TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Janković, Radmila
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5614
AB  - Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.
PB  - Elsevier Inc.
T2  - Environmental Research
T1  - Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
VL  - 252
IS  - 1
DO  - 10.1016/j.envres.2024.118680
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Savić, Miroslav and Batinić, Bojan and Janković, Radmila and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.",
publisher = "Elsevier Inc.",
journal = "Environmental Research",
title = "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach",
volume = "252",
number = "1",
doi = "10.1016/j.envres.2024.118680"
}

Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Kotur-Stevuljević, J., Ivanišević, J., Savić, M., Batinić, B., Janković, R., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research
Elsevier Inc.., 252(1).
https://doi.org/10.1016/j.envres.2024.118680

Živančević K, Baralić K, Vukelić D, Marić Đ, Kotur-Stevuljević J, Ivanišević J, Savić M, Batinić B, Janković R, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research. 2024;252(1).
doi:10.1016/j.envres.2024.118680 .

Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Savić, Miroslav, Batinić, Bojan, Janković, Radmila, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach" in Environmental Research, 252, no. 1 (2024),
https://doi.org/10.1016/j.envres.2024.118680 . .

TY  - JOUR
AU  - Božić, Dragica
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5531
AB  - Cancer is a leading cause of death worldwide, for which finding the optimal therapy remains an ongoing challenge. Drug resistance, toxic side effects, and a lack of specificity pose significant difficulties in traditional cancer treatments, leading to suboptimal clinical outcomes and high mortality rates among cancer patients. The need for alternative therapies is crucial, especially for those resistant to conventional methods like chemotherapy and radiotherapy or for patients where surgery is not possible. Over the past decade, a novel approach known as bacteria-mediated cancer therapy has emerged, offering potential solutions to the limitations of conventional treatments. An increasing number of in vitro and in vivo studies suggest that the subtype of highly virulent Pseudomonas aeruginosa bacterium called Pseudomonas aeruginosa mannose-sensitive-hemagglutinin (PA-MSHA) can successfully inhibit the progression of various cancer types, such as breast, lung, and bladder cancer, as well as hepatocellular carcinoma. PA-MSHA inhibits the growth and proliferation of tumor cells and induces their apoptosis. Proposed mechanisms of action include cell-cycle arrest and activation of pro-apoptotic pathways regulated by caspase-9 and caspase-3. Moreover, clinical studies have shown that PA-MSHA improved the effectiveness of chemotherapy and promoted the activation of the immune response in cancer patients without causing severe side effects. Reported adverse reactions were fever, skin irritation, and pain, attributed to the overactivation of the immune response. This review aims to summarize the current knowledge obtained from in vitro, in vivo, and clinical studies available at PubMed, Google Scholar, and ClinicalTrials.gov regarding the use of PA-MSHA in cancer treatment in order to further elucidate its pharmacological and toxicological properties.
PB  - MDPI
T2  - Cancers
T1  - Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects
VL  - 16
IS  - 3
DO  - 10.3390/cancers16030524
ER  - 

@article{
author = "Božić, Dragica and Živanović, Jovana and Živančević, Katarina and Baralić, Katarina and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Cancer is a leading cause of death worldwide, for which finding the optimal therapy remains an ongoing challenge. Drug resistance, toxic side effects, and a lack of specificity pose significant difficulties in traditional cancer treatments, leading to suboptimal clinical outcomes and high mortality rates among cancer patients. The need for alternative therapies is crucial, especially for those resistant to conventional methods like chemotherapy and radiotherapy or for patients where surgery is not possible. Over the past decade, a novel approach known as bacteria-mediated cancer therapy has emerged, offering potential solutions to the limitations of conventional treatments. An increasing number of in vitro and in vivo studies suggest that the subtype of highly virulent Pseudomonas aeruginosa bacterium called Pseudomonas aeruginosa mannose-sensitive-hemagglutinin (PA-MSHA) can successfully inhibit the progression of various cancer types, such as breast, lung, and bladder cancer, as well as hepatocellular carcinoma. PA-MSHA inhibits the growth and proliferation of tumor cells and induces their apoptosis. Proposed mechanisms of action include cell-cycle arrest and activation of pro-apoptotic pathways regulated by caspase-9 and caspase-3. Moreover, clinical studies have shown that PA-MSHA improved the effectiveness of chemotherapy and promoted the activation of the immune response in cancer patients without causing severe side effects. Reported adverse reactions were fever, skin irritation, and pain, attributed to the overactivation of the immune response. This review aims to summarize the current knowledge obtained from in vitro, in vivo, and clinical studies available at PubMed, Google Scholar, and ClinicalTrials.gov regarding the use of PA-MSHA in cancer treatment in order to further elucidate its pharmacological and toxicological properties.",
publisher = "MDPI",
journal = "Cancers",
title = "Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects",
volume = "16",
number = "3",
doi = "10.3390/cancers16030524"
}

Božić, D., Živanović, J., Živančević, K., Baralić, K.,& Đukić-Ćosić, D.. (2024). Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects. in Cancers
MDPI., 16(3).
https://doi.org/10.3390/cancers16030524

Božić D, Živanović J, Živančević K, Baralić K, Đukić-Ćosić D. Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects. in Cancers. 2024;16(3).
doi:10.3390/cancers16030524 .

Božić, Dragica, Živanović, Jovana, Živančević, Katarina, Baralić, Katarina, Đukić-Ćosić, Danijela, "Trends in Anti-Tumor Effects of Pseudomonas aeruginosa Mannose-Sensitive-Hemagglutinin (PA-MSHA): An Overview of Positive and Negative Effects" in Cancers, 16, no. 3 (2024),
https://doi.org/10.3390/cancers16030524 . .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5552
AB  - Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ...
AB  - Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji
T1  - Possibilities and challenges of applying artificial intelligence in toxicology
SP  - 159
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5552
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ..., Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji, Possibilities and challenges of applying artificial intelligence in toxicology",
pages = "159-160",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5552"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):159-160,
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5514
AB  - Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ...
AB  - In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Komparativna toksikogenomska baza podataka: Nove mogućnosti
T1  - The Comparative Toxicogenomic Database: New possibilities
SP  - 157
EP  - 158
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5514
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ..., In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Komparativna toksikogenomska baza podataka: Nove mogućnosti, The Comparative Toxicogenomic Database: New possibilities",
pages = "157-158",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5514"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Komparativna toksikogenomska baza podataka: Nove mogućnosti" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):157-158,
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

TY  - CONF
AU  - Bonderović, Vera
AU  - Manić, Luka
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Stojilković, Nikola
AU  - Jorgovanović, Dragica
AU  - Grahovac, Lazar
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5510
AB  - Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ...
AB  - In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama
T1  - Informed mom, healthy baby - How to live safely with chemicals
SP  - 117
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5510
ER  - 

@conference{
author = "Bonderović, Vera and Manić, Luka and Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Stojilković, Nikola and Jorgovanović, Dragica and Grahovac, Lazar and Anđelković, Milena and Repić, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ..., In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama, Informed mom, healthy baby - How to live safely with chemicals",
pages = "117-118",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5510"
}

Bonderović, V., Manić, L., Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Stojilković, N., Jorgovanović, D., Grahovac, L., Anđelković, M., Repić, A., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2023). Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510

Bonderović V, Manić L, Živančević K, Baralić K, Vukelić D, Marić Đ, Stojilković N, Jorgovanović D, Grahovac L, Anđelković M, Repić A, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B, Buha-Đorđević A. Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

Bonderović, Vera, Manić, Luka, Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Stojilković, Nikola, Jorgovanović, Dragica, Grahovac, Lazar, Anđelković, Milena, Repić, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):117-118,
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

TY  - CONF
AU  - Živančević, Katarina
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5170
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
T1  - Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor
VL  - 384
IS  - S1
SP  - S78
EP  - S78
DO  - 10.1016/S0378-4274(23)00454-X
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5170
ER  - 

@conference{
author = "Živančević, Katarina and Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Marić, Đurđica and Vukelić, Dragana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia",
title = "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor",
volume = "384",
number = "S1",
pages = "S78-S78",
doi = "10.1016/S0378-4274(23)00454-X",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5170"
}

Živančević, K., Živanović, J., Baralić, K., Božić, D., Marić, Đ., Vukelić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
Elsevier., 384(S1), S78-S78.
https://doi.org/10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170

Živančević K, Živanović J, Baralić K, Božić D, Marić Đ, Vukelić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia. 2023;384(S1):S78-S78.
doi:10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

Živančević, Katarina, Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Marić, Đurđica, Vukelić, Dragana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor" in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia, 384, no. S1 (2023):S78-S78,
https://doi.org/10.1016/S0378-4274(23)00454-X .,
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

TY  - CONF
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Janković, Radmila
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5424
AB  - Izloženost olovu (Pb), kadmijumu (Cd), živi (Hg) i arsenu (As) iz životne sredine, kako pojedinačno tako
i njihovim smešama jedan je od faktora za razvoj brojnih zdravstvenih poremećaja, među kojima su i
štetni efekti na nivou centralnog nervnog sistema. ...
AB  - Lead (Pb), cadmium (Cd), mercury (Hg) and arsenic (As) are top ranked toxic metal(oid)s on the list of
the most important environmental pollutants from the aspect of public health. Literature data show
that exposure to individual metals, as well as their mixtures, is one of the factors for numerous health
disorders development, including adverse effects on the central nervous system. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine
T1  - Neurotoxicity of lead, cadmium, mercury and arsenic low dosed mixtures relevant to environmental exposure
SP  - 37
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5424
ER  - 

@conference{
author = "Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Savić, Miroslav and Batinić, Bojan and Janković, Radmila and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Izloženost olovu (Pb), kadmijumu (Cd), živi (Hg) i arsenu (As) iz životne sredine, kako pojedinačno tako
i njihovim smešama jedan je od faktora za razvoj brojnih zdravstvenih poremećaja, među kojima su i
štetni efekti na nivou centralnog nervnog sistema. ..., Lead (Pb), cadmium (Cd), mercury (Hg) and arsenic (As) are top ranked toxic metal(oid)s on the list of
the most important environmental pollutants from the aspect of public health. Literature data show
that exposure to individual metals, as well as their mixtures, is one of the factors for numerous health
disorders development, including adverse effects on the central nervous system. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine, Neurotoxicity of lead, cadmium, mercury and arsenic low dosed mixtures relevant to environmental exposure",
pages = "37-38",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5424"
}

Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Kotur-Stevuljević, J., Ivanišević, J., Savić, M., Batinić, B., Janković, R., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5424

Živančević K, Baralić K, Vukelić D, Marić Đ, Kotur-Stevuljević J, Ivanišević J, Savić M, Batinić B, Janković R, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5424 .

Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Savić, Miroslav, Batinić, Bojan, Janković, Radmila, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Neurotoksičnost smeše niskih doza olova, kadmijuma, žive i arsena značajnih za izloženost iz životne sredine" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):37-38,
https://hdl.handle.net/21.15107/rcub_farfar_5424 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5168
AB  - Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ...
AB  - Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19
T1  - In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease
SP  - 37
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5168
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ..., Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19, In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease",
pages = "37-38",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5168"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):37-38,
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

TY  - CONF
AU  - Baralić, Katarina
AU  - Božović, Predrag
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Živanović, Jovana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5176
AB  - Chemical exposure can occur through a variety of means (ingestion, inhalation, or skin contact), by food and water consumption, polluted air, use of consumer products, etc. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining
VL  - 384
IS  - S1
SP  - S224
EP  - S225
DO  - 10.1016/S0378-4274(23)00793-2
ER  - 

@conference{
author = "Baralić, Katarina and Božović, Predrag and Božić, Dragica and Živančević, Katarina and Živanović, Jovana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Chemical exposure can occur through a variety of means (ingestion, inhalation, or skin contact), by food and water consumption, polluted air, use of consumer products, etc. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining",
volume = "384",
number = "S1",
pages = "S224-S225",
doi = "10.1016/S0378-4274(23)00793-2"
}

Baralić, K., Božović, P., Božić, D., Živančević, K., Živanović, J.,& Đukić-Ćosić, D.. (2023). Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining. in Toxicology Letters
Elsevier., 384(S1), S224-S225.
https://doi.org/10.1016/S0378-4274(23)00793-2

Baralić K, Božović P, Božić D, Živančević K, Živanović J, Đukić-Ćosić D. Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining. in Toxicology Letters. 2023;384(S1):S224-S225.
doi:10.1016/S0378-4274(23)00793-2 .

Baralić, Katarina, Božović, Predrag, Božić, Dragica, Živančević, Katarina, Živanović, Jovana, Đukić-Ćosić, Danijela, "Screening for the most promising protective agent against chemical and/or radiation-induced adverse human health effects: toxicogenomic data mining" in Toxicology Letters, 384, no. S1 (2023):S224-S225,
https://doi.org/10.1016/S0378-4274(23)00793-2 . .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5172
AB  - Sulforaphane (SFN) is a compound found in cruciferous vegetables which have been studied as a molecule with the potential in disease prevention and treatment. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis
VL  - 384
IS  - S1
SP  - S115
EP  - S115
DO  - 10.1016/S0378-4274(23)00536-2
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živanović, Jovana and Živančević, Katarina and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforaphane (SFN) is a compound found in cruciferous vegetables which have been studied as a molecule with the potential in disease prevention and treatment. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis",
volume = "384",
number = "S1",
pages = "S115-S115",
doi = "10.1016/S0378-4274(23)00536-2"
}

Božić, D., Baralić, K., Živanović, J., Živančević, K.,& Đukić-Ćosić, D.. (2023). Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis. in Toxicology Letters
Elsevier., 384(S1), S115-S115.
https://doi.org/10.1016/S0378-4274(23)00536-2

Božić D, Baralić K, Živanović J, Živančević K, Đukić-Ćosić D. Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis. in Toxicology Letters. 2023;384(S1):S115-S115.
doi:10.1016/S0378-4274(23)00536-2 .

Božić, Dragica, Baralić, Katarina, Živanović, Jovana, Živančević, Katarina, Đukić-Ćosić, Danijela, "Comparative study of positive and negative sulforaphane activity against different tumor types via bioinformatic analysis" in Toxicology Letters, 384, no. S1 (2023):S115-S115,
https://doi.org/10.1016/S0378-4274(23)00536-2 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4651
AB  - Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal carcinoma (CRC) advancement. Sulforaphane (SFN), isothiocyanate from cruciferous vegetables, diminishes chemical carcinogenesis susceptibility, but has been shown to act as a friend or a foe depending on various factors. By conducting the mechanistic toxicogenomic data mining approach, this research aimed to determine if SFN can alleviate toxic-metal and/or phthalate/BPA mixture-induced CRC at the gene level. Comparative Toxicogenomics Database, ToppGene Suite portal, Cytoscape software, InteractiVenn and Gene Expression Omnibus (GEO) database (GEO2R tool) was used. Among the mutual genes for all the investigated substances, SFN had a protective impact only through PTGS2. Other proposed protective SFN-targets included ABCA1, ALDH2, BMP2, DPYD, MYC, SLCO2A1, and SOD2, only in the case of phthalates/BPA exposure. The only additional gene relevant for SFN protection against the toxic metal mixture-induced CRC was ABCB1. Additionally, the majority of the top 15 molecular pathways extracted for SFN impact on phthalate and BPA mixture-linked CRC development were directly linked with cancer development, which was not the case with the toxic metal mixture. The current research has indicated that SFN is a more effective chemoprotective agent against CRC induced by phthalates/BPA mixture than by toxic-metal mixture. It has also presented the value of computational methods as a simple tool for directing further research, selecting appropriate biomarkers and exploring the mechanisms of toxicity.
PB  - Academic Press Inc.
T2  - Environmental Research
T1  - Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study
VL  - 227
DO  - 10.1016/j.envres.2023.115818
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Marić, Đurđica and Božić, Dragica and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal carcinoma (CRC) advancement. Sulforaphane (SFN), isothiocyanate from cruciferous vegetables, diminishes chemical carcinogenesis susceptibility, but has been shown to act as a friend or a foe depending on various factors. By conducting the mechanistic toxicogenomic data mining approach, this research aimed to determine if SFN can alleviate toxic-metal and/or phthalate/BPA mixture-induced CRC at the gene level. Comparative Toxicogenomics Database, ToppGene Suite portal, Cytoscape software, InteractiVenn and Gene Expression Omnibus (GEO) database (GEO2R tool) was used. Among the mutual genes for all the investigated substances, SFN had a protective impact only through PTGS2. Other proposed protective SFN-targets included ABCA1, ALDH2, BMP2, DPYD, MYC, SLCO2A1, and SOD2, only in the case of phthalates/BPA exposure. The only additional gene relevant for SFN protection against the toxic metal mixture-induced CRC was ABCB1. Additionally, the majority of the top 15 molecular pathways extracted for SFN impact on phthalate and BPA mixture-linked CRC development were directly linked with cancer development, which was not the case with the toxic metal mixture. The current research has indicated that SFN is a more effective chemoprotective agent against CRC induced by phthalates/BPA mixture than by toxic-metal mixture. It has also presented the value of computational methods as a simple tool for directing further research, selecting appropriate biomarkers and exploring the mechanisms of toxicity.",
publisher = "Academic Press Inc.",
journal = "Environmental Research",
title = "Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study",
volume = "227",
doi = "10.1016/j.envres.2023.115818"
}

Baralić, K., Živančević, K., Marić, Đ., Božić, D., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. in Environmental Research
Academic Press Inc.., 227.
https://doi.org/10.1016/j.envres.2023.115818

Baralić K, Živančević K, Marić Đ, Božić D, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. in Environmental Research. 2023;227.
doi:10.1016/j.envres.2023.115818 .

Baralić, Katarina, Živančević, Katarina, Marić, Đurđica, Božić, Dragica, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study" in Environmental Research, 227 (2023),
https://doi.org/10.1016/j.envres.2023.115818 . .

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Antonijević-Miljaković, Evica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Bulat, Petar
AU  - Radovanović, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4650
AB  - Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found to induce various toxic mechanisms leading to organ physiological disruption. Therefore, the purpose of the study was to simulate low-dose Pb exposure in an animal model with the aim of assessing oxidative status and essential element levels as the main mechanism of Pb toxicity in the liver and kidneys. Furthermore, dose–response modelling was performed in order to determine the benchmark dose (BMD). Forty-two male Wistar rats were divided into seven groups: one control group, and six groups treated for 28 days with 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg b.w./day, respectively. Oxidative status parameters (superoxide dismutase activity (SOD), superoxide anion radical (O2−), malondialdehyde (MDA), total sulfhydryl groups (SHG), and advanced oxidation protein products (AOPP)) and Pb, copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) levels were measured. Lowering Cu levels (BMD: 2.7 ng/kg b.w./day), raising AOPP levels (BMD: 0.25 µg/kg b.w./day) in the liver, and inhibiting SOD (BMD: 1.3 ng/kg b.w./day) in the kidneys appear to be the main mechanisms of Pb toxicity. The lowest BMD was derived for a decrease in Cu levels in liver, indicating that this effect is the most sensitive.
PB  - MDPI
T2  - Toxics
T1  - Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats
VL  - 11
IS  - 3
DO  - 10.3390/toxics11030256
ER  - 

@article{
author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Antonijević-Miljaković, Evica and Baralić, Katarina and Živančević, Katarina and Bulat, Petar and Radovanović, Jelena and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found to induce various toxic mechanisms leading to organ physiological disruption. Therefore, the purpose of the study was to simulate low-dose Pb exposure in an animal model with the aim of assessing oxidative status and essential element levels as the main mechanism of Pb toxicity in the liver and kidneys. Furthermore, dose–response modelling was performed in order to determine the benchmark dose (BMD). Forty-two male Wistar rats were divided into seven groups: one control group, and six groups treated for 28 days with 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg b.w./day, respectively. Oxidative status parameters (superoxide dismutase activity (SOD), superoxide anion radical (O2−), malondialdehyde (MDA), total sulfhydryl groups (SHG), and advanced oxidation protein products (AOPP)) and Pb, copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) levels were measured. Lowering Cu levels (BMD: 2.7 ng/kg b.w./day), raising AOPP levels (BMD: 0.25 µg/kg b.w./day) in the liver, and inhibiting SOD (BMD: 1.3 ng/kg b.w./day) in the kidneys appear to be the main mechanisms of Pb toxicity. The lowest BMD was derived for a decrease in Cu levels in liver, indicating that this effect is the most sensitive.",
publisher = "MDPI",
journal = "Toxics",
title = "Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats",
volume = "11",
number = "3",
doi = "10.3390/toxics11030256"
}

Vukelić, D., Buha-Đorđević, A., Anđelković, M., Antonijević-Miljaković, E., Baralić, K., Živančević, K., Bulat, P., Radovanović, J., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2023). Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats. in Toxics
MDPI., 11(3).
https://doi.org/10.3390/toxics11030256

Vukelić D, Buha-Đorđević A, Anđelković M, Antonijević-Miljaković E, Baralić K, Živančević K, Bulat P, Radovanović J, Đukić-Ćosić D, Antonijević B, Bulat Z. Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats. in Toxics. 2023;11(3).
doi:10.3390/toxics11030256 .

Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Antonijević-Miljaković, Evica, Baralić, Katarina, Živančević, Katarina, Bulat, Petar, Radovanović, Jelena, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats" in Toxics, 11, no. 3 (2023),
https://doi.org/10.3390/toxics11030256 . .

TY  - JOUR
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4425
AB  - Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained scientific popularity due to its antioxidant and anti-cancer properties. However, its toxicity profile and potential to cause adverse effects remain largely unidentified. Thus, this study aimed to generate SFN-triggered adverse outcome pathway (AOP) by looking at the relationship between SFN-chemical structure and its toxicity, as well as SFN-gene interactions. Quantitative structure-activity relationship (QSAR) analysis identified 2 toxophores (Derek Nexus software) that have the potential to cause chromosomal damage and skin sensitization in mammals or mutagenicity in bacteria. Data extracted from Comparative Toxicogenomics Database (CTD) linked SFN with previously proposed outcomes via gene interactions. The total of 11 and 146 genes connected SFN with chromosomal damage and skin diseases, respectively. However, network analysis (NetworkAnalyst tool) revealed that these genes function in wider networks containing 490 and 1986 nodes, respectively. The over-representation analysis (ExpressAnalyst tool) pointed out crucial biological pathways regulated by SFN-interfering genes. These pathways are uploaded to AOP-helpFinder tool which found the 2321 connections between 19 enriched pathways and SFN which were further considered as key events. Two major, interconnected AOPs were generated: first starting from disruption of biological pathways involved in cell cycle and cell proliferation leading to increased apoptosis, and the second one connecting activated immune system signaling pathways to inflammation and apoptosis. In both cases, chromosomal damage and/or skin diseases such as dermatitis or psoriasis appear as adverse outcomes.
PB  - Elsevier
T2  - Biomedicine and Pharmacotherapy
T1  - Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells
VL  - 160
DO  - 10.1016/j.biopha.2023.114316
ER  - 

@article{
author = "Božić, Dragica and Živančević, Katarina and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained scientific popularity due to its antioxidant and anti-cancer properties. However, its toxicity profile and potential to cause adverse effects remain largely unidentified. Thus, this study aimed to generate SFN-triggered adverse outcome pathway (AOP) by looking at the relationship between SFN-chemical structure and its toxicity, as well as SFN-gene interactions. Quantitative structure-activity relationship (QSAR) analysis identified 2 toxophores (Derek Nexus software) that have the potential to cause chromosomal damage and skin sensitization in mammals or mutagenicity in bacteria. Data extracted from Comparative Toxicogenomics Database (CTD) linked SFN with previously proposed outcomes via gene interactions. The total of 11 and 146 genes connected SFN with chromosomal damage and skin diseases, respectively. However, network analysis (NetworkAnalyst tool) revealed that these genes function in wider networks containing 490 and 1986 nodes, respectively. The over-representation analysis (ExpressAnalyst tool) pointed out crucial biological pathways regulated by SFN-interfering genes. These pathways are uploaded to AOP-helpFinder tool which found the 2321 connections between 19 enriched pathways and SFN which were further considered as key events. Two major, interconnected AOPs were generated: first starting from disruption of biological pathways involved in cell cycle and cell proliferation leading to increased apoptosis, and the second one connecting activated immune system signaling pathways to inflammation and apoptosis. In both cases, chromosomal damage and/or skin diseases such as dermatitis or psoriasis appear as adverse outcomes.",
publisher = "Elsevier",
journal = "Biomedicine and Pharmacotherapy",
title = "Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells",
volume = "160",
doi = "10.1016/j.biopha.2023.114316"
}

Božić, D., Živančević, K., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. in Biomedicine and Pharmacotherapy
Elsevier., 160.
https://doi.org/10.1016/j.biopha.2023.114316

Božić D, Živančević K, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. in Biomedicine and Pharmacotherapy. 2023;160.
doi:10.1016/j.biopha.2023.114316 .

Božić, Dragica, Živančević, Katarina, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells" in Biomedicine and Pharmacotherapy, 160 (2023),
https://doi.org/10.1016/j.biopha.2023.114316 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4371
AB  - Environmentally relevant toxic substances may affect human health, provoking numerous harmful effects on central nervous, respiratory, cardiovascular, endocrine and reproductive system, and even cause various types of carcinoma. These substances, to which general population is constantly and simultaneously exposed, enter human body via food and water, but also by inhalation and dermal contact, while accumulating evidence suggests that probiotic cultures are able to efficiently adsorb and/or degrade them. Cell wall of probiotic bacteria/fungi, which contains structures such as exopolysaccharide, teichoic acid, protein and peptidoglycan components, is considered the main place of toxic substances adsorption. Moreover, probiotics are able to induce metabolism and degradation of various toxic substances, making them less toxic and more suitable for elimination. Other probable in vivo protective effects have also been suggested, including decreased intestinal absorption and increased excretion of toxic substances, prevented gut microbial dysbiosis, increase in the intestinal mucus secretion, decreased production of reactive oxygen species, reduction of inflammation, etc. Having all of this in mind, this review aims to summarize the state-of-the-art knowledge regarding the potential protective effects of different probiotic strains against environmentally relevant toxic substances (mycotoxins, polycyclic aromatic hydrocarbons, pesticides, perfluoroalkyl and polyfluoroalkyl substances, phthalates, bisphenol A and toxic metals)
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge
VL  - 172
DO  - 10.1016/j.fct.2022.113582
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Environmentally relevant toxic substances may affect human health, provoking numerous harmful effects on central nervous, respiratory, cardiovascular, endocrine and reproductive system, and even cause various types of carcinoma. These substances, to which general population is constantly and simultaneously exposed, enter human body via food and water, but also by inhalation and dermal contact, while accumulating evidence suggests that probiotic cultures are able to efficiently adsorb and/or degrade them. Cell wall of probiotic bacteria/fungi, which contains structures such as exopolysaccharide, teichoic acid, protein and peptidoglycan components, is considered the main place of toxic substances adsorption. Moreover, probiotics are able to induce metabolism and degradation of various toxic substances, making them less toxic and more suitable for elimination. Other probable in vivo protective effects have also been suggested, including decreased intestinal absorption and increased excretion of toxic substances, prevented gut microbial dysbiosis, increase in the intestinal mucus secretion, decreased production of reactive oxygen species, reduction of inflammation, etc. Having all of this in mind, this review aims to summarize the state-of-the-art knowledge regarding the potential protective effects of different probiotic strains against environmentally relevant toxic substances (mycotoxins, polycyclic aromatic hydrocarbons, pesticides, perfluoroalkyl and polyfluoroalkyl substances, phthalates, bisphenol A and toxic metals)",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge",
volume = "172",
doi = "10.1016/j.fct.2022.113582"
}

Baralić, K., Živančević, K., Božić, D.,& Đukić-Ćosić, D.. (2023). Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge. in Food and Chemical Toxicology
Elsevier Ltd., 172.
https://doi.org/10.1016/j.fct.2022.113582

Baralić K, Živančević K, Božić D, Đukić-Ćosić D. Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge. in Food and Chemical Toxicology. 2023;172.
doi:10.1016/j.fct.2022.113582 .

Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Đukić-Ćosić, Danijela, "Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge" in Food and Chemical Toxicology, 172 (2023),
https://doi.org/10.1016/j.fct.2022.113582 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Pavić, Aleksandar
AU  - Javorac, Dragana
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Radaković, Nataša
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4334
AB  - Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative Toxicogenomics Database (CTD), ShinyGO, ToppCluster and Cytoscape were used for bioinformatic analysis. In vivo subacute study was performed on rats - five groups (n = 6): (1) Control: corn oil, (2) DEHP: 50 mg/kg b.w./day, (3) DBP: 50 mg/kg b.w./day, (4) BPA: 25 mg/kg b.w./day, (5) MIX: DEHP + DBP + BPA. Zebrafish embryos were exposed to the investigated substances in different doses, singularly and combined (binary and ternary mixtures). Liver injury was linked to 75 DEHP, DBP, and BPA genes, mostly connected to inflammation/oxidative stress. In rats, significant alterations in redox status/bioelements and pathohistology were most notable or exclusively present in MIX (probable additive effects). BPA decreased liver area (LA) index in dose-dependent manner. DEHP (< 2 µg/mL) and DBP (≤ 5 µg/mL) reduced LA values, while their higher doses increased LA index. The effect of DBP in binary mixtures led to a lethal outcome at the two highest concentrations, while the hepatotoxicity of DEHP/DBP/BPA mixture was dictated by BPA (confirmed by the benchmark dose analysis).
PB  - Elsevier B.V.
T2  - Journal of Hazardous Materials
T1  - Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A
VL  - 445
DO  - 10.1016/j.jhazmat.2022.130404
ER  - 

@article{
author = "Baralić, Katarina and Pavić, Aleksandar and Javorac, Dragana and Živančević, Katarina and Božić, Dragica and Radaković, Nataša and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative Toxicogenomics Database (CTD), ShinyGO, ToppCluster and Cytoscape were used for bioinformatic analysis. In vivo subacute study was performed on rats - five groups (n = 6): (1) Control: corn oil, (2) DEHP: 50 mg/kg b.w./day, (3) DBP: 50 mg/kg b.w./day, (4) BPA: 25 mg/kg b.w./day, (5) MIX: DEHP + DBP + BPA. Zebrafish embryos were exposed to the investigated substances in different doses, singularly and combined (binary and ternary mixtures). Liver injury was linked to 75 DEHP, DBP, and BPA genes, mostly connected to inflammation/oxidative stress. In rats, significant alterations in redox status/bioelements and pathohistology were most notable or exclusively present in MIX (probable additive effects). BPA decreased liver area (LA) index in dose-dependent manner. DEHP (< 2 µg/mL) and DBP (≤ 5 µg/mL) reduced LA values, while their higher doses increased LA index. The effect of DBP in binary mixtures led to a lethal outcome at the two highest concentrations, while the hepatotoxicity of DEHP/DBP/BPA mixture was dictated by BPA (confirmed by the benchmark dose analysis).",
publisher = "Elsevier B.V.",
journal = "Journal of Hazardous Materials",
title = "Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A",
volume = "445",
doi = "10.1016/j.jhazmat.2022.130404"
}

Baralić, K., Pavić, A., Javorac, D., Živančević, K., Božić, D., Radaković, N., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A. in Journal of Hazardous Materials
Elsevier B.V.., 445.
https://doi.org/10.1016/j.jhazmat.2022.130404

Baralić K, Pavić A, Javorac D, Živančević K, Božić D, Radaković N, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A. in Journal of Hazardous Materials. 2023;445.
doi:10.1016/j.jhazmat.2022.130404 .

Baralić, Katarina, Pavić, Aleksandar, Javorac, Dragana, Živančević, Katarina, Božić, Dragica, Radaković, Nataša, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A" in Journal of Hazardous Materials, 445 (2023),
https://doi.org/10.1016/j.jhazmat.2022.130404 . .

TY  - CONF
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4632
AB  - Alternative form of cancer treatment includes targeting natural compounds such as
sulfur-rich dietary phytochemical sulforaphane (SFN). However, data on SFN safety,
interactions on the protein level and target of SFN in human organism are limited (1). The
aim of this study was to elucidate the target interactions of SFN in human body in order to
rationalize possible side-effects and predict off-targets by using in silico approach. STITCH
database (http://stitch.embl.de) was used to obtain the information about chemical–protein
interactions, while Metascape (https://metascape.org/) highlighted protein-protein
interaction enrichment (PPIE).
SwissTargetPrediction (http://www.swisstargetprediction.ch/) indicated the target
molecule classes of SFN in human. Human genes that had the strongest interaction with SFN
were NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1 and
GSTM1. PPIE analysis singled out fluid shear stress and atherosclerosis, NRF2 pathway and
chemical carcinogenesis - reactive oxygen species (ROS) as the most significant interactions.
The most represented class of SFN targeted molecules in human organism were enzymes
(26.7%). Epidermal growth factor receptor erbB1, macrophage migration inhibitory factor,
nitric oxide synthase (inducible) showed the highest probability target rate. In our previous
study (2), we pointed out that the genome of cancer patients could affect SFN safety. The
current study provides a set of target genes, emphasizes the importance of oxidative stress in
the suggested genetic interactions and predicts classes of target molecules, which should
further be examined.
AB  - Alternativni oblik lečenja raka uključuje upotrebu prirodnih jedinjenja kao što je
fitohemikalija bogata sumporom, sulforafan (SFN). Međutim, podaci o interakcijama SFN na
nivou proteina i ciljnih mesta dejstva SFN u ljudskom organizmu su ograničeni (1). Cilj ove
studije bio je da se ukaže na ciljne interakcije SFN kod ljudi kako bi se racionalizovali mogući
neželjeni efekti i predvidela nova ciljna mesta toksičnosti korišćenjem in silico pristupa.
STITCH baza podataka (http://stitch.embl.de) korišć ena je za dobijanje informacija o
interakcijama između hemikalija i proteina, dok je Metascape (https://metascape.org/)
izdvojio protein-protein interakcije (PPIE).
SwissTargetPrediction (http://vvv.svisstargetprediction.ch/) ukazao je na ciljana
mesta dejstva SFN kod ljudi. Izdvojeni su geni koji kod ljudi imaju najjaču interakciju sa SFN:
NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1, GSTM1.
Ateroskleroza, NRF2 signalni put i hemijska karcinogeneza - reaktivne vrste kiseonika (ROS)
označeni su kao najznačajnije protein-protein interakcije. Najzastupljenija klasa SFN ciljanih
molekula u ljudskom organizmu bili su enzimi (26,7%). Receptor epidermalnog faktora rasta
erbB1, faktor inhibitora migracije makrofaga i sintaza azot oksida (inducibilna) pokazali su
najveć u stopu verovatnoć e ciljnog mesta dejstva. U našoj prethodnoj studiji (2) istakli smo
da bi genom pacijenata obolelih od raka mogao uticati na bezbednost primene SFN. Međutim,
ova studija daje dodatni set ciljnih gena i naglašava važnost oksidativnog stresa u
predloženim interakcijama između gena, kao i predviđenim klasama ciljnih molekula na koje
deluje SFN i koje bi trebalo dalje ispitati.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes
T1  - Predviđanje štetnih efekata sulforafana in silico ispitivanjem njegovog ciljanog dejstva na gene, protein‐protein interakcije i klase molekula
VL  - 72
IS  - 4 suplement
SP  - S591
EP  - S592
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4632
ER  - 

@conference{
author = "Živančević, Katarina and Baralić, Katarina and Božić, Dragica and Javorac, Dragana and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "Alternative form of cancer treatment includes targeting natural compounds such as
sulfur-rich dietary phytochemical sulforaphane (SFN). However, data on SFN safety,
interactions on the protein level and target of SFN in human organism are limited (1). The
aim of this study was to elucidate the target interactions of SFN in human body in order to
rationalize possible side-effects and predict off-targets by using in silico approach. STITCH
database (http://stitch.embl.de) was used to obtain the information about chemical–protein
interactions, while Metascape (https://metascape.org/) highlighted protein-protein
interaction enrichment (PPIE).
SwissTargetPrediction (http://www.swisstargetprediction.ch/) indicated the target
molecule classes of SFN in human. Human genes that had the strongest interaction with SFN
were NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1 and
GSTM1. PPIE analysis singled out fluid shear stress and atherosclerosis, NRF2 pathway and
chemical carcinogenesis - reactive oxygen species (ROS) as the most significant interactions.
The most represented class of SFN targeted molecules in human organism were enzymes
(26.7%). Epidermal growth factor receptor erbB1, macrophage migration inhibitory factor,
nitric oxide synthase (inducible) showed the highest probability target rate. In our previous
study (2), we pointed out that the genome of cancer patients could affect SFN safety. The
current study provides a set of target genes, emphasizes the importance of oxidative stress in
the suggested genetic interactions and predicts classes of target molecules, which should
further be examined., Alternativni oblik lečenja raka uključuje upotrebu prirodnih jedinjenja kao što je
fitohemikalija bogata sumporom, sulforafan (SFN). Međutim, podaci o interakcijama SFN na
nivou proteina i ciljnih mesta dejstva SFN u ljudskom organizmu su ograničeni (1). Cilj ove
studije bio je da se ukaže na ciljne interakcije SFN kod ljudi kako bi se racionalizovali mogući
neželjeni efekti i predvidela nova ciljna mesta toksičnosti korišćenjem in silico pristupa.
STITCH baza podataka (http://stitch.embl.de) korišć ena je za dobijanje informacija o
interakcijama između hemikalija i proteina, dok je Metascape (https://metascape.org/)
izdvojio protein-protein interakcije (PPIE).
SwissTargetPrediction (http://vvv.svisstargetprediction.ch/) ukazao je na ciljana
mesta dejstva SFN kod ljudi. Izdvojeni su geni koji kod ljudi imaju najjaču interakciju sa SFN:
NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1, GSTM1.
Ateroskleroza, NRF2 signalni put i hemijska karcinogeneza - reaktivne vrste kiseonika (ROS)
označeni su kao najznačajnije protein-protein interakcije. Najzastupljenija klasa SFN ciljanih
molekula u ljudskom organizmu bili su enzimi (26,7%). Receptor epidermalnog faktora rasta
erbB1, faktor inhibitora migracije makrofaga i sintaza azot oksida (inducibilna) pokazali su
najveć u stopu verovatnoć e ciljnog mesta dejstva. U našoj prethodnoj studiji (2) istakli smo
da bi genom pacijenata obolelih od raka mogao uticati na bezbednost primene SFN. Međutim,
ova studija daje dodatni set ciljnih gena i naglašava važnost oksidativnog stresa u
predloženim interakcijama između gena, kao i predviđenim klasama ciljnih molekula na koje
deluje SFN i koje bi trebalo dalje ispitati.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes, Predviđanje štetnih efekata sulforafana in silico ispitivanjem njegovog ciljanog dejstva na gene, protein‐protein interakcije i klase molekula",
volume = "72",
number = "4 suplement",
pages = "S591-S592",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4632"
}

Živančević, K., Baralić, K., Božić, D., Javorac, D., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S591-S592.
https://hdl.handle.net/21.15107/rcub_farfar_4632

Živančević K, Baralić K, Božić D, Javorac D, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes. in Arhiv za farmaciju. 2022;72(4 suplement):S591-S592.
https://hdl.handle.net/21.15107/rcub_farfar_4632 .

Živančević, Katarina, Baralić, Katarina, Božić, Dragica, Javorac, Dragana, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S591-S592,
https://hdl.handle.net/21.15107/rcub_farfar_4632 .

TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Bulat, Petar
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4052
AB  - We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening
VL  - 161
DO  - 10.1016/j.fct.2022.112839
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Božić, Dragica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Bulat, Petar and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "We aimed to examine the molecular basis of the positive effect of berberine against environmentally relevant toxic metal-linked Alzheimer’s disease (AD). The Comparative Toxicogenomic Database (CTD) retrieved a set of genes common to lead, cadmium, methylmercury and arsenic linked to AD development and a set of genes through which berberine exerts a therapeutic mode of action in AD. GeneMania prediction server revealed detailed gene interactions, while Metascape highlighted protein-protein interaction enrichment (PPIE). SwissADME evaluated physicochemical properties of berberine. Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Gene network analysis revealed interactions predicted by the server (45.29%) and physical interactions (18.39%) as the most important. Enriched biological processes analysis showed apoptotic signaling pathway, positive regulation of organelle organization and response to oxidative stress as dominant pathways involved in berberine protective effects against toxic metal mixture, while PPIE analysis showed regulation of apoptotic signaling pathway as the main gene ontology process targeted by berberine. Physicochemical properties and pharmacokinetics of berberine are in concordance with its beneficial properties in AD due to the high gastrointestinal absorption and capability to pass the blood-brain barrier.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening",
volume = "161",
doi = "10.1016/j.fct.2022.112839"
}

Živančević, K., Baralić, K., Božić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B., Bulat, P.,& Đukić-Ćosić, D.. (2022). Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. in Food and Chemical Toxicology
Elsevier Ltd., 161.
https://doi.org/10.1016/j.fct.2022.112839

Živančević K, Baralić K, Božić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Bulat P, Đukić-Ćosić D. Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. in Food and Chemical Toxicology. 2022;161.
doi:10.1016/j.fct.2022.112839 .

Živančević, Katarina, Baralić, Katarina, Božić, Dragica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Bulat, Petar, Đukić-Ćosić, Danijela, "Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening" in Food and Chemical Toxicology, 161 (2022),
https://doi.org/10.1016/j.fct.2022.112839 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Jennen, Danyel
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4026
AB  - This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www. disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in 67, 65 and 116 pathways, respectively. Among these, 53 genes/proteins and 42 pathways were common to all three substances. 31 genes/proteins had matching interactions for all three investigated substances, while more than half of these genes/proteins (56.49%) were in co-expression. 7 of the common genes/proteins (6 relevant to humans: CCL2, IL6, LPL, PPARG, SERPINE1, and TNF) were identified in all the investigated obesity comorbidities, while PPARG and LPL were most closely linked to obesity. These genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP, DBP and BPA mixture obesogenic properties. Analysis reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD.
PB  - Tech Science Press
T2  - Biocell
T1  - Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach
VL  - 46
IS  - 2
SP  - 519
EP  - 533
DO  - 10.32604/biocell.2022.018271
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Jennen, Danyel and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www. disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in 67, 65 and 116 pathways, respectively. Among these, 53 genes/proteins and 42 pathways were common to all three substances. 31 genes/proteins had matching interactions for all three investigated substances, while more than half of these genes/proteins (56.49%) were in co-expression. 7 of the common genes/proteins (6 relevant to humans: CCL2, IL6, LPL, PPARG, SERPINE1, and TNF) were identified in all the investigated obesity comorbidities, while PPARG and LPL were most closely linked to obesity. These genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP, DBP and BPA mixture obesogenic properties. Analysis reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD.",
publisher = "Tech Science Press",
journal = "Biocell",
title = "Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach",
volume = "46",
number = "2",
pages = "519-533",
doi = "10.32604/biocell.2022.018271"
}

Baralić, K., Živančević, K., Božić, D., Jennen, D., Buha-Đorđević, A., Antonijević-Miljaković, E.,& Đukić-Ćosić, D.. (2022). Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach. in Biocell
Tech Science Press., 46(2), 519-533.
https://doi.org/10.32604/biocell.2022.018271

Baralić K, Živančević K, Božić D, Jennen D, Buha-Đorđević A, Antonijević-Miljaković E, Đukić-Ćosić D. Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach. in Biocell. 2022;46(2):519-533.
doi:10.32604/biocell.2022.018271 .

Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Jennen, Danyel, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, "Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach" in Biocell, 46, no. 2 (2022):519-533,
https://doi.org/10.32604/biocell.2022.018271 . .

TY  - JOUR
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Zhang, Yi
AU  - Yang, Li
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4018
AB  - Colorectal cancer (CRC) is a significant global health burden that ranks as the third most diagnosed and second most common cause of cancer related deaths worldwide. New therapeutic strategies include chemoprevention and use of molecules which could prevent, suppress or reverse CRC progression such as sulforaphane (SFN). However, evidences about its safety in CRC patients are still lacking. The aim of this in silico investigation was to predict SFN-induced adverse effects in CRC patients by computational analysis. The study showed that 334 genes were consistently dysregulated in CRC (223 downregulated and 111 upregulated), while 38 were recognized as significant and might be used as predictive biomarkers for overall survival and metastasis (TCGA, GEO, R studio). Among them, SFN interacted with 86 genes, out of which 11 were marked as significant (correlate with overall prognosis and metastasis). Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD). Pathway enrichment analysis revealed that SFN stimulated Transcriptional activation of RUNX2, AURKA activation by TPX2, IL-10 signaling, while inhibited Differentiation of White and Brown Adipocyte process, an underlying pathway which inactivation led to obesity (Cytoscape ClueGo + CluePedia, DAVID). Thus, genome signature of CRC patients could serve as important factor when addressing the risk-to-benefit profile of SFN. Patients with colon cancer and increased expression of TIMP1, CCL20, SPP1, AURKA, CEP55, NEK2, SOX9 and CDK1, or downregulation of CRYAB, PLCE1, MMP28, BMP2 and PLAC8 may not be ideal candidates for SFN chemoprevention.
PB  - Elsevier Masson s.r.l.
T2  - Biomedicine and Pharmacotherapy
T1  - Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation
VL  - 146
DO  - 10.1016/j.biopha.2021.112598
ER  - 

@article{
author = "Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Antonijević, Biljana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Zhang, Yi and Yang, Li and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "Colorectal cancer (CRC) is a significant global health burden that ranks as the third most diagnosed and second most common cause of cancer related deaths worldwide. New therapeutic strategies include chemoprevention and use of molecules which could prevent, suppress or reverse CRC progression such as sulforaphane (SFN). However, evidences about its safety in CRC patients are still lacking. The aim of this in silico investigation was to predict SFN-induced adverse effects in CRC patients by computational analysis. The study showed that 334 genes were consistently dysregulated in CRC (223 downregulated and 111 upregulated), while 38 were recognized as significant and might be used as predictive biomarkers for overall survival and metastasis (TCGA, GEO, R studio). Among them, SFN interacted with 86 genes, out of which 11 were marked as significant (correlate with overall prognosis and metastasis). Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD). Pathway enrichment analysis revealed that SFN stimulated Transcriptional activation of RUNX2, AURKA activation by TPX2, IL-10 signaling, while inhibited Differentiation of White and Brown Adipocyte process, an underlying pathway which inactivation led to obesity (Cytoscape ClueGo + CluePedia, DAVID). Thus, genome signature of CRC patients could serve as important factor when addressing the risk-to-benefit profile of SFN. Patients with colon cancer and increased expression of TIMP1, CCL20, SPP1, AURKA, CEP55, NEK2, SOX9 and CDK1, or downregulation of CRYAB, PLCE1, MMP28, BMP2 and PLAC8 may not be ideal candidates for SFN chemoprevention.",
publisher = "Elsevier Masson s.r.l.",
journal = "Biomedicine and Pharmacotherapy",
title = "Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation",
volume = "146",
doi = "10.1016/j.biopha.2021.112598"
}

Božić, D., Baralić, K., Živančević, K., Antonijević-Miljaković, E., Ćurčić, M., Antonijević, B., Buha-Đorđević, A., Bulat, Z., Zhang, Y., Yang, L.,& Đukić-Ćosić, D.. (2022). Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation. in Biomedicine and Pharmacotherapy
Elsevier Masson s.r.l.., 146.
https://doi.org/10.1016/j.biopha.2021.112598

Božić D, Baralić K, Živančević K, Antonijević-Miljaković E, Ćurčić M, Antonijević B, Buha-Đorđević A, Bulat Z, Zhang Y, Yang L, Đukić-Ćosić D. Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation. in Biomedicine and Pharmacotherapy. 2022;146.
doi:10.1016/j.biopha.2021.112598 .

Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Antonijević, Biljana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Zhang, Yi, Yang, Li, Đukić-Ćosić, Danijela, "Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation" in Biomedicine and Pharmacotherapy, 146 (2022),
https://doi.org/10.1016/j.biopha.2021.112598 . .

TY  - CONF
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Tavrić, J
AU  - Plankoš, A
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4350
PB  - Elsevier B.V.
C3  - Toxicology Letters
T1  - Mechanistic studies of sulforaphane induced toxicity: in silico approach
VL  - 368
IS  - Supplement
SP  - S87
EP  - S87
DO  - 10.1016/j.toxlet.2022.07.252
ER  - 

@conference{
author = "Božić, Dragica and Živančević, Katarina and Baralić, Katarina and Tavrić, J and Plankoš, A and Ćurčić, Marijana and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
publisher = "Elsevier B.V.",
journal = "Toxicology Letters",
title = "Mechanistic studies of sulforaphane induced toxicity: in silico approach",
volume = "368",
number = "Supplement",
pages = "S87-S87",
doi = "10.1016/j.toxlet.2022.07.252"
}

Božić, D., Živančević, K., Baralić, K., Tavrić, J., Plankoš, A., Ćurčić, M., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Mechanistic studies of sulforaphane induced toxicity: in silico approach. in Toxicology Letters
Elsevier B.V.., 368(Supplement), S87-S87.
https://doi.org/10.1016/j.toxlet.2022.07.252

Božić D, Živančević K, Baralić K, Tavrić J, Plankoš A, Ćurčić M, Antonijević B, Đukić-Ćosić D. Mechanistic studies of sulforaphane induced toxicity: in silico approach. in Toxicology Letters. 2022;368(Supplement):S87-S87.
doi:10.1016/j.toxlet.2022.07.252 .

Božić, Dragica, Živančević, Katarina, Baralić, Katarina, Tavrić, J, Plankoš, A, Ćurčić, Marijana, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Mechanistic studies of sulforaphane induced toxicity: in silico approach" in Toxicology Letters, 368, no. Supplement (2022):S87-S87,
https://doi.org/10.1016/j.toxlet.2022.07.252 . .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4641
AB  - Sulforaphane (SFN) and Pseudomonas aeruginosa – mannose sensitive hemagglutinin
(PA-MSHA) are known immune modulators with shown anti-tumor characteristics and
ability to inhibit the growth and progression of cancer cells. However, the benefit/risk ratio
of their combinational use is not fully explained and needs further investigation. Thus, this
study aims to understand the potential of the given therapy mixture to induce side/toxic
effects in cancer patients. With the help of in-depth in silico toxicogenomics analysis, we have
previously demonstrated that SFN (1) and PA-MSHA (unpublished data) dysregulated 13
and 64 genes in cancer patients, among which 5 and 16 were repressed, while 8 and 48 were
induced by the given molecule, respectively. A total of 21 downregulated and 56 upregulated
genes were analyzed with computational tools such as ToppGene ToppFun
(https://toppgene.cchmc.org/)
and REACTOME (https://reactome.org/PathwayBrowser/#/) to determine the most
important Gene Ontology terms and molecular pathways influenced by SFN/PA-MSHA
combination. As expected, this therapy approach can lead to dysregulation of cell cycle and
p53 signalling pathway, but also acute kidney failure. On the other hand, the set of SFN/PA-
MSHA upregulated genes were enriched for leukocyte activation, positive regulation of cell
population proliferation, TNF and other cytokines signalling pathways, as well as
inflammatory diseases such as psoriasis, ulcerative colitis, or Crohn disease. Thus, the
combinational treatment of the given immune modulators might have the potential to cause
severe adverse outcomes and should be used with caution in cancer patients with renal
insufficiency or immune diseases.
AB  - Sulforafan (SFN) i Pseudomonas aeruginosa – hemaglutinin osetljiv na manozu (PA-
MSHA) su imunomodulatori koji ispoljavaju antitumorske osobine i mogu da inhibiraju rast i
progresiju ćelija raka. Međutim, odnos korist/rizik njihove kombinovane upotrebe nije u
potpunosti razjašnjen zbog čega je potrebno detaljnije ispitati farmakološko-toksikološki
profil ovakve kombinacije. Stoga, ova studija ima za cilj da razjasni potencijal kombinovane
primene SFN/PA-MSHA da izazove neželjene/toksične efekte kod pacijenata obolelih od
raka. Uz pomoć detaljne in silico tokiskogenomske analize podataka, prethodno smo pokazali
da SFN (1) i PA-MSHA (nepublikovani podaci) utiču na ekspresiju 13 i 64 gena, među kojima
je 5 i 16 inhibirano, dok je 8 i 48 indukovano datim molekulima, redom. Ukupno 21
inaktiviran gen i 56 gena čija je ekspresija stimulisana analizirano je pomoću računarskih
alata kao što su ToppGene ToppFun (https://toppgene.cchmc.org/) i REACTOME
(https://reactome.org/PathvaiBrovser/#/) kako bi bile utvrđene najznačajnije molekularne
funkcije, biološke procese i molekularne puteve na koje utiče kombinacija SFN/PA-MSHA.
Kao što je i očekivano, ovakav terapijski pristup može dovesti do disregulacije ćelijskog
ciklusa i signalnog puta p53, ali i do akutnog zapaljenja bubrega. S druge strane, skup
aktiviranih SFN/PA-MSHA gena je uključen u aktivaciju leukocita, pozitivnu regulaciju
proliferacije ćelija, TNF i druge signalne puteve citokina, ali i inflamatorne bolesti kao što su
psorijaza, ulcerozni kolitis ili Kronova bolest. Stoga, kombinovani tretman ispitivanih
imunomodulatora može imati potencijal da izazove ozbiljne neželjene ishode zbog čega ga
treba sa oprezom koristiti kod pacijenata sa bubrežnom insuficijencijom ili postojećim
imunološkim oboljenjima.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Toxic potential of combined sulforaphane/Pseudomonas aeruginosa mannose sensitive hemagglutinin treatment in cancer patients
T1  - Toksični potencijal kombinovane primene sulforafana i pseudomonas aeruginosa ‐ hemaglutinin osetljiv na manozu kod pacijenata obolelih od raka
VL  - 72
IS  - 4 suplement
SP  - S607
EP  - S608
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4641
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "Sulforaphane (SFN) and Pseudomonas aeruginosa – mannose sensitive hemagglutinin
(PA-MSHA) are known immune modulators with shown anti-tumor characteristics and
ability to inhibit the growth and progression of cancer cells. However, the benefit/risk ratio
of their combinational use is not fully explained and needs further investigation. Thus, this
study aims to understand the potential of the given therapy mixture to induce side/toxic
effects in cancer patients. With the help of in-depth in silico toxicogenomics analysis, we have
previously demonstrated that SFN (1) and PA-MSHA (unpublished data) dysregulated 13
and 64 genes in cancer patients, among which 5 and 16 were repressed, while 8 and 48 were
induced by the given molecule, respectively. A total of 21 downregulated and 56 upregulated
genes were analyzed with computational tools such as ToppGene ToppFun
(https://toppgene.cchmc.org/)
and REACTOME (https://reactome.org/PathwayBrowser/#/) to determine the most
important Gene Ontology terms and molecular pathways influenced by SFN/PA-MSHA
combination. As expected, this therapy approach can lead to dysregulation of cell cycle and
p53 signalling pathway, but also acute kidney failure. On the other hand, the set of SFN/PA-
MSHA upregulated genes were enriched for leukocyte activation, positive regulation of cell
population proliferation, TNF and other cytokines signalling pathways, as well as
inflammatory diseases such as psoriasis, ulcerative colitis, or Crohn disease. Thus, the
combinational treatment of the given immune modulators might have the potential to cause
severe adverse outcomes and should be used with caution in cancer patients with renal
insufficiency or immune diseases., Sulforafan (SFN) i Pseudomonas aeruginosa – hemaglutinin osetljiv na manozu (PA-
MSHA) su imunomodulatori koji ispoljavaju antitumorske osobine i mogu da inhibiraju rast i
progresiju ćelija raka. Međutim, odnos korist/rizik njihove kombinovane upotrebe nije u
potpunosti razjašnjen zbog čega je potrebno detaljnije ispitati farmakološko-toksikološki
profil ovakve kombinacije. Stoga, ova studija ima za cilj da razjasni potencijal kombinovane
primene SFN/PA-MSHA da izazove neželjene/toksične efekte kod pacijenata obolelih od
raka. Uz pomoć detaljne in silico tokiskogenomske analize podataka, prethodno smo pokazali
da SFN (1) i PA-MSHA (nepublikovani podaci) utiču na ekspresiju 13 i 64 gena, među kojima
je 5 i 16 inhibirano, dok je 8 i 48 indukovano datim molekulima, redom. Ukupno 21
inaktiviran gen i 56 gena čija je ekspresija stimulisana analizirano je pomoću računarskih
alata kao što su ToppGene ToppFun (https://toppgene.cchmc.org/) i REACTOME
(https://reactome.org/PathvaiBrovser/#/) kako bi bile utvrđene najznačajnije molekularne
funkcije, biološke procese i molekularne puteve na koje utiče kombinacija SFN/PA-MSHA.
Kao što je i očekivano, ovakav terapijski pristup može dovesti do disregulacije ćelijskog
ciklusa i signalnog puta p53, ali i do akutnog zapaljenja bubrega. S druge strane, skup
aktiviranih SFN/PA-MSHA gena je uključen u aktivaciju leukocita, pozitivnu regulaciju
proliferacije ćelija, TNF i druge signalne puteve citokina, ali i inflamatorne bolesti kao što su
psorijaza, ulcerozni kolitis ili Kronova bolest. Stoga, kombinovani tretman ispitivanih
imunomodulatora može imati potencijal da izazove ozbiljne neželjene ishode zbog čega ga
treba sa oprezom koristiti kod pacijenata sa bubrežnom insuficijencijom ili postojećim
imunološkim oboljenjima.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Toxic potential of combined sulforaphane/Pseudomonas aeruginosa mannose sensitive hemagglutinin treatment in cancer patients, Toksični potencijal kombinovane primene sulforafana i pseudomonas aeruginosa ‐ hemaglutinin osetljiv na manozu kod pacijenata obolelih od raka",
volume = "72",
number = "4 suplement",
pages = "S607-S608",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4641"
}

Božić, D., Baralić, K., Živančević, K.,& Đukić-Ćosić, D.. (2022). Toxic potential of combined sulforaphane/Pseudomonas aeruginosa mannose sensitive hemagglutinin treatment in cancer patients. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S607-S608.
https://hdl.handle.net/21.15107/rcub_farfar_4641

Božić D, Baralić K, Živančević K, Đukić-Ćosić D. Toxic potential of combined sulforaphane/Pseudomonas aeruginosa mannose sensitive hemagglutinin treatment in cancer patients. in Arhiv za farmaciju. 2022;72(4 suplement):S607-S608.
https://hdl.handle.net/21.15107/rcub_farfar_4641 .

Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Đukić-Ćosić, Danijela, "Toxic potential of combined sulforaphane/Pseudomonas aeruginosa mannose sensitive hemagglutinin treatment in cancer patients" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S607-S608,
https://hdl.handle.net/21.15107/rcub_farfar_4641 .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Jorgovanović, Dragica
AU  - Živančević, Katarina
AU  - Javorac, Dragana
AU  - Stojilković, Nikola
AU  - Radović, Biljana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević-Miljaković, Evica
AU  - Antonijević, Biljana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3958
AB  - While experimental animal investigation has historically been the most conventional
approach conducted to assess drug safety and is currently considered the main method for
determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over
the last 20 years, there have been significant advances in computational sciences and computer
data processing, while knowledge of alternative techniques and their application has developed
into a valuable skill in toxicology. Thus, the application of in silico methods in drug safety
assessment is constantly increasing. They are very complex and are grounded on accumulated
knowledge from toxicology, bioinformatics, biochemistry, statistics, mathematics, as well as
molecular biology. This review will summarize current state-of-the-art scientific data on the use
of in silico methods in toxicity testing, taking into account their shortcomings, and highlighting
the strategies that should deliver consistent results, while covering the applications of in silico
methods in preclinical trials and drug impurities toxicity testing.
AB  - Ispitivanja na eksperimentalnim životinjama ne samo da su u prošlosti bila smatrana najkonvencionalnijim pristupom za procenu bezbednosti lekova, već su i trenutno osnovna metoda za utvrđivanje njihove toksičnosti. Međutim, ova ispitivanja su skupa, vremenski zahtevna i za njihovo sprovođenje neophodne su etičke dozvole. Tokom poslednjih 20 godina došlo je do napretka u računarskoj nauci i kompjuterskoj obradi podataka, dok se znanje o alternativnim tehnikama i njihovoj primeni razvilo u dragocenu veštinu u toksikologiji. Stoga, primena in silico metoda u proceni bezbednosti lekova neprestano raste. Ove metode su veoma složene i zasnivaju se na saznanjima iz toksikologije, bioinformatike, biohemije, statistike, matematike i molekularne biologije. Ovaj pregledni rad će rezimirati trenutna naučna saznanja koja se tiču upotrebe in silico metoda u ispitivanju toksičnosti lekova, uzimajući u obzir njihova ograničenja i ističući strategije pomoću kojih se mogu dobiti konzistentni rezultati, sa posebnim osvrtom na primenu in silico metoda u pretkliničkim ispitivanjima i ispitivanjima toksičnosti nečistoća u lekovima.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - In silico toxicology methods in drug safety assessment
T1  - "In silico" metode u toksikologiji za procenu bezbednosti lekova
VL  - 71
IS  - 4
SP  - 257
EP  - 278
DO  - 10.5937/arhfarm71-32966
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Jorgovanović, Dragica and Živančević, Katarina and Javorac, Dragana and Stojilković, Nikola and Radović, Biljana and Marić, Đurđica and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević-Miljaković, Evica and Antonijević, Biljana",
year = "2021",
abstract = "While experimental animal investigation has historically been the most conventional
approach conducted to assess drug safety and is currently considered the main method for
determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over
the last 20 years, there have been significant advances in computational sciences and computer
data processing, while knowledge of alternative techniques and their application has developed
into a valuable skill in toxicology. Thus, the application of in silico methods in drug safety
assessment is constantly increasing. They are very complex and are grounded on accumulated
knowledge from toxicology, bioinformatics, biochemistry, statistics, mathematics, as well as
molecular biology. This review will summarize current state-of-the-art scientific data on the use
of in silico methods in toxicity testing, taking into account their shortcomings, and highlighting
the strategies that should deliver consistent results, while covering the applications of in silico
methods in preclinical trials and drug impurities toxicity testing., Ispitivanja na eksperimentalnim životinjama ne samo da su u prošlosti bila smatrana najkonvencionalnijim pristupom za procenu bezbednosti lekova, već su i trenutno osnovna metoda za utvrđivanje njihove toksičnosti. Međutim, ova ispitivanja su skupa, vremenski zahtevna i za njihovo sprovođenje neophodne su etičke dozvole. Tokom poslednjih 20 godina došlo je do napretka u računarskoj nauci i kompjuterskoj obradi podataka, dok se znanje o alternativnim tehnikama i njihovoj primeni razvilo u dragocenu veštinu u toksikologiji. Stoga, primena in silico metoda u proceni bezbednosti lekova neprestano raste. Ove metode su veoma složene i zasnivaju se na saznanjima iz toksikologije, bioinformatike, biohemije, statistike, matematike i molekularne biologije. Ovaj pregledni rad će rezimirati trenutna naučna saznanja koja se tiču upotrebe in silico metoda u ispitivanju toksičnosti lekova, uzimajući u obzir njihova ograničenja i ističući strategije pomoću kojih se mogu dobiti konzistentni rezultati, sa posebnim osvrtom na primenu in silico metoda u pretkliničkim ispitivanjima i ispitivanjima toksičnosti nečistoća u lekovima.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "In silico toxicology methods in drug safety assessment, "In silico" metode u toksikologiji za procenu bezbednosti lekova",
volume = "71",
number = "4",
pages = "257-278",
doi = "10.5937/arhfarm71-32966"
}

Đukić-Ćosić, D., Baralić, K., Jorgovanović, D., Živančević, K., Javorac, D., Stojilković, N., Radović, B., Marić, Đ., Ćurčić, M., Buha-Đorđević, A., Bulat, Z., Antonijević-Miljaković, E.,& Antonijević, B.. (2021). In silico toxicology methods in drug safety assessment. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(4), 257-278.
https://doi.org/10.5937/arhfarm71-32966

Đukić-Ćosić D, Baralić K, Jorgovanović D, Živančević K, Javorac D, Stojilković N, Radović B, Marić Đ, Ćurčić M, Buha-Đorđević A, Bulat Z, Antonijević-Miljaković E, Antonijević B. In silico toxicology methods in drug safety assessment. in Arhiv za farmaciju. 2021;71(4):257-278.
doi:10.5937/arhfarm71-32966 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Jorgovanović, Dragica, Živančević, Katarina, Javorac, Dragana, Stojilković, Nikola, Radović, Biljana, Marić, Đurđica, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević-Miljaković, Evica, Antonijević, Biljana, "In silico toxicology methods in drug safety assessment" in Arhiv za farmaciju, 71, no. 4 (2021):257-278,
https://doi.org/10.5937/arhfarm71-32966 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Milenković, Milan
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukomanović, Predrag
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3996
AB  - The aim of this study was to explore the mechanisms of bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) mixture-induced asthma development and test probiotic as a potential positive intervention. Comparative Toxicogenomics Database (CTD) and ToppGene Suite were used as the main tools for in silico analysis. In vivo 28-day experiment was conducted on rats - seven groups (n = 6): (1) Control: corn oil, (2) P: probiotic (8.78 * 108 CFU/kg/day); (3) DEHP: 50 mg/kg b.w./day, (4) DBP: 50 mg/kg b.w./day, (5) BPA: 25 mg/kg b.w./day; (6) MIX: DEHP + DBP + BPA; (7) MIX + P. Lungs, thymus and kidneys were extracted and prepared for redox status and essential metals analysis. By conducting additional in vitro experiment, probiotic phthalate and BPA binding ability was explored. There were 24 DEHP, DBP and BPA asthma-related genes, indicating the three most probable mechanisms - apoptosis, inflammation and oxidative stress. In vivo experiment confirmed that significant changes in redox status/essential metal parameters were either prominent, or only present in the MIX group, indicating possible additive effects. In vitro experiment confirmed the ability of the multy-strain probiotic to bind DEHP/DBP/BPA mixture, while probiotic administration ameliorated mixtureinduced changes in rat tissue.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention
VL  - 158
DO  - 10.1016/j.fct.2021.112671
ER  - 

@article{
author = "Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Milenković, Milan and Javorac, Dragana and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukomanović, Predrag and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2021",
abstract = "The aim of this study was to explore the mechanisms of bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) mixture-induced asthma development and test probiotic as a potential positive intervention. Comparative Toxicogenomics Database (CTD) and ToppGene Suite were used as the main tools for in silico analysis. In vivo 28-day experiment was conducted on rats - seven groups (n = 6): (1) Control: corn oil, (2) P: probiotic (8.78 * 108 CFU/kg/day); (3) DEHP: 50 mg/kg b.w./day, (4) DBP: 50 mg/kg b.w./day, (5) BPA: 25 mg/kg b.w./day; (6) MIX: DEHP + DBP + BPA; (7) MIX + P. Lungs, thymus and kidneys were extracted and prepared for redox status and essential metals analysis. By conducting additional in vitro experiment, probiotic phthalate and BPA binding ability was explored. There were 24 DEHP, DBP and BPA asthma-related genes, indicating the three most probable mechanisms - apoptosis, inflammation and oxidative stress. In vivo experiment confirmed that significant changes in redox status/essential metal parameters were either prominent, or only present in the MIX group, indicating possible additive effects. In vitro experiment confirmed the ability of the multy-strain probiotic to bind DEHP/DBP/BPA mixture, while probiotic administration ameliorated mixtureinduced changes in rat tissue.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention",
volume = "158",
doi = "10.1016/j.fct.2021.112671"
}

Baralić, K., Božić, D., Živančević, K., Milenković, M., Javorac, D., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukomanović, P., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2021). Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention. in Food and Chemical Toxicology
Elsevier Ltd., 158.
https://doi.org/10.1016/j.fct.2021.112671

Baralić K, Božić D, Živančević K, Milenković M, Javorac D, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Vukomanović P, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention. in Food and Chemical Toxicology. 2021;158.
doi:10.1016/j.fct.2021.112671 .

Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Milenković, Milan, Javorac, Dragana, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukomanović, Predrag, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention" in Food and Chemical Toxicology, 158 (2021),
https://doi.org/10.1016/j.fct.2021.112671 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Jorgovanović, Dragica
AU  - Bojanin, Dragana
AU  - Radovanović, Jelena
AU  - Gojković, Tamara
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Mandinić, Zoran
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3916
AB  - Linkage between bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA) coexposure and type 2 diabetes mellitus (T2DM), as well as ability of multi-strained probiotic to reduce DEHP, DBP and BPA mixture-induced oxidative damage in rat pancreas were investigated. The Comparative Toxicogenomics Database, Cytoscape software and ToppGene Suite were used for data-mining. Animals were sorted into seven groups (n = 6): (1) Control group: corn oil, (2) P: probiotic: Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus plantarum LP 6595 + Lactobacillus plantarum HEAL9; (3) DEHP: 50 mg/kg b.w./day, (4) DBP: 50 mg/kg b.w./day, (5) BPA: 25 mg/kg b.w./day, and (6) MIX: 50 mg/kg b.w./day DEHP + 50 mg/kg b.w/ day DBP + 25 mg/kg b.w./day BPA; (7) MIX + P. Rats were sacrificed after 28 days of oral exposure. In silico investigation highlighted 44 DEHP, DBP and BPA mutual genes linked to the T2DM, while apoptosis and oxidative stress were highlighted as the main mechanisms of DEHP, DBP and BPA mixture-linked T2DM. In vivo experiment confirmed the presence of significant changes in redox status parameters (TOS, SOD and SH groups) only in the MIX group, indicating possible additive effects, while probiotic ameliorated mixture-induced redox status changes in rat pancreatic tissue.
PB  - Elsevier
T2  - Food and Chemical Toxicology
T1  - Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis
VL  - 154
DO  - 10.1016/j.fct.2021.112325
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Jorgovanović, Dragica and Bojanin, Dragana and Radovanović, Jelena and Gojković, Tamara and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Mandinić, Zoran and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2021",
abstract = "Linkage between bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA) coexposure and type 2 diabetes mellitus (T2DM), as well as ability of multi-strained probiotic to reduce DEHP, DBP and BPA mixture-induced oxidative damage in rat pancreas were investigated. The Comparative Toxicogenomics Database, Cytoscape software and ToppGene Suite were used for data-mining. Animals were sorted into seven groups (n = 6): (1) Control group: corn oil, (2) P: probiotic: Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus plantarum LP 6595 + Lactobacillus plantarum HEAL9; (3) DEHP: 50 mg/kg b.w./day, (4) DBP: 50 mg/kg b.w./day, (5) BPA: 25 mg/kg b.w./day, and (6) MIX: 50 mg/kg b.w./day DEHP + 50 mg/kg b.w/ day DBP + 25 mg/kg b.w./day BPA; (7) MIX + P. Rats were sacrificed after 28 days of oral exposure. In silico investigation highlighted 44 DEHP, DBP and BPA mutual genes linked to the T2DM, while apoptosis and oxidative stress were highlighted as the main mechanisms of DEHP, DBP and BPA mixture-linked T2DM. In vivo experiment confirmed the presence of significant changes in redox status parameters (TOS, SOD and SH groups) only in the MIX group, indicating possible additive effects, while probiotic ameliorated mixture-induced redox status changes in rat pancreatic tissue.",
publisher = "Elsevier",
journal = "Food and Chemical Toxicology",
title = "Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis",
volume = "154",
doi = "10.1016/j.fct.2021.112325"
}

Baralić, K., Živančević, K., Jorgovanović, D., Bojanin, D., Radovanović, J., Gojković, T., Buha-Đorđević, A., Ćurčić, M., Mandinić, Z., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2021). Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis. in Food and Chemical Toxicology
Elsevier., 154.
https://doi.org/10.1016/j.fct.2021.112325

Baralić K, Živančević K, Jorgovanović D, Bojanin D, Radovanović J, Gojković T, Buha-Đorđević A, Ćurčić M, Mandinić Z, Bulat Z, Antonijević B, Đukić-Ćosić D. Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis. in Food and Chemical Toxicology. 2021;154.
doi:10.1016/j.fct.2021.112325 .

Baralić, Katarina, Živančević, Katarina, Jorgovanović, Dragica, Bojanin, Dragana, Radovanović, Jelena, Gojković, Tamara, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Mandinić, Zoran, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis" in Food and Chemical Toxicology, 154 (2021),
https://doi.org/10.1016/j.fct.2021.112325 . .

TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Jorgovanović, Dragica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3780
AB  - This in silico toxicogenomic analysis aims to: (i) testify the hypothesis about the influence of the environmentally
relevant toxic metals (lead, methylmercury (organic form of mercury), cadmium and arsenic) on molecular
mechanisms involved in amyotrophic lateral sclerosis (ALS), Parkinson’s Disease (PD) and Alzheimer’s disease
(AD) development; and (ii) demonstrate the capability of in silico toxicogenomic data-mining for distinguishing
the probable mechanisms of mixture-induced toxic effects. The Comparative Toxicogenomics Database (CTD;
http://ctd. mdibl.org) and Cytoscape software were used as the main data-mining tools in this analysis. The
results have shown that there were 7, 13 and 14 common genes for all the metals present in the mixture for each
of the selected neurodegenerative disease (ND), respectively: ALS, PD and AD. Physical interactions (68.18%)
were the most prominent interactions between the genes extracted for ALS, co-expression (60.85%) for PD and
interactions predicted by the server (44.30%) for AD. SOD2 gene was noted as the mutual gene for all the
selected ND. Oxidative stress, folate metabolism, vitamin B12, AGE-RAGE, apoptosis were noted as the key
disrupted molecular pathways that contribute to the neurodegenerative disease’s development. Gene ontology
analysis revealed biological processes affected by the investigated mixture (glutathione metabolic process was
listed as the most important for ALS, cellular response to toxic substance for PD, and neuron death for AD). Our
results emphasize the role of oxidative stress, particularly SOD2, in neurodegeneration triggered by environmental toxic metal mixture and give a new insight into common molecular mechanisms involved in ALS, PD and
AD pathology.
PB  - Elsevier
T2  - Environmental Research
T1  - Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining
VL  - 194
DO  - 10.1016/j.envres.2021.110727
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Jorgovanović, Dragica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Antonijević, Biljana and Bulat, Zorica",
year = "2021",
abstract = "This in silico toxicogenomic analysis aims to: (i) testify the hypothesis about the influence of the environmentally
relevant toxic metals (lead, methylmercury (organic form of mercury), cadmium and arsenic) on molecular
mechanisms involved in amyotrophic lateral sclerosis (ALS), Parkinson’s Disease (PD) and Alzheimer’s disease
(AD) development; and (ii) demonstrate the capability of in silico toxicogenomic data-mining for distinguishing
the probable mechanisms of mixture-induced toxic effects. The Comparative Toxicogenomics Database (CTD;
http://ctd. mdibl.org) and Cytoscape software were used as the main data-mining tools in this analysis. The
results have shown that there were 7, 13 and 14 common genes for all the metals present in the mixture for each
of the selected neurodegenerative disease (ND), respectively: ALS, PD and AD. Physical interactions (68.18%)
were the most prominent interactions between the genes extracted for ALS, co-expression (60.85%) for PD and
interactions predicted by the server (44.30%) for AD. SOD2 gene was noted as the mutual gene for all the
selected ND. Oxidative stress, folate metabolism, vitamin B12, AGE-RAGE, apoptosis were noted as the key
disrupted molecular pathways that contribute to the neurodegenerative disease’s development. Gene ontology
analysis revealed biological processes affected by the investigated mixture (glutathione metabolic process was
listed as the most important for ALS, cellular response to toxic substance for PD, and neuron death for AD). Our
results emphasize the role of oxidative stress, particularly SOD2, in neurodegeneration triggered by environmental toxic metal mixture and give a new insight into common molecular mechanisms involved in ALS, PD and
AD pathology.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining",
volume = "194",
doi = "10.1016/j.envres.2021.110727"
}

Živančević, K., Baralić, K., Jorgovanović, D., Buha-Đorđević, A., Ćurčić, M., Antonijević-Miljaković, E., Antonijević, B.,& Bulat, Z.. (2021). Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining. in Environmental Research
Elsevier., 194.
https://doi.org/10.1016/j.envres.2021.110727

Živančević K, Baralić K, Jorgovanović D, Buha-Đorđević A, Ćurčić M, Antonijević-Miljaković E, Antonijević B, Bulat Z. Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining. in Environmental Research. 2021;194.
doi:10.1016/j.envres.2021.110727 .

Živančević, Katarina, Baralić, Katarina, Jorgovanović, Dragica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Antonijević, Biljana, Bulat, Zorica, "Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining" in Environmental Research, 194 (2021),
https://doi.org/10.1016/j.envres.2021.110727 . .