., Sladojević, M., Marković, M., Vujčić, A., Filipović, N., Davidović, L., "Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study" in Frontiers in Surgery, 10 (2023),
https://doi.org/10.3389/fsurg.2023.1095224 . .

TY  - CONF
AU  - Korićanac, V.
AU  - Janković, S.
AU  - Vranić, D.
AU  - Stanković, Ivan
AU  - Nikolić, D.
AU  - Petrović, Z.
AU  - Milićević, D.
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4005
AB  - Acrylamide forms when some foods are prepared at temperatures usually above 120°C and in low moisture conditions, due to a Maillard reaction between certain amino acids, such as asparagine, and reducing sugars. Acrylamide is carcinogenic to experimental mice and rats, neurotoxic and probably also carcinogenic and genotoxic for humans. The aim of this study was to determine the presence of acrylamide in various groups of food products in which its formation is expected to occur during the production process. In the period December 2017 to March 2021, 529 samples of different types of food products were tested. Samples were collected from the Serbian market. Most of the tested foods, almost half of them (44%), were various types of biscuits. The presence of acrylamide was determined using LC-MS/MS accredited method, with a limit of quantification (LOQ) of 50 µg kg-1and a limit of detection (LOD) of 25 µg kg-1. All samples from the snack product and waffle product groups contained acrylamide. Acrylamide was detected in almost all (98.98%) fine bakery products and biscuits (90.43%). In contrast, only 15.38% of bakery products contained acrylamide. Most of the tested foods contained acrylamide, 83.74% of them.
PB  - IOP Publishing Ltd
C3  - IOP Conference Series: Earth and Environmental Science
T1  - The presence of acrylamide in various type of food products from the Serbian market
VL  - 854
IS  - 1
DO  - 10.1088/1755-1315/854/1/012045
ER  - 

@conference{
author = "Korićanac, V. and Janković, S. and Vranić, D. and Stanković, Ivan and Nikolić, D. and Petrović, Z. and Milićević, D.",
year = "2021",
abstract = "Acrylamide forms when some foods are prepared at temperatures usually above 120°C and in low moisture conditions, due to a Maillard reaction between certain amino acids, such as asparagine, and reducing sugars. Acrylamide is carcinogenic to experimental mice and rats, neurotoxic and probably also carcinogenic and genotoxic for humans. The aim of this study was to determine the presence of acrylamide in various groups of food products in which its formation is expected to occur during the production process. In the period December 2017 to March 2021, 529 samples of different types of food products were tested. Samples were collected from the Serbian market. Most of the tested foods, almost half of them (44%), were various types of biscuits. The presence of acrylamide was determined using LC-MS/MS accredited method, with a limit of quantification (LOQ) of 50 µg kg-1and a limit of detection (LOD) of 25 µg kg-1. All samples from the snack product and waffle product groups contained acrylamide. Acrylamide was detected in almost all (98.98%) fine bakery products and biscuits (90.43%). In contrast, only 15.38% of bakery products contained acrylamide. Most of the tested foods contained acrylamide, 83.74% of them.",
publisher = "IOP Publishing Ltd",
journal = "IOP Conference Series: Earth and Environmental Science",
title = "The presence of acrylamide in various type of food products from the Serbian market",
volume = "854",
number = "1",
doi = "10.1088/1755-1315/854/1/012045"
}

Korićanac, V., Janković, S., Vranić, D., Stanković, I., Nikolić, D., Petrović, Z.,& Milićević, D.. (2021). The presence of acrylamide in various type of food products from the Serbian market. in IOP Conference Series: Earth and Environmental Science
IOP Publishing Ltd., 854(1).
https://doi.org/10.1088/1755-1315/854/1/012045

Korićanac V, Janković S, Vranić D, Stanković I, Nikolić D, Petrović Z, Milićević D. The presence of acrylamide in various type of food products from the Serbian market. in IOP Conference Series: Earth and Environmental Science. 2021;854(1).
doi:10.1088/1755-1315/854/1/012045 .

Korićanac, V., Janković, S., Vranić, D., Stanković, Ivan, Nikolić, D., Petrović, Z., Milićević, D., "The presence of acrylamide in various type of food products from the Serbian market" in IOP Conference Series: Earth and Environmental Science, 854, no. 1 (2021),
https://doi.org/10.1088/1755-1315/854/1/012045 . .

TY  - CONF
AU  - Nikolić, D.
AU  - Tasić, Ljiljana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/782
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Principi upravljanja rizikom i značaj za farmaceutsku industriju
VL  - 56
IS  - 4
SP  - 510
EP  - 510
UR  - https://hdl.handle.net/21.15107/rcub_farfar_782
ER  - 

@conference{
author = "Nikolić, D. and Tasić, Ljiljana",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Principi upravljanja rizikom i značaj za farmaceutsku industriju",
volume = "56",
number = "4",
pages = "510-510",
url = "https://hdl.handle.net/21.15107/rcub_farfar_782"
}

Nikolić, D.,& Tasić, L.. (2006). Principi upravljanja rizikom i značaj za farmaceutsku industriju. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 510-510.
https://hdl.handle.net/21.15107/rcub_farfar_782

Nikolić D, Tasić L. Principi upravljanja rizikom i značaj za farmaceutsku industriju. in Arhiv za farmaciju. 2006;56(4):510-510.
https://hdl.handle.net/21.15107/rcub_farfar_782 .

Nikolić, D., Tasić, Ljiljana, "Principi upravljanja rizikom i značaj za farmaceutsku industriju" in Arhiv za farmaciju, 56, no. 4 (2006):510-510,
https://hdl.handle.net/21.15107/rcub_farfar_782 .